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用高氮钢制造复杂高强度零件(英文)

中国有色金属学会会刊：英文版 2012年第S2期22卷 512-518页

作者： hannes NONEDER Marion MERKlEIN Chair of Manufacturing Technology Egerlandstra.e 13 91058 Erlangen Germany

High performance components, e.g., fasteners, nowadays are usually made out of cold forged and heat treated steels like steel 1.5525 (20MnB4). To overcome the problems of heat treatment, e.g., low surface quality, new workpiece materials for cold forging should be found to achieve the needlessness of heat treatment after cold forging. One possible material is given by high nitrogen steels like steel 1.3815 (X8CrMnN19-19). Due to the high strain hardening of these materials the process and tool design for an industrial batch process are challenging and should be conducted by FE-simulation. The numerical results show that, high strength tool materials, like PM-steels or cemented carbides, in most cases, are inevitable. Additionally to the selection of suitable tool materials, the tool layout should be developed further to achieve a high loadability of the tools. The FE-models, used for process and tool design, are validated with respect to the materials' flow and occurring forming force to assure a proper design process. Also the comparison of strength of components made out of steel 1.5525 in quenched and tempered conditions and steel 1.3815 in strain hardened condition is done. The results show that the component made of steel 1.3815 has a significantly higher strength than the component made of steel 1.5525. This shows that by the use of high nitrogen steels a high performance component can be manufactured by cold forging.

关键词： high nitrogen steel heat treatable steel cold forging FE-simulation Martens hardness

Alcohol consumption in patients with primary sclerosing cholangitis

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World Journal of Gastroenterology 2012年第24期18卷 3105-3111页

作者： hannes Hagstrm Per Stl Knut Stokkeland Annika Bergquist Department of Gastroenterology and Hepatology Karolinska University HospitalKarolinska Institutet14186 StockholmSweden Department of Medicine Visby HospitalKarolinska Institutet14186 StockholmSweden

AIM:To assess the alcohol drinking patterns in a cohort of primary sclerosing cholangitis(PSC) patients and the possible influence on the development of ***:Ninety-six patients with PSC were evaluated with a validated questionnaire about a patient's lifetime drinking habits:the lifetime drinking history(lDH) *** addition,clinical status,transient elastography and biochemistry values were analysed and *** were defined as having either significant or non-significant *** fibrosis was defined as either an elastography value of ≥ 17.3 kPa or the presence of clinical signs of *** were divided into two groups depending on their alcohol consumption patterns;no/low alcohol consumption(one drink or unit/d) and moderate/high alcohol consumption(≥ 1 drink or unit/d).lDH data were calculated to estimate lifetime alcohol intake(lAI),current alcohol intake,drinks per year before and after diagnosis of *** also calculated the number of episodes of binge-drinking(defined as consuming ≥ 5 drinks per occasion) in total,before and after the diagnosis of ***:The mean lAI was 3882 units of alcohol,giving a mean intake after onset of alcohol consumption of 2.6 units per *** 9% of patients consumed alcohol equal to or more than one unit per *** alcohol intake in patients with significant fibrosis(n = 26) was less than in patients without significant fibrosis(n = 70),as shown by lower values of phosphatidylethanol(B-PEth)(0.1 mol/l vs 0.33 mol/l,respectively,P = 0.002) and carbohydrate-deficient transferrin(CDT)(0.88% vs 1.06%,respectively,P = 0.02).Self-reported lAI was similar between the two *** with significant fibrosis reduced their alcohol intake after diagnosis from 103 to 88 units per year whereas patients without fibrosis increased their alcohol intake after PSC diagnosis from 111 to 151 units/*** were no correlations between elastography values and intake of alcoho

关键词： Alcohol Fibrosis Cirrhosis lifetime drinkinghistory Primary sclerosing cholangitis

First determination of the highly genotoxic fungal contaminant altertoxin II in a naturally infested apple sample

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Emerging Contaminants 2020年第1期6卷 82-86页

作者： hannes Puntscher Doris Marko Benedikt Warth Department of Food Chemistry and Toxicology Faculty of ChemistryUniversity of ViennaWahringer Str.381090ViennaAustria

Altertoxin II is an epoxide-holding perylene quinone and secondary metabolite produced by Alternaria *** genotoxic potential and the high concentrations determined in laboratory fungal cultures resulted in an increased scientific interest in this emerging ***,no natural occurrence in food has been reported to date to the best of our ***,we unambiguously identified altertoxin II in a naturally infected,unprocessed *** a validated lC-MS/MS method,fruit peel spots(approx.1 mm in diameter),typically associated with Alternaria infestation,were tested for 17 mycotoxins produced by this *** concentrations of tentoxin were determined 24 h after harvest,and the dibenzopyrones alternariol,alternariol monomethyl ether(AME)and AME-3-sulfate after six months of ***,these contamination patterns can be considered unlikely to be of toxicological concern for ***,an inconspicuous peel lesion(0.5×1 cm)separately sampled from a stored apple,exhibited considerably high concentrations of 14 Alternaria toxins,including dibenzopyrones,their barely studied modified forms(glucosides and sulfates),as well as genotoxic perylene quinones including altertoxin *** the toxicological potential of this compound,contaminations in such infected fruit parts should not be underestimated,*** the case of exposure through the consumption of fresh smoothies or fruit juices.

