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Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration

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Neuroscience Bulletin 2022年第2期38卷 232-234页

作者： Chongyun Wu Luodan Yang hannah Youngblood Timon Cheng-Yi Liu Rui Duan Laboratory of Regenerative Medicine in Sports Science School of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou 510006China Department of Neuroscience and Regenerative Medicine Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Microglia,the principal immune cells in the brain,play a vital role in the development and homeostasis of the central nervous system[1,2].During early brain development,microglia-mediated synapse pruning contributes to eliminating excess synapses that are unnecessary in adulthood[3].Excessive microglia-mediated pruning in the adult brain is implicated in neurodegeneration-associated behav・ioral deficits[4,5].

关键词： degeneration homeostasis clinical

Yves Klein, 1928-1962

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Yves Klein, 1928-1962

A general spatial-temporal framework for short-term building temperature forecasting at arbitrary locations with crowdsourcing weather data

作者： Weitemeier hannah.

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Building Simulation 2023年第6期16卷 963-982页

作者： Reisa F.Widjaja Wenbo Wu Zhi Zhou Renhao Sun hannah C.Fontenot Bing Dong Department of Management Science&Statistics The University of Texas at San AntonioSan AntonioTX78249USA Energy Systems Division Argonne National LaboratoryLemontIL60439USA Department of Mechanical&Aerospace Engineering Syracuse UniversitySyracuseNY13244USA

Weather forecasting has been a critical component to predict and control building energy consumption for better building energy *** accessibility to other data sources,the onsite observed temperatures or the airport temperatures are used in forecast *** this paper,we present a novel approach by utilizing the crowdsourcing weather data from neighboring personal weather stations(PWS)to improve the weather forecast accuracy around buildings using a general spatial-temporal modeling *** final forecast is based on the ensemble of local forecasts for the target location using neighboring *** approach is distinguished from existing literature in various ***,we leverage the crowdsourcing weather data from PWS in addition to public data *** this way,the data is at much finer time resolution(e.g.,at 5-minute frequency)and spatial resolution(e.g.,arbitrary location vs grid).Second,our proposed model incorporates spatial-temporal correlation information of weather variables between the target building and a set of neighboring PWSs so that underlying correlations can be effectively captured to improve forecasting *** demonstrate the performance of the proposed framework by comparing to the benchmark models on temperature forecasting for a building located at an arbitrary location at San Antonio,Texas,*** general,the proposed model framework equipped with machine learning technique such as Random Forest can improve forecasting by 50%compares with persistent model and has 90%chance to outperform airport forecast in short-term *** a real-time setting,the proposed model framework can provide more accurate temperature forecasting results compared with using airport temperature forecast for most forecast ***,we analyze the sensitivity of model parameters to gain insights on how crowdsourcing data from the neighboring personal weather stations impacts forecasting ***,we implement

关键词： crowdsourcing data machine learning spatial temporal model weather forecasting

Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3950-3965页

作者： Linglong Deng hannah Petrek Mei-Juan Tu Neelu Batra Ai-Xi Yu Ai-Ming Yu Department of Orthopaedic Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityWuhan 430072China Department of Biochemistry and Molecular Medicine UC Davis School of MedicineSacramentoCA 95817USA

With the understanding of microRNA(miRNA or miR) functions in tumor initiation,progression,and metastasis,efforts are underway to develop new miRNA-based *** recently,we demonstrated effectiveness of a novel humanized bioengineered miR-124-3 p prodrug in controlling spontaneous lung metastasis in mouse *** study was to investigate the molecular and cellular mechanisms by which miR-124-3 p controls tumor *** study identified a set of proteins selectively and significantly downregulated by bioengineered miR-124-3 p in A549 cells,which were assembled into multiple cellular components critical for metastatic *** them,plectin(PLEC) was verified as a new direct target for miR-124-3 p that links cytoskeleton components and *** miR-124-3 p-treated lung cancer and osteosarcoma cells,protein levels of vimentin,talin 1(TLN1),integrin beta-1(ITGB1),IQ motif containing GTPase activating protein 1(IQGAP1),cadherin2 or N-cadherin(CDH2),and junctional adhesion molecule A(F11 R or JAMA or JAM1) decreased,causing remodeling of cytoskeletons and disruption of cell-cell ***,miR-124-3 p sharply suppressed the formation of focal adhesion plaques,leading to reduced cell adhesion ***,efficacy and safety of biologic miR-124-3 p therapy was established in an aggressive experimental metastasis mouse model in *** results connect miR-124-3 p-PLEC signaling to other elements in the control of cytoskeleton,cell junctions,and adhesion essential for cancer cell invasion and extravasation towards metastasis,and support the promise of miR-124 therapy.

