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First finding of continental deep subduction in the Sesia Zone of the Western Alps and implications for subduction dynamics

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National Science Review 2023年第5期10卷 154-166页

作者： Yi-Xiang Chen Kun Zhou Qiang He Yong-Fei Zheng hans-Peter Schertl Kun Chen CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of China Center of Excellence for Comparative Planetology Chinese Academy of Sciences Institute of Geology Mineralogy and Geophysics Faculty of GeosciencesRuhr University Bochum

Continental deep subduction after the closure of large oceanic basins is commonly ascribed to the gravitational pull of the subducting oceanic ***,it is not clear how continental lithosphere adjacent to small oceanic basins was subducted to mantle *** Sesia Zone in the Western Alps provides an excellent target for exploration of subduction dynamics in such a tectonic *** we report the first finding of coesite in a jadeite-bearing orthogneiss from the Sesia Zone,providing the first evidence for deep subduction of the continental crust to mantle depths for ultrahigh-pressure(UHP)metamorphism in this *** coesite inclusions were identified by laser Raman spectroscopy in two garnet *** on zircon U-Pb dating and trace element analysis, the UHP metamorphic age was constrained to be 76.0 ±1.0 *** phase equilibrium modeling yields peak metamorphic pressures of2.8-3.3 GPa,demonstrating the continental deep subduction to mantle depths of>80 *** subducted continental crust was a rifted hyperextended continental margin,which was converted to the passive continental margin during seafloor spreading and then deeply subducted during the oblique convergence between the Adria microplate and Eurasian plate in the Late *** the slab pull could only play a limited role in closing small oceanic basins for continental collision,the distal push of either continental breakup or seafloor spreading is suggested as the major driving force for the deep subduction of continental crust in the Western ***,deep subduction of the continental crust bordering small oceanic basins would have been induced by the far-field stress of compression,whereas that bordering large oceanic basins was spontaneous due to the oceanic slab *** provides a new insight into the geodynamic me chanism of continental deep subduction.

关键词： coesite ultrahigh-pressure metamorphism continental deep subduction Western Alps far-field stress

Hybrid Energy Storage to Control and Optimize Electric Propulsion Systems

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Computers, Materials & Continua 2022年第6期71卷 6183-6200页

作者： Sikander hans Smarajit Ghosh Suman Bhullar Aman Kataria Vinod Karar Divya Agrawal Department of Electrical and Instrumentation Engineering Thapar Institute of Engineering&TechnologyPatialaIndia Optical Devices and Systems CSIR-Central Scientific Instruments OrganizationChandigarh 160030India

Today,ship development has concentrated on electrifying ships in commercial and military applications to improve efficiency,support highpower missile systems and reduce ***,the electric propulsion of the shipboard system experiences torque fluctuation,thrust,and power due to the rotation of the propeller shaft and the motion of *** order tomeet these challenges,a new solution is *** paper explores hybrid energy management systems using the battery and ultracapacitor to control and optimize the electric propulsion *** battery type and ultracapacitor are ZEBRA and MAXWELL,*** 3-,4-and 5-blade propellers are considered to produce power and move *** loss factor has been reduced,and the sea states have been found through the Elephant Herding Optimization *** efficiency of the proposed system is greatly enhanced through torque,thrust and *** model predictive controller control strategy is activated to reduce load torque and drive system Root Average Square(RMS)*** implementations are conducted under the MATLAB *** values for torque,current,power,and error are measured and ***,the performance of the proposed methodology is compared with other available algorithms such as BAT and Dragonfly(DF).The simulation results show that the results of the proposed method are superior to those of various techniques and algorithms such as BAT and Dragonfly.

