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Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

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Signal Transduction and Targeted Therapy 2022年第1期7卷 243-257页

作者： Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David hans-martin jack Edith Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk Institute of Transplant Immunology MHHDHanoverGermany Department of Pneumology MHHDHanoverGermany Department of Intensive Care Medicine University of ZurichCHZurichSwitzerland Division of Molecular Immunology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany Department of Gastroenterology Hepatology and Endocrinology MHHDHanoverGermany Center for Individualized Infection Medicine CiiM HanoverGermany lnstitute of Virology MHHDHanoverGermany German Center for Infection Research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 RESIST MHHHanoverGermany German Center for Lung Diseases DZL/BREATH MarburgGermany

The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 *** define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering *** our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and *** patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific *** core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe *** within this sign ature were associated with either disease progression or *** summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity.

关键词： cytokine networks signature

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Fusarium pseudograminearum and *** affect the root system architecture of bread wheat

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The Crop Journal 2023年第1期11卷 316-321页

作者： Ahmed Saad jack Christopher Anke martin Stephen McDonald Cassandra Percy Centre for Crop Health University of Southern QueenslandToowoombaQLD 4350Australia University of Queensland Queensland Alliance for Agriculture and Food Innovation(QAAFI)Leslie Research FacilityToowoombaQLD 4350Australia

Yield losses of bread wheat due to crown rot can be more severe when drought conditions occur during the grain-filling *** architecture characteristics are important for soil exploration and belowground resource acquisition and are essential for adaptation to water-limited *** such as root angle,length and density have been strongly associated with acquisition efficiency and contribute to yield stability of the *** impact of crown rot pathogens on wheat root architecture is poorly *** examined differences in root angle,length and number,as well as dry root weight of the crown rot-susceptible bread wheat cultivar,Livingston inoculated with one of two crown rot pathogens Fusarium culmorum or Fusarium pseudograminearum in a transparent-sided root observation *** adverse impacts on plant health and growth were revealed by visual discolouration of the leaf sheaths;fresh and dry shoot weight;leaf area of the oldest and the youngest fully expanded leaf and leaf *** of most recorded root system measurements were reduced when inoculated with either *** or *** contrast,root angle was increased in the presence of *** but was not significantly changed by *** development of whiteheads and grain losses in bread wheat caused by crown rot have previously been associated with blockages of the vascular *** method employed here was able to identify differences in the pathogen impacts on roots,which were not detected using previous *** research indicates that in the presence of *** and *** infection,not only reductions in the size and biomass of the shoot system but also changes in the length,biomass and architecture of the root system could play an important role in yield loss.

关键词： Crown rot Root characteristics Livingston Wheat

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Microbial diversity and oil biodegradation potential of northern Barents Sea sediments

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Journal of Environmental Sciences 2024年第12期146卷 283-297页

作者： Song-Can Chen Florin Musat hans-Hermann Richnow martin Krüger Department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research–UFZLeipzigGermany Division of Microbial Ecology Department of Microbiology and Ecosystem ScienceUniversity of ViennaViennaAustria Department of Biology Section for MicrobiologyAarhus UniversityAarhusDenmark Department of Molecular Biology and Biotechnology Faculty of Biology and GeologyBabeș-Bolyai UniversityCluj-NapocaRomania Federal Institute for Geosciences and Natural Resources(BGR) Stilleweg 230655HannoverGermany

The Arctic,an essential ecosystem on Earth,is subject to pronounced anthropogenic pressures,most notable being the climate change and risks of crude oil *** crucial elements of Arctic environments,benthic microbiomes are involved in climate-relevant biogeochemical cycles and hold the potential to remediate upcoming ***,the Arctic benthic microbiomes are among the least explored biomes on the *** we combined geochemical analyses,incubation experiments,and microbial community profiling to detail the biogeography and biodegradation potential of Arctic sedimentary microbiomes in the northern Barents *** results revealed a predominance of bacterial and archaea phyla typically found in the deep marine biosphere,such as Chloroflexi,Atribacteria,and *** topmost benthic communities were spatially structured by sedimentary organic carbon,lacking a clear distinction among geographic *** increasing sediment depth,the community structure exhibited stratigraphic variability that could be correlated to redox geochemistry of *** benthic microbiomes harbored multiple taxa capable of oxidizing hydrocarbons using aerobic and anaerobic *** of surface sediments with crude oil led to proliferation of several genera from the so-called rare *** include Alkalimarinus and Halioglobus,previously unrecognized as hydrocarbon-degrading genera,both harboring the full genetic potential for aerobic alkane *** findings increase our understanding of the taxonomic inventory and functional potential of unstudied benthic microbiomes in the Arctic.

