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Liver sinusoidal endothelial and biliary cell repopulation following irradiation and partial hepatectomy

World Journal of Gastroenterology 2010年第31期16卷 3928-3935页

作者： Petra Krause Margret Rave-Frank Hendrik Andreas Wolff Heinz Becker hans christiansen Sarah Koenig Department of General Surgery University Medical Centre Goettingen Department of Radiotherapy University Medical Cen-tre Goettingen

AIM: To investigate whether irradiation (IR) and partial hepatectomy (PH) may prepare the host liver for nonparenchymal cell (NPC) ***: Livers of dipeptidyl peptidase(DPP)-deficient rats were pre-conditioned with external beam IR (25 Gy) delivered to two-thirds of the right liver lobules followed by a one-third PH of the untreated lob-ule. DPP-positive liver cells (NPC preparations enriched for liver sinusoidal endothelial cells (LSECs) and hepatocytes) were transplanted via the spleen into the recipient livers. The extent and quality of donor cell engraftment and growth was studied over a long-term interval of 16 wk after ***: Host liver staining demonstrated 3 different repopulation types. Well def ined clusters of donor-derived hepatocytes with canalicular expression of DPP were detectable either adjacent to or in between large areas of donor cells (covering up to 90% of the section plane) co-expressing the endothelial marker platelet endothelial cell adhesion molecule. The third type consisted of formations of DPP-positive duct-like structures which co-localized with biliary epithelial ***: Liver IR and PH as a preconditioning stimulus enables multiple cell liver repopulation by donor hepatocytes, LSECs, and bile duct cells.

关键词： Cell transplants Dipeptidyl peptidase protein Endothelial cells Liver cell transplantation Liver irradiation Liver repopulation

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On the problem of the dynamical reactions of a rolling wheelset to real track irregularities

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Railway Engineering Science 2023年第1期31卷 1-19页

作者： hans True Lasse Engbo christiansen Andreas Lindhardt Plesner Andreas Lønstrup Ammitzbøll Bjørn Jerram Dahl DTU Compute Technical University of DenmarkRichard Petersens Plads Building 3242800Kgs.LyngbyDenmark

We investigate numerically the dynamical reactions of a moving wheelset model to real measured track *** background is to examine whether the dynamics are suitable as the input to the inverse problem:determine the true track geometry from measured wheelset dynamical *** is known that the method works well for the vertical position of the rails but the computed lateral position is often *** find that the lateral motion of the wheelset often may differ from the track *** cases are investigated closely but the reasons remain *** the wheelset dynamics reflect the larger(>4-6 mm)aperiodic track disturbances and single large disturbances quite well,this does not seem to be the case for general smaller or periodic track irregularities or sections behind single large *** resulting dynamics of a wheelset to lateral track irregularities are in general not sufficiently accurate to be used as the basis for a description of the track irregularities.

关键词： Track monitoring Vehicle dynamical response Inverse problem Numerical analysis Estimate of errors Track irregularity

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