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Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2840-2842页

作者： Jörg Fahrer Division of Food Chemistry and Toxicology Department of ChemistryRPTU Kaiserslautern-Landau67663 KaiserslauternGermany

A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,cancer,and other disorders.2 As an outstanding achievement,the authors identified DSCC1(DNA Replication And Sister Chromatid Cohesion 1)as a critical gene protecting against early developmental defects,genomic instability,reduced proliferative capacity,cohesinopathy-related phenotypes,and tumor development in vivo.

关键词： chromosomal linking Replication

Laser-induced plasma formation in water with up to 400 mJ double-pulse LIBS

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Plasma Science and Technology 2024年第1期26卷 93-100页

作者： Marion HENKEL Michelle SIEMENS Ralf METHLING Benjamin EMDE Jörg HERMSDORF Steffen FRANKE Diego GONZALEZ Leibniz Institute for Plasma Science and Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany Laser Zentrum Hannover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a promising technique for deep-sea *** measurements in shallow water with up to 400 mJ each pulse were done to select laser parameters which promote optimized spectral line emission from plasma even at elevated pressures,where line broadening until loss of most of the spectral information can *** emission spectroscopy,using a Czerny-Turner spectrometer,has been applied to investigate the dependence of the emitted radiation on laser parameters and hydrostatic *** has been found,that higher laser pulse energies,especially with short pulse delay as required in high water pressure,can also have an adverse effect on the measured spectrum.

关键词： double-pulse LIBS underwater plasma formation emission spectrosocpy

Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

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Journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.K.Singh Raman Derrek E.Lobo Christopher D.Easton Mainak Majumder Frank Witte Jörg F.Löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and Engineering Laboratory(NSEL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and Engineering Bayview AvenueClaytonVIC 3168Australia Julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(rgO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

Mechanical thrombectomy in children and adolescents:report of five cases and literature review

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Stroke & Vascular Neurology 2018年第4期3卷 245-252页

作者： Pervinder Bhogal Victoria Hellstern Muhammad AlMatter Oliver Ganslandt hansjörg Bäzner Marta Aguilar Pérez Department of Interventional Neuroradiology Royal London HospitalLondonUK Neuroradiological Clinic NeurocenterKlinikum StuttgartStuttgartGermany Neurosurgical Clinic NeurocenterKlinikum StuttgartStuttgartGermany Medical Faculty University Duisburg-EssenDuisburgGerman

Background Paediatric arterial ischaemic stroke is an important cause of morbidity and mortality among ***,there are no recommendations regarding mechanical thrombectomy in children despite overwhelming evidence of improved outcomes in ***,the need for individual case reports and case series is important to highlight potential advantages and disadvantages in this *** descriptions We retrospectively searched our prospectively maintained database of patients undergoing mechanical thrombectomy for ischaemic *** describe five children,aged between 7 and 17,who underwent mechanical thrombectomy for acute ischaemic *** provide an account of their clinical presentations,operative treatment and postoperative *** Mechanical thrombectomy in children,especially older children,can be performed safely and with existing *** a randomised controlled trial would provide compelling evidence of the potential advantages to this technique,the lack of this should not prevent the use of this procedure by trained neurointerventionists.

关键词： maintained throm treatment

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中国的金融体系:运行方式和改革压力

财经科学 2002年第3期 81-87页

作者： hansjrg Herr 李宏伟德国柏林经济学院

改革开放以来 ,中国的经济出现了高速增长 ,人均收入也有了明显增加 ,80年代末～ 90年代初虽然出现了较为严重的通货膨胀 ,但最终都得以抑制 ,其后出现的通货紧缩 ,以及国内生产总值增长率在较长时间内的下降 ,也都得以克服。计划经济... 详细信息

改革开放以来 ,中国的经济出现了高速增长 ,人均收入也有了明显增加 ,80年代末～ 90年代初虽然出现了较为严重的通货膨胀 ,但最终都得以抑制 ,其后出现的通货紧缩 ,以及国内生产总值增长率在较长时间内的下降 ,也都得以克服。计划经济向货币经济过度的关键一步是以货币预算约束取代计划来建立经济的内在联系 ,在这一过程中 ,中国经济还存在着多方面的问题。中国当前的改革必须以国有企业和银行部门的重组为中心 ,只有密切结合这两个领域的改革 ,改革才会取得成功。

