检索结果-南通市图书馆

Time-Domain Frequency Correction Method for Averaging Low-Field NMR Signals Acquired in Urban Laboratory Environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2012年第10期29卷 213-216页

作者： QIU Long-Qing LIU Chao DONG Hui XU Lu ZHANG Yi hans-joachim krause XIE Xiao-Ming Andreas Offenhäusser State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyShanghai 200050 Peter Grünberg Institute(PGI-8) Forschungszentrum JülichJülichD-52425Germany Joint Research Laboratory on Superconductivity and Bioelectronics Collaboration between CAS-Shanghai and Forschungszentrum JülichShanghai 200050 Graduate University of the Chinese Academy of Sciences Beijing 100049

Using a second-order helium-cooled superconducting quantum interference device gradiometer as the detector,ultra-low-field nuclear magnetic resonance(ULF-NMR)signals of protons are recorded in an urban environment without magnetic *** homogeneity and stability of the measurement field are *** signals of protons are studied at night and during working *** Larmor frequency variation caused by the fluctuation of the external magnetic field during daytime reaches around 5 Hz when performing multiple measurements for about 10 min,which seriously affects the results of *** order to improve the performance of the averaged data,we suggest the use of a data processor,*** so-called time-domain frequency correction(TFC).For a 50-times averaged signal spectrum,the signal-to-noise ratio is enhanced from 30 to 120 when applying TFC while preserving the NMR spectrum *** TFC is also applied successfully to the measurement data of the hetero-nuclear J-coupling in 2,2,2-trifluoroethanol.

关键词： NMR averaged spectrum

Effect of HTS Superconductors on Homogeneity of Measurement Field in Low Field Nuclear Magnetic Resonance Detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2010年第8期27卷 250-252页

作者：董慧张懿 krause hans-joachim 谢晓明 State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 Institute of Bio- and Nanosystems Forschungszentrum Jiilich. D-52425 Jiilieh Germany Graduate University of the Chinese Academy of Sciences Beijing 100049

In recent years, superconducting quantum interference devices （SQUIDs） have been demonstrated to be useful in the low field nuclear magnetic resonance （NMR） measurements. The high temperature superconducting （HTS） SQUID used in our experiments has a frequency-independent sensitivity of 40-50fT/Hz^1/2. When a liquid nitrogen cooled LC circuit is employed to form a tuned circuit with the SQUID, the sensitivity of the system can be further enhanced. The LC circuit consists of a capacitor and a coil made of copper wire or HTS tape, which is inductively coupled to the SQUID. However, the homogeneity of the measurement field deteriorates because of the HTS tape coil in the proximity of the sample. In contrast, the thin film SQUID with a washer area of 1 cm^2 has no effect on the NMR signal. Therefore, the impairment of the measurement field homogeneity in the case of different superconducting elements nearby is discussed by examining the free induction decay signals at 9 kHz. It is found that a square superconducting film with an area of i cm^2 may compensate for the inhomogeneity of the measurement field after the adjustment of its position.

关键词： HIGH temperature superconductors NUCLEAR magnetic resonance SUPERCONDUCTING quantum interference devices PHYSICS experiments LIQUID nitrogen SENSITIVITY analysis

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

Distinct antifibrogenic effects of erlotinib,sunitinib and sorafenib on rat pancreatic stellate cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第24期20卷 7914-7925页

作者： Anne Elsner Falko Lange Brit Fitzner Martin Heuschkel Bernd joachim krause Robert Jaster Department of Medicine Ⅱ Division of GastroenterologyUniversity Medicine Rostock18057 RostockGermany Department of Neurology University Medicine Rostock18119 RostockGermany Department of Nuclear Medicine University Medicine Rostock18057 RostockGermany

AIM: To study if three clinically available small molecule kinase inhibitors (SMI), erlotinib, sunitinib and sorafenib, exert antifibrogenic effects on pancreatic stellate cells (PSC) and analyze the basis of their ac... 详细信息

关键词： Pancreatic stellate cell Fibrosis Erlotinib Sunitinib Sorafenib

Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第2期24卷 170-178页

作者： Peter Wallbaum Sarah Rohde Luise Ehlers Falko Lange Alexander Hohn Carina Bergner Sarah Marie Schwarzenbock Bernd joachim krause Robert Jaster Department of MedicineⅡ Division of GastroenterologyRostock University Medical CenterRostock 18057Germany Oscar-Langendorff-Institute of Physiology Rostock University Medical CenterRostock 18057Germany Department of Nuclear Medicine Rostock University Medical CenterRostock 18057Germany

AIM To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells(PSCs).METHODS Quiescent PSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures(early-activated PSCs) and upon re-culturing(fullyactivated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining. Expression of α-smooth muscle actin(α-SMA), a marker of PSC activation, was monitored by immunofluorescence and immunoblot analysis. The rate of DNA synthesis was quantified by 5-bromo-2'-deoxyuridine(Brd U) incorporation assays. Real-time PCR was employed to monitor gene expression, and protein levels of interleukin-6(IL-6) were measured by ELISA. Uptake of proline was determined using 18 *** Sustained culture of originally quiescent PSCs inducedcell proliferation, loss of lipid droplets and exhibition of stress fibers, indicating cell activation. When added to PSCs in primary culture, all three D-vitamins diminished expression of α-SMA(to 32%-39% of the level of control cells; P < 0.05) and increased the storage of lipids(scores from 1.97-2.15 on a scale from 0-3; controls: 1.49; P < 0.05). No such effects were observed when D-vitamins were added to fully-activated cells, while incorporation of Brd U remained unaffected under both experimental conditions. Treatment of re-cultured PSCs with D-vitamins was associated with lower expression of IL-6(-42% to-49%; P < 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene(209%-321% vs controls; P < 0.05). There was no effect of D-vitamins on the expression of transforming growth factor-β1 and collagen type 1(chain α1). The lowest uptake of proline, a main component of collagen, was observed in calcipotriol-treated *** The three D-vitamins inhibit, with similar efficiencies, activation of PSCs in v

关键词： Pancreatic stellate cells Fibrosis Vitamin D2 Vitamin D3 Calcipotriol