关键词： Dynamic model of the ship elephant herding optimization energy management schemes propeller ultra-capacitor zebra batteries

The histopathological spectrum of myocardial inflammation in relation to circumstance of death:a retrospective cohort study in clinical and forensic autopsies

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Forensic Sciences Research 2022年第2期7卷 238-246页

作者： Romy du Long Judith Fronczek hans W.M.Niessen Allard C.van der Wal hans H.de Boer Department of Pathology Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Department of Forensic Medicine Netherlands Forensic InstituteThe HagueThe Netherlands

Interpreting a myocardial inflammation as causal,contributory or as of no significance at all in the cause of death can be challenging,especially in cases where other pathologic and/or medico-legal findings are also *** further evaluate the significance of myocardial inflammation as a cause of death we performed a retrospective cohort study of forensic and clinical autopsy *** revised the spectrum of histological inflammatory parameters in the myocardium of 79 adult autopsy cases and related these to the reported cause of *** slides were reviewed for the distribution and intensity of inflammatory cell infiltrations,the predominant inflammatory cell type,and the presence of inflammation-associated myocyte injury,fibrosis,edema and ***,the cases were divided over three groups,based on the reported cause of *** 1(n=27)consisted of all individuals with an obvious unnatural cause of *** 2(n=29)included all individuals in which myocarditis was interpreted to be one out of more possible causes of *** 3(n=23)consisted of all individuals in which myocarditis was reported to be the only significant finding at autopsy,and no other cause of death was *** application of our histological parameters showed that only a diffuse increase of inflammatory cells could discriminate between an incidental presence of inflammation(Group 1)or a potentially significant one(Groups 2 and 3).No other histological parameter showed significant differences between the *** results suggest that generally used histological parameters are often insufficient to differentiate an incidental myocarditis from a(potentially)significant one.

关键词： Forensic sciences myocarditis myocardial inflammation diagnosis forensic pathology cause of death autopsy pathology

Dynamics and functions of E‑cadherin complexes in epithelial cell and tissue morphogenesis

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Marine Life Science & Technology 2023年第4期5卷 585-601页

作者： Na Zhang Matthias Häring Fred Wolf Jörg Großhans Deqing Kong Department of Biology Philipps University35043 MarburgGermany Göttingen Campus Institute for Dynamics of Biological Networks(CIDBN) Georg August University Göttingen37073 GöttingenGermany

Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue.E-cadherin–catenin complexes mediate Ca^(2+)-dependent trans-homodimerization and constitute the kernel of adherens *** the basic function of cell–cell adhesion,recent progress sheds light the dynamics and interwind interactions of individual E-cadherin–catenin complex with E-cadherin superclusters,contractile actomyosin and mechanics of the cortex and *** nanoscale architecture of E-cadherin complexes together with cis-interactions and interactions with cortical actomyosin adjust to junctional tension and mechano-transduction by reinforcement or weakening of specific features of the *** post-translational modifications such as phosphorylation and glycosylation have been implicated,their role for specific aspects of in E-cadherin function has remained ***,we provide an overview of the E-cadherin complex in epithelial cell and tissue morphogenesis focusing on nanoscale architectures by super-resolution approaches and post-translational modifications from recent,in particular in vivo,***,we review the computational modelling in E-cadherin complexes and highlight how computational modelling has contributed to a deeper understanding of the E-cadherin complexes.

关键词： Nanoscale architectures Phosphorylation Glycosylation Computational modelling

Cutting force model and damage formation mechanism in milling of 70wt%Si/Al composite

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Chinese Journal of Aeronautics 2023年第7期36卷 114-128页

作者： Guolong ZHAO Lianjia XIN Liang LI Yang ZHANG Ning HE hans Nørgaard hansEN College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Civil and Mechanical Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark

