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Azithromycin Exerts Bactericidal Activity and Enhances Innate Immune Mediated Killing of MDR Achromobacter xylosoxidans

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Infectious Microbes & Diseases 2020年第1期2卷 10-17页

作者： Erlinda R.Ulloa Armin Kousha hannah tsunemoto Joe Pogliano Carmelo Licitra John J.LiPuma George Sakoulas Victor Nizet Monika Kumaraswamy Collaborative to Halt Antibiotic-Resistant Microbes(CHARM) University of California San DiegoLa JollaCA 92093USA Department of Pediatrics University of California San DiegoLa JollaCA 92093USA Division of Infectious Disease Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA Department of Basic Sciences and Aquatic Medicine Norwegian University of Life SciencesOsloNorway Division of Biological Sciences University of California San DiegoLa JollaCA 92093USA Infectious Diseases Orlando Health Medical GroupOrlandoFL 32806USA Department of Pediatrics University of MichiganAnn ArborMI 48109USA Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa JollaCA 92093USA Infectious Diseas Section VA San Diego Healthcare SystemSan DiegoCA 92161USA Department of Medicine University of California San DiegoLa JollaCA 92093USA.

Azithromycin(AZM),the most commonly prescribed antibiotic in the United States,is thought to have no activity against multidrugresistant Gram-negative pathogens such as Achromobacter xylosoxidans(AX)per standard minimum inhibitory concentration testing in cation-adjusted Mueller Hinton *** we provide the first report of AZM bactericidal activity against carbapenemresistant isolates of AX,with a multifold decrease in minimum inhibitory concentration across 12 clinical isolates when examined under physiologic testing conditions that better recapitulate the in vivo human *** pharmaceutical activity,evident in eukaryotic tissue culture media,is associated with enhanced AZM intracellular penetration and synergistic killing with human whole blood,serum,and ***,AZM monotherapy inhibited preformed AX biofilm growth in a dose-dependent manner together with a reduction in viable *** an illustrative case,AZM in combination with piperacillin-tazobactam exerted clear therapeutic effects in a patient with carbapenem-resistant AX mediastinitis,sternal osteomyelitis,and aortic graft *** study reinforces how current antimicrobial testing practices fail to recapitulate the host environment or host-pathogen interactions and may misleadingly declare complete resistance to useful agents,adversely affecting patient *** conclude that AZM merits further exploration in the treatment of drug-resistant AX *** approaches to antimicrobial susceptibility testing that better recapitulate the host environment should be considered,especially as infections caused by multidrug-resistant Gram-negative bacterial pathogens are expanding globally with high morbidity and mortality.

关键词： Achromobacter xylosoxidans antimicrobial susceptibility testing azithromycin treatment host defense multidrug resistance

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Analysis of Machinable Structures and Their Wettability of Rotary Ultrasonic Texturing Method

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1187-1192页

作者： XU Shaolin SHIMADA Keita MIZUTANI Masayoshi KURIYAGAWA tsunemoto Division of Biomechanical Engineering Graduate School of Biomedical Engineering Tohoku University Department of Mechanical Systems Engineering Graduate School of Engineering Tohoku University

Tailored surface textures at the micro- or nanoscale dimensions are widely used to get required functional performances. Rotary ultrasonic texturing （RUT） technique has been proved to be capable of fabricating periodic micro- and nanostructures. In the present study, diamond tools with geometrically defined cutting edges were designed for fabricating different types of tailored surface textures using the RUT method. Surface generation mechanisms and machinable structures of the RUT process are analyzed and simulated with a 3D-CAD program. Textured surfaces generated by using a triangular pyramid cutting tip are constructed. Different textural patterns from several micrometers to several tens of micrometers with few burrs were successfully fabricated, which proved that tools with a proper two-rake-face design are capable of removing cutting chips efficiently along a sinusoidal cutting locus in the RUT process. Technical applications of the textured surfaces are also discussed. Wetting properties of textured aluminum surfaces were evaluated by combining the test of surface roughness features. The results show that the real surface area of the textured aluminum surfaces almost doubled by comparing with that of a flat surface, and anisotropic wetting properties were obtained due to the obvious directional textural features.

