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Model-based optimization of adaptive external counterpulsation therapy

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第2期7卷 208-226页

作者： Soren Weyer hannes Weber Christian Kleeberg Steffen Leonhardt Daniel Teichmann Chair for Medical Information Technology helmholtz Institute RWTH Aachen University Pauwelsstr.20AachenGermany tic Medizintechnik Gmbh&Co.KG Endelner Feld 9 DorstenGermany

External counterpulsation therapy(ECP)is a non-invasive method to assist the circulatory *** main principle of ECP is to initiate a diastolic pulse wave in the arterial system by squeezing the inner leg *** and low veins are compressed due to muscle contractions,which are triggered by functional electrical stimulation(FES).In this work,a new trigger method for the stimulation is *** flow is determined by measuring the pulsatile change of conductivity in the observed segment by impedance *** proposed“adaptive stimulation”allows the automatic adjustment of the start and duration of the stimulation to improve transport of venous *** this purpose,a mathematical circulation model was developed for optimization of the adaptive functional electrical *** model takes into account the effects of gravity,muscle pump with or without FES,and venous *** model was shown to have a behavior similar to that of clinical *** simulation showed a flow enhancement of up to 14%and,furthermore,that the start of the stimulation is less important than the duration of each stimulation ***,an adaptation of the heart rate seems necessary,as the expulsion and refill times must remain relatively constant for an optimal pumping *** a practical approach,it is reasonable to adapt the duration of stimulation to 56%of the cardiac cycle in order to reach a maximum flow.

关键词： Optimization circulation model vein pump activation functional electrical stimulation

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用高氮钢制造复杂高强度零件(英文)

中国有色金属学会会刊：英文版 2012年第S2期22卷 512-518页

作者： hannes NONEDER Marion MERKLEIN Chair of Manufacturing Technology Egerlandstra.e 13 91058 Erlangen Germany

high performance components, e.g., fasteners, nowadays are usually made out of cold forged and heat treated steels like steel 1.5525 (20MnB4). To overcome the problems of heat treatment, e.g., low surface quality, new workpiece materials for cold forging should be found to achieve the needlessness of heat treatment after cold forging. One possible material is given by high nitrogen steels like steel 1.3815 (X8CrMnN19-19). Due to the high strain hardening of these materials the process and tool design for an industrial batch process are challenging and should be conducted by FE-simulation. The numerical results show that, high strength tool materials, like PM-steels or cemented carbides, in most cases, are inevitable. Additionally to the selection of suitable tool materials, the tool layout should be developed further to achieve a high loadability of the tools. The FE-models, used for process and tool design, are validated with respect to the materials' flow and occurring forming force to assure a proper design process. Also the comparison of strength of components made out of steel 1.5525 in quenched and tempered conditions and steel 1.3815 in strain hardened condition is done. The results show that the component made of steel 1.3815 has a significantly higher strength than the component made of steel 1.5525. This shows that by the use of high nitrogen steels a high performance component can be manufactured by cold forging.

关键词： high nitrogen steel heat treatable steel cold forging FE-simulation Martens hardness

First determination of the highly genotoxic fungal contaminant altertoxin II in a naturally infested apple sample

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Emerging Contaminants 2020年第1期6卷 82-86页

作者： hannes Puntscher Doris Marko Benedikt Warth Department of Food Chemistry and Toxicology Faculty of ChemistryUniversity of ViennaWahringer Str.381090ViennaAustria

Altertoxin II is an epoxide-holding perylene quinone and secondary metabolite produced by Alternaria *** genotoxic potential and the high concentrations determined in laboratory fungal cultures resulted in an increased scientific interest in this emerging ***,no natural occurrence in food has been reported to date to the best of our ***,we unambiguously identified altertoxin II in a naturally infected,unprocessed *** a validated LC-MS/MS method,fruit peel spots(approx.1 mm in diameter),typically associated with Alternaria infestation,were tested for 17 mycotoxins produced by this *** concentrations of tentoxin were determined 24 h after harvest,and the dibenzopyrones alternariol,alternariol monomethyl ether(AME)and AME-3-sulfate after six months of ***,these contamination patterns can be considered unlikely to be of toxicological concern for ***,an inconspicuous peel lesion(0.5×1 cm)separately sampled from a stored apple,exhibited considerably high concentrations of 14 Alternaria toxins,including dibenzopyrones,their barely studied modified forms(glucosides and sulfates),as well as genotoxic perylene quinones including altertoxin *** the toxicological potential of this compound,contaminations in such infected fruit parts should not be underestimated,*** the case of exposure through the consumption of fresh smoothies or fruit juices.

