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Volkswagen Beetle Art

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计算机光盘软件与应用（COMPUTER ARTS数码艺术） 2006年第10期 108-109页

作者： JOE roos

为了体现Beetle的嬉皮式风格以吸引那些无拘无束的人．Volkswagen已经用一系列的插画贴花装饰其曲线优美的娱乐车。

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A generic Workflow for the Data FAIRification Process

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Data Intelligence 2020年第1期2卷 56-65页

作者： Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend Mons Erik Schultes Marco roos Mark Thompson Leiden University Medical Center Leiden2333 ZAThe Netherlands gO FAIR International Support&Coordination Office(gFISCO) LeidenThe Netherlands

The FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and *** process of making data FAIR(“FAIRification”)can be described in multiple *** this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data *** FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases *** steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR *** each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to.

关键词： FAIR data FAIRification workflow FAIR data stewardship Hands-on FAIRification FAIR dissemination

Mitogenomes of historical type specimens unravel the taxonomy of sportive lemurs(Lepilemur spp.)in Northwest Madagascar

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Zoological Research 2021年第4期42卷 428-432页

作者： Christian roos Roberto Portela Miguez Richard Sabin Edward E.Louis Jr Michael Hofreiter Dietmar Zinner gene Bank of Primates and Primate genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Natural History Museum London SW7 BDUK Center for Conservation and Research Omaha’s Henry Doorly Zoo and AquariumOmahaNebraska 68107USA Institute for Biochemistry and Biology University of PotsdamPotsdam 14476Germany Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany Department of Primate Cognition Georg-August-UniversityGoettingen 37083Germany

Accurate information on name-bearing types,including corresponding type localities,is essential for proper ***,such geographic information is often missing or *** localities of type specimens collected 100–200 years ago can be difficult to trace due to changes in local names or simple *** a case can be found for the gray-backed sportive lemur(Lepilemur dorsalis),with its type locality imprecisely fixed as Northwest *** recent years,eight species have been newly described for the Inter-River-Systems(IRSs)of this region,however the designation of *** remains controversial due to a lack of a precise type ***,we sequenced the complete mitochondrial genomes(mitogenomes)of type specimens of *** and ***,which is currently recognized as a synonym of *** and compared their sequences with those of samples of known provenance from different *** showed that the two type specimens of *** and *** had identical mitogenome sequences and clustered closely with samples collected in IRS V,indicating that the type locality could be fixed to IRS ***,*** occurs in IRS V,and *** and *** are junior synonyms of *** finding demonstrates the value of type specimens for clarifying phylogeographic and taxonomic questions and clarifies the taxonomy of sportive lemurs in Northwest Madagascar.

关键词： precise identical finding

单个腺病毒颗粒的原子力显微镜液相成像及样品制备方法

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病毒学报 2015年第6期31卷 601-606页

作者：梁艳李晨 Mariska g M van Rosmalen gijs J L Wuite Wouter H roos 中国水产科学研究院黄海水产研究所青岛266071 阿姆斯特丹自由大学

原子力显微镜(Atomic force microscopy,AFM)作为一种纳米级高分辨率的探针扫描显微镜,在病毒形态学研究等领域有广泛的应用。为更好地利用AFM在接近病毒生理环境(液相)中观测单个病毒颗粒,选择合适的基底吸附病毒样品是重要的前提保障... 详细信息

原子力显微镜(Atomic force microscopy,AFM)作为一种纳米级高分辨率的探针扫描显微镜,在病毒形态学研究等领域有广泛的应用。为更好地利用AFM在接近病毒生理环境(液相)中观测单个病毒颗粒,选择合适的基底吸附病毒样品是重要的前提保障。本文介绍了一种病毒样品制备及AFM液相成像方法。首先制备疏水化处理的玻璃盖玻片作为吸附基底,再将观察样品腺病毒重组载体颗粒(Adenovirus type 5F35,Ad5F35)吸附于基底上,建立在液相下单个病毒颗粒的原子力显微镜成像方法。通过该方法获取了单个腺病毒颗粒在液相下的高分辨率纳米级高度图(height image),且病毒颗粒保持了约90nm的正确测量高度。实验结果表明疏水化处理的玻璃基底具有良好的吸附力,有助于病毒颗粒牢固地吸附在基底上,且不会引起较大的形变。本研究为AFM观测病毒等生物样品提供了一种较为合适的吸附基底和在液相中的AFM成像方法,对后期开展病毒形态结构、物理属性及其与宿主细胞受体相互作用的研究打下基础。

