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Method for determining the position of landslide slip-surface with a typical inclinometric curves

Journal of Mountain Science 2024年第2期21卷 413-432页

作者： chen hao WU Hong-gang Ocean College Zhejiang UniversityZhoushan 316000China China Northwest Research Institute Co.Ltd.of CREC Lanzhou 730070China

In the actual monitoring of deep hole displacement,the identification of slip surfaces is primarily based on abrupt changes observed in the inclinometric *** conventional identification methods,inclinometric curves exhibiting indications of sliding can be categorized into three types:B-type,D-type,and *** position of the slip surface is typically determined by identifying the depth corresponding to the point of maximum displacement ***,this method is sensitive to the interval of measurement points and the observation scale of the coordinate axes and suffers from unclear sliding surfaces and uncertain *** on the variation characteristics of these diagonal curves,we classified the landslide into three components:the sliding body,the sliding interval,and the immobile ***,three different generalization models were established to analyze the relationships between the curve form and the slip surface location based on different physical indicators such as displacement rate,relative displacement,and *** results show that the displacement rate curves of an r-type slope exhibit a clustering feature in the sliding interval,and by solving for the depth of discrete points within the step phase,it is possible to determine the location of the slip *** the other hand,D-type slopes have inflection points in the relative displacement curve located at the slip *** acceleration curves of B-type slopes exhibit clustering characteristics during the sliding interval,while the scattered acceleration data demonstrate wandering ***,the slip surface location can be revealed by solving the depth corresponding to the maximum acceleration with cubic spline *** approach proposed in this paper was applied to the monitoring data of a landslide in Yunnan Province,*** results indicate that our approach can accurately identify the slip surface location and enable computability of its po

关键词： Inclinometric curve Slip-surface position Displacement rate Relative displacement Acceleration

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Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies

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Chinese Journal of Natural Medicines 2024年第8期22卷 724-745页

作者： chen hao ZHOU Yang hao Haiping XIONG Jing Department of Pharmacology School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China

Non-alcoholic fatty liver disease(NAFLD)has become a leading cause of chronic liver disease *** initiates with simple steatosis(NAFL)and can progress to the more severe condition of non-alcoholic steatohepatitis(NASH).NASH often advances to end-stage liver diseases such as liver fibrosis,cirrhosis,and hepatocellular carcinoma(HCC).Notably,the transition from NASH to end-stage liver diseases is irreversible,and the precise mechanisms driving this progression are not yet fully ***,there is a critical need for the development of effective therapies to arrest or reverse this *** review provides a comprehensive overview of the pathogenesis of NASH,examines the current therapeutic targets and pharmacological treatments,and offers insights for future drug discovery and development strategies for NASH therapy.

关键词： Metabolic dysfunction Drug development Bile acids Liver-gut axis Inflammation Fibrosis

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Coexistence of All-Order Topological States in a Three-Dimensional Phononic Topological Crystalline Insulator

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Research 2024年第2期2023卷 511-518页

作者： Hua-Shan Lai hao chen Chu-hao Xia Si-Yuan Yu cheng He Yan-Feng chen National Laboratory of Solid State Microstructures&Department of Materials Science and Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjng 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-dimensional phononic topological crystalline insulator that simultaneously exhibits a whole family of first-order quadratic surface,second-order hinge,and third-order corner states within the same *** a topological crystalline insulator hosting all-order phases originates from the different topological nature when hierarchically projected onto different facets and lower dimensions,thus free from trivial cladding *** work offers an ideal platform for either robust wave propagation or localization in on-demand dimensions and may facilitate dimension division multiplexing technology.