High-mass fraction silicon aluminium composite(Si/Al composite) has unique properties of high specific strength, low thermal expansion coefficient, excellent wear resistance and weldability. It has attracted many applications in terms of radar communication, aerospace and automobile industry. However, rapid tool wear resulted from high cutting force and hard abrasion, and damaged machined surfaces are the main problem in machining Si/Al composite. This work aims to reveal the mechanisms of milling-induced damages of 70wt% Si/Al composites. A cutting force analytical model considering the characteristics of both the primary silicon particles and the cutting-edge radius was established. Milling experiments were conducted to verify the validity of the model. The results show that the analytical model exhibits a good consistency with the experimental results, and the error is about 10%. The cutting-edge radius has significant effects on the cutting force, surface roughness and damage formation. With the increase in the cutting-edge radius, both the cutting force and the surface roughness decrease firstly and then increase. When the cutting-edge radius is 27 μm, the surface roughness(Sa) reaches the minimum of 2.3 μ***-induced surface damages mainly contain cracks, pits, scratches, matrix coating and *** damage formation is dominated by the failure mode of primary silicon particles, which includes compressive breakage, intragranular fracture, particle pull-out, and interface debonding. In addition, the high ductility of aluminium matrix leads to matrix coating. This work provides guidance for tool selection and damage inhibition in high-efficiency and high-precision machining of high mass fraction Si/Al composites.

关键词： posite Cutting force analytical model Cutting-edge radius Surface quality Damage formation mechanism

基于卷积神经网络感知功能的极端场景生成方法

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同济大学学报（自然科学版） 2022年第S1期50卷 119-127页

作者： Kun GAO hans-Christian REUSS 斯图加特汽车工程与车辆发动机研究所(FKFS) 德国斯图加特70569 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

近年来,基于卷积神经网络深度学习的感知算法在自动驾驶车辆环境感知系统中发挥着越来越重要的作用。由于在神经网络训练过程中,训练数据无法覆盖所有极端场景,因此如何保证基于深度学习的感知算法在极端场景下的安全性和可靠性,仍是一... 详细信息

近年来,基于卷积神经网络深度学习的感知算法在自动驾驶车辆环境感知系统中发挥着越来越重要的作用。由于在神经网络训练过程中,训练数据无法覆盖所有极端场景,因此如何保证基于深度学习的感知算法在极端场景下的安全性和可靠性,仍是一个亟待解决的问题。传统的基于真实行驶里程的验证方法,在获取极端场景数据上危险性高,经济性差,因此很难检验驾驶功能在极端场景下的性能。基于虚拟场景的仿真验证方法,虽然可以通过设置场景参数来生成大量测试场景,但是通过简单的参数组合并不能有效的生成极端场景。本文展示了一种在虚拟环境中生成极端场景的方法,用于训练和测试基于深度卷积神经网络的车道线识别算法。首先将场景特征用参数进行表示,然后使用deep Q-learning强化学习的方法,来生成极端场景的参数组合。通过与随机组合以及成对组合场景参数的方法进行对比,可以看出该基于强化学习的场景生成方法可以更有效地生成极端场景,因此可提高自动驾驶感知功能的测试效率,同时可为卷积神经网络提供更多的极端场景训练数据。

关键词：自动驾驶极端场景卷积神经网络强化学习

AAV-based gene therapy approaches for genetic forms of tauopathies and related neurogenetic disorders

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BIOCELL 2022年第4期46卷 847-853页

作者： MOHAMED AGHYAD AL KABBANI GILBERT WUNDERLICH CHRISTOPH KÖHLER hans ZEMPEL Faculty of Medicine and University Hospital Cologne Institute of Human GeneticsUniversity of CologneCologne50931Germany Faculty of Medicine and University Hospital Cologne Center for Molecular Medicine Cologne(CMMC)University of CologneCologne50931Germany Faculty of Medicine and University Hospital Cologne Department of NeurologyUniversity of CologneCologne50937Germany Faculty of Medicine and University Hospital Cologne Center for Rare DiseasesUniversity of CologneCologne50937Germany Faculty of Medicine and University Hospital Cologne Center AnatomyDepartment of Molecular and Translational NeuroscienceUniversity of CologneCologne50931Germany

Tauopathies comprise a spectrum of genetic and sporadic neurodegenerative diseases mainly characterized by the presence of hyperphosphorylated TAU protein aggregations in neurons or *** therapy,in particular adeno-associated virus(AAV)-based,is an effective medical approach for difficult-to-treat genetic diseases for which there are no convincing traditional therapies,such as *** AAV-based gene therapy to treat,in particular,genetic tauopathies has many potential therapeutic benefits,but also drawbacks which need to be addressed in order to successfully and efficiently adapt this still unconventional therapy for the various types of *** this Viewpoint,we briefly introduce some potentially treatable tauopathies,classify them according to their etiology,and discuss the potential advantages and possible problems of AAV-based gene ***,we outline a future vision for the application of this promising therapeutic approach for genetic and sporadic tauopathies.

