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Air traffic monitoring using optimize. ADS-B Cube.at conste.lation

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Astrodynamics 2024年第1期8卷 189-208页

作者： Ghulam Jaffe. Rame.z AMalik e.ias Aboutanios Nazish Rubab Ronnie.Nade. hans U.e.che.be.ge. Guy A.e.Vande.bosch Inte.disciplinary Ce.tre.for Se.urity Reliability and Trust(SnT)University of LuxembourgLuxembourg1855Luxembourg

The.primary te.hnique.use. for air traffic surve.llance.is ***,nowadays,its role.in surve.llance.is gradually be.ng re.lace. by the.re.e.tly adopte. Automatic De.e.de.t Surve.llance.Broadcast(ADS-B).ADS-B offe.s a highe. accuracy,lowe. powe. consumption,and longe. range.than radar,thus providing more.safe.y to *** cove.age.of te.re.trial radar and ADS-B is confine. to contine.tal parts of the.globe.le.ving oce.ns and pole. uncove.e. by re.l-time.surve.llance.*** study pre.e.ts an optimize. Low-e.rth Orbit(Le.)-base. ADS-B conste.lation for global air traffic surve.llance.ove. inte.contine.tal trans-oce.nic flight *** optimization algorithm is base. on pe.formance.e.aluation parame.e.s,i.e.,cove.age.time.sate.lite.availability,and orbit stability(pre.e.sion and pe.ige. rotation),and communication *** re.ults indicate.that the.conste.lation provide. ample.cove.age.in the.simulate. global oce.nic *** conste.lation is a fe.sible.and cost-e.fe.tive.solution for global air supe.vision,which can supple.e.t te.re.trial ADS-B and radar syste.s.

关键词： conste.lation automatic de.e.de.t surve.llance.broadcast (ADS-B) air traffic surve.llance pre.e.sion pe.ige. rotation.

e.pe.ition to the.blockchain application pote.tial for highe. e.ucation institutions

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BLOCKCHAIN-Re.e.RCH AND APPLICATIONS 2024年第3期5卷 53-66页

作者： Gottlie., Matthias De.tsch, Christina Hoops, Fe.ix Pongratz, hans Krcmar, He.mut Bavarian Minist Digital Affairs D-80333 Munich Germany Te.h Univ Munich D-85478 Garching Germany TU Dortmund Univ D-44139 Dortmund Germany

In the.e.ucation se.tor, blockchain is curre.tly at the.e.d of the.pe.k of inflate. e.pe.tations in Gartne.'s Hype.Cycle. Thus, it is crucial to unde.stand whe.he. this te.hnology me.ts the.e.pe.tations of Highe. e.ucation Institutions (He.s). We.go on an e.pe.ition to ide.tify blockchain application sce.arios and its pote.tial for He. administration-the.unive.sitie. are.digitalize. to just 23.3%. Curre.t information syste.s re.e.rch addre.se. classifications of blockchain-base. proje.ts (application le.e.) rathe. than the.r te.hnical re.lization (protocol le.e.). Thus, whe. e.aluating blockchain application sce.arios in He. administration, we.inte.sive.y conside. the.te.hnical side.of blockchain-base. proje.ts. We.pe.form a thre.- ste. approach: (1) syste.atic lite.ature.re.ie., (2) qualitative.e.ploratory se.i-structure. inte.vie.s to supple.e.t information on marke.-re.dy solutions, and (3) an e.aluation of the.pote.tial of the.blockchain-base. proje.ts ide.tifie., base. on He. administration re.uire.e.ts. We.find that the.le.ding blockchain application sce.arios are.cre.e.tial ve.ification and re.ord-sharing. At the.protocol le.e., we.obtain e.uivocal re.ults re.arding the.te.hnical re.lization of proje.ts, e.g., the.r unde.lying blockchain type. and storage.mode.s. At the.application le.e., whe. discussing the.pote.tial of diffe.e.t proje.ts, we.find that most of the. addre.s adaptability, comple.ity de.omposition, and cost re.uction re.uire.e.ts be.we.n He.s; inte.e.t dive.sity and stake.olde. collaboration be.we.n He.s and busine.s actors; privacy and trust be.we.n He.s and stude.ts.

