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Estimate of oxygen consumption and intracellular zinc concentration of human spermatozoa in relation to motility

Asian Journal of Andrology 2003年第1期5卷 3-8页

作者： Ralf R.Henkel Kerstin Defosse hans-wilhelm koyro Norbert Weissmann Wolf-Bernhard Schill Center for Dermatology and Andrology University D-35385 Giessen GermanyCenter for Dermatology and Andrology University D-35385 Giessen GermanyInstitute for Plant Ecology University D-35385 Giessen GermanyCenter for Internal Medicine Justus Liebig University D-35385 Giessen GermanyCenter for Dermatology and Andrology University D-35385 Giessen Germany

Aim: To investigate the human sperm oxygen/energy consumption and zinc content in relation to motility. Methods: In washed spermatozoa from 67 ejaculates, the oxygen consumption was determined. Following calculation of the total oxygen consumed by the Ideal Gas Law, the energy consumption of spermatozoa was calculated. In addition, the zinc content of the sperm was determined using an atomic absorption spectrometer. The resulting data were correlated to the vitality and motility. Results: The oxygen consumption averaged 0.24μmol/106 sperm×24 h, 0.28μmol/106 live sperm×24 h and 0.85μmol/106 live & motile sperm×24 h. Further calculations revealed that sperm motility was the most energy consuming process (164.31 mJ/106 motile spermatozoa×24 h), while the oxygen consumption of the total spermatozoa was 46.06 mJ/106 spermatozoa×24 h. The correlation of the oxygen/ energy consumption and zinc content with motility showed significant negative correlations (r= -0.759; P<0.0001 and r=-0.441; P<0.0001, respectively). However, when correlating sperm energy consumption with the zinc content, a significant positive relation (r=0.323; P=0.01) was observed. Conclusion: Poorly motile sperm are actually wasting the available energy. Moreover, our data clearly support the 'Geometric Clutch Model' of the axoneme function and demonstrate the importance of the outer dense fibers for the generation of sperm motility, especially progressive motility.

关键词： oxygen energy consumption human spermatozoa sperm motility zinc

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Impact of a biochar or a biochar-compost mixture on water relation, nutrient uptake and photosynthesis of Phragmites karka

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Pedosphere 2020年第4期30卷 466-477页

作者： Zainul ABIDEEN hans-Werner koyro Bernhard HUCHZERMEYER Bilquees GUL M.Ajmal KHAN Institute of Sustainable Halophyte Utilization University of KarachiKarachi 75270(Pakistan) Institute of Plant Ecology Justus Liebig University GiessenGiessen D-35392(Germany) Institute of Botany Gottfried Wilhelm Leibniz UniversityHannover D-30419(Germany)

Soil water and nutrient status are both of major importance for plant appearance and growth *** objective of this study was to understand the effect of biochar(1.5%)and a biochar-compost mixture(1.5%biochar+1.5%compost)on the performance of Phragmites karka plants grown on a synthetic nutrient-poor sandy clay soil(50% sand,30% clay,and 20% gravel).Indicators of plant performance,such as growth,lignocellulosic biomass,water status(leaf water potential,osmotic potential,and turgor potential),mineral nutrition status,leaf gas exchange,and chlorophyll fluorescence,and soil respiration(carbon dioxide(CO2)flux)were assessed under greenhouse ***-treated plants had higher growth rates and lignocellulosic biomass production than control plants with no biochar and no *** was also a significant increase in soil respiration in the treatments with biochar,which stimulated microbial *** increase in soil water-holding capacity after biochar amendment caused significant improvements in plant water status and plant ion(K^+,Mg^2+,and Ca^2+)contents,leading to an increase in net photosynthesis and a higher energy-use efficiency of photosystem ***-treated plants had lower oxidative stress,increased water-use efficiency,and decreased soil respiration,and the biochar-compost mixture resulted in even greater improvements in growth,leaf turgor potential,photosynthesis,nutrient content,and soil gas *** results suggest that biochar and compost promote plant growth with respect to nutrient uptake,water balance,and photosynthetic system *** summary,both the soil amendments studied could increase opportunities for *** to sequester CO2 and produce more fodder bio-active compounds and biomass for bio-energy on nutrient-poor degraded soils.

