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Multidisciplinary management of ulcerative colitis complicated by immune checkpoint inhibitor-associated colitis with life-threatening gastrointestinal hemorrhage:A case report

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2329-2336页

作者： Na Hong Bo Wang hang-cheng zhou Zheng-Xiang Wu Hua-Ying Fang Geng-Qing Song Yue Yu Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Department of Gastroenterology and Hepatology Metro Health Medical CenterCase Western Reserve UniversityClevelandOH 44109United States

BACKGROUND Programmed cell death 1(PD-1)inhibitors are immune checkpoint inhibitors(ICI)that have demonstrated significant efficacy in treating various advanced malignant *** most patients tolerate treatment well,several adverse drug reactions,such as fatigue,myelosuppression,and ICI-associated colitis,have been *** SUMMARY This case involved a 57-year-old male patient with ulcerative colitis complicated by hepatocarcinoma who underwent treatment with tirelizumab(a PD-1 inhibitor)for six *** treatment led to repeated life-threatening lower gastrointestinal *** patient received infliximab,vedolizumab,and other salvage procedures but ultimately required subtotal colectomy due to uncontrollable massive lower gastrointestinal ***,postoperative gastrointestinal bleeding has stopped,the patient’s stool has turned yellow,and his full blood cell count has returned to *** This case highlights the necessity of early identification,timely and adequate treatment of ICI-related colitis,and rapid escalation to achieve the goal of improving prognosis.

关键词： Ulcerative colitis Hepatocarcinoma Immune checkpoint inhibitor-associated colitis Colectomy Case report

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Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 331-342页

作者： Hua-Chuan Song hang-cheng zhou Ping Gu Bing Bao Quan Sun Tian-Ming Mei Wei Cui Kang Yao Huan-Zhang Yao Shen-Yu Zhang Yong-Shuai Wang Rui-Peng Song Ji-zhou Wang Department of General Surgery Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastrointestinal Surgery Tongcheng People’s HospitalTongcheng 231400Anhui ProvinceChina Department of Gastrointestinal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of General Surgery Xuancheng People’s HospitalXuancheng 242000Anhui ProvinceChina

BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of *** chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of ***,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative *** mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour *** studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with *** To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for *** A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July *** and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological *** Kaplan-Meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low ***<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour *** Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)*** rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1

关键词： Colorectal liver metastases Body mass index Tumour regression grade Preoperative chemotherapy Hepatectomy

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New insight into Ca^(2+)-permeable channel in plant immunity

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Journal of Integrative Plant Biology 2024年第3期66卷 623-631页

作者： Wei Wang hang-Yuan cheng Jian-Min zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Calcium ions(Ca^(2+)) are crucial intracellular second messengers in eukaryotic cells. Upon pathogen perception, plants generate a transient and rapid increase in cytoplasmic Ca^(2+)levels, which is subsequently decoded by Ca^(2+)sensors and effectors to activate downstream immune responses. The elevation of cytosolic Ca^(2+)is commonly attributed to Ca^(2+)influx mediated by plasma membranelocalized Ca^(2+)–permeable channels. However, the contribution of Ca^(2+)release triggered by intracellular Ca^(2+)-permeable channels in shaping Ca^(2+)signaling associated with plant immunity remains poorly understood. This review discusses recent advances in understanding the mechanism underlying the shaping of Ca^(2+)signatures upon the activation of immune receptors, with particular emphasis on the identification of intracellular immune receptors as non-canonical Ca^(2+)-permeable channels. We also discuss the involvement of Ca^(2+)release from the endoplasmic reticulum in generating Ca^(2+)signaling during plant immunity.

关键词： Ca^(2+)-permeable channels endoplasmic reticulum phosphorylation plant immunity resistosome

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Highly efficient and stable 2D/3D perovskite solar cells based on surface reconstruction and energy level alignment

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Science China Chemistry 2024年第9期67卷 3083-3090页

作者： Qiaohui Li hang Liu Tong zhou Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-PlasticsQingdao University of Science and TechnologyQingdao 266042China The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China

Realizing simultaneous adjustment of energy levels and work functions in two-dimensional/three-dimensional(2D/3D)perovskite solar cells(PSCs)is a ***,a pseudohalide 3,5-bis(trifluoromethyl)benzylammonium tetrafluoroborate(TFPMABF_(4))was used to react with unreacted Pb I2on the surface of 3D bulky perovskite to form a mixed halide of 2D perovskite denoted(TF-PMA)_(2)FA_(2)Pb_(3)I_(8)(BF_(4))_(2).This novel 2D/3D perovskite enables the simultaneous adjustment of energy levels and work functions on the surface of active *** to the significantly enhanced quality of 2D/3D perovskite film,decreased surface defects and increased charge carrier lifetime,the 2D/3D PSCs exhibit an outstanding power conversion efficiency(PCE)of 25.15%and a high V_(OC)of 1.194 ***,2D/3D PSCs exhibit remarkable enhancements in environmental stability,unencapsulated devices retaining more than 90%of their initial PCE at 50%humidity for 2,280 h.