关键词： RNA therapy MiR-124-3p Metastasis Proteomics Junctions Cell adhesion Bioengineer Imaging

Grain size effect on wear resistance of WC-Co cemented carbides under different tribological conditions

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Journal of Materials Science & Technology 2019年第11期35卷 2435-2446页

作者： Haibin Wang Mark Gee Qingfan Qiu hannah Zhang Xuemei Liu Hongbo Nie Xiaoyan Song Zuoren Nie College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaBeijing University of TechnologyBeijing 100124China National Physical Laboratory Hampton RoadTeddingtonTW110LWUK Xiamen Tungsten Co. Ltd.Xiamen 361009China

The grain-size dependence of wear resistance of WC-Co cemented carbides(with mean WC grain sizes of 2.2μm,1.6μm,0.8μm and 0.4μm,respectively)was investigated under different tribological *** results showed that the grain size had opposite effects on wear resistance of the cemented carbides in dry sliding wear and microabrasion *** the former condition,with decrease of WC grain size hence the increase of hardness,plastic deformation,fracture,fragmentation and oxidation were all mitigated,leading to a drastic decrease in the wear *** the latter condition,pull-out of WC grains after Co removal dominated the wear,so that the hardness of cemented carbide was not a core *** a result,the wear resistance of the cemented carbide generally showed a decreasing trend with decrease of the grain size,except for a slight increase in the ultrafine-grained cemented ***-pass scratching of the cemented carbides under various loads indicated the same failure mechanism as that in the sliding wear ***,the reasons for severe surface oxidation of the coarse-grained cemented carbides were disclosed.

关键词： Cemented carbide Grain size Fracture Surface oxidation Grain pull-out Wear resistance

Why forefoot striking in minimal shoes might positively change the course of running injuries

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Journal of Sport and Health Science 2017年第2期6卷 154-161页

作者： Irene S.Davis hannah M.Rice Scott C.Wearing Spaulding National Running Center Department of Physical Medicine and Rehabilitation Harvard Medical School Sport and Health Sciences University of Exeter Institute of Health and Biomedical Innovation Queensland University of Technology

It is believed that human ancestors evolved the ability to run bipedally approximately 2 million years ago. This form of locomotion may have been important to our survival and likely has influenced the evolution of our body form. As our bodies have adapted to run, it seems unusual that up to 79% of modern day runners are injured annually. The etiology of these injuries is clearly multifactorial. However, 1 aspect of running that has significantly changed over the past 50 years is the footwear we use. Modern running shoes have become increasingly cushioned and supportive, and have changed the way we run. In particular, they have altered our footstrike pattern from a predominantly forefoot strike(FFS) landing to a predominantly rearfoot strike(RFS) landing. This change alters the way in which the body is loaded and may be contributing to the high rate of injuries runners experience while engaged in an activity for which they were adapted. In this paper, we will examine the benefits of barefoot running(typically an FFS pattern),and compare the lower extremity mechanics between FFS and RFS. The implications of these mechanical differences, in terms of injury, will be discussed. We will then provide evidence to support our contention that FFS provides an optimal mechanical environment for specific foot and ankle structures, such as the heel pad, the plantar fascia, and the Achilles tendon. The importance of footwear will then be addressed, highlighting its interaction with strike pattern on mechanics. This analysis will underscore why footwear matters when assessing mechanics. Finally, proper preparation and safe transition to an FFS pattern in minimal shoes will be emphasized. Through the discussion of the current literature, we will develop a justification for returning to running in the way for which we were adapted to reduce running-related injuries.

关键词： shoes running injuries strike predominantly landing tendon striking plantar locomotion

Psychophysics of the hoverfly: categorical or continuous color discrimination?

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Current Zoology 2019年第4期65卷 483-492页

作者： Lea hannah Adrian G. Dyer Jair E. Garcia Alan Dorin Martin Burd School of Biological Sciences Monash University Clayton Victoria 3800 Australia Hawkesbury Institute for the Environment Western Sydney University Richmond New South Wales 2753 Australia School of Media and Communication RMIT University Melbourne Victoria 3001 Australia Department of Physiology Monash University Clayton Victoria 3800 Australia Faculty of Information Technology Monash University Clayton Victoria 3800 Australia

