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中国药理学通报 2004年第10期20卷 1102-1106页

作者：张小莺郑礼 Rüdiger Schade Horacio Raul Terzolo hanibal pablo chacana Joanna Porankiewicz-Asplund 德国洪堡大学药理毒理研究所中国医药研究开发中心有限公司北京102206

IgY技术正在成为生物技术领域和医药研究中的新热点 ,并且越来越得到国内同仁的重视。因为卵黄抗体 (IgY)化学性质稳定 ,产量高、成本低 ,以及动物种系距离的优势 ,更适于生产特异性抗体 ,具有开发功能性食品和新药的潜能。作为系列介... 详细信息

IgY技术正在成为生物技术领域和医药研究中的新热点 ,并且越来越得到国内同仁的重视。因为卵黄抗体 (IgY)化学性质稳定 ,产量高、成本低 ,以及动物种系距离的优势 ,更适于生产特异性抗体 ,具有开发功能性食品和新药的潜能。作为系列介绍的第二部分 ,本文详细介绍和探讨免疫鸡产生IgY抗体技术的主要技术环节和实践应用方面的具体信息 ,包括动物饲养 ,对鸡的免疫 ,抗体特性 ,IgY提取技术 ,鸡单克隆抗体的制备等方面。

关键词： IgY IgY技术卵黄抗体 IgY制备

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Prognostic Significance of CD31 Expression in Patients with Non-Small-Cell-Lung Cancer

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Advances in Lung Cancer 2016年第3期5卷 21-29页

作者： Alexander Emmert Angelika Oellerich Laszlo Füzesi Regina Waldmann-Beushausen hanibal Bohnenberger Friedrich A. Schöndube Bernhard C. Danner Department of Thoracic and Cardiovascular Surgery University of Gottingen Gottingen Germany Department of Pathology University of Gottingen Gottingen Germany

Non-small cell lung cancer (NSCLC) is the primary cause of cancer related death worldwide. After resection of early stage NSCLC, the benefit of adjuvant chemotherapy for patient survival still remains unclear and investigations for further risk stratification are needed for an improved treatment decision. Microvessel density (MVD) influences both the nutrition of the cancer and the access to the bloodstream for the development of distant metastasis. The aim of this study was to examine the prognostic significance of microvessel density by CD31 staining in patients with resected stage IA-IIIB NSCLC. We used immunohistochemistry (IHC) of CD31 to examine the microvessel density in a cohort of 69 patients who had undergone radical resection for NSCLC. Correlation of IHC values and standard clinicopathologic parameters was analyzed as well as influence on long term survival. Survival analysis revealed a significant better overall survival for patients with higher median microvessel density (log rank p = 0.031) independent of clinicopathologic parameters. Regarding primary cancer related death, the survival was again significantly longer in patients with high CD31 count (log rank p = 0.036). A higher microvessel density was a strong predictor for a longer tumor related survival and could be used for therapeutic decisions of adjuvant chemotherapy after resection of early stage NSCLC.

关键词： NSCLC CD-31 Neoangiogenesis

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Prognostic Significance of Pigment Epithelium-Derived Factor Expression in Patients with Non-Small-Cell-Lung Cancer

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Advances in Lung Cancer 2016年第3期5卷 30-38页

作者： Alexander Emmert Angelika Oellerich Laszlo Füzesi Regina Waldmann-Beushausen Friedrich A. Schöndube hanibal Bohnenberger Bernhard C. Danner Department of Thoracic and Cardiovascular Surgery University Medical Center Gottingen Gottingen Germany Institute of Pathology University Medical Center Gottingen Gottingen Germany

The aims of this study were to examine prognostic significance of pigment epithelium-derived factor (PEDF) in patients with stage IA-IIIB non-small cell lung cancer (NSCLC). Using immunohistochemistry and multivariate analysis, we set out to investigate whether PEDF expression could provide prognostic information in NSCLC in a cohort of 69 patients who had undergone radical resection for NSCLC. The correlation between PEDF and the clinical pathological features of stage I-III NSCLC after radical surgery were analyzed as well as influence on long term survival. No correlation between PEDF intensity, PEDF area or PEDF area index and clinic opathologic parameters was seen. PEDF values showed a slight correlation to the tumor stage. There was a significant negative correlation (T = -0.288, p = 0.002) between pathologic T-stage and median PEDF area and vice versa a positive correlation (T = 0.227, p = 0.016) with median PEDF intensity. We could not detect any correlation between PEDF and long term survival. For PEDF analysis, there was only a slight correlation between expression and T-stage of the tumor.

关键词： NSCLC PEDF Neoangiogenesis

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Interplay between Platelet Endothelial Cell Adhesion Molecule-1 and Pigment Epithelium-Derived Factor in Non-Small-Cell-Lung Cancer

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Open Journal of Thoracic Surgery 2016年第4期6卷 47-56页

作者： Alexander Emmert Angelika Oellerich Laszlo Füzesi Regina Waldmann- Beushausen Friedrich A. Schöndube hanibal Bohnenberger Bernhard C. Danner Department of Thoracic and Cardiovascular Surgery University Medical Center G&ouml ttingen G&ouml ttingen Germany Institute of Pathology University Medical Center G&ouml ttingen G&ouml ttingen Germany

Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, is a multifunctional protein with important roles in regulation of inflammation and angiogenesis. It has recently attracted attention for targeting tumor cells in several types of tumors. PECAM-1 is an integral membrane protein, a cell adhesion molecule with proangiogenic activity and plays an important role in the process of angiogenesis. The correlation between proangiogenic activity PECAM-1 and antiangiogenic activity PEDF in Non-Small-Cell-Lung Cancer has not been reported. The present study was designed to evaluate using immunohistochemical techniques and multivariate analysis the interplay between PECAM-1 and PEDF in NSCLC, especially in adenocarcinoma and in squamous cell carcinoma stage IA-IIIB. Analyzing the mixed study collectively (n = 69), there was no significant correlation (p = 0.553) between PECAM-1 signal and PEDF area. Only including patients with adenocarcinoma (Figure 2), we found a positive correlation between PECAM-1 signal and PEDF area (p = 0.025). In patients with squamous cell carcinoma, we did not find a significant correlation between PECAM-1 signal and PEDF area (p = 0.530). In patients with squamous cell carcinoma, PECAM-1 and PEDF show a significant different expression pattern, measured via staining intensity (p = 0.013). These results might support the hypothesis that squamous cell carcinomas heavily rely on angiogenic processes.

关键词： NSCLC PEDF PECAM-1 Neoangiogenesis

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