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Synthesis, characterization, and stability of iron (III) complex ions possessing phenanthroline-based ligands

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Open j.urnal of Inorganic Chemistry 2013年第1期3卷 7-13页

作者： Shawnt Tosonian Charles j. Ruiz Andrew Rios Elma Frias j.ck F. eichler Department of Chemistry University of California Riverside Riverside USA

It has previously been demonstrated that phenanthroline-based ligands used to make gold metallotherapuetics have the ability to exhibit cytotoxicity when not coordinated to the metal center. In an effort to help assess the mechanism by which these ligands may cause tumor cell death, iron binding and removal experiments have been considered. The close linkage between cell proliferation and intracellular iron concentrations suggest that iron deprivation strategies may be a mechanism involved in inhibiting tumor cell growth. With the creation of iron (III) phen complexes, the iron binding abilities of three polypyridal ligands [1,10-phenanthroline (phen), 2,9-dimethyl-1, 10-phenanthroline (methylphen), and 2,9-di-sec-butyl-1, 10-phenanthroline (sec-butylphen)] can be tested via a competition reaction with a known iron chelator. Therefore, iron (III) complexes possessing all three ligands were synthesized. Initial mass spectrometric and infrared absorption data indicate that iron (III) tetrachloride complex ions with protonated phen ligands (RphenH+) were formed: [phenH][FeCl4], [methylphenH][FeCl4], [sec-butylphenH][FeCl4]. UV-vis spectroscopy was used to monitor the stability of the complex ions, and it was found that the sec-butylpheniron complex was more stable than the phen and methylphen analogues. This was based on the observation that free ligand was observed immediately upon the addition of EDTA to the [phenH][FeCl4] and [methylphenH] [FeCl4] complex ions.

关键词： Polypyridyl Ligands Phenanthroline Iron (III) Complex Ions

Test-retest reliability of the Mini Nutritional Assessment–Short Form(MNA-SF)in older patients undergoing cardiac rehabilitation

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j.urnal of Geriatric Cardiology 2020年第9期17卷 574-579页

作者： Fritz Kather Miralem Hadzic Teresa Hehle Sarah eichler j.lia Klein Heinz Völler Annett Salzwedel Department of Rehabilitation Medicine University of PotsdamFaculty of Health Sciences BrandenburgGermany Klinik am See Rehabilitation Center for Internal MedicineRüdersdorfGermany

Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical outcomes.[1]Depending on the assessments and definition used,the prevalence in older patients ranges between 12%in communitydwelling adults to 60%of patients in geriatric care facilities.[2–5]Older populations are at high risk of nutritional deficiencies because of risk factors such as multimorbidity,polypharmacy,cognitive and physical decline,poor appetite,depressive syndromes and socioeconomic changes.[4,6].

关键词： Cardiac rehabilitation Malnutrition Octogenarians Test-retest reliability

Necrosis zone depth after bipolar plasma vaporization and resection in the human prostate

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Asian j.urnal of Urology 2023年第2期10卷 144-150页

作者： Clara Breitling hans Nenning j.rg Rassler Department of Urology St.Elisabeth HospitalLeipzigGermany Institute for Pathology“Am Elsapark” LeipzigGermany

Obj.ctives:To compare the depth of thermal necrosis after use of bipolar resection and vaporization technique comparing intra-individually bipolar loop and bipolar button ***:Transurethral resection and vaporization of the prostate was performed in 55 male patients(260 specimens in total).In a standardized procedure,a bipolar resection loop was used for resection,and a bipolar button electrode was used for *** electrodes were applied in each patient,either in the left or in the right lateral *** depth of necrotic zones in the resected or vaporized tissue of each patient was measured in a standardized way by light ***:The mean depth with standard deviation of thermal inj.ry caused by the loop electrode was 0.0495±0.0274 *** vaporization electrode caused a mean thermal depth with standard deviation of 0.0477±0.0276 *** mean difference of necrosis zone depths between the two types of electrodes(PlasmaButtoneresection loop)was 0.0018 mm(p=0.691).Conclusion:For the first time,we present directly measured values of the absolute necrosis zone depth after application of plasma in the transurethral treatment of benign prostatic *** measured values were lower than in all other transurethral *** procedures of measurement and evaluation allow a statistically significant statement that the low necrosis depth in bipolar procedures is independent of the applied electrodes.

