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Ensemble projections of climate and streamflow in a typical basin of semi-arid steppes in Mongolian Plateau of 2021-2100

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Advances in Climate Change Research 2024年第2期15卷 230-243页

作者： hang pan Jian-Ping TANG Liang CHENG Man-Chun LI Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China

The Kherlen River is the main water source for Hulun Lake,the largest lake in northern *** to reduced inflow from the Kherlen River,Hulun Lake experienced rapid shrinkage at the beginning of the 21st century,posing a serious threat to the ecological security of northern ***,there is still a significant lack of projections regarding future climate change and its hydrological response in the Kherlen River *** study analyzed the projected climate and streamflow changes in the Kherlen River basin,a vital yet vulnerable international semi-arid steppes type basin.A combination of multi-model ensemble projection techniques,and the soil and water assessment tool(SWAT)model was employed to examine the spatio-temporal changes in precipitation,temperature,streamflow,and the associated uncertainties in the *** temperature(an increase of 1.84-6.42℃)and the precipitation(an increase of 15.0-46.0 mm)of Kherlen River basin are projected to increase by 2100,leading to a rise in streamflow(1.08-4.78 m^(3) s^(-1)).The upstream of the Kherlen River exhibits remarkable increasing trends in precipitation,which has a dominant influence on streamflow of Kherlen *** increases in streamflow are observed in April,August,September,and October compared to the reference period(1971-2000).These findings suggest a partial alleviation of water scarcity in the Kherlen River,but also an increased likelihood of hydrological extreme *** projected temperature increase in the Kherlen River basin exhibits the smallest uncertainty,while more pronounced uncertainties are found in precipitation and *** spread among the results of CMIP6 models is greater than that of CMIP5 models,with lower signal-to-noise ratio(SNR)values for temperature,precipitation,and streamflow.

关键词： Climate change Flow projection Uncertainty SWAT Mongolian Plateau

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Hematopoietic aging:Cellular,molecular,and related mechanisms

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Chinese Medical Journal 2024年第11期137卷 1303-1312页

作者： Li Ye Chuan Tian Ye Li hang pan Jinxiu Hu Liping Shu Xinghua pan The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan ProvinceKunming Key Laboratory of Stem Cell and Regenerative MedicineBasic Medical Laboratory920th Hospital of Joint Logistics Support ForcePLAKunmingYunnan 650032China Department of Immunology of School of Basic Medicine of Guizhou Medical University National and Local Joint Engineering Laboratory of Cell Engineering Biomedical TechnologyKey Laboratory of Regenerative Medicine of Guizhou ProvinceState Key Laboratory of Efficacy and Utilization of Medicinal Plants Co-constructed by Province and MinistryKey Laboratory of Translational Research of Adult Stem Cell of Chinese Academy of Medical SciencesGuiyangGuizhou 550025China

Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow ***-related alterations in the inflammatory response,immunity,and stem cell niches are at the root of hematopoietic *** the molecular mechanisms underlying hematopoietic and bone marrow aging can aid the clinical treatment of aging-related *** particular,it is unknown how the niche reprograms hematopoietic stem cells(HSCs)in an age-dependent manner to maintain normal hematopoiesis in elderly ***,specific inhibitors and blood exchange methods have been shown to reshape the hematopoietic niche and reverse hematopoietic ***,we present the latest scientific discoveries related to hematopoietic aging and hematopoietic system rejuvenation,discuss the relationships between hematopoietic niche aging and HSC aging,and describe related studies on stem cell-mediated regulation of hematopoietic aging,aiming to provide new ideas for further study.

