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Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN

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International Journal of Oral Science 2022年第4期14卷 470-478页

作者： Weilian Liang yang Chen hanzhe Liu Hui Zhao Tingting Luo Hokeung Tang Xiaocheng Zhou Erhui Jiang Zhe Shao Ke Liu Zhengjun Shang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory for Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Shenzhen PKU-HKUST Medical Center(Peking University Shenzhen Hospital) ShenzhenChina Department of Oral and Maxillofacial Surgery School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Oral and Maxillofacial-Head and Neck oncology School&Hospital of StomatologyWuhan UniversityWuhanChina

Tumor volume increases continuously in the advanced stage, and aside from the self-renewal of tumor cells, whether the oncogenic transformation of surrounding normal cells is involved in this process is currently unclear. Here, we show that oral squamous cell carcinoma(OSCC)-derived small extracellular vesicles(s EVs) promote the proliferation, migration, invasion, and epithelial-mesenchymal transition(EMT) of normal epithelial cells but delay their apoptosis. In addition, nuclear-cytoplasmic invaginations and multiple nucleoli are observed in s EV-treated normal cells, both of which are typical characteristics of premalignant lesions of OSCC. Mechanistically, mi Rlet-7c in OSCC-derived s EVs is transferred to normal epithelial cells, leading to the transcriptional inhibition of p53 and inactivation of the p53/PTEN pathway. In summary, we demonstrate that OSCC-derived s EVs promote the precancerous transformation of normal epithelial cells, in which the mi R-let-7c/p53/PTEN pathway plays an important role. Our findings reveal that cancer cells can corrupt normal epithelial cells through s EVs, which provides new insight into the progression of OSCC.

关键词： cor invasion transferred

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A Novel Single-Phase Five-Level Transformer-less Photovoltaic (PV) Inverter

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CES Transactions on Electrical Machines and Systems 2020年第4期4卷 329-338页

作者： Xiaonan Zhu Hongliang Wang Wenyuan Zhang hanzhe Wang Xiaojun Deng Xiumei Yue College of Electrical and Information Engineering Hunan UniversityChangsha 410082China

Multilevel inverters are preferred solutions for photovoltaic(PV)applications because of lower total harmonic distortion(THD),lower switching stress and lower electromagnetic interference(EMI).In order to reduce the leakage current in the single-phase low-power PV inverters,a five-level transformer-less inverter is proposed in this paper.A total of eleven switches are required,while six of them only withstand a quarter of the dc-bus voltage,so the costs for them are *** four switches are turned on or off at the power line cycle,the switching losses for them are *** addition,the flying-capacitors(FCs)voltages are only a quarter of the dc-bus voltage,and they are balanced at the switching frequency,which further reduces the system *** experimental results based on a 1 kW prototype show that the proposed modulation strategy can balance the FCs voltages at Vdc/4 very *** the leakage current can be reduced to about 27 mA under both active and reactive operations,which satisfies the VDE 0126-1-1 standard.

关键词： Leakage current multilevel inverter pulse width modulation

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PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment

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Virologica Sinica 2024年第2期39卷 235-250页

作者： Qiang Zhang hanzhe Ye Cong Liu Haiwu Zhou Mingbin He Xiaodong Liang Yu Zhou Kun Wang Yali Qin Zhifei Li Mingzhou Chen State Key Laboratory of Virology and Modern Virology Research Center College of Life SciencesWuhan UniversityWuhan430072China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan430072China Hubei Jiangxia Laboratory Wuhan430200China

Inclusion bodies(IBs)of respiratory syncytial virus(RSV)are formed by liquid-liquid phase separation(LLPS)and contain internal structures termed“IB-associated granules”(IBAGs),where anti-termination factor M2-1 and viral mRNAs are ***,the mechanism of IBAG formation and the physiological function of IBAGs are ***,we found that the internal structures of RSV IBs are actual M2-1-free viral messenger ribonucleoprotein(mRNP)condensates formed by secondary ***,the RSV nucleoprotein(N)and M2-1 interact with and recruit PABP to IBs,promoting PABP to bind viral mRNAs transcribed in IBs by RNArecognition motif and drive secondary phase ***,PABP-eIF4G1 interaction regulates viral mRNP condensate composition,thereby recruiting specific translation initiation factors(eIF4G1,eIF4E,eIF4A,eIF4B and eIF4H)into the secondary condensed phase to activate viral mRNAs for ribosomal *** study proposes a novel LLPS-regulated translation mechanism during viral infection and a novel antiviral strategy via targeting on secondary condensed phase.