关键词： Alternaria alternata Emerging contaminants Genotoxicity Food safety Plant pathology liquid chromatography tandem mass spectrometry

Taxonomic composition, abundance and biomass of mesozooplankton in the Zhelin Bay—an estuary with intensive aquaculture

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Acta Oceanologica Sinica 2006年第5期25卷 92-111页

作者： DONG Qiaoxiang lIN Xiaoping HE Xin KElSO we HUANG Changjiang School of Environmental Science and Public Health Wenzhou Medical College Wenzhou 325035 China Institute of Marine Biology Shantou University Shantou 515063 China School of Renewable Natural Resources Louisiana State University Agricultural Center Baton Rouge Louisiana 70803 USA

The Zhelin Bay is an estuary that supports intensive aquaculture in South China. Aside from traditional nutrient inputs derived from waste water and agriculture, the increased intensification of aquaculture has accelerated eutrophication during the past deeade, jeopardizing aquacultural production. Annual variations of mesozooplankton in the Zhelin Bay were described, providing baseline data for long-term ecological studies. The taxonomic composition, abundance and biomass of mesozooplankton were stud- ied monthly from July 2001 to July 2002 at 19 stations. Collections yielded 73 taxa, including 60 species of eopopods, three species of cladocerans, as well as tunieates, ehaetognaths, polyehaetes, medusae, ostraceds, rotatori, amphipods, planktonic mollusks, pelagic larvae, and planktonic shrimps. The Zhelin Bay was dominated by small mesozooplankton, with 76% of the species smaller than 1.4 mm, and 97% of the individuals smaller than 1.0 nun. Dominant species （ Paracalanus crassirostris, Oithona brevicornis, and Penilia avirostria） accounting for 60% of the total abundance were less than 0.6 mm in body length. Species diversity, biomass, and total abundance of mesozooplankton were greater in the samples collected outside the bay than inside the bay. Samples from the outer and eastern boundaries of the bay had greater biomass, diversity, and abundance than those from the inner and western boundaries. Total abundance and biomass had a unimodal annual pattern and were the greatest in August 2001 when water temperature was maximum, and the least in February 2002 when water temperature was minimum. Canonical correspondence analysis （CCA） revealed that temperature, turbidity, nutrients and salinity were the main determinants of spatial and temporal distributions of mesozooplankton in the Zhelin Bay, and six distinct zones were identified across the 19 sampling stations.

关键词： Zhelin Bay mesozooplankton community structure spatial and temporal distribution aquaculture

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

A Test Method for the Static/Moving State of Targets Applied to Airport Surface Surveillance MlAT System

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Transactions of Nanjing University of Aeronautics and Astronautics 2016年第4期33卷 425-432页

作者： Huang Rongshun Peng we li Jing Wu Honggang li Xingbo The Second Research Institute of Civil Aviation Administration of China College of Electronic Engineering University of Electronic Science and Technology of China

Due to the particularity of its location algorithm,there are some unique difficulties and features regarding the test of target motion states of multilateration(MlAT)system for airport surface *** paper proposed a test method applicable for the airport surface surveillance MlAT system,which can effectively determine whether the target is static or moving at a certain *** a normalized test statistic designed in the sliding data window,the proposed method not only eliminates the impact of geometry Dilution of precision(GDOP)effectively,but also transforms the test of different motion states into the test of different probability density ***,by adjusting the size of the sliding window,it can fulfill different test performance *** method was developed through strict theoretical extrapolation and performance analysis,and simulations results verified its correctness and effectiveness.