关键词： Stem cells Hematopoietic stem cell Niche Hematopoietic aging

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Ultrahigh-throughput screening of antagonistic bacteria against Erwinia carotovora Ecc15 based on droplet microfluidics

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Food Science and Human Wellness 2024年

作者： Longfeng Wei Shuang Li hang pan Xingjin Jian Renli Ai Zhu Li Chong Zhang Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education)， College of Life Sciences/Institute of Agro-bioengineering， Guizhou University Guizhou Key Laboratory of Agricultural Biotechnology Department of Chemical Engineering， Institute of Biochemical Engineering， Tsinghua University Key Laboratory of Industrial Biocatalysis， Ministry of Education， Tsinghua University

Soft rot is a destructive disease that inflicts significant losses on agricultural production and the economy post-harvest. Biocontrol strategies based on antagonistic microorganisms have a broad application prospect to fight against plant pathogens. This study utilized fluorescence-activated droplet sorting （FADS） technology as an alternative to traditional plate culture methods to isolate microorganisms with antagonistic activity against the soft rot pathogen Erwinia carotovora Ecc15. Initially， the culture performance of the FADS platform was evaluated by analyzing bacterial diversity in droplet culture samples and agar plate culture samples， our data showed that droplet culture exhibited higher species richness and diversity than plate culture， and more than 95% of the OTUs in the droplet samples belonged to the rare biosphere. Additionally， we developed a GFP-Ecc15-based FADS screening system， which achieved an enrichment ratio of up to 148. Using this system， we successfully screened 32 antagonistic bacteria from rhizosphere soil sample of healthy konjac plants， and some may be novel microbial resources， including the genera Lelliottia， Buttiauxella and Leclercia. Notably， strain D-62 exhibited the strongest antibacterial ability against Ecc15， with an inhibition zone diameter of （20.86 ± 1.56） mm. In vivo experiments conducted on the corms of Amorphophallus konjac demonstrated that strain D-62 could effectively reduce the infection ability of Ecc15 to the corms， indicating that strain D-62 has the potential to be developed as a biocontrol agent. Our findings suggested that the FADS screening system showed a screening efficiency approximately 3 × 103times higher than plate screening system， while significantly reducing costs of infrastructure， labor and consumables， it provides theoretical guidance for the screening of other plant pathogen biocontrol bacteria.

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Polycystic ovary syndrome: pathogenic mechanisms and nutritional therapeutic strategies

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Food Science and Human Wellness 2024年

作者： Yanyan Zhao Bin Liu Junying Zhao Yanpin Liu hang pan Yuying Yuan Xiaoyan Tian Weicang Qiao Zhenzhen Zhang Lijun Chen School of Public Health， Shandong Second Medical University National Engineering Research Center of Dairy Health for Maternal and Child， Beijing Sanyuan Foods Co.Ltd. Beijing Engineering Research Center of Dairy， Beijing Technical Innovation Center of Human Milk Research， Beijing Sanyuan Foods Co.Ltd. Key Laboratory of Dairy Science， Ministry of Education， Food Science College， Northeast Agricultural University

Polycystic ovary syndrome (PCOS) is the most common endocrine disease afflicting women of childbearing age. It is characterized by irregular menstruation， clinical or biochemical hyperandrogenemia， and polycystic ovary morphology. As a complex endocrine-metabolic syndrome， PCOS shares several endocrine-metabolic features with the metabolic syndrome (MS)， with insulin resistance at the core of their pathogenic mechanisms. PCOS and MS are interrelated and thus have similarities in treatment. Currently， the common treatment modalities for both are lifestyle intervention， medication， and surgery. More studies have shown that lifestyle intervention and regulation of intestinal flora are more effective and sustainable. However， progress towards treatment and cure is hampered by unclear etiology and mechanisms. This review aimed to summarize the relationship between PCOS and MS， the pathogenesis of metabolic disorders， and the current nutritional therapeutic strategies， especially lifestyle modifications and modulation of intestinal flora. Lifestyle interventions combined with the regulation of gut flora can be a new perspective for treatment. This perspective has a positive significance in the early diagnosis， adoption of personalized treatment plans， and prevention of complications in PCOS and MS. The need to prevent the occurrence of MS in patients with PCOS should be emphasized.

