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Slowed driving-reaction time following concussion-symptom resolution

Journal of Sport and Health Science 2021年第2期10卷 145-153页

作者： Landon B.Lempke Robert C.Lynall Nicole L.Hoffman hannes devos Julianne D.Schmidt UGA Concussion Research Laboratory Department of KinesiologyUniversity of GeorgiaAthensGA 30602USA School of Kinesiology and Recreation Illinois State UniversityNormalIL 61790USA Laboratory for Advanced Rehabilitation Research in Simulation Department of Physical Therapy and Rehabilitation ScienceUniversity of Kansas Medical CenterKansas CityKS 66160USA

Background:Concussed patients have impaired reaction time(RT)and cognition following injury that may linger and impair driving *** research has used direct methods to assess driving-RT *** study compared driving RT during simulated scenarios between concussed and control individuals and examined driving-RT’s relationship with traditional computerized neurocognitive testing(CNT)***:We employed a cross-sectional study among 14 concussed(15.9±9.8 days post-concussion,mean±SD)individuals and 14 healthy controls matched for age,sex,and driving *** completed a driving simulator and CNT(CNS Vital Signs)assessment within 48 h of symptom resolution.A driving-RT composite(ms)was derived from 3 simulated driving scenarios:stoplight(green to yellow),evasion(avoiding approaching vehicle),and pedestrian(person running in front of vehicle).The CNT domains included verbal and visual memory;CNT-RT(simple-,complex-,Stroop-RT individually);simple and complex attention;motor,psychomotor,and processing speed;executive function;and cognitive *** t tests and Hedge d effect sizes assessed driving-RT differences between groups,Pearson correlations(r)examined driving RT and CNT domain relationships among cohorts separately,and p values were controlled for false discovery rate via Benjamini-Hochberg procedures(a=0.05).Results:Concussed participants demonstrated slower driving-RT composite scores than controls(mean difference=292.86 ms;95%confidence interval(95%CI):70.18515.54;p=0.023;d=0.992).Evasion-RT(p=0.054;d=0.806),pedestrian-RT(p=0.258;d=0.312),and stoplight-RT(p=0.292;d=0.585)outcomes were not statistically significant after false-discovery rate corrections but demonstrated medium to large effect sizes for concussed *** concussed individuals,driving-RT outcomes did not significantly correlate with CNT domains(r-range:0.51 to 0.55;p>0.05).No correlations existed between driving-RT outcomes a

关键词： Mild traumatic brain injury Motor vehicle Neurocognitive function Response time Return to driving

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EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid

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Translational Neurodegeneration 2022年第1期11卷 835-844页

作者： hannes devos Kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.Martin Jonathan D.Mahnken William M.Brooks Jeffrey M.Burns Department of Physical Therapy Rehabilitation Scienceand Athletic TrainingUniversity of Kansas Medical CenterKansas CityKS 66160USA Department of Neurology University of Kansas Medical CenterKansas CityKS 66160USA Hoglund Biomedical Imaging Center University of Kansas Medical CenterKansas CityKS 66160USA Department of Population Health University of Kansas Medical CenterKansas CityKS 66160USA Department of Biostatistics and Data Science University of Kansas Medical CenterKansas CityKS 66160USA University of Kansas Alzheimer’s Disease Center University of Kansas Medical CenterKansas CityKS 66160USA.

Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim of the study was to determine the association between elevated Aβ (Aβ+) and cognitive processes measured by the P3 event-related potential (ERP) in cognitively normal (CN) older adults. The second aim was to compare the event- related power between CNAβ+ and CNAβ−. Methods: Seventeen CNAβ+ participants (age: 73 ± 5, 11 females, Montreal Cognitive Assessment [MoCA] score 26 ± 2) and 17 CNAβ- participants group-matched for age, sex, and MOCA completed a working memory task (n-back with n = 0, 1, 2) test while wearing a 256-channel electro-encephalography net. P3 peak amplitude and latency of the target, nontarget and task difference effect (nontarget−target), and event-related power in the delta, theta, alpha, and beta bands, extracted from Fz, Cz, and Pz, were compared between groups using linear mixed models. P3 ampli-tude of the task difference effect at Fz and event-related power in the delta band were considered main outcomes. Correlations of mean Aβ standard uptake value ratios (SUVR) using positron emission tomography with P3 amplitude and latency of the task difference effect were analyzed using Pearson Correlation Coefficient r. Results: The P3 peak amplitude of the task difference effect at Fz was lower in the CNAβ+ group (P = 0.048). Simi-larly, power was lower in the delta band for nontargets at Fz in the CNAβ+ participants (P = 0.04). The CNAβ+ partici-pants also demonstrated higher theta and alpha power in channels at Cz and Pz, but no changes in P3 ERP. Strong correlations were found between the mean Aβ SUVR and the latency of the 1-back (r = − 0.69;P = 0.003) and 2-back (r = − 0.69;P = 0.004) of the task difference effect at channel Fz in the CNAβ+ group. Conclusions: Our data suggest that the elevated amyloid in cognitively normal ol

关键词： Event-related potentials Electro-encephalography Working memory Older adults Preclinical Beta-amyloid

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Automatic object annotation in streamed and remotely explored large 3D reconstructions

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Computational Visual Media 2021年第1期7卷 71-86页

作者： Benjamin Holler Annette Mossel hannes Kaufmann Institute of Visual Computing and Human-Centered Technology Vienna University of TechnologyFavoritenstraβe 9-11/193/06A-1040 ViennaAustria

We introduce a novel framework for 3 D scene reconstruction with simultaneous object annotation,using a pre-trained 2 D convolutional neural network(CNN),incremental data streaming,and remote exploration,with a virtual reality *** enables versatile integration of any 2 D box detection or segmentation *** integrate new approaches to(i)asynchronously perform dense 3 D-reconstruction and object annotation at interactive frame rates,(ii)efficiently optimize CNN results in terms of object prediction and spatial accuracy,and(iii)generate computationally-efficient colliders in large triangulated3 D-reconstructions at run-time for 3 D scene *** method is novel in combining CNNs with long and varying inference time with live 3 D-reconstruction from RGB-D camera *** further propose a lightweight data structure to store the 3 D-reconstruction data and object annotations to enable fast incremental data transmission for real-time exploration with a remote client,which has not been presented *** framework achieves update rates of 22 fps(SSD Mobile Net)and 19 fps(Mask RCNN)for indoor environments up to 800 m^(3).We evaluated the accuracy of 3 D-object *** work provides a versatile foundation for semantic scene understanding of large streamed3 D-reconstructions,while being independent from the CNN’s processing *** code is available for non-commercial use.

关键词： dense 3D reconstruction object detection CNN distributed virtual reality

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Vulnerability and Resilience Research:A Critical Perspective

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International Journal of Disaster Risk Science 2014年第1期5卷 86-87页

作者： hannes Taubenbock Christian Geiв German Remote Sensing Data Center German Aerospace CenterOberpfaffenhofen82234 WesslingGermany

‘‘Vulnerability’’and‘‘resilience’’are terms of such broad conceptual meaning as to be almost useless for careful scientific communication,except as rhetorical indicators of areas of greatest *** is a reflection of the complexity of their meaning,an uncoordinated search among different fields for a common understanding,and maybe the difficulty of systematizing these complicated issues among the various involved parties.

关键词： Resilience difficulty coordinated

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The role of GI-supported methods in crisis management

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International Journal of Digital Earth 2010年第4期3卷 340-354页

作者： hannes Seppänen Kirsi Virrantaus Department of Surveying Aalto University School of Science and TechnologyP.O.Box 11200Aalto 00076Finland

Crisis and disaster management has become an important research field in GIS during recent *** assessment and situation picture-related work are particularly important areas of *** are distinct phases in different crises;these can be roughly divided into mitigation,preparedness,response,and *** this paper a general classification of methods in each phase is given with examples on recent or ongoing research *** framework is based on literature and experiences from crisis and disaster-related *** case studies are based on those *** goal is to clarify the role and usability of various GI-supported methods in the crisis management process by outlining a theoretical framework and presenting examples of the developed *** increasing amount of spatially related geographic information is a huge potential to the GI analysis and modeling methods;the concept of digital earth is the underlying mainstream that gives lots of promise to the research and development work in this field.