关键词： Arctic Deep-sea sediments Benthic microbiomes Biodiversity Oil biodegradation

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Pressureless sintering of ZrC with variable stoichiometry

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Journal of Advanced Ceramics 2017年第2期6卷 165-175页

作者： Katrin SCH(O)NFELD hans-Peter martin Alexander MICHAELIS Fraunhofer Institute for Ceramic Technologies and Systems IKTS Dresden Germany

This paper presents the experiments on the synthesis of zirconium carbide (ZrC) using carbothermal reduction of zirconia (ZrO2).The ratio of ZrO2∶C is used to adapt ZrCxOy with x＜ 1 or ZrC + *** modification of ZrCxOy and the total carbon amount allows the use of pressureless sintering method in combination with sintering temperatures ≤ 2000 ℃.Fully densified ZrC products are *** relevant details of ZrC formation are investigated by X-ray diffraction (XRD).The sintered products are characterized by XRD,field emission scanning electron microscopy (FESEM),as well as mechanical and electrical *** and FESEM investigations show that ZrCxOy is formed during the manufacturing *** grain size and additional zirconia or carbon are related to the ZrO2∶C ratio of the starting powder *** strength up to 300 MPa,Young's modulus up to 400 GPa,fracture toughness up to 4.1 MPa·m1/2,and electrical resistance at room temperature around 10-4 Ω.cm are reached by the pressureless sintered ZrC.

关键词： zirconium carbide (ZrC) carbothermal reduction sintering mechanical properties electrical properties

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Etching Effect on CMP of Different GaN Layers

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稀有金属材料与工程 2011年第S3期40卷 276-280页

作者： Siche Dietmar Rost hans-Joachim Schulz Tobias Albrecht martin Institute of Crystal Growth Max-Born-Str. 2 12489 Berlin Germany

Chemical mechanical polishing (CMP) was used to etch various GaN materials, such as GaN layers on sapphire and silicon carbide substrates grown by metal-organic chemical vapor deposition and thick GaN layers grown by physical vapor transport. It was found that CMP could reveal the dislocations in GaN surfaces due to a selective etching component. After the optimization of CMP condition, the surface finish improved and the subsurface damage was almost completely removed, demonstrated by atomic force microscopy and an electron back-scattered diffraction technique. This study established the correlation between the dislocation density and film quality. The crystalline perfection and optical properties of GaN layers were characterized by high resolution X-ray diffraction and photoluminescence.

关键词： surface etch pits CMP GaN

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Magnetic resonance imaging in children and adolescents with chronic inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1180-1191页

作者： hans-Joachim Mentzel Steffen Reinsch Monika Kurzai martin Stenzel Section of Pediatric Radiology Department of Radiology University Hospital Jena- Friedrich-Schiller-University Jena Section of Pediatric Gastro-enterology Department of Pediatrics University Hospital Jena Friedrich-Schiller-University Jena

Inflammatory bowel diseases(IBD) represent challenges, both from a diagnostic, and therapeutic point of view. Deep-seated anatomic structures are difficult to assess by ultrasound technique alone. As radiation-free alternative cross-sectional imaging method, magnetic resonance imaging of the intestinal structures is costly and time-consuming. Examination of pediatric patients imply additional considerations: reduction of body motions in younger children and consideration of the most appropriate preparation, and examination technique. The demanding Sellink technique is the only means for appropriately distending the lesser intestine in order to detect small bowel strictures. Oral intake of contrast medium(CM) alone shows its limitations regarding distensibility. The need for intravenous contrast media application needs to be considered, too. Active inflammation of both intestinal wall, and mesentery can be demonstrated accurately. Nevertheless, viable alternatives to CM application is desirable, considering non-negligible adverse reactions. Recent data suggest diffusion weighted imaging might fill this diagnostic gap. Irrespective of sequence technique chosen, bowel movement remains a major obstacle. Antispasmolytics in their function as smooth muscle relaxants help in improving image quality, however, their use in children might be off-label. Optimal preparation for the examination and appropriate imaging technique allow for diagnosing typical patterns of changes in IBD, such as bowel wall thickening, ulcers, mural stratification, strictures, creeping fat, and comb sign, and lymphadenopathy. The article gives a detailed overview of current significance of magnetic resonance imaging pediatric patients suffering from IBD, considering indications, limitations, and safety aspects.

关键词： Children, Adolescents, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Magnetic resonance imaging, Enterography

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Selection for production-related traits in Pelargonium zonale: improved design and analysis make all the difference

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Horticulture Research 2017年第1期4卷 365-373页

作者： Heike Molenaar martin Glawe Robert Boehm hans-Peter Piepho Institute of Crop Science University of HohenheimBiostatistics UnitStuttgart70599Germany Klemm+Sohn GmbH&Co.KG Stuttgart70378Germany

Ornamental plant variety improvement is limited by current phenotyping approaches and neglected use of experimental *** present study was conducted to show the benefits of using an experimental design and corresponding analysis in ornamental breeding regarding simulated response to selection in Pelargonium zonale for production-related *** required establishment of phenotyping protocols for root formation and stem cutting counts,with which 974 genotypes were assessed in a two-phase experimental *** present paper evaluates this *** possibility of varietal improvement through indirect selection on secondary traits such as branch count and flower count was assessed by genetic *** response to selection varied greatly,depending on the genotypic variances of the breeding population and traits.A varietal improvement of over 20%is possible for stem cutting count,root formation,branch count and flower *** contrast,indirect selection of stem cutting count by branch count or flower count was found to be *** established phenotypic protocols and two-phase experimental designs are valuable tools for breeding of ***.