关键词： 2D/3D perovskite perovskite solar cells organic spacers energy levels alignment

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Design of integral sliding mode guidance law based on disturbance observer

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Journal of Systems Engineering and Electronics 2024年第1期35卷 186-194页

作者： zhou Jianping Zhang Wenjie zhou hang LI Qiang XIA Qunli School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Informatic Engineering Mianyang Techers’CollegeMianyang 62100China Beijing Institute of Electronic System Engineering Beijing 100854China Beijing Institute of Space Long March Vehicle Beijing 100076China

With the increasing precision of guidance,the impact of autopilot dynamic characteristics and target maneuvering abilities on precision guidance is becoming more and more *** order to reduce or even eliminate the autopilot dynamic operation and the target maneuvering influence,this paper suggests a guidance system model involving a novel integral sliding mode guidance law(ISMGL).The method utilizes the dynamic characteristics and the impact angle,combined with a sliding mode surface scheme that includes the desired line-ofsight angle,line-of-sight angular rate,and second-order differential of the angular *** the same time,the evaluation scenario considere the target maneuvering in the system as the external disturbance,and the non-homogeneous disturbance observer estimate the target maneuvering as a compensation of the guidance *** proposed system’s stability is proven based on the Lyapunov stability *** simulations reveale that ISMGL effectively intercepted large maneuvering targets and present a smaller miss-distance compared with traditional linear sliding mode guidance laws and trajectory shaping guidance ***,ISMGL has a more accurate impact angle and fast convergence speed.

关键词： disturbance observer pilot dynamics integral sliding mode impact angle constraint maneuvering target

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Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin-like peptide

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Insect Science 2024年第4期31卷 1090-1106页

作者： Yi Wei Xiao-Lin zhou Peng Chen Tai-hang Liu cheng Lu Min-Hui Pan State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest UniversityChongqingChina Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang ProvinceChina

The ovary generally undergoes tissue remodeling during larval to pupal transition,which includes membrane degeneration and ovariole *** the same time,the hormones produced by insects significantly change during ***,the regulatory mechanism for ovarian development and hormones is not fully understood in ***,we found that matrix metalloproteinase 2(MMP2)was highly expressed in the ovarian capsules and ovarioles,and the development was abnormal after knocking out MMP2 in Bombyx *** process of abnormal degradation of collagen I due to MMP2 deletion,which resulted in abnormal development of ovarioles and eggs,was analyzed in *** proteomics of ovaries in the MMP2-knock out and wild type strains showed a critically significant difference in the expression of a protein,insulin-like peptide(ILP).Additional analysis revealed significant alteration of ILP during ovarian development,and abnormal expression of ILP significantly affected ovarian development in vivo and MMP2 expression in vitro and in *** results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP *** study provides new insights into the regulatory mechanism of MMP2 and ovarian development in ***.

关键词： Bombyx mori collagen I insulin-like peptide matrix metalloproteinase ovarian development

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Development of underwater electric manipulator based on interventional autonomous underwater vehicle (AUV)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 238-250页

作者： Xiaohui HU Jiawang CHEN hang zhou Ziqiang REN Ocean cllege Zhejiang UniversityZhoushan 316021China Hainan Institute Zhejiang UniversitySanya 572025China The Engineering Research Center of Oceanic Sensing Technology and Equipment Ministry of EducationZhoushan 316021China

In applications such as marine rescue,marine science,archaeology,and offshore industries,autonomous underwater vehicles(AUVs)are frequently used for survey missions and monitoring tasks,with most operations being performed by manned submersibles or remotely operated vehicles(ROVs)equipped with robotic arms,as they can be operated remotely for days without ***,they require expensive marine vessels and specialist pilots to operate *** exploring oceans are no longer satisfied with the use of manned submersibles and *** is a growing desire for seabed exploration to be performed using smarter,more flexible,and automated *** improving the field operation and intervention capability of AUVs,large-scale and long-range seafloor exploration and sampling can be performed without the support of a mother ship,making it a more effective,economical,convenient,and rapid means of seafloor exploration and sampling operations,and playing a critical role in marine resource *** this study,we explored the integration technology of underwater electric robotic arms and AUVs and designed a new set of electric manipulators suitable for water depths greater than 500 *** reliability of the key components was analyzed by finite element analysis and,based on the theory of robot kinematics and dynamics,simulations were performed to verify the reliability of the key *** were conducted on land and underwater,trajectory tracking experiments were completed,and the experimental data in air and water were compared and ***,the objectives for further research on the autonomous control of the manipulator underwater were proposed.