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Water storage changes in the North China Plain from 2004 to 2019

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Science China(Technological Sciences) 2023年第7期66卷 2036-2046页

作者： CHEN MinLan XU YuYue pan hang WANG LuHan School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China National Earth System Science Data Center National Science and Technology Infrastructure of ChinaBeijing 100101China

In the past few decades,the irrational use of water resources has resulted in many issues such as land subsidence in the North China Plain(NCP),hindering its socio-economic *** accurate understanding of water resource changes is important for the allocation of water resources in the *** this study,we employed Gravity Recovery and Climate Experiment(GRACE) satellite data to monitor the total water storage(TWS) change in the NCP during 2004–***,precipitation,and runoff during 2004–2019 were sequentially examined,using the water balance formula(WBF),to retrieve TWS ***,the soil moisture,snow water equivalent,and canopy water storage from the Global Land Data Assimilation System were used to calculate the natural component of the TWS variations.A comparison of these results revealed the drivers of the changes in water *** results showed that:(1) overall TWS retrieved by GRACE decreased substantially as a consequence of human activity,while TWS obtained by WBF fluctuated periodically around zero under the impact of three natural drivers;(2) TWS in the NCP fell at a remarkable rate of-12.39 mm/y from 2004 to 2019,and the natural part of TWS experienced two significant declines,during 2004–2010 and 2013–2016;(3) variations in runoff,precipitation,and evapotranspiration from 2004 to 2019 were not significant,but human activities contributed more to the decreasing TWS than natural *** study provides a reference for water resource management and groundwater exploitation across the NCP under climate change.

关键词： North China Plain water storage GRACE human activities climatic factor

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Effect of AI_(2)O_(3)and MgO on crystallization and structure of Ca0-Si0_(2)-B_(2)0_(3)-based fluorine-free mold flux

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Journal of Iron and Steel Research International 2021年第5期28卷 552-562页

作者： Jun-yu Chen Wan-lin Wang Le-jun Zhou Zi-hang pan School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina National Center for International Cooperation of Clean Metallurgy Changsha 41(K)83HunanChina

The crytallization behavior and melt structure of the CaO-Si0^(2-)B20_(3)-based fluorine-free mold fux were *** results show that the crytallization of the mold fux was first inhibited and then promoted with the increase in Al_(2)0_(3) content from 4 to 12 wt.%.However,it was enhanced by MgO in the range of 2-10 wt.%.The results of Fourier transform infrared spectroscopy and Raman spectroscopy showed that Al_(2)0_(3) worked as a network former in the mold flux melt when its content was in the range of 4-8 wt.%,whereas it worked as the network breaker to provide 0^(2-)when its content was in the range of 8-12 wt.%.In addition,the combined efects from the charge compensation by Mg^(2+)and the network broken by 0^(2-)led to the increase in some typicalT-O-T(AI-O-A1,B-O-B,etc.,)and simpler structural units(Q^(2)(Si),B_^(O-)in the[B0_(2)0^(-)],.etc.)when the MgO content was in the range of 2-6 wt.%.The continuous increase in 0^(2-)provided by the addition of MgO from 6 to 10 wt.%further depolymerized the network of the melt and fnally caused fast crystallizationo.

关键词： Crystallization Single hot thermocouple technique Melt structure Fluorine-free mold flux

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Long-term surface water changes and driving cause in Xiong'an,China:from dense Landsat time series images and synthetic analysis

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Science Bulletin 2018年第11期63卷 708-716页

作者： Chunqiao Song Linghong Ke hang pan Shengan Zhan Kai Liu Ronghua Ma Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China Department of Geography University of CaliforniaLos AngelesLos AngelesCA 90095United States School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China Department of Geographic Information Science Nanjing UniversityNanjing 210023China

