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Potential mechanisms of hepatitis B virus induced liver injury

World Journal of Gastroenterology 2014年第35期20卷 12462-12472页

作者： Mohd Suhail hany abdel-hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri King Fahd Medical Research Center King Abdul Aziz University Department of Medicine University of Colorado Health Sciences Center at Fitzsimons IQ Institute of Infection and Immunity Special Infectious Agents Unit-Biosafety Level 3 King Fahd Medical Research CenterKing Abdul Aziz University Medical Laboratory Technology Department Faculty of Applied Medical Sciences King Abdul Aziz University

Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular *** histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal *** potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral *** viral and cellular factors that contribute to liver injury are discussed in this *** injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and *** consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of *** identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury.

关键词： Hepatitis B virus Hepatitis B virus genotype Hepatocellular carcinoma Woodchuck hepatitis virus Ground squirrel hepatitis virus Peripheral blood mononuclear cells Interferon regulatory factor 7 Interleukin-1 receptor-associated kinase 4 TNF receptor-associated factor 3

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Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第30期20卷 10238-10248页

作者： Ashraf Ali hany abdel-hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri Department of Medical Biotechnology King Fahad Medical Research CenterKing Abdul Aziz UniversityPO Box 80216Jeddah 21589Saudi Arabia Division of Endocrinology Department of Medicine and MetabolismAnschutz Medical CampusUniversity of Colorado DenverAuroraCO 80045United States Department of Biochemistry All India Institute of Medical SciencesNew Delhi 110029India IQ Institute of Infection and Immunity Lahore 54000Pakistan Special Infectious Agents Unit-Biosafety Level 3 King Fahd Medical Research CenterKing Abdul Aziz UniversityJeddah 21589Saudi Arabia Medical Laboratory Technology Department Faculty of Applied Medical SciencesKing Abdul Aziz UniversityJeddah 21589Saudi Arabia

Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)***-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced *** is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in *** might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in *** mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of *** accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major *** article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets.

关键词： Hepatitis B virus Hepatocellular carcinoma Transcription factors Apoptosis Epigenetics Mutants Tumor necrosis factor Activating protein Transforming growth factor Mitogen activated protein kinase

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Host nucleotide polymorphism in hepatitis B virusassociated hepatocellular carcinoma

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World Journal of Hepatology 2016年第10期8卷 485-498页

作者： Shilu Mathew hany abdel-hafiz Abbas Raza Kaneez Fatima Ishtiaq Qadri Center of Excellence in Genomic Medicine Research King Abdul Aziz University University of Colorado Denver AMC Department of Immunobiology University of Vermont IQ-Institute of Infection and Immunity King Fahd Medical Research Center King Abdul Aziz University

Hepatocellular carcinoma(HCC) is etiologically linked with hepatitis B virus(HBV) and is the leading cause of death amongst 80% of HBV patients. Among HBV affected patients, genetic factors are also involved in modifying the risk factors of HCC. However, the genetic factors that regulate progression to HCC still remain to be determined. In this review, we discuss several single nucleotide polymorphisms(SNPs) which were reportedly associated with increased or reduced risk of HCC occurrence in patients with chronic HBV infection such as cyclooxygenase(COX)-2 expression specifically at COX-2-1195G/A in Chinese, Turkish and Egyptian populations, tumor necrosis factor α and the three most commonly studied SNPs: PAT-/+, Lys939Gln(A33512C, rs2228001) and Ala499Val(C21151T, rs2228000). In genome-wide association studies, strong associations have also been found at loci 1p36.22, 11q22.3, 6p21(rs1419881, rs3997872, rs7453920 and rs7768538), 8p12(rs2275959 and rs37821974) and 22q11.21. The genes implicated in these studies include HLA-DQB2, HLA-DQA1, TCF19, HLA-C, UBE2L3, LTL, FDX1, MICA, UBE4 B and PG. The SNPs found to be associated with the above-mentioned genes still require validation in association studies in order to be considered good prognostic candidates for HCC. Screening of these polymorphisms is very beneficial in clinical experiments to stratify the higher or lower risk for HCC and may help in designing effective and efficient HCC surveillance programs for chronic HBV-infected patients if further genetic vulnerabilities are detected.

