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Neural Regeneration Research 2022年第9期17卷 1881-1884页

作者： christian Humpel Laboratory of Psychiatry and Experimental Alzheimer’s Research Medical University of InnsbruckInnsbruckAustria

Neurodegenerative brain disorders are a major burden in our society,such as Alzheimer´s *** order to repair or prevent such diseases,drugs are designed which enter the brain,but the blood-brain barrier limits their entry and the search for alternative pathways is ***,we reported that intranasal delivery of the amyloid-beta degrading enzyme neprilysin eliminated amyloid-beta plaques in transgenic Alzheimer´s disease *** review describes the anatomical structure of the intranasal pathway,explains the intranasal delivery of pure neprilysin,cell-loaded neprilysin(platelets)and collagen-embedded neprilysin to destruct amyloid-beta plaques in Alzheimer´s disease in transgenic APP_SweDI mice and hypothesizes why this may cause compensation and why the amyloid-beta cascade hypothesis may fail.

关键词： amyloid-beta amyloid-beta degrading enzyme clear plaque collagen biomaterial intranasal neprilysin nose-to-brain

Cross-Talk between ROS and Calcium in Regulation of Nuclear Activities

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Molecular Plant 2010年第4期3卷 706-718页

作者： christian Mazars Universite de Toulouse UPS UMR 5546 Surfaces Cellulaires et Signalisation chez les Vegetaux BP 42617 F-31326 Castanet-Tolosan France CNRS UMR 5546 BP 42617 F-31326 Castanet-Tolosan France Universite de Bourgogne UMR Plante-Microbe-Environnement BP 86510 21065 Dijon cedex France UMR INRA 1088 CNRS 5184 Universite de Bourgogne Plante-Microbe-Environnement BP 86510 21065 Dijon cedex France

Calcium and Reactive Oxygen Species （ROS） are acknowledged as crucial second messengers involved in the response to various biotic and abiotic stresses. However, it is still not clear how these two compounds can play a role in different signaling pathways leading the plant to a variety of processes such as root development or defense against pathogens. Recently, it has been shown that the concept of calcium and ROS signatures, initially discovered in the cytoplasm, can also be extended to the nucleus of plant cells. In addition, it has been clearly proved that both ROS and calcium signals are intimately interconnected. How this cross-talk can finally modulate the translocation and/or the activity of nuclear proteins leading to the control of specific genes expression is the main focus of this review. We will especially focus on how calcium and ROS interact at the molecular level to modify their targets.

关键词： Nucleus Calcium ROS Crosstalk Signalling.

Integrating geometallurgical ball mill throughput predictions into short-term stochastic production scheduling in mining complexes

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International Journal of Mining Science and Technology 2023年第2期33卷 185-199页

作者： christian Both Roussos Dimitrakopoulos COSMO–Stochastic Mine Planning Laboratory Department of Mining and Materials EngineeringMcGill UniversityMontreal H3A 0E8Canada

This article presents a novel approach to integrate a throughput prediction model for the ball mill into short-term stochastic production scheduling in mining *** datasets for the throughput prediction model include penetration rates from blast hole drilling(measurement while drilling),geological domains,material types,rock density,and throughput rates of the operating mill,offering an accessible and cost-effective method compared to other geometallurgical ***,the comminution behavior of the orebody was geostatistically simulated by building additive hardness proportions from penetration rates.A regression model was constructed to predict throughput rates as a function of blended rock properties,which are informed by a material tracking approach in the mining ***,the throughput prediction model was integrated into a stochastic optimization model for short-term production *** way,common shortfalls of existing geometallurgical throughput prediction models,that typically ignore the non-additive nature of hardness and are not designed to interact with mine production scheduling,are overcome.A case study at the Tropicana Mining Complex shows that throughput can be predicted with an error less than 30 t/h and a correlation coefficient of up to *** integrating the prediction model and new stochastic components into optimization,the production schedule achieves weekly planned production reliably because scheduled materials match with the predicted performance of the *** to optimization using conventional mill tonnage constraints reveal that expected production shortfalls of up to 7%per period can be mitigated this way.

关键词： Geometallurgy Stochastic optimization Short-term open pit mine production scheduling Measurement while drilling Non-additivity Hardness

Spatio-temporal modelling of the effect of selected environmental and land-use factors on acid grassland vegetation

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Journal of Plant Ecology 2022年第2期15卷 253-264页

作者： christian Damgaard Department of Bioscience Aarhus UniversityVejlsøvej 258600 SilkeborgDenmark

Acid grasslands are threatened both by agricultural intensification with nutrient addition and increased livestock densities as well as by land *** order to understand and quantify the effect of selected environmental and land-use factors on the observed variation and changes in the vegetation of acid grasslands,large-scale spatial and temporal pin-point plant cover monitoring data are fitted in a structural equation *** important sources of measurement and sampling uncertainties have been included using a hierarchical model ***,uncertainties associated with the measurement and sampling are separated from the process uncertainty,which is important when generating ecological predictions that may feed into local conservation management ***,increasing atmospheric nitrogen deposition led to more grass-dominated acid grassland habitats at the expense of the cover of *** soils were relatively more acidic,and the effects of soil type on the vegetation include both direct effects of soil type and indirect effects mediated by the effect of soil type on soil *** soil type and soil pH affected the vegetation of acid *** though only a relatively small proportion of the temporal variation in cover was explained by the model,it would still be useful to quantify the uncertainties when using the model for generating local ecological predictions and adaptive management plans.