关键词：金融体系运行方式改革压力预算约束中国国有企业重组银行重组

Optimizing Growth Conditions for Digoxin Production in Digitalis lanata Ehrh

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World Journal of Traditional Chinese Medicine 2016年第2期2卷 24-35页

作者： Herman A.van Wietmarschen hansj?rg Hagels Ron Peters Jolanda Heistek Jan van der Greef Mei Wang TNO Netherlands Organization for Applied Scientific Research Microbiology & Systems Biology Sino-Dutch Centre for Preventive and Personalized Medicine Boehringer Ingelheim Pharma Gmb H & Co.KG Business Center Klazienaveen Jolanda: Heistek Result Groenloper SU Bio Medicine

Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata Ehrh. plants, known as Mao Hua Yang Di Huang in Chinese medicine. This manuscript presents two studies that were conducted to optimize the cultivation conditions for digoxin production in the TCM Mao Hua Yan Di Huang in a greenhouse under GAP ***: Two experiments were designed in which 4 growth conditions were compared. Levels of digoxin, gitoxin, digitoxin, α-acetyldigoxin, β-acetyl-digoxin were measured using HPLC-UV and compared between the ***: Normal soil, no CO_2 enrichment combined with a cold shock was found to be the optimal condition for producing digoxin in the first experiment. Gitoxin content was significantly lower in plants grown in this condition. Mechanical stress as well as the time of harvesting showed no statistically significant differences in the production of cardenolides. In the second experiment the optimal condition was found to be a combination of cold nights, sun screen, fertilizer use and no milled ***: This study shows that digoxin production can be increased by controlling the growth conditions of D. lanata Ehrh. The effect of cold was important in both experiments for improving digoxin production. Cultivating Chinese herbal medicines in optimized greenhouse conditions might be an economically attractive alternative to regular open air cultivation.

关键词： Digitalis lanata Ehrh mao hua yang di huang cardenolides content optimisation TCM

Modern Concepts in UHV-Sample Transfer and Sample Holders

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Modern Concepts in UHV-Sample Transfer and Sample Holders

Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

2003年纳米和表面科学与技术全国会议

作者： hansjrg R.Ruppender OmniVac Corp. Kaiserslautern Germany

Today’s surface science research requires different analysis and preparation techniques applied to the samples without breaking the vacuum between these steps. We present a concept of easy upgradeable multi-chamber sattelite UHV-systems (SAT) with fast and reliable transfer between different chambers (no wobble sticks) and a minimum of sample contamination.

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

Determination of relationships between thermal conductivity and material properties of rocks

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Journal of University of Science and Technology Beijing 2004年第4期11卷 297-301页

作者： Kazim Grgülü Mining Engineering Dept. Cumhuriyet University58140-SivasTurkeynergy transfer between the adjacent parts of rocks in underground mines is widely influenced by the thermal conductivity of rocks. The relationships between the thermal conductivity and some material properties of rocks such as the uniaxial compressive strength unit mass tensile strength cohesion Young's modulus point load strength Schmidt rebound hardness Shore scleroscope hardness and toughness strength were investigated. The statistical analysis of the data obtained in laboratory tests shows that the thermal conductivity increases with increasing the uniaxial compressive strength unit mass tensile strength cohesion Young's modulus point load strength Schmidt rebound hardness and Shore scleroscope hardness and decreases with increasing the toughness strength.

Energy transfer between the adjacent parts of rocks in underground mines is widely influenced by the thermal conductivity of rocks. The relationships between the thermal conductivity and some material properties of rocks such as the uniaxial compressive strength, unit mass, tensile strength, cohesion, Young’s modulus, point load strength, Schmidt rebound hardness, Shore scleroscope hardness and toughness strength were investigated. The statistical analysis of the data obtained in laboratory tests shows that the thermal conductivity increases with increasing the uniaxial compressive strength, unit mass, tensile strength, cohesion, Young’s modulus, point load strength, Schmidt rebound hardness and Shore scleroscope hardness, and decreases with increasing the toughness strength.

关键词： thermal conductivity material properties underground mines