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International Journal of Mental Health Promotion 2023年第11期25卷 1187-1195页

作者： Seungju Hyun Xyle Ku Sungrok Kang Yoonyoung Choi Jaewon Ko Hyunyup lee Department of Psychology Korea Military AcademySeoul01805Korea Department of Psychology Seoul National UniversitySeoul08826Korea

Owing to the ubiquitous use of smartphones by soldiers, military researchers have an increasing interest in potentially problematicside effects such as smartphone overdependence. This raises a question regarding the psychological mechanisms underlying thepotentially self-damaging use of smartphones. Here, we address this question by analyzing how heterogeneity in commander’sgood leadership explains subordinate soldiers’ differences in self-control and smartphone use. Specifically, we found thatsubordinate soldiers who thought their commander's leadership was good were self-regulated, less dependent on smartphones,less stressed, and finally had good mental health. This result indicates that commander’s good leadership can be used toestimate whether subordinate soldiers exert control over their impulses and use their smartphones properly. Thus, the currentfindings help to identify external factors that lead to a better understanding of problematic smartphone use and can potentiallyhelp to design appropriate preventive mechanisms or interventions that target commander’s good leadership.

关键词： Military commander leadership smartphone overdependence soldier mental health

Review of the status of urban flood monitoring and forecasting in TC region

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Tropical Cyclone Research and Review 2022年第2期11卷 103-119页

作者： Jinping Liu Hyo-Seob Cho Sazali Osman Hyeon-Gyo Jeong Kwonmin lee UNESCAP/WMO Typhoon Committe Seccretarist MacaoChina Han River Flood Control Office Ministry of EnvironmentSeoulRepublic of Korea Department of Irrigation and Drainage Ministry of Natural Resources and WaterPutrajayaMalaysia Department of Climate and Energy Systems Engineering Ewha Womans UniversitySeoulRepublic of Korea

With the impacts of rapid urbanization and climate change,the urban flood has increasingly become a major hazard risk faced by human being in recent *** catastrophic urban flood events appear every year in the world,especially in Asia and Pacific region due to its geographical composition,density population and un-even economic and social *** reduce the urban flood risk and enhance the resilience of vulnerable communities,especially coastal communities,the Members of ESCAP/WMO Typhoon Committee(TC)have made their great efforts including engineering and non-engineering measures based on their different national *** a key part of non-engineering measures,it is recognized that improving urban flood monitoring and forecasting is a measure with high benefit related to cost on urban flood risk *** recent years,TC Members enhanced their capacity building on urban flood monitoring,forecasting and simulation,inundation mapping,*** order to enhance the technical cooperation and exchange on this aspect,Typhoon Committee Working Group on Hydrology(WGH)conducted two projects on“Urban Flood Risk Management in Typhoon Committee Area(UFRM)”and“Operation System for Urban Flood Forecasting and Inundation Mapping(OSUFFIM)”in the past *** paper generally reviewed the situation and causes of urban flood in TC region;briefly summarized the progresses and shortages on urban flood monitoring and forecasting in TC Members;and initially discussed the areas to be enhanced in future for improvement of urban flood monitoring,forecasting and simulation,and inundation mapping with up-to-date development of weather radar and satellite monitoring,image-based monitoring,information technology(IT),Internet of Things(IoT),big data and artificial intelligence(AI).

关键词： Urban flood Monitoring Forecasting

Design and Implementation of 10 Gbps Optical Add-Drop Transponder

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光学学报 2003年第S1期23卷 657-658页

作者： Byoung-Sung Kim Seung-Il Myong Jung-Chan lee Je-Soo Ko Network Laboratory Electronics and Telecommunications Research Institute Daejeon Korea.Network Laboratory Electronics and Telecommunications Research Institute Daejeon Korea.Network Laboratory Electronics and Telecommunications Research Institute Daejeon Korea.Network Laboratory Electronics and Telecommunications Research Institute Daejeon Korea.