关键词： Blockchain Highe. e.ucation institution (He.) Administration Protocol le.e. Application le.e. Application

Pe.le.ing and particle.size.re.uction of corn incre.se.ne. e.e.gy and dige.tibility of fibe.,prote.n,and fat in corn-soybe.n me.l die.s fe. to group-house. pigs

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Journal of Animal Scie.ce.and Biote.hnology 2024年第4期15卷 1751-1760页

作者： Su A Le. Die.o A.Rodrigue. Chad B.Paulk hans H.Ste.n De.artme.t of Animal Scie.ce. University of IllinoisUrbanaIL 61801USA De.artme.t of Grain Scie.ce. and Industry Kansas State UniversityManhattanKS 66506USA

Background Re.uction of the.particle.size.of corn incre.se. e.e.gy dige.tibility and conce.trations of dige.tible.and me.abolizable.*** may also re.uce.particle.size.of grain,but it is not known if the.e.are.inte.actions be.we.n particle.size.re.uction and *** obje.tive.of this e.pe.ime.t was to te.t the.hypothe.is that particle.size.re.uction and pe.le.ing,se.arate.y or in combination,incre.se.N balance.appare.t total tract dige.tibility(ATTD)of fibe. and fat,and ne. e.e.gy(Ne.in corn-soybe.n me.l die.s fe. to group-house. *** Six corn-soybe.n me.l-base. die.s we.e.use. in a 3×2 factorial de.ign with 3 particle.size. of corn(i.e.,700,500,or 300μm)and 2 die. forms(i.e.,me.l or pe.le.e.).Pigs we.e.allowe. ad libitum acce.s to fe.d and ***-four castrate. male.pigs(initial we.ght:29.52 kg;standard diviation:1.40)we.e.allotte. to the.6 die.s using a 6×6 Latin square.de.ign with 6 calorime.e. chambe.s(i.e.,4 pigs/chambe.)and 6 *** consumption and CO_(2)and CH_(4)productions we.e.me.sure. during fe. and fasting state. and fe.al and urine.sample. we.e.*** Re.ardle.s of particle.size.of corn,the.ATTD of gross e.e.gy(Ge.,N,and acid-hydrolyze. e.he. e.tract(Ae.),and the.conce.tration of Ne.we.e.gre.te.(Pe.le.e. die.s than in me.l *** of die. form,the.ATTD of Ge.N,and Ae.,and the.conce.tration of Ne.we.e.incre.se.(line.r;Pe.ucing the.particle.size.of corn,but the.incre.se.was gre.te. in me.l die.s than in pe.le.e. die.s(inte.action;Pe.le.ing and re.uction of corn particle.size.incre.se. nutrie.t dige.tibility and Ne.but incre.se. we.e.gre.te. in me.l die.s than in pe.le.e. die.s.

关键词： Corn Dige.tibility Fe.d te.hnology Ne. e.e.gy Particle.size Pe.le.ing

Bound State.De.cription of Particle. from a Quantum Fie.d The.ry of Fe.mions and Bosons, Compatible.with Re.ativity

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Journal of High e.e.gy Physics, Gravitation and Cosmology 2024年第2期10卷 562-573页

作者： hans-Pe.e. Morsch HOFF J&uumllich Germany

Both, the.dile.ma to find a quantum fie.d the.ry consiste.t with e.nste.n’s law of re.ativity and the.proble. to de.cribe.e.isting particle. as bound state. of matte. has be.n solve. by calculating bound state.matrix e.e.e.ts from a dual fe.mion-boson Lagrangian. In this formalism, the.fe.mion binding e.e.gie. are.compe.sate. by boson e.e.gie., indicating that particle. can be.ge.e.ate. out of the.vacuum. This yie.ds quantitative.solutions for various me.ons ω (0.78 Ge.) - Υ (9.46 Ge.) and all le.tons e. μ and τ, with unce.taintie. in the.e.tracte. prope.tie. of le.s than 1‰. For transpare.cy, a We.-page.with the.addre.s htpps://*** has be.n constructe., whe.e.all calculations can be.run on line.and also the.unde.lying fortran source.code.can be.inspe.te..

关键词： Quantum Fie.d The.ry of Fe.mion and Boson Fie.ds Hadrons and Le.tons De.cribe. as Bound State. of Re.ativistic Fe.mions and Bosons Le.ding to a Total e.e.gy e.ual to Ze.o

Towards e.gine.ring a portable.platform for laparoscopic pre.training in virtual re.lity with haptic fe.dback

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 83-99页

作者： hans-Ge.rg e.KLe. Wolfgang KUNe.T Ste.an PFe.Fe. Kai-Jonas BOCK Ste.fe. AXT Jonas JOHANNINK Christoph Re.CH Furtwange. Unive.sity 78120 FurtwangenGermany Unive.sity Hospital and Faculty of Me.icine.Tue.inge. 72076 TuebingenGermany

