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Deregulation of splicing factors and breast cancer development

Journal of Molecular Cell Biology 2015年第5期7卷 388-401页

作者： Marco Silipo hannah gautrey Alison Tyson-Capper Institute of Cellular Medicine Faculty of Medical SciencesNewcastle UniversityNewcastle upon Tyne NE24HHUK

It is well known that many genes implicated in the development and progression of breast cancer undergo aberrant alternative splicing events to produce *** changes in alternative splicingcan arise frommutations or single-nucleotide polymorphisms(SNPs)within the DNA sequences of cancer-related genes,which can strongly affect the activity of splicing factors and influence the splice site ***,it is important to note that absence of mutations is not sufficient to prevent misleading choices in splice site *** is nowincreasing evidence to demonstrate that the expression profile of ten splicing factors(including SRs and hnRNPs)and eight RNA-binding proteins changes in breast cancer cells compared with normal *** modifications strongly influence the alternative splicing pattern of many cancer-related genes despite the absence of any detrimental mutations within their DNA ***,a comprehensive assessment of the splicing factor status in breast cancer is important to provide insights into the mechanisms that lead to breast cancer development and *** most studies focus on mutations that affect alternative splicing in cancer-related genes,this review focuses on splicing factors and RNA-binding proteins that are themselves deregulated in breast cancer and implicated in cancer-related alternative splicing events.

关键词： alternative splicing splicing factors RNA-binding proteins breast cancer

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