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Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

Translational Neurodegeneration 2020年第2期9卷 248-269页

作者： Luodan Yang hannah youngblood Chongyun Wu Quanguang Zhang Department of Neuroscience and Regenerative Medicine Medical College of GeorgiaAugusta University112015th StreetAugustaGA30912USA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugusta University112015th StreetAugustaGA30912USA

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress,which are important factors contributing to the development of brain *** evidence suggests mitochondria are a promising target for ***,methods targeting mitochondria have been considered as potential approaches for treatment of brain disease through the inhibition of inflammation and oxidative *** review will discuss two widely studied approaches for the improvement of brain mitochondrial respiration,methylene blue(MB)and photobiomodulation(PBM).MB is a widely studied drug with potential beneficial effects in animal models of brain disease,as well as limited human ***,PBM is a non-invasive treatment that promotes energy production and reduces both oxidative stress and inflammation,and has garnered increasing attention in recent *** and PBM have similar beneficial effects on mitochondrial function,oxidative damage,inflammation,and subsequent behavioral ***,the mechanisms underlying the energy enhancing,antioxidant,and anti-inflammatory effects of MB and PBM *** review will focus on mitochondrial dysfunction in several different brain diseases and the pathological improvements following MB and PBM treatment.

关键词： Mitochondrial dysfunction Neuroprotection Methylene blue Photobiomodulation

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Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration

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Neuroscience Bulletin 2022年第2期38卷 232-234页

作者： Chongyun Wu Luodan Yang hannah youngblood Timon Cheng-Yi Liu Rui Duan Laboratory of Regenerative Medicine in Sports Science School of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou 510006China Department of Neuroscience and Regenerative Medicine Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Microglia,the principal immune cells in the brain,play a vital role in the development and homeostasis of the central nervous system[1,2].During early brain development,microglia-mediated synapse pruning contributes to eliminating excess synapses that are unnecessary in adulthood[3].Excessive microglia-mediated pruning in the adult brain is implicated in neurodegeneration-associated behav・ioral deficits[4,5].

关键词： degeneration homeostasis clinical

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