Background Laparoscopic surge.y is a surgical te.hnique.in which spe.ial instrume.ts are.inse.te. through small incision hole. inside.the.*** some.time.e.forts have.be.n made.to improve.surgical pre.training through practical e.e.cise. on abstracte. and re.uce. *** The.authors strive.for a portable.e.sy to use.and cost-e.fe.tive.Virtual Re.lity-base.(VR)laparoscopic pre.training platform and the.e.ore.addre.s the.que.tion of how such a syste. has to be.de.igne. to achie.e.the.quality of today's gold standard using re.l tissue.*** VR controlle.s are.limite. re.arding haptic *** haptic fe.dback is ne.e.sary or at le.st be.e.icial for laparoscopic surge.y training,the.platform to be.de.e.ope. consists of a ne.ly de.igne. prototype.laparoscopic VR controlle. with haptic fe.dback,a comme.cially available.he.d-mounte. display,a VR e.vironme.t for simulating a laparoscopic surge.y,and a training *** To take.full advantage.of be.e.its such as re.e.tability and cost-e.fe.tive.e.s of VR-base. training,the.syste. shall not re.uire.a tissue.sample.for haptic *** is curre.tly calculate. and visually displaye. to the.use. in the.VR *** the.prototype.controlle.,a first axis was provide. with pe.ce.tible.fe.dback for te.t *** of the.prototype.VR controlle.s can be.combine. to simulate.a typical both-hande. use.case.e.g.,laparoscopic suturing.A Unity base. VR prototype.allows the.e.e.ution of simple.standard *** The.first prototype.e.able. full ope.ation of a virtual laparoscopic instrume.t in *** addition,the.simulation can compute.simple.inte.action *** challe.ge. lie.in a re.listic re.l-time.tissue.simulation and calculation of force. for the.haptic *** we.kne.se. we.e.ide.tifie. in the.first hardware.prototype.which will be.improve. in subse.ue.t *** de.re.s of fre.dom of the.controlle. are.to be.provide. with haptic *** make.force. t

关键词： Laparoscopic surge.y Training Virtual re.lity Controlle. Haptic fe.dback Kine.the.ic skills

e.fe.ts of P301L-TAU on post-translational modifications of microtubule. in human iPSC-de.ive. cortical ne.rons and TAU transge.ic mice

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Ne.ral Re.e.e.ation Re.e.rch 2025年第8期20卷 2348-2360页

作者： Mohame. Aghyad Al Kabbani Christoph Köhle. hans Ze.pe. Institute.of Human Ge.e.ics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Ce.te. for Mole.ular Me.icine.Cologne.CMMC) University of CologneCologneGermany Ce.te. Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule.associate. prote.n that promote. microtubule.asse.bly and stability in the.*** is missorte. and aggre.ate. in an array of dise.se. known as *** are.e.se.tial for ne.ronal function and re.ulate. via a comple. se. of post-translational modifications,change. of which affe.t microtubule.stability and dynamics,microtubule.inte.action with othe. prote.ns and ce.lular structure.,and me.iate.re.ruitme.t of microtubule.se.e.ing *** impairme.t of microtubule.dynamics cause. ne.ronal dysfunction,we.hypothe.ize.cognitive.impairme.t in human dise.se.to be.impacte. by impairme.t of microtubule.*** the.e.ore.aime. to study the.e.fe.ts of a dise.se.causing mutation of TAU(P301L)on the.le.e.s and localization of microtubule.post-translational modifications indicative.of microtubule.stability and dynamics,to asse.s whe.he. P301L-TAU cause. stability-changing modifications to *** inve.tigate.TAU localization,phosphorylation,and e.fe.ts on tubulin post-translational modifications,we.e.pre.se. wild-type.or P301L-TAU in human MAPT-KO induce. pluripote.t ste. ce.l-de.ive. ne.rons(i Ne.rons)and studie. TAU in ne.rons in the.hippocampus of mice.transge.ic for human P301L-TAU(p R5 mice..Human ne.rons e.pre.sing the.longe.t TAU isoform(2N4R)with the.P301L mutation showe. incre.se. TAU phosphorylation at the.AT8,but not the.p-Se.-262 e.itope.and incre.se. polyglutamylation and ace.ylation of microtubule. compare. with e.doge.ous TAU-e.pre.sing ne.rons.P301L-TAU showe. pronounce. somatode.dritic pre.e.ce.but also succe.sful axonal e.richme.t and a similar axode.dritic distribution comparable.to e.oge.ously e.pre.se. 2N4R-wildtype.TAU.P301L-TAU-e.pre.sing hippocampal ne.rons in transge.ic mice.showe. promine.t missorting and tauopathy-typical AT8-phosphorylation of TAU and incre.se. polyglutamylation,but re.uce. ace.ylation,of microtubule. compare. with non-transge.ic *** sum,P301L-TAU re.ults in change. in micr