关键词：原子力显微镜液相成像样品制备腺病毒颗粒

The“A”of FAIR-As Open as Possible,as Closed as Necessary

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Data Intelligence 2020年第1期2卷 47-55,303,304页

作者： Annalisa Landi Mark Thompson Viviana giannuzzi Fedele Bonifazi Ignasi Labastida Luiz Olavo Bonino da Silva Santos Marco roos Fondazione per la Ricerca Farmacologica gianni Benzi Onlus 30-70010 Valenzano(BA)Italy Leiden University Medical Center Leiden2333 ZAThe Netherlands Learning and Research Resources Centre(CRAI) Universitat de BarcelonaCatalunya 08007Spain gO FAIR International Support&Coordination Office(gFISCO) LeidenThe Netherlands

In order to provide responsible access to health data by reconciling benefits of data sharing with privacy rights and ethical and regulatory requirements,Findable,Accessible,Interoperable and Reusable(FAIR)metadata should be *** to the H2020 Program guidelines on FAIR Data,data should be"as open as possible and as closed as necessary","open"in order to foster the reusability and to accelerate research,but at the same time they should be"closed"to safeguard the privacy of the *** provisions on the protection of natural persons with regard to the processing of personal data have been endorsed by the European general Data Protection Regulation(gDPR),Reg(EU)2016/679,that came into force in May *** work aims to solve accessibility problems related to the protection of personal data in the digital era and to achieve a responsible access to and responsible use of health *** strongly suggest associating each data set with FAIR metadata describing both the type of data collected and the accessibility conditions by considering data protection obligations and ethical and regulatory ***,an existing FAIR infrastructure component has been used as an example to explain how FAIR metadata could facilitate data sharing while ensuring protection of individuals.

关键词： Accessibility of health data FAIR metadata gDPR Data sharing ELSI

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on the Road

China Today 2004年第8期53卷 38-39页

作者： KATHARINA SCHNEIDER-roos language consultant for the german Department of China Today.

HAVINg stopped work due to pregnancy and the birth of mybeautiful son Benjamin, I enjoy being back on the bike each morning, riding to my new job. I devoutly believe in biking - for distances that take less than half ... 详细信息

关键词：北京道路交通管理机制道路安全

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genes & Diseases 2022年第6期9卷 1506-1520页

作者： Jon Christiansen Anne-Katrin guttsches Ulrike Schara-Schmidt Matthias Vorgerd Christoph Heute Corinna Preusse Werner Stenzel Andreas roos Department of Pediatric Neurology Centre for Neuromuscular DisordersCentre for Translational Neuro-and Behavioral SciencesUniversity Hospital EssenUniversity Duisburg-Essen45147 EssenGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr University Bochum44789 BochumGermany Department of Adult and Pediatric Diagnostic Interventional RadiologyNuclear MedicineBG University Hospital Bergmannsheil Bochum44789 BochumGermany Charite´e Universitatsmedizin Berlin Freie Universitat Berlin10117 BerlinGermany Humboldt-Universitat zu Berlin Department of Neuropathology10117 BerlinGermany Department of Neurology with Institute for Translational Neurology University Hospital MunsterAlbert-Schweitzer-Campus 148149 MunsterGermany Children’s Hospital of Eastern Ontario Research Institute University of OttawaOttawaON K1H 8L1Canada

Anoctamin-5(ANO5)is a multi-pass membrane protein localized to the sarcolemma and the sarcoplasmic *** were linked to rare autosomal recessive muscle ***,we summarize the clinical spectrum,imaging data and molecular research findings as well as results of animal modeling,which significantly moved forward the understanding of mechanisms underlying ANO5-related muscle *** that precise histological information on inflammatory processes taking place in patient-derived muscle are still lacking,an(immuno)histological study on biopsies derived from six ANO5-patients was performed showing focal accumulation of necrotic fibers,mild fiber-size variances and *** addition,MRI data of four ANO5-patients(including a 10-year follow-up in one patient)are presented and discussed in the context of previously published ***,data presented in this article combining a review of the literature with own myopathological findings address scientific trends and open questions on ANO5-related muscle diseases,which would be of significant interest for a wide neuromuscular diseases *** conclude,a clear genotypeephenotype correlation does not exist,and ANO5-related muscle disorders might represent the next entity of a clinical continuum with varying degree of muscle cell *** addition,results of pre-clinical studies allowed the definition of suitable cell and animal models characterized by certain histological and functional pathologies resembling the human *** models might serve as suitable systems for testing of interventional concepts in future.

