检索结果-南通市图书馆

The Top of the Biomimetic Triangle

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2008年第2期5卷 91-94页

作者： Andrei P. Sommer Dan Zhu Matthias Wiora hans-joerg fecht Institute of Micro and Nanomaterials University of Ulm Ulm 89081 Germany Institute for Nanotechnology Forschungszentrum Karlsruhe Karlsruhe 76021 Germany

There is increasing observational evidence indicating that crystalline interfacial water layers play a central role in evolution and biology. For instance in cellular recognition processes, in particular during first contact events, where cells decide upon survival or entering apoptosis. Understanding water layers is thus crucial in biomedical engineering, specifically in the design of biomaterials inspired by biomimetic principles. Whereas there is ample experimental evidence for crystalline interfacial water layers on surfaces in air, their subaquatic presence could not be verified directly, so far. Analysing a polarity dependent asym- metry in the surface conductivity on hydrogenated nanocrystalline diamond, we show that crystalline interfacial water layers persist subaquatically. Nanoscopic interfacial water layers with an order different from that of bulk water have been identified at room temperature on both hydrophilic and hydrophobic model surfaces - in air and subaquatically. Their generalization and systematic inclusion into the catalogue of physical and chemical determinants of biocompatibility complete the biomimetic triangle.

关键词： biomimetic triangle crystalline interfacial water layers nanobionics diamond

It is Time for a Change： oPetri Dishes Weaken Cells

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2012年第3期9卷 353-357页

作者： Andrei P. Sommer Mike Kh. Haddad hans-joerg fecht Institute of Micro and Nanomaterials University of Ulm 89081 Ulm Germany Institute for Nanotechnology Karlsruhe Institute for Technology 76344 Eggenstein-Leopoldshafen Germany

We wish to draw the attention to a potential deficiency in the biocompatibility of polystyrene cell culture dishes which is caused by a softening of the material under relevant culture conditions. The finding confirms the central hypothesis of our previous model study. In it we assumed a local increase in pH at the interface between the hydrophilic polymer and liquid. The finding is of considerable biological interest. Polystyrene tissue culture dishes are now in use for 50 years. To the best of our knowledge their biocompatibility has never been challenged. Here we report the first experimental proof that exposure to water softens the surface of polystyrene Petri dishes. We expect that our results will stimulate the development of a new generation of cell culture devices, including Petri dishes and culture flasks, and the establishment of improved biomimetic settings for tissue engineering and stem cell research. New non-swelling biomaterials or nanocoatings designed to reduce the swelling of polymer ct, lture dishes could improve cell performance. The need for further study is clear.

关键词： Petri dish polystyrene biomimetic triangle nanoindentation stem cells diamond

Ternary Diffusion Coefficients of 1-Hexanol-Hexane-Toluene and 1-Propanol-Water-Ethylene Glycol by Taylor Dispersion Method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2005年第5期10卷 523-528页

作者：任钟旗费维扬 hans-joerg Bart State Key Laboratory of Solvent Extraction Department of Chemical Engineering Tsinghua University Beijing 100084 China Institute of Chemical Engineering University of Kaiserslautern Kaiserslautern 67653 Germany

The Taylor dispersion method was used to measure diffusion coefficients of three-component liquid systems. An improved constrained nonlinear least-square method was used to evaluate the ternary diffusion coefficients directly by fitting the mathematical solutions of the dispersion equation to eluted solute peaks detected using a differential refractometer. Diffusion coefficients of the three-component system of acetone-benzene-CCl4, determined at 25℃, were used to test the procedure. The measured diffusion coefficients were compared with values obtained by optical interferometry and the diaphragm cell method. Ternary diffusion coefficients are also determinated for solutions of 1-hexanol-hexane-toluene and 1-propanol- water-ethylene glycol at 25℃, with an accuracy of approximately 0.05 m^2·s^- 1.