关键词： rotary ultrasonic texturing geometrically defined cutting edges surface generation mechanisms machinable structures,wetting properties

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Recent advances in ultrasonic-assisted machining for the fabrication of micro/nano-textured surfaces

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Frontiers of Mechanical Engineering 2017年第1期12卷 33-45页

作者： Shaolin XU tsunemoto KURIYAGAWA Keita SHIMADA Masayoshi MIZUTANI Division of Biomechanical Engineering Graduate School of BiomedicalEngineering Tohoku University Sendai 980-8579 Japan Department of Mechanical Systems Engineering Graduate School ofEngineering Tohoku University Sendai 980-8579 Japan

In this paper, the state of art of ultrasonic- assisted machining technologies used for fabrication of micro/nano-textured surfaces is reviewed. Diamond machining is the most widely used method in industry for manufacturing precision parts. For fabrication of fine structures on surfaces, conventional diamond machining methods are competitive by considering the precision of structures, but have limitations at machinable structures and machining efficiency, which have been proved to be partly solved by the integration of ultrasonic vibration motion. In this paper, existing ultrasonic-assisted machin- ing methods for fabricating fine surface structures are reviewed and classified, and a rotary ultrasonic texturing （RUT） technology is mainly introduced by presenting the construction of vibration spindles, the texturing principles, and the applications of textured surfaces. Some new ideas and experimental results are presented. Finally, the challenges in using the RUT method to fabricate micro/ nano-textured surfaces are discussed with respect to texturing strategies, machinable structures, and tool wear.

关键词： ultrasonic-assisted machining textured sur-face micro/nano-structures functional performance

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Effects of Topography and Modified Layer by Plasma-Shot Treatment on High-Speed Steel

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Nanomanufacturing and Metrology 2020年第2期3卷 133-141页

作者： Yorihito Shibata Yusuke Sakairi Keita Shimada Masayoshi Mizutani tsunemoto Kuriyagawa Graduate School of Engineering Tohoku University6-6-01AobaAramakiazaAobakuSendaishiMiyagiJapan Graduate School of Biomedical Engineering Tohoku University6-6-01AobaAramakiazaAobakuSendaishiMiyagiJapan

In this study,plasma shot(PS)treatment was applied to high-speed steel(HSS)surfaces using a titanium carbide electrode to confirm the effect of discharge current(Ip)on the formation of a single dimple and analyze a modified *** roughness of modified surfaces increased when Ip increased,and energy-dispersive X-ray spectrometry showed an increase in titanium atom density whenIp and electrode consumption volume(Ve)increased.A friction test confirmed that the modified surface's friction was reduced by discharge dimples under low-load *** hardness test confirmed that the hardness of the modified surface was-300-600 HV higher than that of an untreated HSS ***,it increased with an increase ***,application of PS treatment to the edge of surfaces on the workpiece caused shape *** deterioration size of the edge of the modified layer increased when Ip *** solve this issue,we propose a novel method named position-adjusted PS(PA-PS)***-PS treatment is used to adjust the end of the electrode in the order of tens of micrometers from the edge of the workpiece to avoid the deterioration of the edge *** Ip=21 A,PA-PS formed a modified layer without deteriorating the edge shape of the workpiece,thus confirming the PS characteristics applied to HSS ***,PA-PS treatment solved the shape deterioration of the edge on modified surfaces via PS treatment.

关键词： Plasma-shot treatment Electric discharge machining Surface modification High-speed steel-Tool wear Friction

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Manufacturing technologies toward extreme precision

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International Journal of Extreme Manufacturing 2019年第2期1卷 11-32页

作者： Zhiyu Zhang Jiwang Yan tsunemoto Kuriyagawa Key Laboratory of Optical System Advanced Manufacturing Technology Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033People’s Republic of China 2 Department of Mechanical Engineering Keio UniversityYokohama 223-8522Japan Department of Mechanical Systems Engineering Tohoku UniversitySendai 980-8575Japan

Precision is one of the most important aspects of *** precision creates high quality,high performance,exchangeability,reliability,and added value for industrial *** the past decades,remarkable advances have been achieved in the area of high-precision manufacturing technologies,where the form accuracy approaches the nanometer level and surface roughness the atomic *** extremely high precision manufacturing technologies enable the development of high-performance optical elements,semiconductor substrates,biomedical parts,and so on,thereby enhancing the ability of human beings to explore the macroand microscopic mysteries and potentialities of the natural *** this paper,state-of-the-art high-precision material removal manufacturing technologies,especially ultraprecision cutting,grinding,deterministic form correction polishing,and supersmooth polishing,are reviewed and compared with insights into their principles,methodologies,and *** key issues in extreme precision manufacturing that should be considered for future R&D are discussed.

关键词： ultraprecision cutting grinding polishing supersmooth surface ultraprecision measurement extreme precision

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STUDY ON A NEW TYPE OF THROW-AWAY SOFT GRINDING WHEELS

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Chinese Journal of Mechanical Engineering 2000年第2期13卷 140-144页

作者： English Guo Yinbiao Zheng Xiaoguang Chen Bingkui Liang Xichang (State Key Lab. of Mechanical Transgression, Chongqing University) Syoji Katsuo Kuliyagawn tsunemoto (Tohoku University, Japan) 重庆大学机械传动国家重点实验室重庆 tsunemoto Tohoku Univeersity 日本

In accordance with the difficult problems of belt cross vibrations and effects of belt tension on machine spindle precision in abrasive belt grinding, a new soft grinding wheel is put forward, which is provided with the advantages of belt grinding and can he installed directly on the grinding machine spindle substituting for common grinding wheels. The new soft grinding wheel does not need any ancillary facilities and dressing devices in banding. With analyzing error of wheel and grinding experiment, the high-efficiency grinding characteristics grinding hard-brittle materials has been obtained.

