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Crosslinking of viral nanoparticles with “clickable” fluorescent crosslinkers at the interface

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Science China Chemistry 2010年第6期53卷 1287-1293,1459页

作者： KAUR Gagandeep BARNHILL hannah Department of Chemistry and Biochemistry and Nanocenter University of South Carolina

Cu (I) catalyzed alkyne-azide cycloaddition (CuAAC) reaction,a typical "click" reaction,is one of the modular synthetic approaches which has been broadly used in various organic syntheses,medicinal chemistry,materials development and bioconjugation *** have for the first time synthesized two dialkyne derivatized fluorescent crosslinkers which could be applied to crosslink two biomolecules using CuAAC *** yellow mosaic virus,a plant virus with unique structural and chemical properties,was used as a prototypical scaffold to form a 2D single layer at the interface of two immiscible liquids and crosslinked with these two linkers by the CuAAC *** crosslinking,the fluorescence of both linkers diminished,likely due to the distortion of the polymethylene backbone,which therefore could be used to indicate the completion of the reaction.

关键词： pickering emulsion crosslinking nanoparticles CuAAC reaction click chemistry interfacial assembly

Understanding the timing of brain injury in fetal growth restriction:lessons from a model of spontaneous growth restriction in piglets

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Neural Regeneration Research 2023年第2期18卷 322-323页

作者： hannah Musco Julie A.Wixey UQ Centre for Clinical Research Faculty of MedicineUniversity of QueenslandQueenslandAustralia

Fetal growth restriction(FGR)is one of the most common contributors to increased risk of mortality in the fetal/neonatal period and long-term morbidity in the infant(Malhotra et al.,2019).FGR can arise from many pathophysiological processes associated with maternal,fetal,genetic,or placental compromise;however,placental insufficiency is the most common cause of *** insufficiency during pregnancy results in chronic fetal hypoxia where a lack of oxygen and nutrients supply to the developing fetus impacts normal development of the fetus.

关键词： fetal fetus insufficiency

Sensitivity analysis for stochastic and deterministic models of nascent focal adhesion dynamics

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International Journal of Biomathematics 2017年第7期10卷 237-265页

作者： hannah R. Biegel Alex Quackenbush hannah Callender Highlander Departments of Mathematics and Biology University of Portland 5000 North Willamette Boulevard Portland Oregon 97203 USA Department of Mathematics University of Portland 5000 North Willamette Boulevard Portland Oregon 97203 USA

Sensitivity analysis （SA） is a critical part of modeling any biological system due to the inherent uncertainty in model output, as introduced by parameter values that have not been experimentally determined. SA therefore provides deeper understanding of the system by painting a picture of the extent to which certain model outputs vary in rela- tionship to changes in model parameters. Here we explore two types of global SA for recently developed models of nascent focal adhesion formation, a key step in cellular movement. While many SA methods have been used for deterministic methods, we uti- lize methods for both stochastic and deterministic models, providing a more complete description of the parameters to which the focal adhesion model is most sensitive. Spe- cific recommendations for further experimentation in the process of cellular motility are proposed in response to the SA.

关键词： Sensitivity analysis method of Morris FAST focal adhesion dynamics cel-lular motility stochastic models.

Glyphosate Exposure Associated with Human Neurodegenerative Disorders: A Scoping Review

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Deregulation of splicing factors and breast cancer development

Journal of Behavioral and Brain Science（行为与脑科学期刊） 2024年第7期 187页

作者： hannah Hutchins David M. Compton Kris Dougherty

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分子细胞生物学报:英文版 2015年第5期7卷 388-401页

作者： Marco Silipo hannah Gautrey Alison Tyson-Capper Institute of Cellular Medicine Faculty of Medical SciencesNewcastle UniversityNewcastle upon Tyne NE24HHUK

It is well known that many genes implicated in the development and progression of breast cancer undergo aberrant alternative splicing events to produce *** changes in alternative splicingcan arise frommutations or single-nucleotide polymorphisms(SNPs)within the DNA sequences of cancer-related genes,which can strongly affect the activity of splicing factors and influence the splice site ***,it is important to note that absence of mutations is not sufficient to prevent misleading choices in splice site *** is nowincreasing evidence to demonstrate that the expression profile of ten splicing factors(including SRs and hnRNPs)and eight RNA-binding proteins changes in breast cancer cells compared with normal *** modifications strongly influence the alternative splicing pattern of many cancer-related genes despite the absence of any detrimental mutations within their DNA ***,a comprehensive assessment of the splicing factor status in breast cancer is important to provide insights into the mechanisms that lead to breast cancer development and *** most studies focus on mutations that affect alternative splicing in cancer-related genes,this review focuses on splicing factors and RNA-binding proteins that are themselves deregulated in breast cancer and implicated in cancer-related alternative splicing events.

关键词： alternative splicing splicing factors RNA-binding proteins breast cancer

SPACE AND TOPOGRAPHY IN ANCIENT EGYPT

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Journal of Ancient Civilizations 2023年第1期38卷 69-124,127页

作者： hannah Pethen Honorary Fellow University of Liverpool

Introduction"Space"and "topography"have very specific meanings in the modern world. "Space"is an external void,an empty physical area to be acted upon. "Topography"is the "configuration of the surface relief"of the earth,a human body,or another *** words are technical terms implying the existence of externalities or abstractions;'spaces and topography that can be measured,recorded,observed,and acted *** this they are associated with the Enlightenment concept of "landscape"as external,viewable,and empirically understandable through objective scientific observation and recording,often for imperialist purposes.

