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Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data

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World Journal of Clinical Cases 2021年第33期9卷 10198-10207页

作者： Hong Ki Min Se Hee Kim Jong Han Choi Kyomin Choi Hae-Rim Kim Sang-Heon lee Department of Internal Medicine Konkuk University Medical CenterSeoul KS013South Korea Department of Neurology Konkuk University Medical CenterSeoul KS013South Korea Division of Rheumatology Department of Internal MedicineKonkuk University School of MedicineSeoul KS013South Korea

BACKGROUND Neuropathy is a common chronic complication in type 2 diabetes mellitus(T2DM).Statin and metformin are commonly used medications in T2DM patients,and some studies showed statin-or metformin-induced *** To evaluate the incidence of neuropathy among patients with T2DM associated with statin and metformin *** Korean Health Insurance Review and Assessment national patient sample data from 2016 and 2017 were *** with T2DM and no complications were divided into statin/metformin/statin+metformin users and *** incidence was defined by International Statistical Classification of Diseases and Related Health Problems,10th revision codes and concomitant prescriptions for anticonvulsants or *** regression analyses were conducted to examine the associations between statin/metformin/statin+metformin therapies and the incidence of *** score(PS)matching was performed on the basis of age,sex and *** Overall,34964 and 35887 patients with T2DM and no complications were included in the Korean Health Insurance Review and Assessment national patient sample datasets from 2016 and 2017,*** therapy was associated with increased risks of neuropathy in 2016 and 2017[PS-matched odds ratio(OR)=1.22,95%confidence interval(CI):1.08-1.38;PS-matched OR=1.17,95%CI:1.03-1.33,respectively].Metformin therapy was associated with reduced risks of neuropathy in 2016 and 2017(PS-matched OR=0.30,95%CI:0.21-0.42;PSmatched OR=0.44,95%CI:0.32-0.60,respectively).Combined statin+metformin therapy was not significantly associated with neuropathy in 2016 or 2017(PSmatched OR=0.85,95%CI:0.61-1.19;PS-matched OR=0.95,95%CI:0.66-1.38,respectively).CONCLUSION Statin therapy was associated with enhanced risk of new-onset neuropathy in patients with T2DM,but metformin therapy showed the opposite association.

关键词： Diabetes mellitus Neuropathies Hydroxymethylglutaryl-CoA reductase inhibitors Metformin

微波合成碳负载纳米铂催化剂及其对甲醇氧化的电催化性能

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化学学报 2004年第1期62卷 42-46页

作者：陈卫祥 lee Jim-Yang 刘昭林浙江大学化学系杭州310027 新加坡材料研究与工程所新加坡117576 新加坡国立大学新加坡-麻省理工学院联合体

利用微波辐射快速加热含有XC 72碳的H2 PtCl6的乙二醇混合液合成了碳负载的纳米铂 ,铂负载的质量分数在10 %～ 2 0 % .实验结果表明纳米铂粒子具有均匀的尺寸和形状 ,其平均粒径在 3 6nm ,并均匀地分散在纳米碳的表面 .循环伏安和恒电... 详细信息

利用微波辐射快速加热含有XC 72碳的H2 PtCl6的乙二醇混合液合成了碳负载的纳米铂 ,铂负载的质量分数在10 %～ 2 0 % .实验结果表明纳米铂粒子具有均匀的尺寸和形状 ,其平均粒径在 3 6nm ,并均匀地分散在纳米碳的表面 .循环伏安和恒电位极化表明微波合成的Pt/C比以KBH4作为还原剂制备Pt/C和商业得到E TEKPt/C催化剂对甲醇的电化学氧化具有更高的催化活性 .