关键词： Respiratory syncytial virus(RSV) Inclusion bodies(IBs) Biomolecular condensates Liquid-liquid phase separation(LLPS) Secondary condensed phase mRNA activation

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Feasibility of Integrating CSR and Corporate Governance:a Regional Perspective

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Proceedings of Business and Economic Studies 2020年第5期3卷 41-44页

作者： hanzhe Huo Beijing Technology and Business University 33 Fucheng RdHaidian DistrictBeijingChina

Corporate governance(CG)is regarded as a system of rules and practices to realize the objectives of a *** social responsibility(CSR)is a view that companies should be responsible for not only shareholders,but also general stakeholders who are engaged by the *** this paper,the degree of involvement of CSR in the framework of CG is *** tries to evaluate the performance of CG and CSR in different types of businesses and different ***,it discusses the relations between CG and CSR and their trends of ***,pro and con opinions of stakeholder theory are further ***,MNEs,Asian companies and Mexican companies are focused to explore the involvement of CG and CSR,and the reasons for the development difference among types of businesses in different ***,it describes the most common standard which the companies adopt to report CSR,and its advantages and disadvantages.

关键词： Corporate governance Corporate social responsibility

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Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus

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Bioactive Materials 2024年第3期33卷 85-99页

作者： Jiani Liu Geng Dou Wanmin Zhao Ji’an Hu Zhiwei Jiang Wenzhe Wang hanzhe Wang Shiyu Liu Yan Jin Yimin Zhao Qianming Chen Bei Li Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou310006China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China

Type 2 diabetes mellitus(T2DM)exacerbates irreversible bone loss in periodontitis,but the mechanism of impaired bone regeneration caused by the abnormal metabolic process of T2DM remains *** are regarded as the critical mediator in diabetic impairment of regeneration via organ or tissue ***,we find that abnormally elevated exosomes derived from metabolically impaired liver in T2DM are significantly enriched in the periodontal region and induced pyroptosis of periodontal ligament cells(PDLCs).Mechanistically,fatty acid synthase(Fasn),the main differentially expressed molecule in diabetic exosomes results in ectopic fatty acid synthesis in PDLCs and activates the cleavage of gasdermin *** of liver Fasn effectively mitigates pyroptosis of PDLCs and alleviates bone *** findings elucidate the mechanism of exacerbated bone loss in diabetic periodontitis and reveal the exosome-mediated organ communication in the“liver-bone”axis,which shed light on the prevention and treatment of diabetic bone disorders in the future.

关键词： Exosome Bone loss Type 2 diabetes mellitus Periodontal ligament cell Pyroptosis

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SOFFLFM:Super-resolution optical fluctuation Fourierlight-field microscopy

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Journal of Innovative Optical Health Sciences 2023年第3期16卷 56-64页

作者： Haixin Huang Haoyuan Qiu hanzhe Wu Yihong Ji Heng Li Bin Yu Danni Chen Junle Qu College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen University Shenzhen 518060P.R.China Tsinghua-Berkeley Shenzhen Institute(TBSI) Tsinghua UniversityShenzhen 518055P.R.China

Fourier light-field microscopy(FLFM)uses a microlens aray(MLA)to segment the Fourierplane of the microscopic objective lens to generate multiple two-dimensional perspective views,thereby reconstructing the threedimensional(3D)structure of the sample using 3D deconvo-lution calculation without ***,the resolution of FLFM is stil limited by dif-fraction,and furthermore,it is dependent on the aperture *** order to improve itsresolution,a super-resolution opticai fuctuation Fourier light-field microscopy(SOFFLFM)wasproposed here,in which the super-resolution optical fluctuation imaging(SOFI)with the abilityof super-resolution was introduced into *** uses higher-order cumulants statis-tical analysis on an image sequence collected by FLFM,and then carries out 3D deconvolutioncalculation to reconstruct the 3D structure of the *** theoretical basis of SOFFLFM onimproving resolution was explained and then verified with the *** resultsdemonstrated that SOFFLFM improved the lateral and axial resolution by more than V2 and 2times in the second-and fourth-order accumulations,compared with that of FLFM.

关键词： Fourier light-field microscopy higher-order cumulants super-resolution opticalfluctuation

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支持故障报警的果园对靶变量排肥系统

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农业机械学报 2015年第10期46卷 16-23页

作者：翟长远杨硕张波李瀚哲朱瑞祥西北农林科技大学机械与电子工程学院陕西杨凌712100

针对果园条开沟连续施肥造成肥料浪费,而挖穴施肥作业过程繁琐的问题,基于普通条开沟施肥机具设计了果园对靶变量排肥系统,该系统主要包括果园穴施肥精量排肥器和对靶变量施肥控制器。利用高速摄影技术获得了不同排肥口截面积排肥下落时... 详细信息