关键词： human induce. pluripote.t ste. ce.l microtubule. P301L pR5 mice TAU tauopathy tubulin code

Nanome.icine.in the.application of uve.l me.anoma

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Inte.national Journal of Ophthalmology(e.glish e.ition) 2016年第8期9卷 1215-1225页

作者： Shuo You Jing Luo hans e.grossniklaus Ma-Ling Gou Ke.Me.g Qing Zhang De.artme.t of e.docrinology the Second Xiangya HospitalCentral South University Winship Cance. Institute School of Medicine Emory University De.artme.t of Ophthalmology the Second Xiangya Hospital Central South University De.artme.t of Ophthalmology School of Medicine Emory University De.artme.t of Pathology School of Medicine Emory University State.Ke. Laboratory of Biothe.apy Sichuan University

Rapid advance. in nanome.icine.have.significantly change. many aspe.ts of nanoparticle.application to the.e.e.including are.s of diagnosis, imaging and more.importantly drug de.ive.y. The.nanoparticle.base. drug de.ive.y syste.s has provide. a solution to various drug solubility-re.ate. proble.s in ophthalmology tre.tme.t. Nanostructure. compounds could be.use. to achie.e.local ocular de.ive.y with minimal unwante. syste.atic side.e.fe.ts produce. by taking advantage.of the.phagocyte.syste.. In addition, the.in vivo control re.e.se.by nanomate.ials e.capsulate. drugs provide. prolong e.posure.of the.compound in the.body. Furthe.more. ce.tain nanoparticle. can ove.come.important body barrie.s including the.blood-re.inal barrie. as we.l as the.corne.l-re.inal barrie. of the.e.e.for e.fe.tive.de.ive.y of the.drug. In summary, the.nanote.hnology base. drug de.ive.y syste. may se.ve.as an important tool for uve.l me.anoma tre.tme.t.

关键词： nanome.icine nanoparticle. ge.e.de.ive.y drug de.ive.y uve.l me.anoma

Why e.osyste. characte.istics pre.icte. from re.ote.y se.se. data are.unbiase. and biase. at the.same.time.and how this affe.ts applications

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Fore.t e.osyste.s 2024年第1期11卷 24-31页

作者： Goran Ståhl Te.je.Gobakke. Sve.lana Saare.a He.rik J.Pe.sson Magnus e.strom Se.n P.He.le. Zhiqiang Yang Johan Holmgre. e.a Lindbe.g Ke.ne.h Nystrom e.anue.e.Papucci Patrik Ulvdal hans Ole.rka e.ik Næsse. Zhe.gyang Hou Håkan Olsson Ronald e.McRobe.ts De.artme.t of Fore.t Re.ource.Manage.e.t Swedish University of Agricultural Sciences90183UmeåSweden Faculty of e.vironme.tal Scie.ce. and Natural Re.ource.Manage.e.t Norwegian University of Life SciencesÅsNorway USDA Fore.t Se.vice Rocky Mountain Research StationOgdenUTUSA The.Ke. Laboratory for Silviculture.and Conse.vation of Ministry of e.ucation Beijing Forestry UniversityBeijing100083China De.artme.t of Fore.t Re.ource. University of MinnesotaSt.PaulMNUSA

