检索结果-南通市图书馆

EDISON-WMW: Exact Dynamic Programing Solution of the Wilcoxon–Mann–Whitney Test

Genomics, Proteomics & Bioinformatics 2016年第1期14卷 55-61页

作者： Alexander Marx Christina Backes Eckart Meese hans-peter lenhof Andreas Keller Chair for Clinical Bioinformatics Medical Faculty Saarland University Department of Human Genetics Saarland University University Hospital Chair for Bioinformatics Saarland University

In many research disciplines, hypothesis tests are applied to evaluate whether findings are statistically significant or could be explained by chance. The Wilcoxon-Mann-Whitney （WMW） test is among the most popular hypothesis tests in medicine and life science to analyze if two groups of samples are equally distributed. This nonparametric statistical homogeneity test is commonly applied in molecular diagnosis. Generally, the solution of the WMW test takes a high combinatorial effort for large sample cohorts containing a significant number of ties. Hence, P value is frequently approximated by a normal distribution. We developed EDISON-WMW, a new approach to calcu- late the exact permutation of the two-tailed unpaired WMW test without any corrections required and allowing for ties. The method relies on dynamic programing to solve the combinatorial problem of the WMW test efficiently. Beyond a straightforward implementation of the algorithm, we pre- sented different optimization strategies and developed a parallel solution. Using our program, the exact P value for large cohorts containing more than 1000 samples with ties can be calculated within minutes. We demonstrate the performance of this novel approach on randomly-generated data, benchmark it against 13 other commonly-applied approaches and moreover evaluate molec- ular biomarkers for lung carcinoma and chronic obstructive pulmonary disease （COPD）. We foundthat approximated P values were generally higher than the exact solution provided by EDISON- WMW. Importantly, the algorithm can also be applied to high-throughput omics datasets, where hundreds or thousands of features are included. To provide easy access to the multi-threaded version of EDISON-WMW, a web-based solution of our algorithm is freely available at http：// ***/software/wtest/.

关键词： Wilcoxon-Mann-Whitneytest:Wilcoxon rank-sum test Dynamic programing Exact permutation Parallel optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development

引用

Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres hans-peter lenhof Eckart Meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal Medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal Medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork （COSYCONET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA （miRNA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRNAs regulate different cancer-related pathways including the MAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRNA Cancer COPD Lung Biomarker COSYCONET

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs

引用

Genomics, Proteomics & Bioinformatics 2019年第4期17卷 430-440页

作者： Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes hans-peter lenhof Eckart Meese Andreas Keller Department of Human Genetics Saarland University66421 Homburg/SaarGermany Chair for Clinical Bioinformatics Saarland University66123 Saarbru¨ckenGermany Institut fur Gerontologie Universitat Heidelberg69047 HeidelbergGermany Department of Neurology Christian-Albrechts-University of Kiel24118 KielGermany Center for Neurology and Hertie Institute for Clinical Brain Research Department of NeurodegenerationUniversity of Tuebingen72074 TuebingenGermany German Center for Neurodegenerative Diseases(DZNE) 72076 TuebingenGermany Department of Anesthesiology and Intensive Care St.Franziskus Hospital Muenster48145 MuensterGermany Department of Psychiatry and Psychotherapy University Hospital Tuebingen72016 TuebingenGermany Department of Medicine II Saarland University Medical Center66421 Homburg/SaarGermany Center for Bioinformatics Saarland Informatics Campus66123 SaarbruckenGermany

Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic ***,high-throughput approaches are applied to discover biomarker *** have to be validated in larger cohorts and evaluated by adequate statistical learning ***,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and ***,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by *** computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from ***,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and *** study represents the next important step in translational research for a miRNA-based AD test.