关键词： geo-spatial science geoinformatics GIS digital earth crisis management

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Statistics for Surface Modes of Nanoparticles with Shape Fluctuations

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Communications in Computational Physics 2010年第10期8卷 1224-1241页

作者： Felix Ruting hannes Uecker Institut fur Physik Carl von Ossietzky UniversitatOldenburg D-26111Germany Institut fur Mathematik Carl von Ossietzky UniversitatOldenburg D-26111Germany

We develop a numerical method for approximating the surface modes of sphere-like nanoparticles in the quasi-static limit,based on an expansion of(the angular part of)the potentials into spherical *** of the results obtained in this manner with exact solutions and with a perturbation ansatz prove that the scheme is accurate if the shape deviations from a sphere are not too *** method allows fast calculations for large numbers of particles,and thus to obtain statistics for nanoparticles with random shape *** an application we present some statistics for the distribution of resonances,polariziabilities,and dipole axes for particles with random perturbations.

关键词： Electrostatic(boundary-value problems) collective excitations(plasmons) shape fluctuations numerical scheme spherical harmonics projection method

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Global geospatial data from Earth observation:status and issues

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International Journal of Digital Earth 2017年第4期10卷 328-341页

作者： Ian Dowman hannes I.Reuter Department of Civil Environmental and Geomatic EngineeringUniversity College LondonLondonUK Gisexperts TrierGermany

Data covering the whole of the surface of the Earth in a homogeneous and reliable manner has been accumulating over many *** type of data became available from meteorological satellites from the 1960s and from Earth-observing satellites at a small scale from the early 1970s but has gradually accumulated at larger scales up to the present day when we now have data covering many environmental themes at large *** data have been used to generate information which is presented in the form of global data *** paper will give a brief introduction to the development of Earth observation and to the organisations and sensors which collect data and produce global geospatial data *** of accessing global data sets will set out the types of data available that will be *** elevation models are discussed in a separate section because of their importance in georeferencing image data as well as their application to analysis of thematic *** paper will also examine issues of availability,accuracy,validation and reliability and will look at future challenges.

关键词： Global data sets validation standardisation Earth observation

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Effects of external temperature and dead volume on laboratory measurements of pore pressure and injected volume in a rock fracture

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第5期14卷 1461-1469页

作者： Yinlin Ji Christian Kluge hannes Hofmann Guido Blöcher Helmholtz Centre Potsdam GFZ German Research Centre for GeosciencesPotsdam14473Germany State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou221116China

The accurate evaluation of pore pressure and injected volume is crucial for the laboratory characterization of hydromechanical responses of rock fractures. This study reports a series of laboratory experiments to systematically demonstrate the effects of external temperature and dead volume on laboratory measurements of pore pressure and injected volume in a rock fracture. We characterize the hydraulic aperture of the fracture as a function of effective normal stress using the exponential aperture *** model is then employed to predict the pore pressure change and injected volume in the fracture without the influences of external temperature and dead volume. The external temperature changes in the cyclic loading test due to the Joule-Thompson effect for fluids. The effect of external temperature on pore pressure change in the fracture can be well explained by thermal pressurization of fluids. Our results also show that the external dead volume can significantly lower the pore pressure change in the fracture during the cyclic loading test under undrained conditions. The injected volume can also be substantially enlarged due to the external dead volume in a typical pore pressure system. Internal measurement of the pore pressure in the fracture using a fiber optic sensor cannot exclude the influences of external temperature and dead volume, primarily because of the good hydraulic communication between the fracture and pore pressure system. This study suggests that the effects of external temperature and dead volume on pore pressure response and injected volume should be evaluated for accurate laboratory characterization and inter-laboratory comparison.