关键词： bio-energy crop chlorophyll fluorescence degraded soil plant eco-physiology plant growth photochemical efficiency water status

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XEN® Gel Implant for Glaucoma;Prospective Cohort Study in a High-Volume Department

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Open Journal of Ophthalmology 2023年第2期13卷 208-220页

作者： hans wilhelm Meyer Tiril Sandell Department of Ophthalmology Oslo University Hospital Oslo Norway Department of Ophthalmology Vestre Viken Hospital Trust Drammen Norway

Purpose: To evaluate the 3-year efficiency and safety of XEN® 45 gel stent implantation in a heterogenous group of open angle glaucoma patients. Methods: In this prospective, non-randomized observational study we identified patients who had undergone either stand-alone XEN® implantation (XEN solo) or XEN® implantation in combination with phacoemulsification (XEN combi). All patients who had undergone an implantation during the period 01.04.17-31.10.19 at the Department of Ophthalmology, Drammen Hospital, Norway, were asked to participate. Success was defined as IOP between 5 - 18 mmHg and 20% pressure reduction without medications. Qualified success required the same pressure interval and reduction but allowed medications. The procedure was deemed as failure if pressure requirements were not met, vision was reduced to light perception or worse, or if there was a converion to secondary glaucoma surgery. Results: Out of 115 patients and 133 eyes identified, 87 patients and 99 eyes consented to participate. All patients were Caucasians with a mean age of 73.6 years. The study had a mean (range) follow-up of 38.9 (28 - 54) months. The mean medicated baseline (SD) was reduced from 22.6 (7.9) mmHg on 3.2 (1.1) medications to 14.2 (5.6) mmHg on 1.4 (1.6) medications. Success and qualified success were achieved in 22.2% and 21.2%, respectively. Needling was performed in 34 eyes. Conclusion: XEN® 45 gel stent implantation is a safe procedure, offering a significantly lower IOP and number of medications in a subset of patients with open angle glaucoma.

关键词： Long Term Outcome after XEN® Gel Stent Open Angle Glaucoma OAG Pseudoexfoliative Glaucoma Minimally Invasive Glaucoma Surgeries MIGS

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Why There Will Be No Peak Coal in the Foreseeable Future

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Open Journal of Geology 2012年第2期2卷 57-64页

作者： Thomas Thielemann hans-wilhelm Schiffer Coal Mining RWE Power AG Essen/Cologne Germany General Economic Policy/Science RWE AG Essen Germany

Hard coal and lignite—also referred to here jointly as coal—play a central role in the worldwide supply of humanity with primary energy. As a fossil energy carrier, coal is one of the finite natural resources. The reach of the world’s coal reserves is significant, and coal has the potential to cover some of the global energy and raw-material needs at least into the 22nd century. Precondition for this is a sustainable energy policy, i.e. an equal-ranking view of the goals of environmental and climate compatibility (sustainability), security of supply and competitiveness (affordability). The focus of developments is on resource efficiency and energy savings to obtain more modern and more efficient coal-based power plants. Greater use of coal translates into higher CO2 emissions. So if we are to achieve the climate-protection goals of limiting the rise in temperatures and reducing the CO2 content in the Earth’s atmosphere, the launch of CCS technology is recommended. Within the scope of the climate-protection debate, a discussion is also underway about an alleged drying up of coal availability in the short term (under the heading of “peak coal”). This discussion is an example of how, from the limited perspective of particular interests, a swathe of facts can be ignored. Hence, this article sets out to take a fact-based, sober look at the subject of the “reach of global coal reserves”. How much coal do we really have? And to what extent will coal be available tomorrow to guarantee secure and affordable energy supplies in the future as well? These issues will be investigated here.

关键词： Coal Hard Coal Lignite Reserves Resources Mining Exploration Trade CCS

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中国城乡地区的生态卫生(英文)

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中国给水排水 2006年第23期22卷 103-108页

作者： Michael Hecht hans-wilhelm Alfen 魏玛鲍豪斯大学土木及结构工程学院

在今后的几十年中,中国的城市污水处理领域将需要上百亿美元的投资。当前通过增加城市环境投资来改善水质的做法受到了全球专家的赞许,但是在将卫生策略与高度非逆转投资结合在一起之前,中国应该考虑替代卫生概念的可用性。许多科学家... 详细信息

在今后的几十年中,中国的城市污水处理领域将需要上百亿美元的投资。当前通过增加城市环境投资来改善水质的做法受到了全球专家的赞许,但是在将卫生策略与高度非逆转投资结合在一起之前,中国应该考虑替代卫生概念的可用性。许多科学家、政策顾问及实业家都高度重视生态卫生,因为从生态和经济意义上讲生态卫生比传统卫生体系更具持续性。通过分析中国的水资源现状、环保法规及水务投资等,指出实施生态卫生工程的必要性,并提出了城市生态卫生的价值链。根据中国城市生态卫生试点项目的经验,详细说明了有关的政策问题。

关键词：生态卫生中华人民共和国水务部门城市废水

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The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila

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Horticulture Research 2021年第1期8卷 83-96页