关键词： Soft grinding wheel High-efficiency grinding Error compensation

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温度变化和接触导线磨损对集电性能的影响

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国外铁道车辆 2017年第4期54卷 17-22,46页

作者： Mizuki tsunemoto 周冬妍

通过理论研究和弓网模拟,弄清了温度变化和接触导线磨损对集电性能的影响。

关键词：集电接触导线日本

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Exploratory Trial to Evaluate the Hydroxyapatite Layer Formed by a New Dental Treatment System

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Open Journal of Stomatology 2015年第12期5卷 281-286页

作者： Ryo Akatsuka Kuniyuki I zumita Ayako Nishiyama Chie Kayaba Satoki Kadota Tomonori Hoshi Koji Ikeda tsunemoto Kuriyagawa Keiichi Sasaki Division of Advanced Prosthetic Dentistry Tohoku University Graduate School of Dentistry Sendai Japan Clinical Research Innovation and Education Center Tohoku University Hospital Sendai Japan Division of Biomechanical Engineering Tohoku University Graduate School of Biomedical Engineering Sendai Japan

Objective: A powder jet deposition (PJD) process can be used to create a thick hydroxyapatite (HA) layer on the human tooth surface. The purpose of this exploratory trial was to evaluate the safety and efficacy of the hydroxyapatite layer formed by a new dental treatment system for cases of caries, dentin hypersensitivity, or discolored teeth. Methods: A single facility, non-blinded study comparing before and after treatment interventions, without a comparative control, was conducted. A rubber dam was attached to the teeth followed by the application of Vaseline to the gingival margins. Extra- and intra-oral vacuums and a saliva discharge tube were used to spray HA powder over the target site with the PJD equipment. Results: The formation of an HA layer tended to reduce pain on exposure to cold water and air in the cases with caries, and increase brightness and satisfaction in the cases with tooth discoloration. The pain on exposure to air was significantly reduced in the cases with dentin hypersensitivity. PJD was not observed to cause any inflammation of the surrounding gingiva or pulpal symptoms. Conclusions: HA is anticipated to reduce the need for repeat treatment by offering superior compatibility with the tooth substance when compared with other dental materials.

关键词： Exploratory Trial Hydroxyapatite Layer Powder Jet Deposition

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300km/h以上速度等级简单悬链线系统的开发

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国外铁道机车与动车 2020年第5期 29-34,37页

作者： [日]Mizuki tsunemoto 万芳(译) 张霓虹(校) 不详

新干线的复合悬链线系统将很快进入大规模更换阶段。为了便于更换和降低维护成本,可以将复合悬链线系统替换为简单悬链线系统。该项研究旨在探索新型320 km/h简单悬链线系统,这是新干线商业运行的最高速度。此外,一种360 km/h简单悬链... 详细信息

新干线的复合悬链线系统将很快进入大规模更换阶段。为了便于更换和降低维护成本,可以将复合悬链线系统替换为简单悬链线系统。该项研究旨在探索新型320 km/h简单悬链线系统,这是新干线商业运行的最高速度。此外,一种360 km/h简单悬链线系统也正在开发中。

关键词：新干线悬链线系统日本

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非球面表面形状的线测量技术

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纳米技术与精密工程 2004年第3期2卷 210-216页

作者： ARAI Yoshikazu 高伟 SHIMIZU Hiroki KIYONO Satoshi KURIYAGAWA tsunemoto 日本东北大学纳米机械系纳米系统工程研究室

描述了一种在超精密磨削机床上基于误差分离法的非球面表面形状精密测量系统 .首先 ,论述了一般用于平面形状测量的两点法不能直接用于非球面形状测量的原因在于测头的设置误差会引起很大的形状测量误差 .提出了先通过两点法测量平面形... 详细信息

描述了一种在超精密磨削机床上基于误差分离法的非球面表面形状精密测量系统 .首先 ,论述了一般用于平面形状测量的两点法不能直接用于非球面形状测量的原因在于测头的设置误差会引起很大的形状测量误差 .提出了先通过两点法测量平面形状得出机床的运动误差 ,然后对测量非球面形状的另外一个测头的输出进行补偿以得出正确的非球面形状 .用此系统测量了一个直径为 3 0mm的非球面镜头的表面形状 .

关键词：机床测头超精密磨削非球面镜头平面形状运动误差误差分离表面形状系统测量精密测量

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