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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads christian.andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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优化车门ECU功耗的新概念

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电子技术应用 2007年第4期33卷 11-12页

作者： Armin Winter hans christian Gamer 飞思卡尔半导体德国分公司

在现代汽车中，电子控制单元（ECU）的数量不断增长。现代电子零部件增加了许多功能可为驾驶员提供更多的信息和更舒适的环境，在极大地增强发动机经济效率的同时，也使汽车中的电子功耗更高。这个问题在汽车熄火时会比汽车正常工作时... 详细信息

在现代汽车中，电子控制单元（ECU）的数量不断增长。现代电子零部件增加了许多功能可为驾驶员提供更多的信息和更舒适的环境，在极大地增强发动机经济效率的同时，也使汽车中的电子功耗更高。这个问题在汽车熄火时会比汽车正常工作时显得更加严重。当汽车熄火时，只有汽车蓄电池为ECU供电。为了最大限度地保持蓄电池的使用寿命，需要具有在汽车等待模式时段节约电力的措施。本文介绍了通常需要持续供电的车门模块功耗的优化策略。

关键词：优化策略 ECU 功耗车门电子控制单元现代汽车汽车蓄电池电子零部件

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没有画的画册

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丛书名：安徒生童话绘本典藏

2005年

作者：（丹）安徒生（hans christian.andersen）原（日）佐佐木Maki绘季颖文

本书是日本连环画作品，是月亮讲给一个住在阁楼上的画家听的故事，他向他描述昨夜或者今夜：看到的东西，一幅幅画面，而这些画面是“动”的，时光流逝。——这些故事，关于永恒与瞬间，关于生和死，关于无奈和希望。

ISBN: (纸本)7532617092

关键词：连环画作品日本现代

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Asian Journal of Andrology 2007年第3期9卷 299-304页

作者： Raft Henkel Gesa Maaβ Andreas Jung Gerhard Haidl Wolf-Bernhard Schill hans-christian Schuppe Department of Medical Biosciences University of the Western Cape Bellville 7535 South Africa Centre for Dermatology and Andrology Justus Liebig University 35385 Giessen Germany Department of Dermatology Rheinische Friedrich-Wilhelms University 53105 Bonn Germany

Aim： To investigate age-related inflammatory events in the male genital tract. Methods： In a total of 4 265 randomly collected patients attending the andrological outpatient clinic of the Center for Dermatology and Andrology, University of Giessen, Germany, ejaculate volume, pH-value, sperm concentration, total and progressive sperm motility, concentration of polymorphonuclear （PMN） elastase, number of peroxidase-positive cells and fructose were measured and correlated with patient＇s age. Results： While ejaculate volume, motility and fructose all correlated negatively with age, sperm concentration, PMN elastase and the pH-value showed a positive correlation. The prevalence of male genital tract inflammation （as defined by PMN elastase 〉 250 ng/mL） and its severity increased significantly. PMN elastase did not correlate with sperm motility. Fructose as a marker of seminal vesicle function showed a significant negative relationship with the PMN elastase levels, the number of peroxidase-positive cells and sperm motility. Conclusion： The significant increases of PMN elastase levels as marker of male genital tract inflammation in older men appear to be indicative of age-related changes in local immunoregulatory mechanisms. Because there is no association of PMN elastase with sperm motility, a direct inhibitory effect of this enzyme can be excluded.

关键词： aging men male genital tract inflammation polymorphonuclear elastase leukocytes infertility human semen

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Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz christian Herr Rudolf A. Jorres hans-Peter Lenhof Eckart Meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal Medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal Medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork （COSYCONET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA （miRNA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRNAs regulate different cancer-related pathways including the MAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRNA Cancer COPD Lung Biomarker COSYCONET

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安捷伦液相/离子阱(XCT)质谱检测虾仁及家禽中的硝基呋喃代谢物

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环境化学 2004年第6期23卷 717-721页

作者： Bernhard wüst christian Sauber hans (J) A van Rhijn Agilent Technologies GmbH Hewlett-Packardstr.876337WaldbronnGermanyAgilent Technologies GmbHHewlett-Packardstr.876337WaldbronnGermanyRIKILT Institute of Food SafetyBornsesteeg 456700 AE Wageningenthe Netherlands

在液相/离子阱质谱上,利用液相/质谱/质谱方法对鸡肉及虾仁中硝基呋喃代谢物残留进行了定性定量分析.对于四种硝基呋喃代谢物,其定量限在0125到05μg·kg-1的范围内,分析结果完全满足欧盟的1μg·kg-1的最低检测限量的要求.

关键词：硝基呋喃家禽虾仁 XCT 定量分析检测方法

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月亮看见了

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作者： (丹)汉斯·克里斯汀·安徒生(hans christian.andersen)

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卖火柴的小女孩(英文)

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英语沙龙（初级版） 2005年第3期 24-26页

作者： hans C.andersen

It was terribly cold and nearly darkon the last evening of the old year,andthe snow was failing *** the cold andthe darkness,a poor little girl,with barehead and naked(光赤的)feet。

关键词： naked evening mother anything beautiful leaning mo

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MAPK signaling： A key element in plant defense response to insects

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Insect Science 2015年第2期22卷 157-164页

作者： christian Hettenhausen Meredith C. Schuman Jianqiang Wu Kunming Institute of Botany Chinese Academy of Sciences Kunming China Max Planck Institute for Chemical Ecology Hans-Knoell Str. 8 07745 Jena Germany

Insects have long been the most abundant herbivores, and plants have evolved sophisticated mechanisms to defend against their attack, In particular, plants can perceive specific patterns of tissue damage associated with insect herbivory. Some plant species can perceive certain elicitors in insect oral secretions （OS） that enter wounds during feeding, and rapidly activate a series of intertwined signaling pathways to orchestrate the biosynthesis of various defensive metabolites. Mitogen-activated protein kinases （MAPKs）, common to all eukaryotes, are involved in the orchestration of many cellular processes, including development and stress responses. In plants, at least two MAPKs, salicylic acid-induced protein kinase （SIPK） and wound-induced protein kinase （WlPK）, are rapidly activated by wounding or insect 0S; importantly, genetic studies us- ing transgenic or mutant plants impaired in MAPK signaling indicated that MAPKs play critical roles in regulating the herbivory-induced dynamics of phytohormones, such as jasmonic acid, ethylene and salicylic acid, and MAPKs are also required for transcriptional activation of herbivore defense-related genes and accumulation of defensive metabolites. In this review, we summarize recent developments in understanding the functions of MAPKs in plant resistance to insect herbivores.

关键词： defense FAC insect jasmonate mitogen-activated protein kinase (MAPK) plant-insect interaction

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Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1

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World Journal of Gastroenterology 2007年第36期13卷 4881-4890页

作者： Jens BrΦndum FrΦkjΦr SΦren Due andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes hans Gregersen Center for Visceral Biomechanics and Pain Aalborg Hospital Aalborg Denmark Department of Radiology Aalborg Hospital Aalborg Denmark Department of Endocrinology M Aarhus University Hospital Aarhus Denmark Department of Surgical Gastroenterology L Aarhus University Hospital Aarhus Denmark Center for Sensory-Motor Interaction Department of Health Science and Technology Aalborg University Denmark Center for Sensory-Motor Interaction Department of Health Science and Technology Aalborg University Denmark National Center for Ultrasound in Gastro-enterology Haukeland University Hospital Bergen Norway

AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms.

关键词： Diabetes Autonomic Neuropathy Bio- mechanics Contractility Ultrasound Esophagus Duodenum Deformation Stress

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