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Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs

Genomics, Proteomics & Bioinformatics 2019年第4期17卷 430-440页

作者： Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes hans-Peter Lenhof Eckart Meese Andreas Keller Department of Human Genetics Saarland University66421 Homburg/SaarGermany Chair for Clinical Bioinformatics Saarland University66123 Saarbru¨ckenGermany Institut fur Gerontologie Universitat Heidelberg69047 HeidelbergGermany Department of Neurology Christian-Albrechts-University of Kiel24118 KielGermany Center for Neurology and Hertie Institute for Clinical Brain Research Department of NeurodegenerationUniversity of Tuebingen72074 TuebingenGermany German Center for Neurodegenerative Diseases(DZNE) 72076 TuebingenGermany Department of Anesthesiology and Intensive Care St.Franziskus Hospital Muenster48145 MuensterGermany Department of Psychiatry and Psychotherapy University Hospital Tuebingen72016 TuebingenGermany Department of Medicine II Saarland University Medical Center66421 Homburg/SaarGermany Center for Bioinformatics Saarland Informatics Campus66123 SaarbruckenGermany

Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic ***,high-throughput approaches are applied to discover biomarker *** have to be validated in larger cohorts and evaluated by adequate statistical learning ***,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and ***,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by *** computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from ***,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and *** study represents the next important step in translational research for a miRNA-based AD test.

关键词： miRNAs Neurodegeneration Alzheimer’s disease Biomarker Non-coding RNAs Gene regulation

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A Systems Biology Investigation of Cell Cycle Regulation in Budding Yeast

A Systems Biology Investigation of Cell Cycle Regulation in ...

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21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Matteo Barberis christian Linke hans Lehrach Edda Klipp Sylvia Krobitsch Max Planck Institute for Molecular Genetics Ihnestr.63-7314195Berlin Humboldt University Berlin Theoretical BiophysicsInvalidenstr.4210115Berlin

＜正＞Cell cycle is intensively studied since its misregulation results in *** is an integrated cellular process well suited for a modular systems biology *** budding yeast cell cycle is driven by periodic changes in the Cdkl kinase activity,which is directed by the concentration of *** temporal appearance of cyclins is caused in part by regulated transcription of the cyclin genes,as well as by the Cdkl kinase *** addition,the

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安全等级的合理评估综合性的安全考虑才能保障流程设备的功能安全

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流程工业 2011年第24期 34-36页

作者： hans christian Schroder

在化工生产过程中，错误和故障会带来非常巨大的损失。构建一个高安全等级的系统与系统所使用的零部件的安全等级无关，因此定量分析和建立一套完善的安全评估体系非常重要。

关键词：安全评估体系安全等级功能安全流程设备保障化工生产过程定量分析零部件

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飞箱Ⅰ

长喜欢乐英语

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长喜欢乐英语 2006年第5期 26-29页

作者： hans christian Andersen

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飞箱Ⅱ

长喜欢乐英语

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长喜欢乐英语 2006年第6期 24-27页

作者： hans christian Andersen

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丑小鸭就是我

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作者： (丹)安徒生(hans christian Andersen)

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The Cartography and the Spatial Representations:Search by Perfect Map

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Journal of Geographic Information System 2014年第6期6卷 624-635页

作者： christian Nunes da Silva Joao Marcio Palheta da Silva Clay anderson Nunes Chagas Carlos Jorge Nogueira Castro Federal University of Para(UFPA) BelemBrazil

The activities of the professionals working on cartographic products have been highlighted especially in recent years. The history, the concepts and categories of cartography cannot be neglected in using this type of tool since the use of elements that make a cartographic product, as an example: map, chart, plan, globe, and a scale model should be used since the unawareness of techniques of cartography and the absence of the components of a map may hinder the understanding of what is intended to represent cartographically. This text is a contribution to the discussion of advances in cartography including errors and absence of maps, including a brief discussion of the characteristics of cartographic language nowadays and the search for perfection in cartography.

关键词： Cartography Cartographic Evolution Geographic Space Spatial Representations Perfect Map

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Geography and Mining in Carajas/Para(Northern Region of Brazil)

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International Journal of Geosciences 2014年第12期5卷 1426-1434页

作者： Joao Marcio Palheta da Silva christian Nunes da Silva Clay anderson Nunes Chagas Glaucia Rodrigues Nascimento Medeiros Federal University of Para (UFPA)BelemBrazil

This essay examines the actions of Major Mining Projects in the region of Carajás, the state of Pará, Northern Brazil, which concentrates the projects of one of the largest mining companies of the Planet, the Vale Group, and the relations of power and authority in land use in the corresponding area to the former city of Marabá. The territories exploited by major mining projects, also increase land use that has not been translated into socio-economic development, and add little value to labor and the product. Another issue is lack of a National Mining Policy that truly establishes the regional supply chains, and conducts the multiplier effects to produce new territorial jurisdictions. Mining contributes to socio-economic development of the Amazon region, especially in the Carajás region and promotes the economic organization of the territories for the consolidation of municipalities in which society in its favor uses natural resources. The main objective of this paper is to present the main impacts caused by mining activities in Pará municipalities. Textual elaboration was necessary documentary and bibliographical analysis, in addition to field research in the study area. We can observe, that mining is an important productive activity, but has caused significant changes in Pará territory, both in economy and in the environment, and the way of life of local populations.

关键词： Territory Mining Amazon Carajas

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丑小鸭

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丛书名： WOW！不可思议的漫画英语

2011年

作者： (丹)安徒生(hans christian Andersen)原

本书选取了小朋友们最喜爱的故事丑小鸭，寓教于乐，让小朋友们在阅读故事的乐趣中学习英语。

ISBN: (纸本)7564041609

本书选取了小朋友们最喜爱的故事丑小鸭，寓教于乐，让小朋友们在阅读故事的乐趣中学习英语。

关键词：漫画

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第三十三夜

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新东方英语 2004年第12M期 80-81页

作者： hans christian Andersen 王妍

安徒生的童话陪伴我们的童年。当我们长大后,再去看那些童话,会猛然发现,原未安徒生的故事不只是写给被子看的。本文中,在一样的月光下,月亮看见了,安徒生看见了……邪我们呢,到底看见了什么?

关键词：安徒生故事童话月亮童年发现孩子

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