关键词： Transurethral resection of prostate Bipolar enucleation Plasma resection Plasma vaporization Necrosis depth

Dynamics and functions of E‑cadherin complexes in epithelial cell and tissue morphogenesis

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Marine Life Science & Technology 2023年第4期5卷 585-601页

作者： Na Zhang Matthias Häring Fred Wolf j.rg Großhans Deqing Kong Department of Biology Philipps University35043 MarburgGermany Göttingen Campus Institute for Dynamics of Biological Networks(CIDBN) Georg August University Göttingen37073 GöttingenGermany

Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue.E-cadherin–catenin complexes mediate Ca^(2+)-dependent trans-homodimerization and constitute the kernel of adherens *** the basic function of cell–cell adhesion,recent progress sheds light the dynamics and interwind interactions of individual E-cadherin–catenin complex with E-cadherin superclusters,contractile actomyosin and mechanics of the cortex and *** nanoscale architecture of E-cadherin complexes together with cis-interactions and interactions with cortical actomyosin adj.st to j.nctional tension and mechano-transduction by reinforcement or weakening of specific features of the *** post-translational modifications such as phosphorylation and glycosylation have been implicated,their role for specific aspects of in E-cadherin function has remained ***,we provide an overview of the E-cadherin complex in epithelial cell and tissue morphogenesis focusing on nanoscale architectures by super-resolution approaches and post-translational modifications from recent,in particular in vivo,***,we review the computational modelling in E-cadherin complexes and highlight how computational modelling has contributed to a deeper understanding of the E-cadherin complexes.

关键词： Nanoscale architectures Phosphorylation Glycosylation Computational modelling

Organizing and Disorganizing Resonances of Microtubules, Stem Cells, and Proteins Calculated by a Quantum Equation of Coherence

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j.urnal of Modern Physics 2022年第12期13卷 1530-1580页

作者： hans j. H. Geesink Marcus Schmieke DSM-Research Geleen Netherlands Institute of Existential Consciousness Research (ECR) Berlin Germany Dev Sanskriti University Haridwar India

Conformational states of microtubules and proteins have typical spatial-spectral arrangements of atoms, called spatial coherence, that are characteristic for building, homeostasis, decay, and apoptosis. Microtubules show a principle of a self-organizing-synergetic structure called a Fröhlich-Bose-Einstein state. The spatial coherence of this state can be described by a toroidal quantum equation of coherence. In this space, microtubules and proteins have typical discrete frequency patterns. These frequencies comply with two proposed quantum wave equations of respective coherence (regulation) and decoherence (deregulation), that describe quantum entangled and disentangled states. The proposed equation of coherence shows the following typical scale invariant distribution of energy: En = ħωref 2q3m. The proposed model supports quantum entanglement and is in line with the earlier published models of Fröhlich, Davydov, and Chern. A meta-analysis shows a semi-harmonic scale-invariant pattern for microtubules, stem cells, proteins, and EEG- and MEG-patterns. A fit has been found for about 50 different organizing frequencies and 5 disorganizing frequencies of measured microtubule frequencies that fit with the calculated values of the proposed quantum equations, which are positioned in a nested toroidal geometry. All measured and analysed frequencies of microtubules comply with the same energy distribution found for Bose-Einstein condensates. The overall results show a presence of an informational quantum code, a direct relation with the eigenfrequencies of microtubules, stem cells, DNA, and proteins, that supplies information to realize biological order in life cells and substantiates a collective Fröhlich-Bose-Einstein type of behaviour and further support the models of Tuszynski, Hameroff, Bandyopadhyay, Del Giudice and Vitiello, Katona, Pettini, and Pokorny.

关键词： Quantum Coherence Coherence and Decoherence Electromagnetic Frequencies Quantum Biology Quantum Wave Equation Fröhlich Microtubules Proteins Healthy and Unhealthy Frequency Patterns

A candidate of the Induan-Olenekian boundary stratotype in the Tethyan region

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Science China Earth Sciences 2003年第11期46卷 1182-1200页

作者：童金南 Yuri D.Zakharov Michael j.Orchard 殷鸿福 hans j.hansen Faculty of Earth Science China University of Geosciences Wuhan 430074 China Far Eastern Geological Institute Russian Academy of Sciences Vladivostok 690022Russia Geological Survey of Canada 101-605 Robson Street Vancouver B. C. V6B 5J3 Canada Geological Institute Copenhagen University Oster Voldgade 10 DK-1350 CopenhagenDenmark

The Olenekian Stage of the Lower Triassic is named from the Boreal Realm, but the stage has never been properly defined, nor has it been applied in the low-latitude Tethyan Realm, with exception of North Caucasus and Mangyshlak. This paper proposes a stratotype for the In-duan-Olenekian boundary in the low-latitude Tethyan Realm. South China is one of the main regions in the Tethyan Realm with well-developed Lower Triassic sequences and abundant fossils. According to the basic stratigraphic records and various accumulated data, we believe that the West Pingdingshan Section in Chaohu, Anhui Province is one of the best sequences to define the Induan-Olenekian boundary. The first appearance datum (FAD) of conodont Neospathodus waageni is the preferred index to define the boundary. This datum lies 26 cm below the FAD of the ammonoids Flemingites and Euflemingites, and is located slightly prior to the top of the second Triassic normal magnetozone, and the peak of the first Triassic positive excursion of carbon isotope σ13C.

关键词： proposal, GSSP, Induan-Olenekian boundary, Lower Triassic, Chaohu of China.