关键词： miRNAs Neurodegeneration Alzheimer’s disease Biomarker Non-coding RNAs Gene regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conception of a new 4-quadrant hydrogen compressed air energy storage power plant with an integrated electrolyzer

引用

Energy Reviews 2024年第3期3卷 92-101页

作者： hans-peter Beck Ann-Kathrin Klaas Christoph Klaas Research Center Energy Storage Technologies Clausthal University of TechnologyAm Stollen 19A38640GoslarGermany Institute of Electrical Power Engineering and Energy Systems Clausthal University of TechnologyLeibnizstraße 2838678Clausthal-ZellerfeldGermany

A hydrogen compressed air energy storage power plant with an integrated electrolyzer is ideal for large-scale,long-term energy storage because of the emission-free operation and the possibility to offer multiple ancillary services on the German energy *** paper defines analyzes such a storage concept and conducts an extensive comparison with four additional storage concepts based on various *** results show that the combination of storing compressed air and hydrogen offers a higher efficiency than storing only hydrogen and lower specific investment costs than storing only compressed *** result is confirmed with analysis of the optimal sizing of each power plant component for simultaneous participation on multiple energy markets with a linear optimization dispatch *** hydrogen compressed air energy storage(HCAES)power plant can utilize more revenue possibilities than a hydrogen energy storage because of the higher round-trip efficiency and the combination of the air compressor and the integrated electrolyzer during charging *** integration of the electrolyzer,however,offers a couple of challenges itself because of the highly flexible operation mode.A new concept for the controllable 24-pulse diode-thyristor rectifier of the electrolyzer is presented,that uses mostly common components while offering little to no grid harmonics and a long *** flexible integrated electrolyzer allows for the 4-quadrant operation of the storage power plant.

关键词： Long-term energy storage Hydrogen energy storage Compressed air energy storage Mixed-integer linear programming Electrolyzer 24-Pulse thyristor rectifier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential modulation of crown allometry and stem growth at gap edges in five European tree species by drought conditions

引用

Forest Ecosystems 2024年第5期11卷 618-631页

作者： Luke Bohnhorst peter Biber Torben Hilmers Enno Uhl hans Pretzsch Chair of Forest Growth and Yield Science TUM School of Life SciencesTechnical University of MunichHans-Carl-von-Carlowitz-Platz 285354FreisingGermany Bavarian State Institute of Forestry Hans-Carl-von-Carlowitz-Platz 185354FreisingGermany

Background In Central Europe,forests are increasingly affected by various disturbances,resulting in an increasing gap formation in the *** order to support goal-oriented management,more knowledge is required about the acclimation of the crown and its effects on the basal area growth of trees at the edge of a *** This work compared trees'growth and crown structure at the edge of a transient gap,with a gap size of more than 80m^(2),with trees in the stand that were at least 30m away from the gap.A total of 249 European beeches(Fagus sylvatica L.),Norway spruces(Picea abies ***),Scots pines(Pinus sylvestris L.),oaks(Quercus spp.;Quercus petraea(Matt.)Liebl.,Quercus robur L.),and silver firs(Abies alba Mill.)were examined on long-term experimental plots in southern *** crown measures were developed and calculated using high-resolution terrestrial laser scanning(TLiDAR)to capture the three-dimensional crown *** responses to edge conditions were measured based on tree *** linear mixed models,we predict the basal area increment of edge trees relative to trees in the stand under wet and dry soil moisture conditions after the gap *** We identified i)species-specific acclimation of the crown of edge trees after the gap formation,ii)under wet soil moisture conditions a growth increase of 25%–45%for beech,pine,and oak edge trees and growth losses of 5%–60%for spruce and fir and iii)coniferous tree species benefited from the edge position regarding their basal area increment under dry soil moisture conditions and deciduous tree species grew regardless of the soil moisture conditions at the edge of a *** Gaps have a species-specific effect on the habitus and growth of edge trees and can have both positive and negative impacts on silviculture.