Re.ote.y se.se. data are.fre.ue.tly use. for pre.icting and mapping e.osyste. characte.istics,and spatially e.plicit wall-to-wall information is some.ime. propose. as the.be.t possible.source.of information for ***,wall-to-wall information typically re.ie. on mode.-base. pre.iction,and se.e.al fe.ture. of mode.-base. pre.iction should be.unde.stood be.ore.e.te.sive.y re.ying on this type.of *** such fe.ture.is that mode.-base. pre.ictors can be.conside.e. both unbiase. and biase. at the.same.time.which has important implications in se.e.al are.s of *** this discussion pape.,we.first de.cribe.the.conve.tional mode.-unbiase.ne.s paradigm that unde.pins most pre.iction te.hnique. using re.ote.y se.se.(or othe.)auxiliary *** this point of vie.,mode.-base. pre.ictors are.typically ***,we.show that for spe.ific domains,ide.tifie. base. on the.r true.value.,the.same.mode.-base. pre.ictors can be.conside.e. biase.,and some.ime. se.e.e.y *** sugge.t distinguishing be.we.n conve.tional mode.-bias,de.ine. in the.statistical lite.ature.as the.diffe.e.ce.be.we.n the.e.pe.te. value.of a pre.ictor and the.e.pe.te. value.of the.quantity be.ng pre.icte.,and de.ign-bias of mode.-base. e.timators,de.ine. as the.diffe.e.ce.be.we.n the.e.pe.te. value.of a mode.-base. e.timator and the.true.value.of the.quantity be.ng *** show that mode.-base. e.timators(or pre.ictors)are.typically de.ign-biase.,and that the.e.is a tre.d in the.de.ign-bias from ove.e.timating small true.value. to unde.e.timating large.true.***,we.give.e.ample. of applications whe.e.this is important to acknowle.ge.and to pote.tially make.adjustme.ts to corre.t for the.de.ign-bias *** argue.that re.ying e.tire.y on conve.tional mode.-unbiase.ne.s may le.d to mistake. in se.e.al are.s of application that use.pre.ictions from re.ote.y se.se. data.

关键词： Bias Mode.-base. infe.e.ce De.ign-base. infe.e.ce

Ge.ome.wide.Studie. Re.e.l Ge.e.ic Risk Factors for He.atic Fat Conte.t

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Ge.omics, Prote.mics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li e.ine.H.van de. Be.g Ale.ande. Kurilshikov Dasha V.Zhe.nakova Ranko Gace.a Shixian Hu e.te.an A.Lope.a-Maya Ale.andra Zhe.nakova Life.ine. Cohort Study Vince.t e.de.Me.je. Se.e.a Sanna Robin P.F.Dullaart hans Blokzijl e.e.nora A.M.Fe.te. Jingyuan Fu Rinse.K.We.rsma De.artme.t of Gastroe.te.ology and He.atology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands De.artme.t of Ge.e.ics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands De.artme.t of Gastroe.te.ology and He.atology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Ge.omic Dive.sity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute.of Pre.ision Me.icine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China De.artme.t of Surge.y Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands De.artme.t of e.docrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands De.artme.t of Pe.iatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Ge.e.ic susce.tibility to me.abolic associate. fatty live. dise.se.MAFLD)is comple. and poorly *** characte.ization of the.ge.e.ic background of he.atic fat conte.t would provide.insights into dise.se.e.iology and causality of risk *** pe.forme. ge.ome.wide.association study(GWAS)on two noninvasive.de.initions of he.atic fat conte.t:magne.ic re.onance.imaging proton de.sity fat fraction(MRI-PDFF)in 16,050 participants and fatty live. inde.(FLI)in 388,701 participants from the.Unite. Kingdom(UK)Biobank(UKBB).He.itability,ge.e.ic ove.lap,and similarity be.we.n he.atic fat conte.t phe.otype. we.e.analyze.,and re.licate. in 10,398 participants from the.Unive.sity Me.ical Ce.te. Groninge.(UMCG)Ge.e.ics Life.ine. Initiative.UGLI).Me.a-analysis of GWASs of MRI-PDFF in UKBB re.e.le. five.statistically significant loci,including two nove. ge.omic loci harboring CRe.3L1(rs72910057-T,P=5.40e.09)and GCM1(rs1491489378-T,P=3.16e.09),re.pe.tive.y,as we.l as thre. pre.iously re.orte. loci:PNPLA3,TM6SF2,and *** of FLI in UKBB ide.tifie. 196 ge.ome.wide.significant loci,of which 49 we.e.re.licate. in UGLI,with top signals in ZPR1(P=3.35e.13)and FTO(P=2.11e.09).Statistically significant ge.e.ic corre.ation(rg)be.we.n MRI-PDFF(UKBB)and FLI(UGLI)GWAS re.ults was found(rg=0.5276,P=1.45e.03).Nove. MRI-PDFF ge.e.ic signals(CRe.3L1 and GCM1)we.e.re.licate. in the.FLI *** ide.tifie. two nove. ge.e. for MRI-PDFF and 49 re.licable.loci for *** a diffe.e.ce.in he.atic fat conte.t asse.sme.t be.we.n MRI-PDFF and FLI,a substantial similar ge.e.ic archite.ture.was *** is ide.tifie. as an e.sy and re.iable.approach to study he.atic fat conte.t at the.population le.e..

关键词： He.atic fat conte.t MAFLD Ge.ome.wide.association study Fatty live. inde. Magne.ic re.onance.imaging proton de.sity fat fraction