关键词：碳负载纳米铂催化剂甲醇电化学氧化微波合成电催化性能

Comparative study for predictability of type 1 gastric variceal rebleeding after endoscopic variceal ligation:High-frequency intraluminal ultrasound study

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World Journal of Clinical Cases 2021年第34期9卷 10566-10575页

作者： Jeong Hwan Kim Won Hyeok Choe Sun-Young lee So Young Kwon In-Kyung Sung Hyung Seok Park Department of Internal Medicine Konkuk University School of MedicineKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Konkuk University Medical CenterSeoul 143729South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Internal Medicine Digestive Disease CenterKonkuk University School of MedicineSeoul 05030South Korea

BACKGROUND The efficacy of endoscopic ultrasonography for the follow-up of gastric varices treated with endoscopic variceal ligation(EVL)has not been *** To evaluate the diagnostic correlation of esophagogastroduodenoscopy(EGD)and high-frequency intraluminal ultrasound(HFIUS)for type 1 gastric varices(GOV1)after EVL and to identify the predictability for rebleeding of EGD and *** In liver cirrhosis patients with GOV1,we performed endoscopic follow-up using EGD and HFIUS synchronously after EVL for hemorrhage from *** grading and red color signs were analyzed using EGD,and the largest variceal cross-sectional areas were measured using *** addition,1-year follow-up was *** rebleeding was defined as the presence of hematemesis,hematochezia,or melena without other evidence of bleeding on endoscopic *** In 26 patients with GOV1,variceal cross-sectional areas on HFIUS of GOV1 was poorly correlated with EGD grading of GOV1(r=0.36).In 17 patients who completed the 1-year follow-up,variceal cross-sectional areas on HFIUS was a good predictor of subsequent rebleeding,whereas EGD grading was not a predictor of subsequent *** HFIUS measurement is more predictive of GOV1 rebleeding than EGD grading,so HFIUS measurement may be necessary for endoscopic follow-up after EVL in patients with GOV1.

关键词： Endoscopic variceal ligation Esophagogastroduodenoscopy High-frequency intraluminal ultrasound Rebleeding Type 1 gastric varices

Oncological safety of use of ultrasonic activated shears in gastric cancer surgery: Long-term results of randomized controlled trial

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Chinese Journal of Cancer Research 2018年第5期30卷 492-499页

作者： Su Mi Kim Jae-Moon Bae Min-Gew Choi Jun Ho lee Tae Sung Sohn Sung Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine

Objective： Ultrasonically activated shears （UAS） have been applied in open gastric surgeries with no or little evidence. It was previously reported about the surgical outcome and effectiveness of UAS based on a randomized controlled trial of 256 patients with gastric cancer. We aimed to clarify the long-term oncological safety of the use of UAS in the aspect of overall survival and ***： Gastric cancer patients who underwent gastrectomy with D2 lymph node dissection were enrolled and randomly assigned to either the conventional surgery group （n=125） or the UAS group （n=128）. Survival, recurrence and long-term postoperative complications were compared between the two groups. The median follow-up period was 56 ***： Gastric cancer-related death was higher in patients of the UAS group compared with the conventional group （P=0.019）. Overall survival rates stratified by stage were not significantly different between the two groups （P=0.170）. Disease-free survival rates stratified by stage and recurrence-free survival rates of gastric cancer were similar between the conventional group and the UAS group （P=0.313 and 0.199, respectively）. The postoperative complication rate was not significantly different between the groups （P=1.000）. Conclusions： It is suggested that the use of UAS in gastrectomy for gastric cancer showed oncologically acceptable safety compared with conventional electric instruments even in long-term period.

关键词： Stomach cancer gastrectomy ultrasonically activated shears (UAS) oncological safety

Successful treatment of a high-risk nonseminomatous germ cell tumor using etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5334-5340页

作者： Jina Yun Sang W lee Sung H Lim Se H Kim Chan K Kim Seong K Park Department of Internal Medicine Division of Hematology-OncologySoonchunhyang University Bucheon HospitalSoonchunhyang University School of MedicineBucheon 14584South Korea Department of Urology and Internal Medicine Soonchunhyang University Bucheon HospitalSoonchunhyang University School of MedicineBucheon 14584South Korea