关键词： breeding traits branch

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Discrete particle modeling of granular temperature distribution in a bubbling fluidized bed

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Particuology 2012年第4期10卷 428-437页

作者： Yurong He Tianyu Wang Niels Deen martin van Sint Annaland hans Kuipers Dongsheng Wen Department of Power Engineering College of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemical Engineering and Chemistry Eindhoven University of TechnologyPO Box 5135600 MB EindhovenThe Netherlands School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondon El 4NSUK

The discrete hard sphere particle model （DPM） is applied in this work to study numerically the distribu- tions of particle and bubble granular temperatures in a bubbling fluidized bed. The dimensions of the bed and other parameters are set to correspond to those of Miuller et al（2008）. Various drag models and oper- ational parameters are investigated to find their influence on particle and bubble granular temperatures. Various inlet superficial gas velocities are used in this work to obtain their effect on flow characteristics. It is found that the superficial gas velocity has the most important effect on granular temperatures including bubble granular temperature, particle translational granular temperature and particle rotational granular temperature. The drag force model affects more seriously the large scale variables such as the bubble gran- ular temperature. Restitution coefficient influences all granular temperatures to some degree. Simulation results are compared with experimental results by Muller et al. （2008） showing reasonable agreement.

关键词： Bubbling fluidized bedDiscrete hard sphere modelParticle and bubble granular temperature

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Near-infrared-reflection spectroscopy as measuring method to determine the state of the process for automatic control of anaerobic digestion

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International Journal of Agricultural and Biological Engineering 2013年第2期6卷 63-72页

作者： Andrea Stockl Daniel Löffler hans Oechsner Thomas Jungbluth Klaus Fischer martin Kranert State Institute of Agricultural Engineering and Bioenergy University of Hohenheim70593 Stuttgart-PlieningenGermany Institute for Sanitary Engineering Water Quality and Solid Waste ManagementUniversity of StuttgartBandtäle 270569 StuttgartGermany State Institute of Agricultural Engineering Livestock System EngineeringUniversity of Hohenheim70593 Stuttgart-PlieningenGermany

A recently developed control strategy for the anaerobic digestion process requires secure knowledge about the state of the *** near infrared reflection spectroscopy(NIRS),provides the possibility to determine process parameters of the anaerobic digestion process online and directly at the *** investigate if the NIRS measurements can successfully be used for the characterization of the state of the process within the control strategy the control was operated on two experimental *** NIR spectra were recorded during the *** values of the process parameters(mainly concentrations of organic acids)obtained by NIRS differ from the values of the chemical analyses during the *** the state of the process is categorized equally on the basis of both measurement *** can consequently be stated that NIRS is expected to meet the requirements of the control strategy.

关键词： near-infrared-reflection spectroscopy(NIRS) state of the process automatic process control anaerobic digestion biogas

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Chapter model systems in heterogeneous catalysis at the atomic level: a personal view

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Science China Chemistry 2020年第4期63卷 426-447页

作者： hans-Joachim Freund Markus Heyde Helmut Kuhlenbeck Niklas Nilius Thomas Risse Thomas Schmidt Shamil Shaikhutdinov martin Sterrer Fritz Haber Institute of the Max Planck Society Faradayweg 4-6Berlin D-14195Germany Fakultat V-Mathematik und Naturwissenschaften Carl von Ossietzky Universitat OldenburgGermany Institut fur Chemie und Biochemie Freie UniversitatBerlinGermany Institute of Physics University of GrazGrazAustria

The review presents an overview of studies in the surface science of oxide and related surfaces with an emphasis of the studies performed in the authors’ group. Novel instruments and technique developments, as well as their applications are reported, in an attempt to cover studies on model systems of increasing complexity, including some of the key ingredients of an industrially applied heterogeneous catalyst and its fabrication. The review is intended to demonstrate the power of model studies in understanding heterogeneous catalysis at the atomic level. The studies include those on supported nano-particles, both, prepared in vacuum and from solution, interaction of surfaces and the underlying bulk with molecules from the gas phase, strong metal support interaction, as well as the first attempt to include studies on reactions in confined spaces.

关键词： model catalysts oxide surfaces structure and spectroscopy supported nanoparticles reactions in the confined space

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