关键词： Anoctamin-5 LgMDR12 MMD3 Muscle inflammation Muscle MRI

Systolic and Diastolic Strain Measurements Show Left Ventricular Dysfunction in Women with Turner Syndrome

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Congenital Heart Disease 2021年第4期16卷 357-368页

作者： Allard T.van den Hoven Sultan Yilmazer Lidia R.Bons Roderick W.Jvan grootel L.W.geenen An M.van Berendoncks Anthonie L.Duijnhouwer hans-Marc J.Siebelink Jolien W.roos-Hesselink Annemien E.van den Bosch Department of Congenital Cardiology Erasmus MCRotterdamNetherlands Department of Cardiology Radboud University Medical CenterNijmegenNetherlands Department of Cardiology Leiden University Medical CenterRotterdamNetherlands

Aim:This study aimed to describe the systolic left ventricular global longitudinal strain(LvgLS)and left ventricular peak early diastolic strain rate(Sre)in adult women with Turner syndrome(TS)and to determine its relationship with exercise capacity and clinical ***:In this cross-sectional cohort study,consecutively included adult TS women underwent an electrocardiogram,transthoracic echocardiogram(TTE)and cardiopulmonary exercise test(CPET)on the same *** and Sre were measured using 2D speckle tracking analysis(STE)and compared with age-matched healthy female ***:Ninety-four adult women(age 36±13 years)with TS and 32 healthy age-matched female controls were *** with TS had a significantly impaired/reduced systolic LvgLS(–17.82±2.98%vs.–21.80±1.85%,p0.001),compared to healthy female ***,TS women had reduced diastolic function as measured by conventional echocardiographic parameters:A higher A-wave(pger deceleration time(p=0.006),and a higher E/E’-ratio(pgnificantly reduced maximal workload(p=0.033),reduced oxygen uptake(pg *** linear regression analysis revealed that Age,karyotype and QT-duration were significantly associated with Sre,but not with LvgLS,in the TS ***:Systolic and diastolic strain and exercise capacity were significantly reduced in TS women compared to healthy *** correlation between strain itself and exercise capacity could be demonstrated,but correlations with conventional TTE parameters and baseline characteristics were found.

关键词： Turnersyndrome speckletracking echocardiography strain exercise capacity

The Effect of Music Therapy for Patients With Huntington＇s Disease： A Systematic Literature Review

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Journal of Literature and Art Studies 2015年第1期5卷 30-40页

作者： Monique van Bruggen - Ruff Raymund roos ArtEZConservatory School of Music Enschede The NetherlandsLeiden University Medical Center Leiden The NetherlandsAtlant Care Group Apeldoorn The Netherlands Leiden University Medical Center Leiden The Netherlands

Huntington＇s disease is a progressive, neurodegenerative, and autosomal dominant disease characterized by motor- and psychiatric disturbances, and cognitive decline. Since there is no cure, all treatment is aimed at improving quality of life. One form of non-drug therapy which is barely recognized, is music therapy. The literature on its use and effect in patients with Huntington＇s disease is limited. We therefore performed a detailed literature survey in order to delineate the different types of music therapy interventions and their aims. Music therapy studies were included when targeting：（1） motor disturbances; （2） cognitive disturbances; （3） psychiatric disturbances; and （4） emotional/social disturbances. A total of eight studies that met these criteria were analyzed. We found that music therapy interventions vary throughout the different stages of the disease and are not yet applied optimally. Not the stage of the disease but the individual treatment goals seem to be more determinative for the music therapy indications. In conclusion, precise aims and methods in relation to the stage of the disease are not well determined. There is a need for systematic study of this treatment option.

关键词： music music therapy Huntington's disease quality of life