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First steps in reconstructing Early Jurassic sea water temperatures in the Andean Basin of northern Chile based on stable isotope analyses of oyster and brachiopod shells

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Journal of Palaeogeography 2020年第1期9卷 71-87页

作者： Matthias Alberti Franz T.Fürsich Nils andersen Institut für Geowissenschaften Christian-Albrechts-Universitat zu KielLudewig-Meyn-Straβe 1024118 KielGermany GeoZentrum Nordbayern Fachgruppe PalaoUmweltFriedrich-Alexander-Universitat Erlangen-NürnbergLoewenichstraβe 2891054 ErlangenGermany Leibniz Laboratory for Radiometric Dating and Stable Isotope Research Christian-Albrechts-Universitat zu KielMax-Eyth-Straβe 1124118 KielGermany

The stable isotope(δ13 C,δ18 O)composition of a collection of Lower Jurassic brachiopods and oysters from the Andean Basin of northern Chile was *** results allow the first reconstruction of absolute water temperatures for several ammonite zones in the Lower Jurassic of South *** temperature record starts with comparatively high values in the Late Sinemurian(average:27.0℃;Raricostatum Zone).Just before the Sinemurian–Pliensbachian transition,temperatures dropped to an average of 24.3℃.The lowest temperature value in the dataset was recorded for a brachiopod shell of the latest Pliensbachian Spinatum Zone(19.6℃).No data are available for the Early Toarcian,but results for the late Toarcian show again comparatively warm conditions(average:24.4℃;Thouarsense–Levesquei zones).Even though more material and analyses are necessary to corroborate the recorded temperatures,the present dataset seems to indicate the global nature of the Late Pliensbachian Cooling *** contrast,the global warming during the Toarcian Oceanic Anoxic Event has not been recorded due to a lack of Early Toarcian ***δ13 C record of brachiopods and oysters documents a gradual increase in values representing background *** shells were used for high-resolution stable isotope analyses and show seasonal temperature fluctuations over a period of around 3 years in the life time of the *** explained only by temperatures,theδ18 O values point to a minimum estimate for the seasonality in the late Toarcian of slightly more than 3℃.

关键词： Early Jurassic Chile Stable isotopes Palaeoclimate Water temperatures Seasonality

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一个豆荚里的五粒豆

新东方英语(中学生) 2009年第11期 60-63页

作者： hans christian.andersen 张玲贾臻臻

不论卑微还是高贵,不论身处何处,只要你能尽力去帮助别人,就有了存在的价值。从前,在一个豆荚里有五粒豌豆。这些豌豆是绿色的,豆荚也是绿色的,于是它们就认为整个世界都是绿色的。

关键词：豌豆花安徒生

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小驴儿

长喜欢乐英语

长喜欢乐英语 2005年第10期 32-35页

作者： hans christian.andersen 陈秀丽

Solvent Interactions with Polymeric Heat Transfer Surfaces

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材料科学与工程（中英文A版） 2013年第9期3卷 591-600页

作者： christian Dreiser hans-Joeg Bart Chair of Separation Science and Technology University of Kaiserslautern Kaiserslautern D-67653 Germany

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安徒生童话精选

Safety and efficacy of Profermin~to induce remission in ulcerative colitis

2014年

作者： (丹)H.C. 安徒生(hans christian.andersen)

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World Journal of Gastroenterology 2012年第15期18卷 1773-1780页

作者： Aleksander Krag hans Israelsen Bjrn von Ryberg Klaus K andersen Flemming Bendtsen Gastrounit Medical Devision 360Copenhagen University Hospital Hvidovre Faculty of Health Sciences Copenhagen UniversityDK-2650 HvidovreDenmark Nordisk Rebalance A/S M.D.Madsensvej 14-16DK-3450 AllerdDenmark Statistics Section Informatics and Mathematical ModellingTechnical University of DenmarkDK-2800 LyngbyDenmark

AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 *** SCCAI was reported observer blinded via the ***:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in *** secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to *** was generally well ***:Profermin is safe and may be effective in inducing remission of active UC.

关键词： Ulcerative colitis Diet Probiotic Profermin Inflammatory bowel disease Dietary management Medical foods

Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer’s disease

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Translational Neurodegeneration 2021年第2期10卷 230-239页

作者： Mari Aksnes hans christian DAass Ann Tiiman Trine Holt Edwin Lars Terenius Nenad Bogdanovic Vladana Vukojevic Anne-Brita Knapskog Department of Geriatric Medicine Institute of Clinical MedicineFaculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalOsloNorway Department of Clinical Neurosciences(CNS) Center for Molecular Medicine CMM L8:01Karolinska InstitutetStockholmSweden Department of Geriatric Medicine The Memory ClinicOslo University HospitalOsloNorway Institute of Health and Society Faculty of MedicineUniversity of OsloOsloNorway Norwegian National Advisory Unit on Ageing and Health Vestfold Hospital TrustTonsbergNorway Department of Neurobiology Care Science and Society(NVS)Division of Clinical GeriatricsKarolinska InstitutetHuddingeSweden