Sodium Stress in the Halophyte Thellungiella halophila and Transcriptional Changes in a thsos1-RNA Interference Line

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j.urnal of Integrative Plant Biology 2007年第10期49卷 1484-1496页

作者： Dong-Ha Oh Qingqiu Gong Alex Ulanov Quan Zhang Youzhi Li Wenying Ma Dae-j.n Yun Ray A. Bressan hans j. Bohnert Division of Applied Life Science (BK21 Program) and Environmental Biotechnology National Core Research Center Graduate School of Gyeongsang National University j.nj. 660-701 Korea Departments of Plant Biology and of Crop Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 USA Key Laboratory of Plant Stress Research College of Life Science Shandong Normal University j.nan 250014 China Key Laboratory of the Ministry of Education for Microbial and Plant Genetic Engineering Guangxi University Nanning 530005 China Department of Horticulture and Landscape Architecture Purdue University West-Lafayette IN 47907 USA

The plasma membrane Na＋/H＋-antiporter salt overly sensitive1 （SOS1） from the halophytic Arabidopsis-relative Thellungiella halophila （ThSOS1） shows conserved sequence and domain structure with the orthologous genes from Arabidopsis thaliana and other plants. When expression of ThSOSt was reduced by RNA interference （RNAi）, pronounced characteristics of salt-sensitivity were observed. We were interested in monitoring altered transcriptional responses between Thellungiella wild type and thsost-4, a representative RNAi line with particular emphasis on root responses to salt stress at 350 mmol/L NaCI, a concentration that is only moderately stressful for mature wild type plants. Transcript profiling revealed several functional categories of genes that were differently affected in wild-type and RNAi plants. Down-regulation of SOS1 resulted in different gene expression even in the absence of stress. The pattern of gene induction in the RNAi plant under salt stress was similar to that of glycophytic Arabidopsis rather than that of wild type Thellungiella. The RNAi plants failed to down-regulate functions that are normally reduced in wild type Thellungiella upon stress and did not up-regulate functions that characterize the Thellungiella salt stress response. Metabolite changes observed in wild type Thellungiella after salt stress were less pronounced or absent in RNAi plants. Transcript and metabolite behavior suggested SOS1 functions including but also extending its established function as a sodium transporter. The down-regulation of ThSOS1 converted the halophyte Thellungiella into a salt-sensitive plant.

关键词： salt stress salt overly sensitive1 RNA interference Thellungiella halophila transcript profiling.

N*-Program at COSY-j.lich

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Chinese Physics C 2009年第12期33卷 1102-1104页

作者： hans Strher Institut fr Kernphysik and j.lich Center for Hadron Physics Forschungszentrum Jülich 52425 Jlich Germany

The paper gives a brief introduction into the COSY-facility, the currently used detector systems （ANKE, TOF and WASA） and the targets （cluster j.t, pellet and ABS）, and it presents some recent results, which were ... 详细信息

关键词： handron-induced reactions nucleon and hyperon resonances

Structures and characteristics of carbohydrates in diets fed to pigs: a review

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j.urnal of Animal Science and Biotechnology 2019年第3期10卷 601-617页

作者： Diego M.D.L.Navarro j.rubella j.Abelilla hans H.Stein Department of Animal Sciences University of IllinoisUrbana 61801USA Division of Nutritional Sciences University of IllinoisUrbana 61801USA

The current paper reviews the content and variation of fiber fractions in feed ingredients commonly used in swine *** serve as the main source of energy in diets fed to *** may be classified according to their degree of polymerization: monosaccharides,disaccharides,oligosaccharides,and *** carbohydrates include sugars,digestible starch,and glycogen that may be digested by enzymes secreted in the gastrointestinal tract of the ***-digestible carbohydrates,also known as fiber,may be fermented by microbial populations along the gastrointestinal tract to synthesize short-chain fatty acids that may be absorbed and metabolized by the *** non-digestible carbohydrates include two disaccharides,oligosaccharides,resistant starch,and non-starch *** concentration and structure of non-digestible carbohydrates in diets fed to pigs depend on the type of feed ingredients that are included in the mixed ***,arabinoxylans,and mixed linked β-(1,3)(1,4)-D-glucans are the main cell wall polysaccharides in cereal grains,but vary in proportion and structure depending on the grain and tissue within the *** walls of oilseeds,oilseed meals,and pulse crops contain cellulose,pectic polysaccharides,lignin,and *** crops and legumes also contain significant quantities of galacto-oligosaccharides including raffinose,stachyose,and ***,understanding the structure,characteristics and measurable chemical properties of fiber in feed ingredients may result in more accurate diet formulations,resulting in an improvement in the utilization of energy from less expensive high-fiber ingredients and a reduction in reliance on energy from more costly cereal grains.

关键词： Carbohydrates Carbohydrate composition Chemical structure Feed ingredients Fiber Pigs