关键词： Taylor dispersion method ternary diffusion coefficient constrained nonlinear least-squared method Fick law

Evaluation of Hydroabrasion in a Slurry Tank

在线全文

学校读者我要写书评

暂无评论

Journal of Energy and Power Engineering 2013年第12期7卷 2273-2284页

作者： Mehdi Azimian hans-joerg Bart Chair of Separation Science and Technology Mechanical and Process Engineering Faculty University of KaiserslauternKaiserslautern D-67663 Germany

A slurry erosion tank test rig was designed and built to investigate the erosion rates of different materials and effects of the influencing parameters on material loss and erosion profiles. A CFD （computational fluid dynamics） tool is applied to study the flow impact velocity, solid concentration and particle size effects on the erosion rate of sample plates in the liquid-solid mixture in a cylindrical tank. The MRF （multiple reference frames） method is applied to model the rotating parts inside the tank. The flow behavior and liquid-solid interactions in the slurry tank test rig are simulated and the results are validated with the experimental data. It was approved that changing the height and diameter of each rotating zone （MRF zones） have a negligible effect on simulation results. It was observed that the erosion mass losses are increasing with increase in flow velocity and sand concentration. Both variations can be predicted with a logarithmic dependence of mass loss to rotational velocity and sand concentration. The increase in erosion rate by increase in particle size was also observed for three various particle size distributions.

关键词： CFD liquid-solid mixture slurry tank erosion rate.

Swelling Kinetics Associated with Diffusion of Poly （N-isopropylacrylamide） Hydrogel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料科学与工程（中英文B版） 2011年第3期1卷 247-258页

作者： Naddaf Aisha Ahmad hans-joerg Bart Chair of Separation Science and Technology Kaiserslautern University Kaiserslautern 67653 Germany

A Double-Blind, Randomized, Placebo-Controlled Nutritional Study Using an Insoluble Yeast Beta-Glucan to Improve the Immune Defense System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2012年第6期3卷 738-746页

作者： hans-Joachim Graubaum Regina Busch Heike Stier joerg Gruenwald Analyze & Realize AG Berlin Germany.

Purpose: In a placebo-controlled, double-blind, randomized clinical trial, the effect of an insoluble yeast beta-glucan preparation on the incidences of common colds and its effect on common cold symptoms were compared to placebo. Methods: 100 healthy participants with recurring infections were randomly assigned to receive either placebo or yeast beta-glucan (Yestimun?;n = 50 each group) over a period of 26 weeks. The subjects had to document each common cold episode in a diary, and rate 6 predefined infections symptoms on a 3-point rating scale during an infection period, resulting in an infection score. The common cold episodes were confirmed by the investigators. Results: A total of 171 common cold episodes were documented. Of these, 76 were experienced by 38 subjects in the beta-glucan group and 96 were experienced by 48 subjects in the placebo group (p = 0.406). The beta-glucan group had significantly more subjects without incidences of common cold than the placebo group (15.6% vs 2.0%;p = 0.019). During the most intense infection season (first 13 weeks of the study), the beta-glucan group had significantly less infections compared to placebo (p = 0.02). Beta-glucan significantly reduced the typical cold symptoms (“sore throat and/or difficulty swallowing”, “hoarseness and/or cough” and “runny nose”) as opposed to placebo. Conclusion: The present study demonstrates a prophylactic effect of yeast beta-glucan on the occurrence of common colds as opposed to placebo. In addition, when these episodes occurred, they were from the beginning less pronounced and subsided faster.

关键词： Randomized Placebo-Controlled Study Insoluble Yeast Beta-Glucan Common Cold Immune System

Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第39期11卷 6104-6109页

作者： Gerhild Becker Tarik Soezgen Manfred Olschewski joerg Laubenberger Hubert Erich Blum hans-Peter Allgaier for the Hcc Study Group Department of Medicine Ⅱ Department of Medical Biometry and Statistics and Department of RadiologyUniversity Hospital FreiburgGermany

AIM： To assess whether the effectiveness of a combination of transarterial chemoembolization （TACE） and percutaneous ethanol injection （PEI） in the treatment of unresectable hepatocellular carcinoma （HCC） is superior to TACE alone a randomized controlled trial was performed. METHODS： The effect of combination therapy on longterm survival rates and duration of hospitalization was evaluated in 52 previously untreated HCCs, randomly allocated to TACE-PEI （27 pts） or TACE alone （25 pts）. RESULTS： The cumulative survival rate of the TACE group was 75.8% at 6 mo, 62.9% at 12 mo, and 18.0% at 24 mo and of the TACE-PEI group 76.9%, 61.5%, and 38.7%, respectively. Comparison of overall survival in both groups showed no statistically significant difference. Regarding the patients with HCCs Okuda stage I （n = 26）, the median survival of the TACE-PEI group was significantly longer （〉24 mo, median not yet reached in the study period） compared to the TACE group （18.4 mo [range 11.6-21.7 mo]; P = 0.04）. TACE-PEI reduced the relative risk for mortality to 0.4 （95% CI 0.15-0.96） compared to patients who received TACE alone. Median survival in patients with HCCs Okuda stage Ⅱ or Ⅲ was 5.0 mo in the TACE group （1.7 rno-not defined） compared to 10.4 mo in the TACE-PEI group. CONCLUSION： The combination TACE-PEI improved survival time compared to TACE alone. Our study revealed a statistically significant improved survival in HCCs Okuda stage I. Side effects were minor and the combination therapy did not prolong duration of hospitalization considerably.