关键词： SPACE recording earth

Advances of nanotechnologies for hydraulic fracturing of coal seam gas reservoirs:potential applications and some limitations in Australia

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International Journal of Coal Science & Technology 2022年第2期9卷 1-18页

作者： hannah Marsden Sudeshna Basu Alberto Striolo Melanie MacGregor Department of Chemical Engineering University College LondonLondon WC1E 7JEUK Future Industries Institute University of South AustraliaMawson Lakes BvdMawson LakesSA 5195Australia Department of Earth Sciences University College LondonLondon WC1E 6BSUK School of Chemical Biological and Materials EngineeringUniversity of OklahomaNormanOK 73019USA Flinders Institute for Nanoscale Science&Technology College of Science and EngineeringFlinders UniversityBedford ParkSA 5042Australia

Some of the most promising potential applications of nanotechnology to hydraulic fracturing of coal seam gas(CSG)are reviewed with a focus on Australian CSG *** propitious applications were identifed:(1)Nanoparticle enhanced viscoelastic surfactants(VES)fracturing fuids to prevent fuid loss by up to 30%,made possible by the formation of pseudo-flter cakes and reducing the viscosity of the VES ***,there is no requirement of clay control additives or biocides.(2)Nano-proppants to extend fracture networks and reduce proppant embedment by introducing them prior to the emplacement of larger *** Ash nanoparticles can be particularly efective because of their high sphericity and mechanical strength.(3)Nanoparticle-coated proppants,to mitigate the migration of particle fnes by restricting them close to their source by adsorption,with MgO being the most *** use of nanotechnology in hydraulic fracturing applications is currently hindered due to a discordant regulatory environment compounded by the cost of the nanoparticles themselves,as well as,a lack of feld data to validate the technology under real downhole *** the necessary feld tests are unlikely to be conducted for as long as abundant natural gas is available,exploratory studies could pave the way for future applications.

关键词： Coal bed methane Nanoparticles Fracturing fuids Proppant Natural gas

Speech,language,and hearing function in twins with Alport syndrome:A seven-year retrospective case report

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Journal of Otology 2017年第2期12卷 86-96页

作者： Ramesh Kaipa hannah Tether Department of Communication Sciences and Disorders Oklahoma State UniversityUnited States

Alport syndrome is an X-linked syndrome that results in nephritis, renal failure, sensorineural hearing loss, and eye deficits. As a result of sensorineural hearing loss, these individuals are likely to experience difficulties in the area of speech and language. While studies in the past have examined the speech and language characteristics of children with syndromic sensorineural hearing loss, to our knowledge there are no previous studies to have documented the speech and language characteristics of these children on a long-term basis. The current study addresses this limitation by reporting speech, language, hearing, and function of twin brothers with X-linked Alport syndrome across a seven-year *** was collected by examining the medical records of the participants as well as through a verbal interview with the participants' guardian. Results revealed that the participants' hearing abilities gradually deteriorated over the seven-year period which affected their speech and language development as well. The kidney function tests revealed significant presence of hematuria(blood in the urine) as well as proteinuria(protein in the urine) suggesting chronic kidney dysfunction. This longitudinal study demonstrates the functional relationship between the kidneys and the cochlea, although they appear to be independent of one another. As individuals with Alport syndrome exhibit systemic complications, interdisciplinary collaboration is essential among health care providers including audiologists, speech-language pathologists,nephrologists, and ophthalmologist to promote evidence-based practice.

关键词： Alport syndrome Hearing loss Speech and language development Kidney function

Color change in a marine isopod is adaptive in reducing predation

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Current Zoology 2015年第4期61卷 739-748页

作者： Kristin M. HULTGREN hannah MITTELSTAEDT Department of Biology Seattle University 901 12^th ave. Seattle WA 98122

Although background matching is a common form of camouflage across a wide diversity of animals, there has been surprisingly little experimental work testing the fitness consequences of this camouflage strategy, especially in marine ecosystems. In this study, we tested whether color camouflage enhances survival of the intertidal marine isopod Pentidotea （Idotea） wosnesenskii, quantified patterns of camouflage in different algal habitats, and examined how algal diet affected color change and growth using laboratory assays. In the field, isopods collected from two differently colored algal habitats （the brown alga Fucus distichus and the red alga Odonthaliafloccosa） matched the color of their respective algal habitats, and also differed significantly in body size： smaller red isopods were found on red algae, while larger brown isopods were found on brown algae. Predation ex- periments demonstrated these color differences had fitness benefits： brown isopods that matched their brown algae habitats sur- vived at higher rates than red unmatched isopods. Surprisingly, despite the propensity of isopods to match their algal habitats, algal diet had no effect on color change in color change experiments. Instead, isopods in all treatments turned browner, matching the color of the algal habitat that many isopods are found on as adults. In summary, our data supported our hypothesis that back- ground matching serves an adaptive function in reducing predation, with important evolutionary implications for explaining the wide variation in color change mechanisms in idoteid isopods [Current Zoology 61 （4）： 739-748, 2015].

关键词： Isopod Pentidotea wosnesenskii. Camouflage Crypsis Background matching Color change