关键词： Underwater electric manipulator Inverse kinematics Trajectory planning Trajectory tracking accuracy

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In-situ defect passivation assisted three-step printing of efficient and stable formamidine-lead bromide solar cells

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Journal of Energy Chemistry 2024年第9期96卷 396-405页

作者： hang Yang Tao zhou Haoyu Cai Wenjian Shen Hao Chen Yongjun Liu Juan Zhao Yi-Bing cheng Jie Zhong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528216GuangdongChina School of Automobile Engineering Wuhan University of TechnologyWuhan 430070HubeiChina

Perovskite solar cells(PSCs)emerge as the most promising photovoltaics(PV)for their high performance and potential convenient cost-effective production routes comparing to the sophomore PV *** printed PSCs with simplified device architecture and fabrication procedures could further enhance the competitive strength of PSC *** this work,we present an in-situ defect passivation(ISDP)assisted full-printing of high performance formamidine-lead bromide(FAPbBr_(3))*** three rapid printing steps are involved for electron transporting layer(ETL),perovskite and carbon to form a complete solar cell on the low-cost fluorine-doped tin oxide(FTO)***-chain polymer monomethyl ether polyethylene glycol is particularly utilized as the ISDP passivator,leading to conformal coating on the rough FTO and defect passivation for both ETL and perovskite during printing.A high efficiency of 10.85%(certified 10.14%)and a high V_(oc)up to 1.57 V are achieved for the printed *** unencapsulated PSCs maintain above 90%of the initial efficiency after continuously heating at 85℃for 1000 h and over 80%of the efficiency after the maximum power point tracking for 3500 *** fully printed semitransparent PSCs with carbon grids(CGs)show average visible light transmittance over 33%and an efficiency of 8.81%.

关键词： Formamidinium lead bromide Fully printed Lowcosts Carbon electrode Semitransparent

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Random gradient-free method for online distributed optimization with strongly pseudoconvex cost functions

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Control Theory and Technology 2024年第1期22卷 14-24页

作者： Xiaoxi Yan cheng Li Kaihong Lu hang Xu School of Electrical and Information Engineering Jiangsu UniversityZhenjiang212013JiangsuChina College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao266590ShandongChina

This paper focuses on the online distributed optimization problem based on multi-agent systems. In this problem, each agent can only access its own cost function and a convex set, and can only exchange local state information with its current neighbors through a time-varying digraph. In addition, the agents do not have access to the information about the current cost functions until decisions are made. Different from most existing works on online distributed optimization, here we consider the case where the cost functions are strongly pseudoconvex and real gradients of the cost functions are not available. To handle this problem, a random gradient-free online distributed algorithm involving the multi-point gradient estimator is proposed. Of particular interest is that under the proposed algorithm, each agent only uses the estimation information of gradients instead of the real gradient information to make decisions. The dynamic regret is employed to measure the proposed algorithm. We prove that if the cumulative deviation of the minimizer sequence grows within a certain rate, then the expectation of dynamic regret increases sublinearly. Finally, a simulation example is given to corroborate the validity of our results.

关键词： Multi-agent system Online distributed optimization Pseudoconvex optimization Random gradient-free method

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Fabricating functionally graded Fe-Cr-Co permanent magnetic alloys via laser powder bed fusion

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Journal of Iron and Steel Research International 2024年第3期31卷 729-737页

作者： Ya-zhou He Ya-qing Hou Peng Shen Hao Zhang Dong zhou hang Su Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China Material Digital R&D Center China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China

Laser powder bed fusion(LPBF)in-situ alloying technology offers the possibility to construct gradient materials with varied structures and *** graded Fe-Cr-Co permanent magnetic alloys were fabricated by LPBF and in-situ alloying mixed powders of Fe,Cr,and Co *** effects of different Fe,Cr and Co contents on the microstructure,magnetic properties and hardness of Fe-Cr-Co alloys prepared by LPBF were *** as-built Fe-Cr-Co alloys present a single body-centered-cubic phase and have a homogeneous distribution of *** mechanical properties and magnetic properties of the compositionally graded sample show a gradient *** the increase in Cr content,the Vickers hardness of the sample increases,and the saturation magnetization of the sample *** optimal magnetic properties in an isotropic state are given as coercivity HcB=21.65 kA/m,remanence Br=0.70 T and energy product(BH)_(max)=5.35 kJ/m^(3),which are comparable to or higher than the reported magnetic properties in an isotropic state prepared by traditional powder *** in-situ alloying technology has the potential to further explore Fe-Cr-Co magnetic materials,such as those consisting of multiple or more constituent elements,and to maximize the compositional flexibility of magnetic materials.

关键词： Fe-Cr-Co alloy Laser powder bed fusion In-situ alloying Functional material Magnetic property

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