关键词： Alternaria alternata Emerging contaminants Genotoxicity Food safety Plant pathology Liquid chromatography tandem mass spectrometry

Abscisic Acid Transport and homeostasis in the Context of Stomatal Regulation

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Molecular Plant 2015年第9期8卷 1321-1333页

作者： Ebe Merilo Pirko Jalakas Kristiina Laanemets Omid Mohammadi hanna horak hannes Koliist Mikael Brosche Institute of Technology University of Tartu Nooruse 1 50411 Tartu Estonia Division of Plant Biology Department of Biosciences University of Helsinki P.O. Box 65 (Viikinkaari 1) F1-00014 Hetsinki Finland

The discovery of cytosolic ABA receptors is an important breakthrough in stomatal research; signaling via these receptors is involved in determining the basal stomatal conductance and stomatal responsiveness. however, the source of ABA in guard cells is still not fully understood. The level of ABA increases in guard cells by de novo synthesis, recycling from inactive conjugates via β-glucosidases BG1 and BG2 and by import, whereas it decreases by hydroxylation, conjugation, and export. ABA importers include the NRT1/PTR family protein AIT1, ATP-binding cassette protein ABCG40, and possibly ABCG22, whereas the DTX family member DTX50 and ABCG25 function as ABA exporters. here, we review the proteins involved in ABA transport and homeostasis and their physiological role in stomatal regulation. Recent experiments suggest that functional redundancy probably exists among ABA transporters between vascu- lature and guard cells and ABA recycling proteins, as stomatal functioning remained intact in abcg22, abcg25, abcg40, aitl, and bglbg2 mutants. Only the initial response to reduced air humidity was significantly delayed in abcg22. Considering the reports showing autonomous ABA synthesis in guard cells, we discuss that rapid stomatal responses to atmospheric factors might depend primarily on guard cellsynthesized ABA, whereas in the case of long-term soil water deficit, ABA synthesized in the vasculature might have a significant role.

关键词： abscisic acid transport guard cell stomatal regulation air humidity C02

Pancreatitis, panniculitis and polyarthritis syndrome: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4412-4418页

作者： hannes Pichler Thomas Stumpner Dietmar Schiller Martin Bischofreiter Reinhold Ortmaier Department of Orthopedic Surgery Ordensklinikum Linz Barmherzige SchwesternVinzenzgruppe Center of Orthopedic ExcellenceTeaching HospitalParacelsus Medical University SalzburgLinz 4010Austria Department of Gastroenterology Ordensklinikum Linz Barmherzige SchwesternLinz 4010Austria

BACKGROUND Pancreatitis,panniculitis,and polyarthritis(PPP)syndrome is a rare form of pancreatic *** is characterized by bullous erythematous skin lesions and arthritis,and both are triggered by pancreatic *** cases have been described in the literature thus *** to the inconsistency in its clinical presentation,its diagnosis can be a *** therapy initiation is essential to reduce mortality;however,there is currently no gold standard for *** SUMMARY A 66-year-old polymorbid male patient presented with several superficial abscesses on both lower legs and painful swelling in the *** for septic arthritis and septic skin infection over several weeks *** general condition deteriorated gradually and worsened with sudden onset of abdominal pain.A diagnosis of necrotizing pancreatitis was *** subsequently underwent a laparotomy and drainage of the ***,our patient improved,and his abdominal complaints,knee pain,and dermal lesions *** PPP syndrome is rare and easily misdiagnosed,as abdominal symptoms may be delayed or *** should consider PPP syndrome if they encounter refractory panniculitis in combination with joint infection.

关键词： Pancreatitis Panniculitis Polyarthritis Pancreatitis,panniculitis,and polyarthritis syndrome Septic arthritis Case report

Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 903-917页

作者： Julia Spiegelberg hannes Neeff Philipp holzner Mira Runkel Stefan Fichtner-Feigl Torben Glatz Department of General and Visceral Surgery Medical Center–University of FreiburgFreiburg 79106Germany Department of Surgery Marien Hospital HerneRuhr-University BochumHerne 44625Germany

BACKGROUND Cytoreductive surgery(CRS)in combination with hyperthermic intraperitoneal chemotherapy(hIPEC)improves patient survival in colorectal cancer(CRC)with peritoneal carcinomatosis(PC).Commonly used cytotoxic agents include mitomycin C(MMC)and *** have reported varying results,and the evidence for the choice of the hIPEC agent and uniform procedure protocols is *** To evaluate therapeutic benefits and complications of CRS+MMC vs oxaliplatin hIPEC in patients with peritoneal metastasized CRC as well as prognostic *** One hundred and two consecutive patients who had undergone CRS and hIPEC for CRC PC between 2007 and 2019 at the Medical Center of the University Freiburg regarding interdisciplinary cancer conference decision were retrospectively *** and MMC were used in 68 and 34 patients,*** patient’s demographics and tumour characteristics,operative details,postoperative complications and survival were *** were stratified and graded using Clavien/Dindo *** outcome factors were identified using univariate and multivariate analysis of *** The two groups did not differ significantly regarding baseline *** found no difference in median overall survival between MMC and oxaliplatin *** postoperative complications,patients treated with oxaliplatin hIPEC suffered increased complications(66.2%vs 35.3%;P=0.003),particularly intestinal atony,intraabdominal infections and urinary tract infection,and had a prolonged intensive care unit stay compared to the MMC group(7.2 d vs 4.4 d;P=0.035).Regarding univariate analysis of survival,we found primary tumour factors,nodal positivity and resection margins to be of prognostic value as well as peritoneal cancer index(PCI)-score and the completeness of cytoreduction regarding peritoneal *** analysis of survival confirmed primary distant metastasis and primary tumour resec