关键词： Hepatitis B virus Hepatocellular carcinoma Subtypes Genetic polymorphism Liver cirrhosis

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Novel design of a compact tunable dual band wireless power transfer(TDB-WPT)system for multiple WPT applications

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 616-628页

作者： hany A.ATALLAH Rasha Hussein AHMED Adel B.abdel-RAHMAN Department of Communications and Electronics Faculty of EngineeringSouth Valley UniversityQena 83523Egypt Egypt-Japan University of Science and Technology Alexandria 21934Egypt

In this study we present the design and realization of a tunable dual band wireless power transfer(TDB-WPT)coupled resonator *** frequency response of the tunable band can be controlled using a surface-mounted *** transmitter(Tx)and the receiver(Rx)circuits are *** top layer contains a feed line with an impedance of 50Ω.Two identical half rings defected ground structures(HR-DGSs)are loaded on the bottom using a varactor *** propose a solution for restricted WPT systems working at a single band application according to the operating *** effects of geometry,orientation,relative distance,and misalignments on the coupling coefficients were *** validate the simulation results,the proposed TDB-WPT system was fabricated and *** system occupied a space of 40 mm×40 *** can deliver power to the receiver with an average coupling efficiency of 98%at the tuned band from 817 to 1018 MHz and an efficiency of 95%at a fixed band of 1.6 GHz at a significant transmission distance of 22 *** results of the measurements accorded well with those of an equivalent model and the simulation.

关键词： Defected ground structure(DGS) Surface-mounted Tunable dual band wireless power transfer(TDB-WPT) Varactor

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多用途新颖紧凑可调谐双频无线电能传输系统设计（英文）

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Frontiers of Information Technology & Electronic Engineering 2024年第4期 616-629页

作者： hany A.ATALLAH Rasha Hussein AHMED Adel B.abdel-RAHMAN 南谷大学工程学院通信与电子学系埃及-日本科技大学

本文设计并实现了一个可调谐双频无线电能传输耦合谐振器系统。可调谐波段的频率响应可以使用表面贴装变容二极管进行控制。发射器和接收器电路是对称的。顶层包含一个阻抗为50Ω的馈线。通过使用变容二极管，两个相同的半环缺陷接地结... 详细信息

本文设计并实现了一个可调谐双频无线电能传输耦合谐振器系统。可调谐波段的频率响应可以使用表面贴装变容二极管进行控制。发射器和接收器电路是对称的。顶层包含一个阻抗为50Ω的馈线。通过使用变容二极管，两个相同的半环缺陷接地结构被加载在底部。针对工作在单频段（基于工作频率）的受限无线电能传输系统，提出一种解决方案。研究了几何形状、方向、相对距离和偏移对耦合系数的影响。为验证仿真结果，制作并测试了所提可调谐双频无线电能传输系统。系统面积为40 mm×40 mm。在有效传输距离为22 mm时，在817～1018 MHz调谐频段，以98%的平均耦合效率向接收器输送电能，在1.6GHz固定频段，效率为95%。测量结果与等效模型的模拟结果吻合较好。

关键词：缺陷接地结构表面贴装可调谐双频无线电能传输变容二极管

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Can lanthanum doping enhance catalytic performance of silver in direct propylene epoxidation over NaMoAg/SiO_2?

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Journal of Rare Earths 2019年第5期37卷 500-507页

作者： hany M.abdel Dayem Shar S.Al-Shihry Salah A.Hassan Chemistry Department Faculty of Science Ain Shams University Chemistry Department College of Science King Faisal University

In the attempt to reduce surface free energy of silica to improve interaction of silica with silver, silica was doped by different amounts of low surface energy lanthanum, La_2O_3, through impregnation. The doped and undoped silica were used as supports for preparation of Na/Ag/Mo/La_2O_3-SiO_2 catalysts. Catalytic performances of the catalysts were evaluated in direct epoxidation of propylene(DPO) using molecular oxygen under atmospheric pressure and without adding hydrogen. Adding 5 wt%La to the Na/Ag/Mo/SiO_2 catalyst improves both the catalysts electivity in DPO and its stability over 20h of *** characterization results show that La_2O_3 species interact strongly with silver particles on the silica surface which result in significant improvement in the dispersion profile of silver and marked decrease in the size of silver nanoparticles(AgNPs). The estimated mean diameter of AgNPs is ca. 4.0 nm in Na/Ag/Mo/5 wt%La_2O_3-SiO_2, which is smaller than that(53.9 nm) found in Na/Ag/SiO_2. The presence of subnanometer AgNPs on Ag/La_2O_3-SiO_2 prior addition of MoO_3 and NaCl to the sample can enhance the mutual electronic synergism between Ag, MoO_3 and Na for selective production of propylene oxide.