BACKGROUND Choriocarcinoma is an infrequent entity and the most aggressive subtype of germcell *** of early metastatic spread and rapid disease progression,choriocarcinoma patients display poor *** etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA-CO)regimen is widely used to treat gestational trophoblastic tumors in females,its role in treating male choriocarcinoma is seldom *** SUMMARY A 32-year-old man was diagnosed with burned-out primary germ cell tumors(GCT)with retroperitoneum,liver and lung *** of the liver revealed pure *** patient received bleomycin,etoposide,and cisplatin *** two cycles of treatment,response evaluation revealed the mixed ***-CO regimen was used in the second-line *** eight cycles,the patient showed a potentially resectable state and thus,all residual masses were surgically *** patient was completely cured,and 10 years later,he is leading a healthy life without *** This paper is the first case of high-risk nonseminomatous GCT in a male patient to be successfully treated with the EMA-CO *** EMA-CO regimen can be used actively in patients with high-risk nonseminomatous GCT.

关键词： Antineoplastic combined chemotherapy protocols Choriocarcinoma Testicular neoplasms Cyclophosphamide Methotrexate Case report

Comparison of renal safety of tenofovir and entecavir in patients with chronic hepatitis B: Systematic review with meta-analysis

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World Journal of Gastroenterology 2019年第23期25卷 2961-2972页

作者： Hyo-Young lee Hyunwoo Oh Chan-Hyuk Park Yee-Hui Yeo Mindie H Nguyen Dae-Won Jun Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri 11923South Korea Division of Gastroenterology and Hepatology Stanford University Medical CenterStanford UniversityStanford 94305CAUnited States

BACKGROUND Recently, the American Association for the Study of Liver Disease suggested no preference between tenofovir(TDF) and entecavir(ETV) regarding potential long-term risks of renal complications. Over the years, renal safety has become a critical concern in nucleos(t)ide analog-treated patients due to the long-term use of these drugs. However, existing studies do not show significant differences in renal dysfunction between these two drugs. Further, there is a paucity of studies comparing the long-term renal effects of TDF and *** To investigate the effects of TDF and ETV on renal function, we performed systematic review and *** Two investigators independently searched the Cochrane Library, MEDLINE, and Embase databases for randomized controlled trials and nonrandomized studies(NRSs) using the keywords 'CHB', 'Tenofovir', and 'Entecavir', and additional references were obtained from the bibliographies of relevant articles published through December 2017. The quality of each study was assessed using the Newcastle-Ottawa scale and the Grading of Recommendations Assessment,Development and Evaluation criteria. The primary outcome was the change in serum creatinine level in the TDF and ETV groups at baseline, 6 mo, 12 mo and24 *** NRSs comprising 2263 participants met the inclusion criteria. Changes in creatinine levels were higher in the TDF group than in the ETV group at 6 mo[mean difference(MD) = 0.03 mg/dL;95%CI: 0.02-0.04;I2 = 0%], 12 mo(MD =0.05 mg/dL;95%CI: 0.02-0.08;I2 = 78%), and 24 mo(MD = 0.07 mg/dL;95%CI:0.01-0.13;I2 = 93%). The change in estimated glomerular filtration rate(eGFR) was significantly higher in the TDF group than in the ETV group at 6 mo[standardized mean difference(SMD),-0.22;95%Cl:-0.36--0.08;I2 = 0%], 12 mo(SMD =-0.24;95%Cl:-0.43--0.05;I2 = 50%), and 24 mo(-0.35;95%Cl:-0.61--0.09;I2= 67%).CONCLUSION TDF statistically significantly increased serum creatinine levels and decreased the eGFR in 6-24 mo compa

关键词： Hepatitis B Chronic Tenofovir Entecavir Safety Review Systematic Meta-analysis

Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第8期22卷 2592-2600页

作者： Myong Ki Baeg Seung Kew Yoon Sun-Hye Ko Yong-Sun Noh In-Seok lee Myung-Gyu Choi Department of Internal Medicine The Catholic University of Korea College of Medicine

