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Thermodynamic behavior of D-sphingosine/cholesterol monolayers and the topography observed by AFM

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Science China Chemistry 2009年第2期52卷 219-225页

作者： hao changchun SUN RunGuang ZHANG Jing CHANG YiGuang NIU ChunLing College of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China College of Food Engineering and Nutritional Science Shaanxi Normal UniversityXi’an 710062China

Lipid rafts are of a dynamic microdomain structure found in recent years, enriched in sphingolipids, cholesterol and particular proteins. The change of structure and function of lipid rafts could result in many diseases. In this work, the monolayer behavior of mixed systems of D-sphingosine with cholesterol was investigated in terms of the mean surface area per molecule (A m), excess molecular area (ΔA ex), surface excess Gibbs energy (ΔG ex), interaction parameter (ω), activity coefficients (f 1 and f 2) as well as elasticity (C s ?1) of formed films. The deposited Langmuir-Blodgett (LB) monolayers were investigated with atomic force microscopy (AFM). Thermodynamic analysis indicates ΔA ex and ΔG ex in the binary systems with negative deviations from the ideal behavior, suggesting attractive interaction between molecules. The stability, elasticity and activity coefficients show a marked dependence on the mole faction of D-sphingosine. The results of observation by AFM show that the single D-sphingosine molecular film took on small granule structure. When mixing the D-sphingosine and cholesterol at different ratios, the mixed films transform from the chains structure to larger slice and net coexisting structure with the increasing of the cholesterol content. In the end, pure cholesterol forms more aggregated structure. AFM experiments effectively support the above findings and interpretation.

关键词： monolayers excess Gibbs energy activity coefficients elastic modulus atomic force microscopy

Influence of Metal Cations and Cholesterol on Lipid-amphotericin Membrane

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Chemical Research in Chinese Universities 2017年第3期33卷 447-453页

作者： WANG Juan SUN Runguang hao changchun LI Tuo TIAN Yuan ZHANG Lei Engineering Technology Research Center of Controllable Neutron Source and Its Application Department of Applied Statistics and Science Xijing University Xi 'an 710123 P. R. China Laboratory of Biophysics and Biomedicine College of Physics and Information Technology Shaanxi Normal University Xi'an 710119 P. R. China

Amphotericin B（AmB） has been widely used in antifungal therapy. AraB molecules combine with cholesterol to form pores that can be toxic to human cells, thus greatly limiting its clinical application. The interaction between Arab and the cell membrane may be influenced by potassimn, sodium and calcium ions. Lq this study, the bilayer in large unilamellar lipid-drug liposomes with or without cholesterol was employed as a model membrane. N-（7-Nitrobenz-2-oxa-1,3-diazol-4-yl）-1,2-dipalmitoyl-sn-glycero-3-phosphoetheanolamine（N-BD-PE） and 1-palmi-toyl-2-[6（7-nitrobenz-2-oxa-1,3-diazol-4-yl）aminodoclecanoyl]-sn-glysero-3-phosphocholine（6-NBD-PC） are two kinds of fluorescent lipid probes, and the NBD group is attached to the polar lipid headgroup in the former, but to the sn-2 fatty acyl chain in the latter. The effect of these metal cations on the lipid-drug membrane was monitored by red edge excitation shift（REES）, fluorescence polarization, and the fluorescence lifetime of lipid probes in hydrophilic and hydrophobic areas of the membrane. These ions have different effects on the lipid-AraB membrane. Cholesterol can strengthen the packing ability of the membrane, which is influenced differently by potassium, sodium and calcium ions. Moreover, the influence of these ions on the membrane may be relative to the method of ion transportation through the membrane. This study is significant to understand the reduction of AraB＇s cellular toxicity.

关键词： Amphotericin B NBD-labeled lipid Red edge excitation shift Metal cation Fluorescence polarization

Study the Photoelectric Overall Technology by Using System Optimization Idea

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Systems Science and Systems Engineering 2000年第3期10卷 380-385页

作者： JIANG Hui\|lin,\ YANG Hua\|min,\ XI hao changchun Institute of Optics and Fine Mechanics, changchun 130022, China

In this paper, we try to study the photoelectric overall technology by using system optimization idea. The evaluation indices of photoelectric system′s overall performance are clarified, and then the problems of syst... 详细信息

关键词： photoelectric overall technology system optimization

DMPC and DMPS mediating the interaction of Ag nanoparticles-based DNA material in models for cellular membranes

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DMPC and DMPS mediating the interaction of Ag nanoparticles-...

BjuIR:A multi-omics database with various tools for accelerating functional genomics research in Brassica juncea

中国化学会第十七届全国胶体与界面化学学术会议

作者： Hongjin Qu changchun hao Runguang Sun School of Physics and Information Technology Shaanxi Normal University

Developing metal nanoparticles-based biological materials has emerged a broad prospect. In this paper, sliver nanoparticle modified by Polyallyl Amine Hydrochloride（PAH） combined with deoxyribonucleic acid（DNA） via electrostatic attraction formed AgNPs-DNA nanocomposites. By using Langmuir technology, adsorption behavior of AgNPs-DNA on 1, 2-dimyristoyl-sn-glycero-3-phosphocholine（DMPC） and 1, 2-dimyristoyl-sn-glycero-3--phospho-L-serine（DMPS） mixed lipid monolayers has been investigated. It was found that AgNPs-DNA nanocomposites showed a great adsorptivity on lipid films. Excess mean area and thermodynamic analysis of excess Gibbs energy demonstrated that AgNPs-DNA enlarged the interval between DMPC and DMPS molecules, whose phenomena might be the electrostatic repulsion between AgNPs-DNA molecules. Finally, morphology of interface observed by Atomic Force Microscope（AFM） was agreement with the experimental results above. Taken together, this paper reported a new type of nanocomposites and interaction with two typical lipids in cell membranes. This work might provide a novel idea and useful theoretical basis for the development of metal nanoparticles-based biological materials.