There is increasing interest in flies as potentially important pollinators. Flies are known to have a complex visual system, in eluding 4 spectral classes of photoreceptors that con tribute to the perception of color. Our current understanding of how color signals are perceived by flies is based on data for the blowfly Lucilia sp., which after being conditi oned to rewarded mono chromatic light stimuli, showed evidenee of a categorical color visual system. The resulting opponent fly color space has 4 distinct categories, and has been used to interpret how some fly pollinators may perceive flower colors. However, formal proof that flower flies (Syrphidae) only use a simple, categorical color process remains outstanding. In free-flying experiments, we tested the hoverfly Eristalis tenax, a Batesian mimic of the honeybee, that receives its nutrition by visiting flowers. Using a range of broadband similar-dissimilar color stimuli previously used to test color perception in pollinating hymenopteran species, we evaluated if there are steep changes in behavioral choices with continuously increasing color differences as might be expected by categorical color processing. Our data revealed that color choices by the hoverfly are mediated by a continuous monotonic function. Thus, these flies did not use a categorical processing, but showed evidenee of a color discrimination function similar to that observed in several bee species. We therefore empirically provide data for the minimum color distanee that can be discriminated by hoverflies in fly color space, enabling an improved un derstandi ng of plant-poll in ator interactions with a non-model insect species.

关键词： chromatic signal color model floral color fly pollination plant-pollinator vision

BAK-up:the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking

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Stress Biology 2023年第1期3卷 463-467页

作者： Vahid Fallahzadeh-Mamaghami hannah Weber Birgit Kemmerling ZMBP University TubingenAuf der Morgenstelle 32Tübingen 72076Germany

BRI1-ASSOCIATED KINASE 1(BAK1/SERK3)and its closest homolog BAK1-LIKE 1(BKK1/SERK4)are leucine-rich repeat receptor kinases(LRR-RKs)belonging to the SOMATIC EMBRYOGENESIS RECEPTOR KINASE(SERK)*** act as co-receptors of various other LRR-RKs and participate in multiple signaling events by complexing and transphosphorylating ligand-binding *** identified as the brassinosteroid receptor BRASSINOSTEROID INSENSITIVE 1(BRI1)co-receptor,BAK1 also functions in plant immunity by interacting with pattern recognition *** in BAK1 and BKK1 cause severely stunted growth and cell death,characterized as autoimmune cell *** factors play a role in this type of cell death,including RKs and components of effector-triggered immunity(ETI)signaling pathways,glycosylation factors,ER quality control components,nuclear trafficking components,ion channels,and Nod-like receptors(NLRs).The Shan lab has recently discovered a novel RK BAK-TO-LIFE 2(BTL2)that interacts with BAK1 and triggers cell death in the absence of BAK1 and *** RK compensates for the loss of BAK1-mediated pattern-triggered immunity(PTI)by activating phytocytokine-mediated immune and cell death responses.

关键词： BAK1 Cell death Receptor kinase BTL2 PTI ETI

Fixed bimonthly aflibercept in nave and switched neovascular age-related macular degeneration patients:one year outcomes

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1156-1162页

作者： Alasdair N Warwick hannah H Leaver Andrew J Lotery Srini V Goverdhan Clinical Neurosciences Research Group Clinical and Experimental Sciences Faculty of Medicine University of Southampton Southampton Eye Unit University Hospital Southampton NHS Foundation Trust

AIM: To determine real life clinical outcomes in poorly responsive and treatment-nave neovascular age-related macular degeneration(nv AMD) patients using bimonthly fixed dosing aflibercept ***: This was a retrospective study of 165 eyes with nv AMD started on aflibercept at Southampton Eye Unit between June 2013 and June 2014. Patients were either switched from pro re nata(PRN) ranibizumab/bevacizumab due to poor response(107 eyes), or treatment- nave( 58 eyes). Patients initially received 3-monthly intravitreal aflibercept injections followed by 2-monthly fixed doses. Clinic visits were scheduled at month 0, 4, 10 and 12. Mean change in best-corrected visual acuity(BCVA) and central retinal thickness(CRT)from baseline were assessed using the Wilcoxon signedrank test. The proportion of patients maintaining BCVA(<15 letters loss) at 12 mo was also ***: Mean BCVA change at month 12 was +3.29 and +4.67 letters in the switched and nave aflibercept groups respectively(P <0.01). BCVA was maintained in 95.3% of switched and 96.6% of nave patients. CRT at month 12 showed a decrease of -6.16 μm in the switched group and -35.36 μm in the nave group(P <0.01).Patients previously treated with ranibizumab/bevacizumab had on average received 7.4 ranibizumab/bevacizumab injections over 12.6 mo, attending 10 clinic visits. The fixed dosing aflibercept regimen required an average of 7.1 injections(nave group), 7.5 injections(switched group) and 4 clinic visits per ***: Fixed bimonthly aflibercept is effective in both treatment-nave and poorly responsive nv AMD patients. Adopting a fixed dosing regimen can reduce patient burden without compromising on outcomes.

关键词： age-related macular degeneration ranibizumab aflibercept anti-vascular endothelial growth factor