10 Gbps optical add-drop transponder, which can accommodate VSR (very short reach) to LR (long reach) subnetworks, is designed and implemented. The transponder consists of an OCA (optical transport network connection ... 详细信息

关键词： SONET VSR very LR FEC of Design and Implementation of 10 Gbps Optical Add-Drop Transponder SCA

ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions

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动物学研究(英文) 2023年第5期44卷 848-859页

作者： Ming-Hong Sun Wen-Jie Jiang Xiao-Han Li Song-Hee lee Geun Heo Dongjie Zhou Zhi Chen Xiang-Shun Cui Department of Animal Science Chungbuk National UniversityCheongjuSouth Korea 28644Korea College of Animal Science and Technology Yangzhou UniversityYangzhouJiangsu 225009China

Activating transcription factor 6(ATF6),one of the three sensor proteins in the endoplasmic reticulum(ER),is an important regulator of ER stress-induced ***6 resides in the ER and,upon activation,is translocated to the Golgi apparatus,where it is cleaved by site-1 protease(S1P)to generate an amino-terminal cytoplasmic *** recent studies have made progress in elucidating the regulatory mechanisms of ATF6,its function during early porcine embryonic development under high-temperature(HT)stress remains *** this study,zygotes were divided into four groups:control,HT,HT+ATF6 knockdown,and HT+PF(S1P inhibitor).Results showed that HT exposure induced ER stress,which increased ATF6 protein expression and led to a decrease in the blastocyst ***,ATF6 expression was knocked down in HT embryos under microinjection of ATF6 double-stranded RNA(dsRNA).Results revealed that ATF6 knockdown(ATF6-KD)attenuated the increased expression of CHOP,an ER stress marker,and Ca2+release induced by *** addition,ATF6-KD alleviated homeostasis dysregulation among organelles caused by HT-induced ER stress,and further reduced Golgi apparatus and mitochondrial dysfunction in HT ***2 is an important downstream effector of *** showed that ATF6-KD reduced the occurrence of AIFM2-mediated embryonic apoptosis at *** together,our findings suggest that ATF6 is a crucial mediator of apoptosis during early porcine embryonic development,resulting from HT-induced ER stress and disruption of organelle homeostasis.

关键词： ATF6 Embryo High temperature ER stress Organelle homeostasis

Structural and Dielectric Properties of Dy-doped(Ba,Sr,Ca) TiO_3 Thick Films

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材料科学与工程学报 2007年第6期25卷 928-931页

作者： Hyun-Ji Noh Sung-Gap lee Sang-Man Park Sang-Eun Yun Dept.of ceramic Engineering Eng.Res.Insti.Gyeongsang National University 900 GajwaJinju-siGyeongnam 660-701Korea

Preparation and electrocatalytic activities of Pt-TiO_2 nanotubes(Ba_ 0.57Sr_ 0.33Ca_ 0.10)TiO_3 powders,prepared by the sol-gel method,were doped MnCO_3 as acceptor and Dy_2O_3 as *** powder was mixed with an organic vehicle and BSCT thick films were fabricated by the screen-printing techniques on alumina *** structural and dielectric properties of BSCT thick films were investigated with variation of Dy_2O_3 *** a result of the differential thermal analysis(DTA),exothermic peak was observed at around 670℃ due to the formation of the polycrystalline perovskite *** the BSCT thick films showed the XRD patterns of a typical polycrystalline perovskite *** average grain size of BSCT thick films decreased with increasing amount of Dy_2O_*** relative dielectric constant and dielectric loss of the BSCT thick film doped Dy_2O_3 0.1mol% were 4637.4 and 1.6% at 1kHz,respectively.

关键词：介电性能结构性能镝厚膜丝网印刷术

Tissue-specific Tregs in cancer metastasis:opportunities for precision immunotherapy

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Cellular & Molecular Immunology 2022年第1期19卷 33-45页

作者： Laura A.Huppert Michael D.Green Luke Kim Christine Chow Yan Leyfman Adil I.Daud James C.lee Division of Hematology/Oncology Department of MedicineUniversity of CaliforniaSan FranciscoSan FranciscoCAUSA Department of Radiation Oncology University of Michigan School of MedicineAnn ArborMIUSA Veterans Affairs Ann Arbor Healthcare System Ann ArborMIUSA University of California San Francisco School of MedicineSan FranciscoCAUSA Penn State College of Medicine HersheyPAUSA Parker Institute for Cancer Immunotherapy San FranciscoCAUSA

Decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide longterm treatment responses in certain metastatic cancer ***,cures remain infrequent,and most patients ultimately succumb to treatment-refractory metastatic *** insights suggest that tumors at certain organ sites exhibit distinctive response patterns to immunotherapy and can even reduce antitumor immunity within anatomically distant tumors,suggesting the activation of tissue-specific immune tolerogenic mechanisms in some cases of therapy *** immune cells known as regulatory T cells(Tregs)are present within all tissues in the body and coordinate the suppression of excessive immune activation to curb autoimmunity and maintain immune *** the high volume of research on Tregs,the findings have failed to reconcile tissue-specific Treg functions in organs,such as tolerance,tissue repair,and regeneration,with their suppression of local and systemic tumor immunity in the context of immunotherapy *** improve the understanding of how the tissue-specific functions of Tregs impact cancer immunotherapy,we review the specialized role of Tregs in clinically common and challenging organ sites of cancer metastasis,highlight research that describes Treg impacts on tissue-specific and systemic immune regulation in the context of immunotherapy,and summarize ongoing work reporting clinically feasible strategies that combine the specific targeting of Tregs with systemic cancer *** knowledge of Tregs in the framework of their tissue-specific biology and clinical sites of organ metastasis will enable more precise targeting of immunotherapy and have profound implications for treating patients with metastatic cancer.

关键词： Tissue Tregs Immunotherapy Organ-specific tolerance Metastasis Cancer

Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation

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Neural Regeneration Research 2020年第8期15卷 1483-1489页

作者： Su Hwan Bae Mi Ran Yoo Ye Yeong Kim In Kyung Hong Mi Hee Kim Seung Hak lee Dae Yul Kim Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

Macrophage migration inhibitory factor(MIF)is a chemokine that plays an essential role in immune system *** studies suggested that MIF protects neurons in ischemic ***,few studies are reported on the role of MIF in neurological recovery after ischemic *** purpose of this study is to identify the molecular mechanism of neuroprotection mediated by *** neuroblastoma cells were incubated in Dulbecco’s modified Eagle’s medium under oxygen-glucose deprivation(OGD)for 4 hours and then returned to normal aerobic environment for reperfusion(OGD/R).30 ng/mL MIF recombinant(30 ng/mL)or ISO-1(MIF antagonist;50μM)was administered to human neuroblastoma *** cell cultures were assigned to one of four groups:control,OGD/R,OGD/R with MIF,OGD/R with *** viability was analyzed using WST-1 *** levels of brain-derived neurotrophic factor(BDNF),microtubule-associated protein 2(MAP2),Caspase-3,Bcl2,and Bax were detected by western blot assay and immunocytochemistry in each group to measure apoptotic ***-1 assay results revealed that compared to the OGD/R group,cell survival rate was significantly higher in the OGD/R with MIF group and lower in the OGD/R with ISO-1 *** blot assay and immunocytochemistry results revealed that expression levels of BDNF,Bcl2,and MAP2 were significantly higher,and expression levels of Caspase-3 and Bax were significantly lower in the MIF group than in the OGD/R *** levels of BDNF,Bcl2,and MAP2 were significantly lower,and expression levels of Caspase-3 and Bax were significantly higher in the ISO-1 group than in the OGD/R *** administration promoted neuronal cell survival and induced high expression levels of BDNF,MAP2,and Bcl2(anti-apoptosis)and low expression levels of Caspase-3 and Bax(pro-apoptosis)in an OGD/R *** results suggest that MIF administration is effective for inducing expression of BDNF and leads to neuroprotection of neuronal cells

关键词： apoptosis brain-derived neurotrophic factor hypoxia in vitro ischemic stroke macrophage migration inhibitory factor nerve regeneration neuroprotective effect reperfusion

Challenges of Artificial Intelligence in Space Medicine

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Space(Science & Technology) 2022年第1期2022卷 363-369页

作者： Ethan Waisberg Joshua Ong Phani Paladugu Sharif Amit Kamran Nasif Zaman Andrew G.lee Alireza Tavakkoli University College Dublin School of Medicine BelfieldDublinIreland Michigan Medicine University of MichiganAnn ArborMichiganUSA Brigham and Women’s Hospital Harvard Medical SchoolBostonMassachusettsUSA Human-Machine Perception Laboratory Department of Computer Science and EngineeringUniversity of NevadaRenoRenoNevadaUSA Center for Space Medicine Baylor College of MedicineHoustonTexasUSA Department of Ophthalmology Blanton Eye InstituteHouston Methodist HospitalHoustonTexasUSA

The human body undergoes many changes during long-duration spaceflight including musculoskeletal,visual,and behavioral *** of these microgravity-induced effects serve as potential barriers to future exploration *** advent of artificial intelligence(AI)in medicine has progressed rapidly and has many promising applications for maintaining and monitoring astronaut health during ***,the austere environment and unique nature of spaceflight present with challenges in successfully training and deploying successful systems for upholding astronaut health and mission *** this article,the dynamic barriers facing AI development in space medicine are *** diverse challenges range from limited astronaut data for algorithm training to ethical/legal considerations in deploying automated diagnostic systems in the setting of the medically limited space *** to address these challenges is then discussed and future directions for this emerging field of research.