关键词： Hepatocellular carcinoma Chemoembolization Ethanol injection Combination therapy

颗粒物质控制膜污染的增强型膜生物反应器工艺的研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

膜科学与技术 2010年第2期30卷 74-78页

作者： Stefan Krause 学贤董正军 hans joerg Heckmann Microdyn-Nadir GmbH Wiesbaden 65203 迈纳德膜技术(厦门)有限公司厦门361022

用于废水处理的膜生物反应器工艺(MBR),是指通过膜过滤实现活性污泥与产水的分离的新型生化法处理废水技术.由于MBR具有占地面积小和出水水质好的优点,膜生物反应器成功应用到废水处理中的案例正在迅速增加.膜污染是MBR废水处理工艺面... 详细信息

用于废水处理的膜生物反应器工艺(MBR),是指通过膜过滤实现活性污泥与产水的分离的新型生化法处理废水技术.由于MBR具有占地面积小和出水水质好的优点,膜生物反应器成功应用到废水处理中的案例正在迅速增加.膜污染是MBR废水处理工艺面临的主要问题之一.膜污染会导致膜的渗透性能降低,为此必须通过化学清洗才能恢复膜的性能.为了实现无化学清洗的MBR工艺,研究使用持续物理冲刷去除膜污染层的方法.在活性污泥中加入颗粒物质(粉料),通过这些颗粒物质的持续冲刷作用实现去除膜污染层的目的.经过8个多月的实验,膜组件的渗透性能保持不变,通量可以达到40 L/(m2.h)以上.系统安装了在线的浊度仪作为产水质量的检测,在试验过程中,浊度始终没有变化.作为对比,同时也进行了一个参照实验(MBR标准工艺,没有加入颗粒物质),实验结果表明,传统的MBR工艺的膜组件渗透性能会不断下降导致通量下降,需要进行化学清洗.新型MBR工艺高通量和无需化学清洗的优势,将极大地提高MBR工艺的成本效益.

关键词： MBR 颗粒污染控制聚合平板膜

Early response evaluation and prediction in neoadjuvant-treated patients with esophageal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2009年第1期1卷 30-37页

作者： joerg Theisen Bernd Krause Christian Peschel Roland Schmid hans Geinitz Helmut Friess Department of Surgery Klinikum rechts der IsarTU Muenchen Department of Nuclear Medicine Klinikum rechts der IsarTU Muenchen Department of Oncology Klinikum rechts der IsarTU Muenchen Department of Gastroenterology Klinikum rechts der IsarTU Muenchen Department of Radiation Oncology Klinikum rechts der IsarTU Muenchen

Since the introduction of multimodal therapy regimens,the prognosis of esophageal cancer has *** is undoubtedly true for patients with surgically resected tumors in the case of a response to neoadjuvant chemotherapy or *** conclusions can be drawn from this regarding the indication for perioperative therapies,the radicality of surgery,or the surgical ***,most of the current research in this f ield is aimed at the early identif ication of this subset of patients,at the beginning of,or even before,neoadjuvant *** staging tools have failed to predict responses to neoadjuvant ***,molecular imaging methods,*** emission tomography(PET)-scans,have shown promising results in the early selection of responders and non-responders during the course of neoadjuvant therapy,allowing physicians to alter the treatment plan *** more desirable is the identif ication of potential responders before the start of neoadjuvant *** molecular data on biopsy specimens demonstrate the possibility of early response prediction in these *** present the current knowledge on response evaluation and prediction in esophageal cancer and draw conclusions for future clinical practice and studies in this review.

关键词： Esophageal cancer Response prediction Individualized therapy