关键词： Colorectal cancer Peritoneal carcinomatosis Cytoreductive surgery hyperthermic intraperitoneal chemotherapy Chemotherapy Mitomycin

Non-compliant and compliant balloons for endovascular rescue therapy of cerebral vasospasm after spontaneous subarachnoid haemorrhage: experiences of a single- centre institution with radiological follow- up of the treated vessel segments

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Stroke & Vascular Neurology 2021年第1期6卷 16-24页

作者： Alexander Neumann Jan Küchler Claudia Ditz Kara Krajewski Jan Leppert Peter Schramm hannes Schacht Neuroradiology University Medical Center Schleswig Holstein Lubeck CampusLubeckGermany Neurosurgery University Medical Center Schleswig Holstein Lubeck CampusLubeckGermany

Background For endovascular rescue therapy(ERT)of cerebral vasospasm(CVS)due to spontaneous subarachnoid haemorrhage(sSAh),non-compliant(NCB)and compliant(CB)balloons are used with both balloon types bearing the risk of vessel injury due to specific mechanical *** severe delayed arterial narrowing after transluminal balloon angioplasty(TBA)for CVS has sporadically been described,valid data concerning incidence and relevance are *** aim was to analyse the radiological follow-up(RFU)of differently TBA-treated arteries(CB or NCB).Methods Twelve patients with utilisation of either NCB or CB for CVS were retrospectively analysed for clinical characteristics,ERT,functional outcome after 3 months and *** with the initial angiogram,we classified delayed arterial narrowing as mild,moderate and severe(60% calibre reduction).Results Twenty-three arteries were treated with CB,seven with *** median first RFU was 11 months after TBA with CB and 10 after *** was performed with catheter angiography in 18 arteries(78%)treated with CB and in five(71%)after NCB;magnetic resonance angiography was acquired in five vessels(22%)treated with CB and in two(29%)after *** arterial narrowing was detected in three arteries(13%)after CB and in one(14%)after *** or severe findings were neither detected after use of CB nor *** We found no relevant delayed arterial narrowing after TBA for CVS after *** previous assumptions that CB provides for more dilatation in segments adjacent to CVS,we observed no disadvantages concerning long-term adverse *** data support TBA as a low-risk treatment option.

关键词： balloon cerebral after

hot electron electrochemistry at silver activated by femtosecond laser pulses

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Opto-Electronic Advances 2023年第6期6卷 31-36页

作者： Oskar Armbruster hannes Pöhl Wolfgang Kautek University of Natural Resources and Life Sciences ViennaDepartment of BionanosciencesMuthgasse 111190 ViennaAustria University of Vienna Department of Physical ChemistryWähringer Straße 421090 ViennaAustria

A silver microelectrode with a diameter of 30μm in an aqueous K_(2)SO_(4) electrolyte was irradiated with 55 fs and 213 fs laser *** caused the emission of electrons which transiently charged the electrochemical double *** two applied pulse durations were significantly shorter than the electron-phonon relaxation *** laser pulse durations had negligible impact on the emitted charge,which is incompatible with multiphoton *** the other hand,the ob-served dependence of emitted charge on laser fluence and electrode potential supports the thermionic emission mechanism.

关键词： hot electron emission femtosecond laser laser electrochemistry silver electrode

Molecular mechanism of base pairing infidelity during DNA duplication upon one-electron oxidation

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World Journal of Clinical Oncology 2010年第1期1卷 12-17页

作者： Jóhannes Reynisson Department of Chemistry and Auckland Bioengineering Institute The University of AucklandAuckland 1142New Zealand

The guanine radical cation(G?+)is formed by one-electron oxidation from its parent guanine(G).G?+is rapidly deprotonated in the aqueous phase resulting in the formation of the neutral guanine radical[G(-h)?].The loss of proton occurs at the N1 nitrogen,which is involved in the classical Watson-Crick base pairing with cytosine(C).Employing the density functional theory(DFT),it has been observed that a new shifted base pairing configuration is formed between G(-h)?and C constituting only two hydrogen bonds after deprotonation *** the DFT method,G(-h)?was paired with thymine(T),adenine(A)and G revealing substantial binding energies comparable to those of classical G-C and A-T base ***,G(-h)?does not display any particular specificity for C compared to the other *** into account the long lifetime of the G(-h)?radical in the DNA helix(5 s)and the rapid duplication rate of DNA during mitosis/meiosis(5-500 bases per s),G(-h)?can pair promiscuously leading to errors in the duplication *** scenario constitutes a new mechanism which explains how one-electron oxidation of the DNA double helix can lead to mutations.

关键词： Base pairing Density functional theory Deprotonation DNA duplication Duplication rate Guanine neutral radical Nucleotides Oxidative DNA damage Radical lifetime