关键词： AgNPs DNA Lipid monolayers AFM

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Plant Communications 2024年第8期5卷 96-99页

作者： Linna Zhang Jinyuan Xiao Congyuan Liang Yifan Chen changchun Yu Xinle Zhao Jiawei Li Mingli Yan Qian Yang hao Chen Zhongsong Liu Zhengjie Wan Zhiquan Yang Qing-Yong Yang National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of InformaticsHuazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics and Hubei Engineering Technology Research Center of Agricultural Big Data College of InformaticsHuazhong Agricultural UniversityWuhan 430070China National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Yazhouwan National Laboratory Sanya 572025China National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Crop Research Institute Hunan Academy of Agricultural SciencesChangsha 410125China College of Agronomy Hunan Agricultural UniversityChangsha 410128China

Dear Editor,Advances in high-throughput omics technologies,along with methodologies for integrating multi-omics datasets,have substantially enhanced the efficiency of identifying candidate genes in breeding(Gusev et al.,2018;Gupta et al.,2019).However,this process is often complex and *** address this challenge,databases that integrate extensive data and enable convenient and efficient functional genomics studies are being developed(Ma et al.,2021;Yang et al.,2023).

关键词： functional integrating convenient

Enhancing SAEAs with unevaluated solutions:a case study of relation model for expensive optimization

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Science China(Information Sciences) 2024年第2期67卷 41-58页

作者： hao hao Xiaoqun ZHANG Aimin ZHOU Institute of Natural Sciences Shanghai Jiao Tong University Shanghai Frontiers Science Center of Molecule Intelligent Syntheses School of Computer Science and Technology East China Normal University

Surrogate-assisted evolutionary algorithms(SAEAs) hold significant importance in resolving expensive optimization problems. Extensive efforts have been devoted to improving the efficiency of SAEAs through the development of proficient model-assisted solution selection methods, which, however, first requires generating high-quality solutions. The fundamental paradigm of evaluating a limited number of solutions in each generation within SAEAs reduces the variance of adjacent populations, thereby affecting the quality of offspring solutions. This is a frequently encountered issue yet receives little attention. To address the issue, this paper presents a framework using unevaluated solutions to enhance the efficiency of *** surrogate model is employed to identify high-quality solutions for the direct generation of new solutions without evaluation. To ensure dependable selection, we have introduced two tailored relation models to select the optimal solution and the unevaluated population. A comprehensive experimental analysis is performed on two test suites, which showcases the superiority of the relation model over regression and classification models in the solution selection phase. Furthermore, the surrogate-selected unevaluated solutions with high potential have been shown to enhance the efficiency of the algorithm significantly.

关键词： expensive optimization unevaluated solutions relation model surrogate-assisted evolutionary algorithm

CMOS APS Imaging System Application in Star Tracker

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CMOS APS Imaging System Application in Star Tracker

A Global Optimality Principle for Fully Coupled Mean-field Control Systems

Photonics Asia 2004;Sensors and Imaging

作者： Jie Li a,b Jinguo Liu a Xuekui Li a Yaxia liu a Zhihang hao a a.changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,changchun 130033,China b.Electronic Informational Engineering College,changchun University,changchun 130022

Small satellites are capable of performing space explore missions that require accurate attitude determination and control. However, low weight, size, power and cost requirements limit the types of at

关键词： CMOS APS,star tracker,noise model analysis,accuracy analysis

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 379-413页

作者： Tao hao School of Statistics and Mathematics Shandong University of Finance and EconomicsJinan 250014China

This paper concerns a global optimality principle for fully coupled mean-field control *** the first-order and the second-order variational equations are fully coupled mean-field linear FBSDEs. A new linear relation is introduced, with which we successfully decouple the fully coupled first-order variational equations. We give a new second-order expansion of Y^(ε) that can work well in mean-field framework. Based on this result, the stochastic maximum principle is proved. The comparison with the stochastic maximum principle for controlled mean-field stochastic differential equations is supplied.

关键词： optimal control global maximum principle fully coupled general mean-field FBSDE adjoint equation recursive utility

Nonclassical correlations in two-dimensional graphene lattices

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Communications in Theoretical Physics 2024年第4期76卷 72-79页

作者： hao Wang Shanghai Normal University Tianhua College ShangHai 201815China

We investigate nonclassical correlations via negativity,local quantum uncertainty(LQU)and local quantum Fisher information(LQFI)for two-dimensional graphene *** explicitly analytical expressions for negativity,LQU and LQFI are *** close forms of LQU and LQFI confirm the inequality between the quantum Fisher information and skew information,where the LQFI is always greater than or equal to the LQU,and both show very similar behavior with different ***,the effects of the different system parameters on the quantified quantum correlation are *** LQFI reveals more nonclassical correlations than LQU in a two-dimensional graphene lattice system.

关键词： negativity local quantum uncertainty(LQU) local quantum Fisher information(LQFI) graphene lattices nonclassical correlations