关键词： legal directions barriers

Nuclear and chloroplast genome diversity revealed by low-coverage whole-genome shotgun sequence in 44 Brassica oleracea breeding lines

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Horticultural Plant Journal 2021年第6期7卷 539-551页

作者： Sampath Perumal Nomar Espinosa Waminal Jonghoon lee Hyun-Jin Koo Boem-soon Choi Jee Young Park Kyounggu Ahn Tae-Jin Yang Department of Agriculture Forestry and BioresourcesPlant Genomics and Breeding Instituteand Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Global Institute for Food Security University of Saskatchewan421 Downey RoadSaskatoonSK S7N 4L8Canada Agriculture and Agri-Food Canada 107 Science PlaceSaskatoon S7N 0X2Canada Chromosome Research Institute Department of Life ScienceSahmyook UniversitySeoul 01795Republic of Korea Joeun Seeds.Co. LtdGoesan-GunChungcheongbuk-Do 367-833Republic of Korea Phyzen Genomics Institute 13Seongnam-daero 331beon-gilBundang-guSeongnam-siGyeonggi-do 13558Republic of Korea

Whole-genome shogun sequence(WGS)data generated by next-generation sequencing(NGS)platforms are a valuable resource for crop *** produced 5–6×WGS coverage of 44 Brassica oleracea breeding lines representing seven subspecies/morphotypes:cabbage,broccoli,cauliflower,kailan,kale,Brussels sprout,and kohlrabi to systematically evaluate the nuclear and chloroplast(Cp)diversity in the 44 *** breeding *** then exploited the impact of low-coverage NGS by evaluating nuclear genome diversity and assembly,annotation of complete chloroplast(Cp)genomes and 45 S nuclear ribosomal DNA(45S nrDNA)sequences,and copy number variation for major *** genome diversity analysis has revealed a total of 496463 SNPs and 37493 indels in the nuclear genome across the 44 ***,some SNPs showed subspecies enrichment at certain chromosomal *** assembly of complete Cp genomes contained 153361–153372 bp with 37 variants including SNPs and *** 45S nrDNA transcription unit was 5802 bp long with a total of 31 SNPs from the 44 *** phylogenetic tree inferred from the nuclear and Cp genomes coincided and clustered broccoli,cauliflower,and kailan in one group and cabbage,Brussels sprout,kale,and kohlrabi in another *** morphotypes diverged during the last 0.17 million *** Cp genome diversity reflected the unique cytoplasm of each subspecies,and revealed that the cytoplasm of many breeding lines was replaced and intermingled via inter-subspecies crosses during the breeding process *** polymorphic Cp markers provide a classification system for the cytoplasm types in ***,copy numbers of major transposable elements(TEs)showed high diversity among the 44 accessions,indicating that many TEs have become active ***,we demonstrated a comprehensive utilization of low-coverage NGS data and might shed light on the genetic diversity and evolution of diverse *** morphotypes.

关键词： Brassica oleracea subspecies Chloroplast genome Nuclear ribosomal DNA Genetic diversity Phylogeny

Biology by the numbers on the Hawaiian Islands

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Frontiers of Electrical and Electronic Engineering in China 2013年第3期8卷 221-226页

作者： Rajat Bhatnagar Russell M. Gordley Volkan Sevim Connie M. lee Center for Systems and Synthetic Biology University of California San Francisco San Francisco CA 94158 USA Department of Biochemistry and Biophysics California Institute for Quantitative Biosciences University of California San Francisco San Francisco CA 94158 USA Department of Cellular and Molecular Pharmacology University of California San Francisco San Francisco CA 94158 USA Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco CA 94158 USA

One could imagine it might be hard to focus on science at a beautiful location such as the famous Waikiki Beach on Oahu Island, Hawaii. Amazingly, however, that＇s just what more than 330 participants did at the First... 详细信息

关键词： Artemisinin Synthetic Biology Artemisinic Acid Craig Venter Synthetic Biology Approach