AIM: To determine whether Helicobacter pylori (H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease (NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to 13C urea breath tests. NAFLD was defined using the hepatic steatosis index (HSI) and NAFLD liver fat score (NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS > -0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for ***: Three thousand six hundred and sixty-three people were analyzed and 1636 (44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects (median 33.2, interquartile range (IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median -1.7, IQR -2.4 - -0.7 vs median -1.8, IQR -2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differ between infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for ***: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Hepatic steatosis index Nonalcoholic fatty liver disease liver fat score Urea breath test

Complete resection of large-cell neuroendocrine and hepatocellular carcinoma of the liver: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8277-8283页

作者： Byeong Gwan Noh Hyung-Il Seo Young Mok Park Suk Kim Seung Baek Hong So Jeong lee Division of HBP Surgery and Transplantation Department of SurgeryPusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Combined tumors comprising large-cell neuroendocrine carcinoma and hepatocellular carcinoma have been rarely reported in the *** SUMMARY We report a case of a 73-year-old woman with chronic hepatitis B suspected to have a malignant hepatic mass(segment 3;size,4.5 cm)and lymph node metastasis based on computed tomography and magnetic resonance *** being Child-Pugh class A,esophageal varices were *** underwent left lateral sectionectomy and lymph node *** examination revealed a collision tumor consisting of large-cell neuroendocrine(90%)and hepatocellular(10%)*** combined carcinoma had metastasized to one of the three lymph nodes *** patient recovered without any postoperative complications and was discharged in good condition on postoperative day *** chemotherapy was not *** recurrence occurred during a follow-up period of 24 *** To improve the therapeutic management of combined tumors in the liver,it is necessary to discuss each clinical experience and consider an appropriate method for the preoperative diagnosis and treatment.

关键词： Hepatocellular carcinoma Neuroendocrine carcinoma Chronic hepatitis B Case report

Epidemiology and risk factors for sports-and recreation-related eye injury:a multicenter prospective observational study

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 133-140页

作者： Dong Eun lee Hyun Wook Ryoo Sungbae Moon Jae Yun Ahn Jung Ho Kim Jong-Yeon Kim Department of Emergency Medicine Kyungpook National University Chilgok HospitalSchool of MedicineKyungpook National UniversityDaegu 41944Republic of Korea Department of Emergency Medicine Kyungpook National University HospitalSchool of MedicineKyungpook National UniversityDaegu 41944Republic of Korea Department of Emergency Medicine Yeungnam University College of MedicineDaegu 42415Republic of Korea Department of Public Health Kyungpook National University HospitalDaegu 41944Republic of Korea

AIM:To identify the epidemiologic characteristics of sportsand recreation-related eye injuries in a large metropolitan city and investigate risk factors associated with visual ***:We performed a multicenter prospective observational study on patients using the regional eye injury registry *** study included patients with sportsand recreation-related eye injury in four tertiary teaching hospitals in Daegu,Republic of Korea,from August 2016 to July *** primary outcome was visual impairment at the first hospital *** of sex,age,place,and causative materials were analyzed according to causative *** examine the association between causative activities and visual impairment,a Logistic regression analysis was ***:Of the 349 sports-and recreation-related eye injuries,soccer was the most common causative activity,with 21.8%(n=76).Sports-and recreation-related eye injuries occurred mainly in teenagers,individuals in their 20 s,and *** and soccer were significantly associated with visual impairment at the first hospital visit compared with combat sports[(adjusted odds ratio(AOR),5.18;95%confidence interval(CI),1.67-16.09 for badminton and AOR,3.87;95%CI,1.36-10.99 for soccer].CONCLUSION:Intervention efforts such as deployment of protective eyewear in sports facilities and schools and promotion of wearing protective eyewear during these activities in teenagers and individuals in their 20 s are mandatory.

关键词： epidemiology eye injury sports injury prevention