Background:The aggregation of amyloidβ(Aβ)is central in the pathogenesis of Alzheimer’s disease(AD).Recently it has been shown that specifically,larger,Thioflavin T-binding Aβaggregates are associated with increased neuroinflammation and cytokine *** study was aimed to quantify fibrillary amyloid aggregates,so-called nanoplaques,and investigate their relationship with cytokines in the cerebrospinal fluid(CSF).Methods:CSF was collected from 111 patients assessed for cognitive complaints at the Oslo University Hospital Memory *** patients were grouped based on their amyloid *** CSF nanoplaque concentration was quantified with the Thioflavin T-fluorescence correlation spectroscopy(ThT-FCS)*** levels of nine cytokines(eotaxin-1,granulocyte stimulating factor,interleukin[IL]-6,IL-7,IL-8,monocyte chemoattractant protein-1,gammainduced protein 10,macrophage inflammatory protein[MIP]-1α,and MIP-1β)were quantified with a magnetic bead-based multiplex assay and read on a Luminex IS 200 ***:There were 49 amyloid-negative and 62 amyloid-positive patients in the cohort;none of the cytokines differed significantly between the amyloid *** increased nanoplaque levels were associated with levels of MIP-1βbelow the lower limit of quantification,and with decreased levels of MIP-1αand *** associations remained significant when adjusted for age,sex,cognitive function,apolipoproteinε4 status and CSF core biomarker ***:The cytokine levels were not associated with amyloid status in this *** nanoplaque levels were negatively associated with MIP-1β,MIP-1αand IL-8,which is in line with recent findings suggesting that the upregulation of some cytokine markers has a protective role and is negatively associated with AD progression.

关键词： Alzheimer's disease Amyloid Amyloid beta peptides Amyloidogenic proteins Biomarkers Cerebrospinal fluid Cytokines Inflammation Fluorescence correlation spectroscopy Thioflavin T

Central Retinal Microperimetry by Scanning Laser Ophthalmoscopy in Chiasmal Patients with Visual Inattention Temporally at Monocular Visual Acuity Testing

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Open Journal of Ophthalmology 2017年第1期7卷 44-50页

作者： hans C. Fledelius Mads Nis V. andersen Rigshospitalet University Eye Department Copenhagen Demark

Background: In a previous study, a specific visual behaviour was described in four chiasmal patients. It manifested as inattention/ignorance within the temporal visual space (“visual blocking”) at monocular visual acuity testing. Moreover, in 3 out of the 4, the process of reading a text appeared cognitively impaired. Methods: As a supplement to conventional visual field testing, the present analysis focus was on microperimetry by Scanning Laser Ophthalmocopy (SLO). Our aim was to identify the perceptual retinal counterparts to the temporally located visual field defects as caused by the visual pathway lesion on a chiasmal level, possibly also to indicate the apparently ineffective saccadic movements underlying that only part of the line on the chart could be given. Results and Conclusions: The central retinal areas with lacking recognition by SLO testing were given by black rectangles expressing scotomatous points;they clustered in a zone extending nasally from the fixation area, as expected. The methodology further depicted an orderly fixation in two cases, and only minor deviation in two. Fixation saccades thus were considered by and large within normal and with only exceptional outlier points recorded. All considered, the shortcomings of the perceptual mechanisms underlying the lateralised visual inattention as observed in the four patients have remained without a satisfactory explanation.

关键词： Microperimetry Laser Ophthalmoscope Monocular Visual Acuity Testing Optic Chiasm

Functions of Lysosomes in Mammalian Female Reproductive System

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Reproductive and Developmental Medicine 2020年第2期4卷 109-122页

作者： Yuehuan Li Zidao Wang christian L.andersen Xiaoqin Ye Department of Physiology and Pharmacology College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Toxicology Program University of GeorgiaAthensGA 30602USA

The lysosome is the most acidic membrane-bound intracellular *** acidity is primarily maintained by vacuolar H+-ATPase(V-ATPase)and counter ion *** are>60 hydrolytic enzymes in the lysosome for its fundamental digestive *** also play important roles in endocytosis,exocytosis,autophagy,and cell *** that have implicated roles of lysosomes in the female reproductive system are reviewed *** the ovary,lysosomes are implicated in the preparation of free cholesterol for steroidogenesis and degradation of regulators of steroidogenesis,regulation of follicular atresia,follicle rupture during ovulation,luteal cell survival,and luteal *** the oviduct,lysosomes are involved in endocytosis of both serum and oviductal luminal *** the uterus during the menstrual/estrous cycle,lysosomes are associated with endometrial secretion,apoptosis,and *** the uterus during early pregnancy,lysosomes are involved in the temporal and directional changes of endocytosis,uterine epithelial acidification upon embryo implantation initiation,and embryo-maternal mutual communications via extracellular *** the placenta,lysosomes are implicated in nutrient transport and placental separation from the uterus for *** the mammary gland,lysosomes are important for mammary gland development and *** findings suggest/demonstrate functions of lysosomes in multiple processes of female reproduction,from ovulation to ovarian steroidogenesis for pregnancy maintenance,and from essential in utero nurturing of developing embryos/fetuses via embryo/fetal-maternal communications,to optional postpartum nurturing of newborns via *** studies using genetically or modified animal models and pharmacological approaches will provide novel insights into the functions and mechanisms of lysosomes in the mammalian female reproductive system.

关键词： Autophagy Endocytosis Lysosome Ovary Steroidogenesis Uterus

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