针对果园条开沟连续施肥造成肥料浪费,而挖穴施肥作业过程繁琐的问题,基于普通条开沟施肥机具设计了果园对靶变量排肥系统,该系统主要包括果园穴施肥精量排肥器和对靶变量施肥控制器。利用高速摄影技术获得了不同排肥口截面积排肥下落时间,使用间歇旋转机构实现定量穴排肥,提出了扇叶旋转落肥感知方法并设计了排肥故障监测装置,进而设计了果园穴施肥精量排肥器。使用光电传感器实时感知果树树干以获得排肥位置,利用接近开关感知地轮转速计算行进速度,以STC12C5A60S2单片机为核心设计了对靶变量施肥控制器。搭建了试验平台,进行了实验室试验,结果表明,1～5排肥量挡位下,平均排肥量与理论排肥量最大误差为10 g,最大变异系数为4.6%;平均排肥长度为20.2～40.9 cm;偏移距离绝对值最大为5.5 cm,最小为0.6 cm,偏移距离标准差平均值为4.26 cm;单次排肥故障监测装置最少感知落肥通断信号次数为2次,故障监测准确率达到100%。果园试验表明,针对100棵枸杞树进行对靶施肥,其排肥准确率为97%。该系统实现了果园靶标实时探测、对靶精量排肥控制和排肥故障报警功能,达到了条开沟对靶穴施肥的果园作业要求。

关键词：果园施肥对靶施肥变量施肥故障报警排肥器

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广州金融城有轨电车与无轨电车的系统运能分析

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城市轨道交通研究 2017年第9期20卷 79-82页

作者：蔡涵哲广州地铁设计研究院有限公司广州工程师510010

现代有轨电车和储能式无轨电车都属于节能环保的新型城市公共交通。以广州都会区规划的金融城线为例,对半专用路权下有轨电车和无轨电车的运营组织和运能进行了分析。其中,着重分析了二者的路口通行能力和车站通行能力。分析结果表明:... 详细信息

现代有轨电车和储能式无轨电车都属于节能环保的新型城市公共交通。以广州都会区规划的金融城线为例,对半专用路权下有轨电车和无轨电车的运营组织和运能进行了分析。其中,着重分析了二者的路口通行能力和车站通行能力。分析结果表明:在半专用路权条件下,路口通行能力是系统运能的瓶颈;在提供同样运能服务水平的条件下,无轨电车所占用的路口通行相位时长比例低于有轨电车,无轨电车在车站段占用的道路宽度大于有轨电车。二者各有优劣,应根据实际情况选择。

关键词：有轨电车无轨电车路口通行能力车站通行能力

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Mean Square Consensus under Coopetitive Social Networks with Communication Noise

Mean Square Consensus under Coopetitive Social Networks with...

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第40届中国控制会议

作者： hanzhe Cai Fanli Yuan Haili Liang Zhao Zhou Shanghai Key Laboratory of Power Station Automation Technology School of Mechatronic Engineering and AutomationShanghai University Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and Technology

This paper aims to investigate a stochastic Altafini model, in which individuals are disturbed by the communication noise. We use coopetitive networks to describe their affiliation of classes. Different from the general situations with noises, when the opinion values in the classes converge, the noise will decrease. We consider the communication noise, when the differences of opinion values are larger, the influences of noise are greater. When the opinion values are reaching to biparite consensus,the influences of noise are decreasing, such a design is more in line with the reality. By constructing the appropriate Lyapunov function, the conditions for the stochastic stability of the system are obtained. We get the conclusion of mean square biparite consensus. In addition, numerical simulation results can verify the theoretical results.

关键词： Opinion dynamic Coopetitive networks Undirected graph Altafini model Communication noise

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Research of Collaborative Search and Rescue System for Photovoltaic Mobile Robot Based on Edge Computing Framework

Research of Collaborative Search and Rescue System for Photo...

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第32届中国控制与决策会议

作者： Fan Feng Dan Li Jiayu Zhao hanzhe Sun School of Automation Wuhan University of Technology

Personnel search and rescue work is a kind of emergency rescue work mainly to save the lives of *** only firefighters carry out search in unknown areas in the field,the efficiency is too low and it is easy to delay the best rescue *** a joint search is carried out using mobile robots and firefighters,it will be beneficial to find missing persons with vital signs in a timely manner,and it will be convenient to soothe the emotions of family members in a timely manner,embodying the humanistic care and humanitarian *** order to solve the problem that the current rescue robot has high energy consumption and short flight time,and can not undertake a large number of long-time search and rescue *** project proposes a multi-robot collaborative search and rescue system based on renewable energy to extend the mobile robot’s battery life,this system is mainly divided into five parts:new solar system,search and rescue robot,Internet of Things networking,cloud server,and WeChat *** the same time,Multiple robots carry out collaborative search and rescue operations through the ZigBee wireless network,and the camera carried by a single robot can identify the human body with edge *** networking,the 4 G mobile network is used to send the personnel recognition results to the background terminal,to indicate if a missing person was *** that the efficiency and accuracy of searching need to be improved urgently,an improved golden section method is proposed to keep the output power of the solar panel at the highest level to increase flight *** project meets the urgent needs of high-efficiency rescue,energy conservation and environmental protection.

关键词： Search and rescue robot Renewable energy Internet of things Maximum power point tracking

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