关键词： Canopy gaps Disturbance Growth TLiDAR Drought stress Crown structure Acclimation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bound State Description of Particles from a Quantum Field Theory of Fermions and Bosons, Compatible with Relativity

引用

Journal of High Energy Physics, Gravitation and Cosmology 2024年第2期10卷 562-573页

作者： hans-peter Morsch HOFF J&uumllich Germany

Both, the dilemma to find a quantum field theory consistent with Einstein’s law of relativity and the problem to describe existing particles as bound states of matter has been solved by calculating bound state matrix elements from a dual fermion-boson Lagrangian. In this formalism, the fermion binding energies are compensated by boson energies, indicating that particles can be generated out of the vacuum. This yields quantitative solutions for various mesons ω (0.78 GeV) - Υ (9.46 GeV) and all leptons e, μ and τ, with uncertainties in the extracted properties of less than 1‰. For transparency, a Web-page with the address htpps://*** has been constructed, where all calculations can be run on line and also the underlying fortran source code can be inspected.

关键词： Quantum Field Theory of Fermion and Boson Fields Hadrons and Leptons Described as Bound States of Relativistic Fermions and Bosons Leading to a Total Energy Equal to Zero

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health risk ranking of antibiotic resistance genes in the Yangtze River

引用

Environmental Science and Ecotechnology 2024年第5期21卷 113-122页

作者： Chunxia Jiang Zelong Zhao hans-peter Grossart Feng Ju Yi Zhao Geoffrey Michael Gadd Ewa Korzeniewska Yuyi Yang Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan430074China University of Chinese Academy of Sciences Beijing100049China Danjiangkou Wetland Ecosystem Field Scientific Observation and Research Station Chinese Academy of Sciences&Hubei ProvinceWuhan430074China Liaoning Key Laboratory of Marine Fishery Molecular Biology Liaoning Key Lab of Germplasm Improvement and Fine Seed Breeding of Marine Aquatic AnimalsLiaoning Ocean and Fisheries Science Research InstituteDalian116023China Leibniz-Institute for Freshwater Ecology and Inland Fisheries(IGB) Neuglobsow16775Germany Institute for Biochemistry and Biology Potsdam UniversityPotsdam14469Germany Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou310030China School of Water Resources and Environment China University of Geosciences(Beijing)Beijing100083China Geomicrobiology Group School of Life SciencesUniversity of DundeeDundeeDD15EHScotlandUK State Key Laboratory of Heavy Oil Processing State Key Laboratory of Petroleum Pollution ControlChina University of PetroleumBeijing102249China Department of Water Protection Engineering and Environmental Microbiology Faculty of GeoengineeringUniversity of Warmia and Mazury in OlsztynOlsztyn10-720Poland

Antibiotic resistance is an escalating global health concern,exacerbated by the pervasive presence of antibiotic resistance genes(ARGs)in natural *** Yangtze River,the world's third-longest river,traversing areas with intense human activities,presents a unique ecosystem for studying the impact of these genes on human ***,we explored ARGs in the Yangtze River,examining 204 samples from six distinct habitats of approximately 6000 km of the river,including free-living and particle-associated settings,surface and bottom sediments,and surface and bottom bank *** shotgun sequencing,we generated an average of 13.69 Gb reads per *** findings revealed a significantly higher abundance and diversity of ARGs in water-borne bacteria compared to other habitats.A notable pattern of resistome coalescence was observed within similar habitat *** addition,we developed a framework for ranking the risk of ARG and a corresponding method for calculating the risk *** them,we identified water-borne bacteria as the highest contributors to health risks,and noted an increase in ARG risks in particle-associated bacteria correlating with heightened anthropogenic *** analysis using a weighted ARG risk index pinpointed the ChengdueChongqing and Yangtze River Delta urban agglomerations as regions of elevated health *** insights provide a critical new perspective on ARG health risk assessment,highlighting the urgent need for strategies to mitigate the impact of ARGs on human health and to preserve the ecological and economic sustainability of the Yangtze River for future human use.