关键词： Direct epoxidation Propylene Gas phase Silver Subnanometer Lanthanum

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Crystallization kinetics of overlapping phases in Se70Te15Sb15 using isoconversional methods

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Progress in Natural Science:Materials International 2015年第2期25卷 169-177页

作者： M.A.abdel-Rahim M.M.hafiz A.Z.Mahmoud Physics Department Faculty of ScienceAssiut University Assiut 71516 Egypt

The crystallization kinetics of Se70Te15Sb15 chalcogenide glass was studied by Differential Scanning Calorimetry(DSC) under non-isothermal conditions. This glass was found to have a double glass transition and double overlapped crystalline phases. The overlapped crystalline phases were successfully separated using the Gaussian fit model. The activation energy, Ec, and Avrami index, n, were determined by analyzing the data using the Matausita et. al. method. A strong heating rate depending on the activation energy for the two crystalline peaks was observed. The results indicated that the transformation from amorphous to crystalline phases is a complex process involving different mechanisms of nucleation and growth. The variation of activation energy with crystalline fraction was determined by Kissenger–Akahira–Sunose(KAS) method. The obtained results of directly fitting the experimental DSC data to the calculated DSC curves indicated that the crystallization process of Se70Te15Sb15 glass cannot be satisfactorily described by the Johnson–Mehl–Avrami(JMA) model. Simulation results indicated that the Sestak–Berggren(SB) model is more suitable to describe the crystallization process for the studied glass. The crystalline phases for the two events were identified by using x-ray diffraction(XRD) and scanning electron microscopy(SEM).

关键词： Chalcogenides glasses Differential Scanning Calorimetry(DSC) Electron Microscopy X-ray diffraction

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Rare earth oxides doped NiO/γ-Al_2O_3 catalyst for oxidative dehydrogenation of cyclohexane

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Journal of Rare Earths 2015年第6期33卷 611-618页

作者： hany M.abdelD ayem M.Faiz Hesham S.abdel-Samad Salah A.Hassan Center of Research Excellence in Petroleum Refining & Petrochemicals (CoR E-PRP) King Fahd University of Petroleum & Minerals Chemistry Department College of Science King Faisal University Chemistry Department Faculty of Science Ain Shams University Surface Science Laboratory Physics Department King Fahd University of Petroleum &Minerals Department of Basic Sciences and Technology Community College Taibah University

The effect of rare earth oxides （RE=Ce, La, Gd, and Dy） doping of alumina support in NiO/7-A1203 system was investi- gated on its catalytic performance in oxidative dehydrogenation （ODH） of cyclohexane. The physicochemical properties of various samples were followed up through N2 physisorption, temperature programmed reduction （H2-TPR）, X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS） and potentiometric acid-base titration techniques. In the parent NiO/y-A1203 catalyst, Ni species were found to be strongly interacted with alumina surface. Addition of rare earth dopants to ）＇-A1203 in the catalyst system affected the nickel-alumina interaction and resulted in significant modifications in the catalytic performances in the ODH reaction. The results re- vealed the beneficial role of both La203 and Gd2Os doping in enhancing the ODH catalytic activity and selectivity to cyclohexene. H2-TPR and XPS results indicated that majority of Ni species in NiO/La203 modified T-A1203 were more weakly interacted with La203 and alumina whereas both NiO like species and nickel aluminate were present on the surface. Doping with cerium or dyspro- sium increased the nickel-support interaction and led to a decrease in surface nickel concentration. In case of doping with Ce, surface concentration of cerium oxide was higher than those of the other RE oxides; the doped catalyst reached its steady state activity faster than the other catalysts. The acid-base results suggested that RE metals were interacted most likely with acidic surface hydroxyl groups. The degree of nickel-alumina interaction decreased in the following order： LaAI〉GdAI〉CeAI〉DyA1.

