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Paracrine factors for neurodegenerative disorders:special emphasis on Parkinson's disease

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Neural Regeneration Research 2016年第4期11卷 570-571页

作者： Stefano Di Santo hans rudolf widmer Department of Neurosurgery Neurocenter and Regenerative Neuroscience ClusterUniversity Hospital BernSwitzerland University of Bern

The progressive loss of dopaminergic neurons in the ventral mesencephalon is the main pathological hallmark of Parkinson’s disease（PD）.Drugs currently available only alleviate the principal symptomatic motor-relate... 详细信息

关键词： Paracrine factors for neurodegenerative disorders ECM MSC

Nogo-A and its functions beyond axonal inhibition: the controversial role of Nogo-A in Parkinson's disease

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Neural Regeneration Research 2015年第8期10卷 1223-1224页

作者： Stefanie Seiler hans R.widmer Department of Neurosurgery Neurocenter and Regenerative Neuroscience Cluster University Hospital Bern Switzerland University of Bern Graduate School for Cellular and Biomedical Sciences University of Bern

Nogo-A belongs to the reticulon family（RTN4）and is generally assumed to be one of the most potent myelin associated neurite outgrowth inhibitors in the central nervous system（CNS）.Together with other inhibitors su... 详细信息

关键词： Nogo axonal myelin belongs glycoprotein potent controversial assumed Together amyotrophic

UV/Vis Characterization and Fate of Organic Amendment Fractions in a Dune Soil in Dakar, Senegal

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Pedosphere 2015年第3期25卷 372-385页

作者： Silwan DAOUK Mohammad HASSOUNA Anne GUEYE-GIRARDET Seydou NIANG hans-rudolf PFEIFER Institute of Earth Sciences Faculty of Geosciences and Environment(FGSE)University of Lausanne Laboratory of Wastewater Treatment Fundamental Institute of North Africa (IFAN)Cheikh Anta Diop University of Dakar

The application of organic amendments on soils poor in organic matter(OM) can improve long-term soil fertility, but may also enhance the mineralization of native soil organic matter. Three organic amendments, compost, sewage sludge and horse manure, used by urban market gardeners in Dakar, Senegal were analyzed for their OM maturity. Their fate was evaluated in a 45-d agronomic trial in a sandy Arenosol with lettuce. In each case, water-extractable organic matter(WEOM) and humic-like substances(HLS)were isolated from raw amendments and amended soils, and characterized using ultraviolet-visible(UV/Vis) spectroscopy. Results highlighted the general more aromatic character of HLS and WEOM fractions extracted from compost compared to the other two amendments. When applied to soils, however, these differences were not clearly observed. The aromaticity and humification degree of the labile fraction(WEOM) increased with depth in the first 30 cm for all amendments. This indicated the high lixiviation rates that fresh OM underwent in the studied sandy soil. Finally, a statistical analysis of the results was able to discriminate between surface and deeper horizons and between amended- and non-amended soil samples. Spectroscopic indices showed indeed strong increase/decrease with depth linked with the mineralization/humification processes that the fresh OM from amendments underwent during the 45 d of the agronomic trial. This study highlights the potential of spectroscopic techniques to study agricultural amendment organic matter fractions and their fate in soils.

关键词： absorbance spectroscopy compost fluorescence spectroscopy horse manure humic-like substances sewage sludge,water-extractable organic matter

利用强子探针研究奇特原子核的点质子分布半径及强子探针效应

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Science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo Christoph Scheidenberger Satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad Soumya Bagchi Dolores Cortina-Gil Iris Dillmann Alfredo Estradé Alexey Evdokimov Fabio Farinon hans Geissel Giulia Guastalla rudolf Janik Satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov Michele Marta Magdalena Mostazo Ivan Mukha Chiara Nociforo Hooi Jin Ong Stephane Pietri Andrej Prochazka Branislav Sitar Peter Strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick John Stuart Winfield School of Physics Beihang UniversityBeijing 100191China Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GSI Helmholtzzentrum für Schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de Santiago de Compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first *** from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both *** allows us to deduce proton radii(R_p)for the first time from the cross sections on *** identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen *** calls for further experimental and theoretical investigations.