关键词： topological dimensions crystalline

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Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions

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Science China Chemistry 2024年第9期67卷 3039-3049页

作者： Xiao Xu Wenqi Xie Ting Wu chen chen Xiaoning chen Yuheng Yang hao Lian hao chen Xiaofeng cheng Zhitong chen Guojun chen Chaoqun Liu Lanlan chen Yu He Zhaowei chen Bernard P.Binks Huanghao Yang New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhou 350002China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Biomedical Engineering and the Rosalind&Morris Goodman Cancer Research Institute McGill UniversityMontreal QC H3A 1A3Canada School of Pharmacy Henan UniversityKaifeng 475004China Department of Chemistry University of HullHull HU67RXUK

Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global ***,traditional disposal strategies have limitations,including high energy consumption,use of aggressive reagents and generation of toxic ***,inspired by the compartmentalized architecture and detoxification mechanism of bacterial microcompartments,we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant(2-chloroethyl ethyl sulfide,CEES)under sweet *** exemplified droplet systems were developed with two-enzyme(glucose oxidase/chloroperoxidase)and threeenzyme(invertase/glucose oxidase/chloroperoxidase)cascades,both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and>99% selectivity towards non-toxic *** found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination *** importantly,the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles,following long-term storage and in far-field locations.

关键词： Pickering emulsion biomimetics chemical warfare agent bacterial microcompartment biocatalysis

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Analysis of multiple-faults of high-voltage circuit breakers based on non-negative matrix decomposition

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Global Energy Interconnection 2024年第2期7卷 179-189页

作者： Yongrong Zhou Zhaoxing Ma hao chen Ruihua Wang State Key Laboratory of Technology and Equipment for Defense against Power System Operational Risks Nanjing 211106P.R.China Nari Group Co. Ltd.Nanjing 211106P.R.China Qingdao University of Technology School of Information and Control EngineeringQingdao 266520P.R.China State Grid Nanjing Power Supply Company Nanjing 211000P.R.China

High-voltage circuit breakers are the core equipment in power networks,and to a certain extent,are related to the safe and reliable operation of power ***,their core components are prone to mechanical *** study proposes a component separation method to detect multiple mechanical faults in circuit breakers that can achieve online real-time ***,a model and strategy are presented for obtaining mechanical voiceprint signals from circuit ***,the component separation method was used to decompose the voiceprint signals of multiple faults into individual component *** on this,the recognition of the features of a single-fault voiceprint signal can be ***,multiple faults in high-voltage circuit breakers were identified through an experimental simulation and verification of the circuit breaker voiceprint signals collected from the substation *** research results indicate that the proposed method exhibits excellent performance for multiple mechanical faults,such as spring structures and loose internal components of circuit *** addition,it provides a reference method for the real-time online monitoring of high-voltage circuit breakers.

关键词： High voltage circuit breaker Signal separation Monitor Multiple faults Power system

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Distributed Economic MPC for Synergetic Regulation of the Voltage of an Island DC Micro-Grid

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 734-745页

作者： Yi Zheng Yanye Wang Xun Meng Shaoyuan Li hao chen IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China Haixi Institutes Chinese Academy of SciencesJinjiang 362216China

In this paper,distributed model predictive control(DMPC) for island DC micro-grids(MG) with wind/photovoltaic(PV)/battery power is proposed,which coordinates all distributed generations(DG) to stabilize the bus voltage together with the insurance of having computational efficiency under a real-time *** on the feedback of the bus voltage,the deviation of the current is dispatched to each DG according to cost over the prediction ***,to avoid the excessive fluctuation of the battery power,both the discharge-charge switching times and costs are considered in the model predictive control(MPC) optimization problems.A Lyapunov constraint with a time-varying steady-state is designed in each local MPC to guarantee the stabilization of the entire *** voltage stabilization of the MG is achieved by this strategy with the cooperation of *** numeric results of applying the proposed method to a MG of the Shanghai Power Supply Company shows the effectiveness of the distributed economic MPC.

关键词： Distributed model predictive control(DMPC) Lyapunovbased model predictive control micro-grid(MG) voltage control

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A New Random Sampling Method and Its Application in Improving Progressive BKZ Algorithm

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Journal of Systems Science & Complexity 2024年第5期37卷 2262-2292页

作者： SUN Minghao WANG Shixiong chen hao QU Longjiang College of Sciences National University of Defense Technology Academy of Military Sciences College of Information Science and Technology/Cyber Security Jinan University

Random sampling algorithm was proposed firstly by Schnorr in 2003 to find short lattice vectors, as an alternative to enumeration. The follow-up developments in random sampling were mainly proposed by Fukase and Kashiwabara in 2015 and Aono and Nguyen in 2017. Although they extended the sampling space compared to Schnorr's work through the natural number representation, they did not show how to sample specifically in practice and what vectors should be sampled, in order to find short enough lattice vectors. In this paper, the authors firstly introduce a practical random sampling algorithm under some reasonable assumptions which can find short enough lattice vectors ***, as an application of this new random sampling algorithm, the authors show that it can improve the performance of progressive BKZ algorithm in practice. Finally, the authors solve the Darmstadt's Lattice Challenge and get a series of new records in the dimension from 500 to 825, using the improved progressive BKZ algorithm.