关键词： multilateration(MlAT) hypothesis testing motion state detection sliding window geometric Dilution of precision(GDOP)

Association between the level of CD4^+T lymphocyte microRNA-155 and coronary artery disease in patients with unstable angina pectoris

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Journal of Geriatric Cardiology 2018年第10期15卷 611-617页

作者： Zi-liang we Hai-li lU Qiang SU lang li Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityGuangxi Cardiovascular InstituteNanningGuangxiChina Department of Orthodontics the Affiliated Dental Hospitdl of Guangxi Medical UniversityNanningCruangxiChina

Objective To study the association between the expression of microRNA-155(miRNA-155)in peripheral blood CD4^+T lymphocytes and the level of semrn interferon-7(IFN-7)concentration and the severity of coronary artery disease (CAD).Methods After coronary angiography,252patients with suspected unstable angina pectoris (UAP)were divided into the UAP group (128patients with CAD confirmed by angiography)and the control group (124patients without CAD confirmed by angiography).Fresh peripheral blood was extracted 16-24h before coronary angiography,CD4^+T lymphocytes was tested using immunomagnetic beads,the expression ofmiRNA-155was tested using quantitative PCR and the expression of IFN-7was tested using enzyme-linked immunosorbent assay (ElISA).According to the results of angiography,Gensini score of coronary artery lesions was ***,we also analysis the association between the level of miRNA-155in peripheral blood CD4^+T lymphocytes,the level of serum IFN-γand Gensini score of coronary *** The levels ofmiRNA-155(0.49±0.08vs.0.23±0.09)and IFN-7(227.58±26.01vs.141.23±17.89)in the UAP group were significantly higher than that of the control group,the difference was statistically *** level of miRNA-155and IFN-γwere positively correlated with Gensini score of CAD (r =0.534,r =0.713,respectively,all P level of miRNA-155was positively correlated with the level of IFN-γ,(r =0.686,P lusions The level of miRNA-155in peripheral blood CD4^+T lymphocytes and the level of IFN-γ are closely correlated with the severity of CAD.

关键词： CD4^+T lymphocyte Coronary artery disease IFN-γ MicroRNA-155

Pancreatitis, panniculitis and polyarthritis syndrome: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4412-4418页

作者： hannes Pichler Thomas Stumpner Dietmar Schiller Martin Bischofreiter Reinhold Ortmaier Department of Orthopedic Surgery Ordensklinikum Linz Barmherzige SchwesternVinzenzgruppe Center of Orthopedic ExcellenceTeaching HospitalParacelsus Medical University SalzburgLinz 4010Austria Department of Gastroenterology Ordensklinikum Linz Barmherzige SchwesternLinz 4010Austria

BACKGROUND Pancreatitis,panniculitis,and polyarthritis(PPP)syndrome is a rare form of pancreatic *** is characterized by bullous erythematous skin lesions and arthritis,and both are triggered by pancreatic *** cases have been described in the literature thus *** to the inconsistency in its clinical presentation,its diagnosis can be a *** therapy initiation is essential to reduce mortality;however,there is currently no gold standard for *** SUMMARY A 66-year-old polymorbid male patient presented with several superficial abscesses on both lower legs and painful swelling in the *** for septic arthritis and septic skin infection over several weeks *** general condition deteriorated gradually and worsened with sudden onset of abdominal pain.A diagnosis of necrotizing pancreatitis was *** subsequently underwent a laparotomy and drainage of the ***,our patient improved,and his abdominal complaints,knee pain,and dermal lesions *** PPP syndrome is rare and easily misdiagnosed,as abdominal symptoms may be delayed or *** should consider PPP syndrome if they encounter refractory panniculitis in combination with joint infection.

关键词： Pancreatitis Panniculitis Polyarthritis Pancreatitis,panniculitis,and polyarthritis syndrome Septic arthritis Case report

lensless diffractive imaging with ultra-broadbandtable-top sources: from infrared to extreme-ultravioletwavelengths

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light(Science & Applications) 2014年第1期3卷 274-281页

作者： Stefan Witte Vasco T Tenner Daniel we Noom Kjeld SE Eikema laserlaB Amsterdam VU University Amsterdam1081 HV AmsterdamThe Netherlands Present address:Huygens-Kamerlingh Onnes laboratorium Universiteit Leiden2333 CA LeidenThe Netherlands

lensless imaging is an approach to microscopy in which a high-resolution image of an object is reconstructed from one or more measured diffraction patterns,providing a solution in situations where the use of imaging optics is not ***,current lensless imaging methods are typically limited by the need for a light source with a narrow,stable and accurately known *** have developed a general approach to lensless imaging without spectral bandwidth limitations or sample *** use two time-delayed coherent light pulses and show that scanning the pulse-to-pulse time delay allows the reconstruction of diffraction-limited images for all the spectral components in the *** addition,we introduce an iterative phase retrieval algorithm that uses these spectrally resolved Fresnel diffraction patterns to obtain high-resolution images of complex extended *** demonstrate this two-pulse imaging method with octave-spanning visible light sources,in both transmission and reflection geometries,and with broadband extreme-ultraviolet radiation from a high-harmonic generation *** approach enables effective use of low-flux ultra-broadband sources,such as table-top high-harmonic generation systems,for high-resolution imaging.

关键词： coherent diffractive imaging extreme ultraviolet Fourier transform spectroscopy high-harmonic generation lensless imaging