关键词： Exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr rudolf A. Jorres hans-Peter Lenhof Eckart Meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal Medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal Medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork （COSYCONET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA （miRNA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRNAs regulate different cancer-related pathways including the MAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRNA Cancer COPD Lung Biomarker COSYCONET

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涡轮叶片经济性研磨加工方略

现代制造 2013年第49期 52-54页

作者： hans-rudolf DRESSLER

在加工制造涡轮叶片时要对弯曲而进行内加工和外加工，还有此涡轮叶片部位接近性差，而且涡轮叶片材料也难于切削。

关键词：涡轮叶片研磨加工经济性加工制造叶片部位叶片材料外加工内加工

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涡轮叶片经济性研磨加工方略

现代制造 2013年第47期 28-28,30,31页

作者： hans—rudolf DRESSLER

在加工制造涡轮叶片时要对弯曲面进行内加工和外加工，还有些涡轮叶片部位接近性差，而且涡轮叶片材料也难于切削，

关键词：涡轮叶片研磨加工经济性加工制造叶片部位叶片材料外加工内加工

影响五倍子水悬浮液对马铃薯晚疫病田间防治效果的主要气象因素

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植物病理学报 2008年第6期38卷 619-625页

作者：胡同乐王树桐闫峰杨军玉 hans-rudolf Forrer 曹克强河北农业大学植物保护学院、河北省农作物病虫害生物防治工程技术研究中心保定071001 河北省高碑店市气象局高碑店074000 Agroscope FAL Reckenholz Reckenholzstrasse 191 CH-8046 Zurich

将4.0%五倍子水悬浮液喷施田间马铃薯品种Bintje的叶片,于不同处理时间后,剪下叶片带回室内人工接种致病疫霉孢子囊悬浮液,保湿培养后调查各处理的发病情况。结果表明,喷施五倍子水悬浮液后48h内未经历降雨的处理,病情指数仅为7.41,与... 详细信息

将4.0%五倍子水悬浮液喷施田间马铃薯品种Bintje的叶片,于不同处理时间后,剪下叶片带回室内人工接种致病疫霉孢子囊悬浮液,保湿培养后调查各处理的发病情况。结果表明,喷施五倍子水悬浮液后48h内未经历降雨的处理,病情指数仅为7.41,与清水对照相比,防效为92.59%;喷施后96h接种的处理,由于在田间经历了降雨,完全丧失了防效,病情指数达100。室内毒力测定结果显示,0.4%五倍子水悬浮液喷施96h后,对致病疫霉游动孢子释放的抑制率仍在80%以上,在室外避雨不避光条件下五倍子水悬浮液96h内抑菌效果无显著降低,表明日光的影响作用较小。在室内盆栽条件下,通过喷淋水滴模拟田间降雨对药液的冲刷作用。结果表明,冲刷作用可导致五倍子水悬浮液对马铃薯晚疫病的防效显著降低。进一步说明,降雨是导致五倍子水悬浮液对马铃薯晚疫病田间防治效果降低的主要气象因素。

关键词：五倍子致病疫霉马铃薯晚疫病气象因素降雨

Results of Sleeve Gastrectomy in Germany—Data on Nationwide Survey on Quality Assurance in Bariatric Surgery in Germany

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Surgical Science 2012年第4期3卷 169-176页

作者： Christine Stroh rudolf Weiner Thomas Horbach Kaja Ludwig Miriam Dressler Stefanie Wolff hans Lippert Martin Büsing Uwe Schmidt Thomas Manger Department of General Abdominal and Pediatric Surgery Municipal Hospital Gera Germany Department of General Abdominal and Vascular Surgery University Hospital Magdeburg Magdeburg Germany Friedrich Alexander University Erlangen-Nürnberg Erlangen Germany Hospital Knappschaft Recklinghausen Recklinghausen Germany Hospital Rostock Südstadt Rostock Germany Hospital Sachsenhausen Frankfurt am Main Frankfurt Main Germany Muncipial Hospitals Dresden Neustadt Dresden Germany StatConsult Magdeburg Magdeburg Germany

Background: Since January 1st of 2005, the situation of bariatric surgery is being analyzed in Germany. The data is registered prospectively in cooperation with the Institute of Quality Assurance in Surgery at the Otto-von-Guericke University Magdeburg. Methods: The data is registered through an online database which includes all information for primary and revision bariatric procedures as well as yearly follow-up. Participation in the quality assurance study is optional. All certificated centers have to participate at the survey. Results: From January 2006 to December 2009, 1478 sleeve gastrectomies (SG) were performed at 45 hospitals. The number of procedures has increased from 126 in 2007 to 933 in 2009. The main complication is leakage of the staple-line. Initial leakage rate was 7% in 2007. Leakage rate dropped down to 2.3% in 2008 and 2.5% in 2009. Mean age of patients was 43.1 years and mean BMI was 52.83 kg/m2. Age and BMI were significantly higher in patients with SG than in all other patients undergoing bariatric surgery. Conclusion: SG is a common and hype bariatric procedure in Germany, but postoperative complication rate is high. Data on the long-term effect of SG on weight loss and amelioration of comorbidities need to be evaluated. More detailed analyzes are necessary to establish the position of SG in the bariatric surgery. Further studies should also include examinations on long-term complications and redo-procedure after SG.

关键词： Bariatric Surgery Sleeve Gastrectomy German Multicenter Trial Leakage Complications