关键词： nickel oxide rare-earth oxides doping Ni-A1203 interaction surface acidity oxidative dehydrogenation cyclohexane rare earths

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Reinforcement Learning with an Ensemble of Binary Action Deep Q-Networks

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Computer Systems Science & Engineering 2023年第9期46卷 2651-2666页

作者： A.M.hafiz M.Hassaballah Abdullah Alqahtani Shtwai Alsubai Mohamed abdel Hameed Department of Electronics&Communication Engineering Institute of TechnologyUniversity of KashmirSrinagarJ&K190006India Department of Computer Science Faculty of Computers and InformationSouth Valley UniversityQenaEgypt College of Computer Engineering and Sciences Prince Sattam bin Abdulaziz UniversityAlkhrjKSA Department of Computer Science Faculty of Computers and InformationLuxor UniversityLuxorEgypt

With the advent of Reinforcement Learning(RL)and its continuous progress,state-of-the-art RL systems have come up for many challenging and real-world *** the scope of this area,various techniques are found in the *** such notable technique,Multiple Deep Q-Network(DQN)based RL systems use multiple DQN-based-entities,which learn together and communicate with each *** learning has to be distributed wisely among all entities in such a scheme and the inter-entity communication protocol has to be carefully *** more complex DQNs come to the fore,the overall complexity of these multi-entity systems has increased many folds leading to issues like difficulty in training,need for high resources,more training time,and difficulty in fine-tuning leading to performance *** a cue from the parallel processing found in the nature and its efficacy,we propose a lightweight ensemble based approach for solving the core RL *** uses multiple binary action DQNs having shared state and *** benefits of the proposed approach are overall simplicity,faster convergence and better performance compared to conventional DQN based *** approach can potentially be extended to any type of DQN by forming its *** extensive experimentation,promising results are obtained using the proposed ensemble approach on OpenAI Gym tasks,and Atari 2600 games as compared to recent *** proposed approach gives a stateof-the-art score of 500 on the Cartpole-v1 task,259.2 on the LunarLander-v2 task,and state-of-the-art results on four out of five Atari 2600 games.

关键词： Deep Q-networks ensemble learning reinforcement learning OpenAI Gym environments

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Histopathological,histochemical and biochemical postmortem changes in induced fatal hypothermia in rats

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Forensic Sciences Research 2022年第2期7卷 211-227页

作者： Mahrous abdelbasset Ibrahim Sally Salem Mohammed hany Goda Tammam Rehab Ibrahim abdel-Karim Medhat Mohammed Farag Forensic Medicine&Clinical Toxicology College of MedicineJouf UniversitySakakahSaudi Arabia Forensic Medicine&Clinical Toxicology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Histology and Cell Biology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Forensic Medicine and Clinical Toxicology Department Faculty of MedicineAl-Azhar UniversityCairoEgypt Medical biochemistry Department College of MedicineShaqra UniversityShaqraaSaudi Arabia Medical Biochemistry&Molecular Biology Department Faculty of MedicineBenha UniversityBenhaEgypt

Reaching a postmortem diagnosis of hypothermia is challenging in forensic ***,this study was conducted to detect the histopathological,histochemical and biochemical changes that occur in adult albino rats following exposure to induced fatal ***-four adult albino rats were divided into the negative control,moderate hypothermia,severe hypothermia and hypoxia *** in the control group were euthanized when those in the moderate hypothermic group *** samples were collected via heart puncture,and the cerebrum,heart,suprarenal gland,kidney,liver and skeletal muscle were removed to investigate the biochemical,histochemical and histopathological *** assessment depicted significant changes in lipid peroxidation,represented by increased malondialdehyde levels in the studied organs of the rats in hypothermic and hypoxia *** examination of the rats’organs revealed degeneration and necrosis in the hypothermia and hypoxia *** taken from the severe hypothermic rats revealed a loss of normal cardiac tissue architecture,necrotic changes in the pyramidal cells in the cerebral cortex,and massive necrosis,mainly in the tubules of the renal cortex and *** findings suggest that histological changes might be used as biochemical markers for postmortem diagnosing of fatal hypothermia,particularly in severe hypothermic conditions.

关键词： Forensic sciences forensic medicine legal medicine autopsy forensic pathology histochemical hypothermia

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