关键词： Antibiotic resistance genes Yangtze River Habitat Coalescence Health risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrogenic sulfur oxidation mediated by cable bacteria and its ecological effects

引用

Environmental Science and Ecotechnology 2024年第4期20卷 34-41页

作者： Zhenyu Wang Leonid Digel Yongqiang Yuan Hui Lu Yonggang Yang Carsten Vogt hans-Hermann Richnow Lars peter Nielsen Department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research e UFZPermoserstraße 1504318LeipzigGermany Center for Electromicrobiology Department of BiologyAarhus UniversityDK-8000AarhusDenmark Key Laboratory of Karst Georesources and Environment Ministry of EducationCollege of Resources and Environmental EngineeringGuizhou UniversityGuiyang550025China School of Environmental Science and Engineering Sun Yat-Sen UniversityGuangzhou510006China School of Life Science and Engineering Foshan UniversityFoshan528225China State Key Laboratory of Applied Microbiology Southern China Institute of MicrobiologyGuangdong Academy of SciencesGuangzhou510007China

At the sediment-water interfaces,filamentous cable bacteria transport electrons from sulfide oxidation along their filaments towards oxygen or nitrate as electron *** multicellular bacteria belonging to the family Desulfobulbaceae thus form a biogeobattery that mediates redox processes between multiple *** bacteria were first reported in *** the past years,cable bacteria have been found to be widely distributed across the *** potential in shaping the surface water environments has been extensively studied but is not fully *** this review,the biogeochemical characteristics,conduction mechanisms,and geographical distribution of cable bacteria,as well as their ecological effects,are systematically reviewed and *** insights for understanding and applying the role of cable bacteria in aquatic ecology are summarized.

关键词： Cable bacteria Electrogenic sulfur oxidation Long-distance electron transfer Aquatic ecology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Interview with peter Deadman—Acupuncture Pioneer and Founder of The Journal of Chinese Medicine

引用

Chinese Medicine and Culture 2024年第1期7卷 19-28页

作者： Ioannis Solos Charles Buck peter Deadman Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom British Acupuncture Council London W129HQthe United Kingdom The Register of Chinese Herbal Medicine London WC1N 3GSthe United Kingdom

This interview was conducted on August 21st, 2022 by Charles Buck and Ioannis Solos. peter Deadman has worked in the field of health promotion for 50 years. He co-founded Infinity Foods(an organic and natural foods workers co-op) in 1971, followed by the Brighton Natural Health Centre-a charity dedicated to teaching ways to improve personal, community and planetary health and wellbeing. He qualified as an acupuncturist in 1978 and in Chinese herbal medicine in 1990. He founded The Journal of Chinese Medicine(UK) in 1979(Fig. 1), and co-authored A Manual of Acupuncture(published in 1998). He is the author of Live Well Live Long: Teachings from the Chinese Nourishment of Life Tradition. He has taught Chinese medicine and health promotion internationally for decades and is a dedicated practitioner and teacher of Qi Gong(气功).

关键词： Acupuncture Medicine herbal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental investigation on slip conditions during thread rolling with flat dies

引用

Friction 2024年第1期12卷 136-143页

作者： Stefan VOLZ peter GROCHE Institute for Production Engineering and Forming Machines Technical University DarmstadtOtto-Berndt Straße 2Darmstadt 64287Germany

The process design of flat die rolling operations can be a tedious and costly process due to the challenges posed by small process *** this work,an effort is made to closely investigate and understand the process limits caused by excessive slippage of the *** measurements are carried out to capture the characteristics of excessive slippage and the influence of the stroke rate and the tribological system on this process *** differences in slippage were observed,depending on the tribological *** systems with polymer based lubricants showed excessive slippage at low stroke rates,systems using oil or no lubricant endured higher stroke rates before process limits were *** optical measurements revealed three major forms of slippage:successful rolling without slippage,failure due to excessive slippage at process start,and failure due to excessive slippage at around one workpiece rotation.

关键词： rolling incremental forming thread rolling slippage profile rolling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：