关键词： Darmstadt’s lattice challenge lattice lattice reduction algorithm post-quantum cryptography random sampling

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A target parameter estimation method via atom-reconstruction in radar mainlobe jamming

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Journal of Systems Engineering and Electronics 2024年第2期35卷 350-360页

作者： ZHOU Bilei LIU Weijian LI Rongfeng chen Hui ZHANG Liang DU Qinglei LI Binbin chen hao Air Force Early Warning Academy Wuhan 430019China Aerospace Nanhu Electronic Information Technology Co. Ltd.Jingzhou 434000China

Mainlobe jamming(MLJ)brings a big challenge for radar target detection,tracking,and *** suppression of MLJ is a hard task and an open problem in the electronic counter-counter measures(ECCM)*** parameters and target direction estimation is difficult in radar MLJ.A target parameter estimation method via atom-reconstruction in radar MLJ is proposed in this *** proposed method can suppress the MLJ and simultaneously provide high estimation accuracy of target range and ***,the eigen-projection matrix processing(EMP)algorithm is adopted to suppress the MLJ,and the target range is estimated effectively through the beamforming and pulse *** the target angle can be effectively estimated by the atom-reconstruction *** any prior knowledge,the MLJ can be canceled,and the angle estimation accuracy is well ***,the proposed method does not have strict requirement for radar array construction,and it can be applied for linear array and planar ***,the proposed method can effectively estimate the target azimuth and elevation simultaneously when the target azimuth(or elevation)equals to the jamming azimuth(or elevation),because the MLJ is suppressed in spatial plane dimension.

关键词： mainlobe jamming anti-jamming atom-reconstruction radar

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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： hao chen Xianzhe Tang Yueye Huang chen chen Yuheng Yang Chaojie hao Wenqi Xie Tingjing Huang Xiaofeng cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei chen Zhitong chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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A novel algorithm for evaluating cement azimuthal density based on perturbation theory in horizontal well

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Petroleum Science 2024年第1期21卷 244-251页

作者： Ji-Lin Fan Feng Zhang Qian chen hao-chen Song Lu-Yu Zhong Yue-Xiang Dai National Key Laboratory of Deep Oil and Gas School of GeosciencesChina University of Petroleum(East China)Qingdao 266580ShandongChina China National Logging Corporation Xi'an 710076ShaanxiChina Sinopec Matrix Corporation Qingdao 266001ShandongChina

Cement density monitoring plays a vital role in evaluating the quality of cementing projects,which is of great significance to the development of oil and ***,the presence of inhomogeneous cement distribution and casing eccentricity in horizontal wells often complicates the accurate evaluation of cement azimuthal *** this regard,this paper proposes an algorithm to calculate the cement azimuthal density in horizontal wells using a multi-detector gamma-ray detection *** spatial dynamic response functions are simulated to obtain the influence of cement density on gamma-ray counts by the perturbation theory,and the contribution of cement density in six sectors to the gamma-ray recorded by different detectors is obtained by integrating the spatial dynamic response *** with the relationship between gamma-ray counts and cement density,a multi-parameter calculation equation system is established,and the regularized Newton iteration method is employed to invert casing eccentricity and cement azimuthal *** approach ensures the stability of the inversion process while simultaneously achieving an accuracy of 0.05 g/cm^(3) for the cement azimuthal *** accuracy level is ten times higher compared to density accuracy calculated using calibration ***,this algorithm enhances the accuracy of cement azimuthal density evaluation,provides valuable technical support for the monitoring of cement azimuthal density in the oil and gas industry.

关键词： Cement azimuthal density Perturbation theory Casing eccentricity Spatial dynamic response function Regularized Newton iteration

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