关键词： Tauopathies Neurogenetic diseases AAV-based gene therapy Neurodegeneration Alzheimer disease TAU

Fluid effect on zircon O and U-Pb isotopes during ultrahigh-pressure metamorphism:Insights from the Dora-Maira Massif of the Western Alps

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Geoscience Frontiers 2023年第6期14卷 210-223页

作者： Kun Zhou Yi-Xiang Chen Jia-Wei Xiong hans-Peter Schertl Xiao-Ping Xia CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology University of Science and Technology of ChinaHefei 230026China Institute of Geology Mineralogy and GeophysicsFaculty of GeosciencesRuhr University Bochum44780 BochumGermany College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

Zircon geochemistry such as U-Pb and O isotopes have been widely used in dating and tracing complex geological ***,it still remains unclear how fluid action affects zircon geochemistry during metamorphic and metasomatic processes in subduction *** a systematic study on zircon U-Pb dating,O isotopes and trace elements as well as whole-rock O isotopes was carried out for the coesite-bearing whiteschists,jadeite quartzites and granitic gneisses from the Dora-Maira Massif,Western ***-rock and zircon geochemistry supports a common protolith,i.e.,Permian S-type granites,for the above three types of rocks and an intense fluid metasomatism during the Alpine orogeny to form whiteschists and jadeite *** cores in all samples have nearly identicalδ^(18)O values(9‰–11‰),whereas their apparent^(206)Pb/^(238)U ages show a greater variability due to Pb loss during *** rims formed in the late Eocene to early Oligocene can be categorized into two ***-Ⅰrims occur in granitic gneisses and jadeite *** have highδ^(18)O values consistent with zircon cores,but much lower contents of P and Y as well as lower Th/U ratios than the *** growth can be attributed to internal metamorphic fluid action at the UHP metamorphic ***-II rims occur in whiteschists and jadeite *** have remarkably lowerδ^(18)O values(5‰–8‰)and Th/U ratios(<0.01),compared with zircon cores and Type-Ⅰ*** growth can be ascribed to external fluids during the metasomatic *** zircon domains in whiteschists and jadeite quartzites show a positive correlation betweenδ^(18)O values and apparent^(206)Pb/^(238)U ages,which suggest the simultaneous impacts on U-Pb-O isotopes during external fluid *** process can be attributed to the fluidassisted dissolution and recrystallization of protolith ***,coesite inclusions that would have been expected to occur only in young zircon rims formed duri

关键词： Subduction zone Fluid action Metasomatism Zircon O isotope U-Pb dating

BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES

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Frontiers of Agricultural Science and Engineering 2022年第1期9卷 82-97页

作者： Mingbo QU hans MERZENDORFER Bernard MOUSSIAN Qing YANG School of Bioengineering Dalian University of TechnologyDalian 116024China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Institute of Biology University of Siegen57076 SiegenGermany Interfaculty Institute of Cell Biology University of Tübingen72076 TübingenGermany Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China

Bioinsecticides are naturally-occurring substances from different sources that control insect *** bioinsecticides should have low toxicity to non-target *** should also be easily degraded in sewage treatment works and natural environments,highly effective in small quantities and affect target pests *** concerns about possible side-effects of synthetic pesticides have accelerated bioinsecticide research and ***,to develop bioinsecticides into mainstream products,their high production costs,short shelf-life and often uncertain modes of action need to be *** review summarizes current progress on bioinsecticides which are categorized as biochemical insecticides and their derivatives,plant-incorporated protectants,and microbial *** current constraints that prevent bioinsecticides from being widely used are discussed and future research directions are proposed.

关键词： biochemical insecticide bioinsecticide microbial bioinsecticides plant-incorporated protectant RNA insecticide