关键词： joint distribution of plant abundance spatial and temporal variation of cover hierarchical Bayesian models pin-point cover data structural equation modelling acid grassland vegetation

Solvent Interactions with Polymeric Heat Transfer Surfaces

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材料科学与工程（中英文A版） 2013年第9期3卷 591-600页

作者： christian Dreiser hans-Joeg Bart Chair of Separation Science and Technology University of Kaiserslautern Kaiserslautern D-67653 Germany

Little Tiny or Thumbelina （III）

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考试与评价（英语高二专刊） 2017年第6期 44-45,38页

作者： hans christian Andersen 曹硕不详吉林长春

Little Tiny or Thumbelina （I）

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考试与评价（英语高二专刊） 2017年第4期 44-46,39页

作者： hans christian Andersen 曹硕不详吉林长春

世界上有一些书是可以从小读到老的，丹麦作家安徒生的童话就具有这种独特魅力。人们如此隆重地纪念一位童话作家，是因为他的童话作品已成为一代又一代读者心目中的经典，而经典的魅力是不会随时间的流逝而改变的。本期向你讲述其中的... 详细信息

世界上有一些书是可以从小读到老的，丹麦作家安徒生的童话就具有这种独特魅力。人们如此隆重地纪念一位童话作家，是因为他的童话作品已成为一代又一代读者心目中的经典，而经典的魅力是不会随时间的流逝而改变的。本期向你讲述其中的一个故事——拇指姑娘。

关键词：中等教育英语阅读理解

Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer’s disease

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Translational Neurodegeneration 2021年第2期10卷 230-239页

作者： Mari Aksnes hans christian DAass Ann Tiiman Trine Holt Edwin Lars Terenius Nenad Bogdanovic Vladana Vukojevic Anne-Brita Knapskog Department of Geriatric Medicine Institute of Clinical MedicineFaculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Clinical Neurosciences(CNS) Center for Molecular Medicine CMM L8:01Karolinska InstitutetStockholmSweden Department of Geriatric Medicine The Memory ClinicOslo University HospitalOsloNorway Institute of Health and Society Faculty of MedicineUniversity of OsloOsloNorway Norwegian National Advisory Unit on Ageing and Health Vestfold Hospital TrustTonsbergNorway Department of Neurobiology Care Science and Society(NVS)Division of Clinical GeriatricsKarolinska InstitutetHuddingeSweden

Background:The aggregation of amyloidβ(Aβ)is central in the pathogenesis of Alzheimer’s disease(AD).Recently it has been shown that specifically,larger,Thioflavin T-binding Aβaggregates are associated with increased neuroinflammation and cytokine *** study was aimed to quantify fibrillary amyloid aggregates,so-called nanoplaques,and investigate their relationship with cytokines in the cerebrospinal fluid(CSF).Methods:CSF was collected from 111 patients assessed for cognitive complaints at the Oslo University Hospital Memory *** patients were grouped based on their amyloid *** CSF nanoplaque concentration was quantified with the Thioflavin T-fluorescence correlation spectroscopy(ThT-FCS)*** levels of nine cytokines(eotaxin-1,granulocyte stimulating factor,interleukin[IL]-6,IL-7,IL-8,monocyte chemoattractant protein-1,gammainduced protein 10,macrophage inflammatory protein[MIP]-1α,and MIP-1β)were quantified with a magnetic bead-based multiplex assay and read on a Luminex IS 200 ***:There were 49 amyloid-negative and 62 amyloid-positive patients in the cohort;none of the cytokines differed significantly between the amyloid *** increased nanoplaque levels were associated with levels of MIP-1βbelow the lower limit of quantification,and with decreased levels of MIP-1αand *** associations remained significant when adjusted for age,sex,cognitive function,apolipoproteinε4 status and CSF core biomarker ***:The cytokine levels were not associated with amyloid status in this *** nanoplaque levels were negatively associated with MIP-1β,MIP-1αand IL-8,which is in line with recent findings suggesting that the upregulation of some cytokine markers has a protective role and is negatively associated with AD progression.

关键词： Alzheimer's disease Amyloid Amyloid beta peptides Amyloidogenic proteins Biomarkers Cerebrospinal fluid Cytokines Inflammation Fluorescence correlation spectroscopy Thioflavin T

Collaborative Assessments in Computer Science Education: A Survey

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Tsinghua Science and Technology 2019年第4期24卷 435-445页

作者： hans Yuan Paul Cao the Computer Science & Engineering Department University of CaliforniaSan Diego

As computer science enrollments continue to surge, assessments that involve student collaboration may play a more critical role in improving student learning. We provide a review on some of the most commonly adopted collaborative assessments in computer science, including pair programming, collaborative exams, and group projects. Existing research on these assessment formats is categorized and compared. We also discuss potential future research topics on the aforementioned collaborative assessment formats.

关键词： assessment collaboration pair programming collaborative exam group project

DYNAMIC MODEL AND SIMULATION OF THE PLATELETS'ROLE IN BLOOD COAGULATION

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Acta Mechanica Sinica 2002年第4期18卷 420-428页

作者：许传青曾衍钧 hans Grgersen Biomechanics Research Center Beijing Polytechnic Univ.Beijing 100022China Armed Forced InstituteBeijing 100072China Biomechanics Research Center Beijing Polytechnic Univ.Beijing 100022China Center for Sensory-Motor Interaction Aalborg UniversityDenmark

In order to confirm which process is the most important in the blood coagulation cascade,a dynamic model on the function of platelets in blood coagulation is presented based on biochemical *** on qualitative analysis and mathematical simulation,a series of conclusions about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin(IIa)are *** is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation *** value is related to the binding constant d_2 of the platelet. The stability of the equilibrium value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on *** proportion of platelets activated at any given time is designated *** each c,we obtain a maximum concentration of *** is evident that when the level of factor IX is below 1% of the normal level,the rate of thrombin generation reduces dramatically,resulting in severe bleeding tendency.

关键词： dynamic system numerical simulation biochemical process blood coagulation waterfall mechanism