作者： Xiaolong Hao Chenhong Xie Qingyan Ruan Xichen Zhang Chao Wu Bing Han Jun Qian Wei Zhou hans-wilhelm Nutzmann Guoyin Kai Laboratory of Medicinal Plant Biotechnology College of PharmacyZhejiang Chinese Medical University310053 HangzhouChina Institute of Plant Biotechnology School of Life SciencesShanghai Normal University200234 ShanghaiChina The Milner Centre for Evolution Department of Biology and BiochemistryUniversity of BathClaverton DownBath BA27AYUK

The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical *** example of this is camptothecin,a monoterpene indole alkaloid with potent anticancer activity that is extracted at very low concentrations from woody ***,camptothecin biosynthesis has been shown to become biotechnologically amenable in hairy-root systems of the natural producer Ophiorrhiza ***,time-course expression and metabolite analyses were performed to identify novel transcriptional regulators of camptothecin biosynthesis in *** is shown here that camptothecin production increased over cultivation time and that the expression pattern of the WRKY transcription factor encoding gene OpWRKY2 is closely correlated with camptothecin *** of OpWRKY2 led to a more than three-fold increase in camptothecin ***,silencing of OpWRKY2 correlated with decreased camptothecin levels in the *** detailed molecular characterization by electrophoretic mobility shift,yeast one-hybrid and dual-luciferase assays showed that OpWRKY2 directly binds and activates the central camptothecin pathway gene *** together,the results of this study demonstrate that OpWRKY2 acts as a direct positive regulator of camptothecin *** such,a feasible strategy for the over-accumulation of camptothecin in a biotechnologically amenable system is presented.

关键词： camptothecin enable alkaloid

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Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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Current Urology 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame Strauß Joost wilhelm Voß hans Christoph von Knobloch Hannah Maria Neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Cancer Index Composite *** and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity ***:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative continence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Prostate cancer Robot-assisted radical prostatectomy Expanded Prostate Cancer Index Composite 26 Urinary incontinence Surgical approach Nerve sparing

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Health economic evaluation of moist wound care in chronic cutaneous leishmaniasis ulcers in Afghanistan

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Infectious Diseases of Poverty 2018年第1期7卷 129-144页

作者： hans-Christian Stahl Faridullah Ahmadi Sami Mohammad Nahzat Heng-Jin Dong Kurt-wilhelm Stahl Rainer Sauerborn Institute of Public Health University Hospital HeidelbergHeidelbergGermany Malaria and Leishmaniasis Centre Provincial Civil Balkh HospitalMazar-e-SharifAfghanistan National Malaria and Leishmaniasis Control Program Ministry of Public HealthKabulAfghanistan Center for Health Policy Studies School of MedicineZhejiang UniversityHangzhouChina NGO Waisenmedizin e.V.–Promoting Access to Essential Medicine FreiburgGermany

Background:The present health economic evaluation in Afghanistan aims to support public health decision makers and health care managers to allocate resources efficiently to appropriate treatments for cutaneous leishmaniasis(CL)elicited by Leishmania tropica or Leishmania ***:A decision tree was used to analyse the cost and the effectiveness of two wound care regimens versus intra-lesional antimony in CL patients in *** were collected from a societal *** was measured in wound free *** incremental cost-effectiveness ratio(ICER)and incremental net monetary benefit(NMB)were *** model was parameterized with baseline parameters,sensitivity ranges,and parameter ***,the model was simulated and results were evaluated with deterministic and probability sensitivity *** outcomes were the efficiency of the regimens and a budget impact analysis in the context of ***:Average costs per patients were US$11(SE=0.016)(Group I:Intra-dermal Sodium Stibogluconate[IL SSG]),US$16(SE=7.58)(Group II:Electro-thermo-debridement[ETD]+Moist wound treatment[MWT])and US$25(SE=0.48)(Group III:MWT)in patients with a single chronic CL *** a societal perspective the budget impact analysis shows that the regimens’drug costs are lower than indirect disease *** effectiveness in wound free days are 177(SE=0.36)in Group II,147(SE=0.33)in Group III,and 129(SE=0.27)in Group *** ICER of Group II versus Group I was US$0.09 and Group III versus Group I US$0.77,which is very costeffective with a willingness-to-pay threshold of US$2 per wound free *** a Monte-Carlo probabilistic sensitivity analysis Group II was cost-effective in 80%of the cases starting at a willingness-to-pay of 80 cent per wound free ***:Group II provided the most cost-effective *** non-treatment alternative is not an option in the management of chronic CL *** of Group III should at le

关键词： Cutaneous leishmaniasis Wound healing Cost-effectiveness Sodium Stibogluconate Moist wound treatment

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