关键词： Fracture aperture Thermal pressurization External dead volume Pressure attenuation Injected volume Fiber optic sensor

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Alcohol consumption in patients with primary sclerosing cholangitis

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World Journal of Gastroenterology 2012年第24期18卷 3105-3111页

作者： hannes Hagstrm Per Stl Knut Stokkeland Annika Bergquist Department of Gastroenterology and Hepatology Karolinska University HospitalKarolinska Institutet14186 StockholmSweden Department of Medicine Visby HospitalKarolinska Institutet14186 StockholmSweden

AIM:To assess the alcohol drinking patterns in a cohort of primary sclerosing cholangitis(PSC) patients and the possible influence on the development of ***:Ninety-six patients with PSC were evaluated with a validated questionnaire about a patient's lifetime drinking habits:the lifetime drinking history(LDH) *** addition,clinical status,transient elastography and biochemistry values were analysed and *** were defined as having either significant or non-significant *** fibrosis was defined as either an elastography value of ≥ 17.3 kPa or the presence of clinical signs of *** were divided into two groups depending on their alcohol consumption patterns;no/low alcohol consumption(one drink or unit/d) and moderate/high alcohol consumption(≥ 1 drink or unit/d).LDH data were calculated to estimate lifetime alcohol intake(LAI),current alcohol intake,drinks per year before and after diagnosis of *** also calculated the number of episodes of binge-drinking(defined as consuming ≥ 5 drinks per occasion) in total,before and after the diagnosis of ***:The mean LAI was 3882 units of alcohol,giving a mean intake after onset of alcohol consumption of 2.6 units per *** 9% of patients consumed alcohol equal to or more than one unit per *** alcohol intake in patients with significant fibrosis(n = 26) was less than in patients without significant fibrosis(n = 70),as shown by lower values of phosphatidylethanol(B-PEth)(0.1 mol/L vs 0.33 mol/L,respectively,P = 0.002) and carbohydrate-deficient transferrin(CDT)(0.88% vs 1.06%,respectively,P = 0.02).Self-reported LAI was similar between the two *** with significant fibrosis reduced their alcohol intake after diagnosis from 103 to 88 units per year whereas patients without fibrosis increased their alcohol intake after PSC diagnosis from 111 to 151 units/*** were no correlations between elastography values and intake of alcoho

关键词： Alcohol Fibrosis Cirrhosis Lifetime drinkinghistory Primary sclerosing cholangitis

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Canonical Workflows in Simulation-based Climate Sciences

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Data Intelligence 2022年第2期4卷 212-225页

作者： Ivonne Anders Karsten Peters-von Gehlen hannes Thiemann German Climate Computing Center(DKRZ) BundesstraBe 45aD-20146 HamburgGermany

In this paper we present the derivation of Canonical Workflow Modules from current workflows in simulation-based climate science in support of the elaboration of a corresponding framework for simulationbased *** first identified the different users and user groups in simulation-based climate science based on their reasons for using the resources provided at the German Climate Computing Center(DKRZ).What is special about this is that the DKRZ provides the climate science community with resources like high performance computing(HPC),data storage and specialised services,and hosts the World Data Center for Climate(WDCC).Therefore,users can perform their entire research workflows up to the publication of the data on the same *** analysis shows,that the resources are used by two primary user types:those who require the HPC-system to perform resource intensive simulations to subsequently analyse them and those who reuse,build-on and analyse existing *** then further subdivided these top-level user categories based on their specific goals and analysed their typical,idealised workflows applied to achieve the respective project *** find that due to the subdivision and further granulation of the user groups,the workflows show apparent ***,similar"Canonical Workflow Modules"can be clearly made *** modules are"Data and Software(Re)use","Compute","Data and Software Storing","Data and Software Publication","Generating Knowledge"and in their entirety form the basis for a Canonical Workflow Framework for Research(CWFR).It is desirable that parts of the workflows in a CWFR act as FDOs,but we view this aspect ***,we reflect on the question whether the derivation of Canonical Workflow modules from the analysis of current user behaviour still holds for future systems and work processes.

关键词： Canonical Workflow Fair Digital Objects HPC infrastructures Data services Climate science

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