China＇s government statement recently reported the plan of constructing Xiong＇an New Area, which aims to phase out some extra capital functions from Beijing and to explore an innovative urban development mode with the priority in eco-environmental protection. The New Area is located in the semi-arid North China Plain （NCP） and is home to NCP＇s largest natural freshwater wetland, Baiyangdian Lake. A comprehensive realization of surface water dynamics would be crucial for policy-makers to outline a sustainable environment development strategy for New Area. In this study, we used a total of 245 time slices of cloud-free Landsat images to document the continuous changes of water bodies within Xiong＇an City dur- ing 1984-2016 and to provide detailed evidence of water presence and persistency states and changes under the influences of climate change and human actions. Our results reveal that the New Area water body areas varied dramatically during the past 33 years, ranging from 0.44 km^2 in April 1988 to 317.85 km^2 in February 1989. The change of surface water area was not characterized by a monotonically decreasing tendency. The evolution processes can be divided into four sub-stages： the first extreme desiccation in mid-1980s, the wet stage with the most extensive inundation areas and strong inter-annual fluctuations from late-1988 to late 1999, another desiccation stage in early 2000s, and the overall recovering stage between 2007 and 2016. We also mapped the maximum water inundation extents and frequencies of all-season, pre-wet season （February-May） and post-wet season （September-December） for the 33 years and different sub-periods. Although there is good agreement between time series of surface water area evolution in the New Area and station-based precipitation and evaporation variations, multipie lines of evidences reviewed in previous research indicate that the degraded Baiyangdian Lake was also tightly associated with human activities from various aspects, inc

关键词： Xiong'an New Area Surface water Baiyangdian Lake Remote sensing Climate change Landsat

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DTY4500往复式压缩机油液在线监测系统改造实例

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压缩机技术 2024年第4期 47-51页

作者：吴勇吴思宇陈希潘航中国石油集团济柴动力有限公司成都分公司四川成都610100 中国石油物资有限公司北京100029

往复式天然气压缩机在气体增压、集输中占有重要地位。针对在用的DTY4500压缩机组,进行油液在线监测系统改造。通过实时监测机组油液运行参数、展示油液参数变化曲线、综合各项指标、在油品劣化之前提前预警等手段,实现了压缩机油液在... 详细信息

往复式天然气压缩机在气体增压、集输中占有重要地位。针对在用的DTY4500压缩机组,进行油液在线监测系统改造。通过实时监测机组油液运行参数、展示油液参数变化曲线、综合各项指标、在油品劣化之前提前预警等手段,实现了压缩机油液在线监测,同时与压缩机组远程监测云平台相互结合,提高了故障判断准确率,且在最后提出了问题与改进建议。

关键词：油液在线监测系统 DTY4500压缩机组改造

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虚拟导航支气管镜联合EBUS-GS技术在直径≤2 cm的肺外周结节诊断中的应用

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现代生物医学进展 2024年第5期24卷 925-929页

作者：潘航程杨旸潘霞武良权杨健张秀伟南京医科大学附属江宁医院呼吸与危重症医学科江苏南京211100

目的:探究虚拟导航支气管镜联合EBUS-GS技术在直径≤2 cm的肺外周结节诊断中的诊断价值。方法:本研究采用回顾性分析的方法,选取2019年5月-2022年5月期间在我院就诊的140例直径≤2 cm的肺外周结节患者作为研究对象,随机分为对照组和实验... 详细信息

目的:探究虚拟导航支气管镜联合EBUS-GS技术在直径≤2 cm的肺外周结节诊断中的诊断价值。方法:本研究采用回顾性分析的方法,选取2019年5月-2022年5月期间在我院就诊的140例直径≤2 cm的肺外周结节患者作为研究对象,随机分为对照组和实验组,各70例。对照组使用传统支气管镜技术进行诊断,实验组使用虚拟导航支气管镜联合EBUS-GS技术进行诊断,并进行随访实验。记录并比较两组患者的可视率、操作时间、诊断率及并发症发生率等指标。结果:对照组和实验组中的病灶位置比较,两组差异无统计学意义(P>0.05)。实验组与对照组病变大小相比差异无统计学意义(P>0.05),实验组可视率高于对照组。对照组和实验组的支气管镜操作总时间比较,无明显统计学差异(P>0.05),探及病灶位置时间与对照组相比,实验组低于对照组(P<0.05)。实验组中恶性病变的诊断率为89.74%,良性肺结节的诊断率为83.87%,而对照组恶性病变的诊断率为60%,良性结节的诊断率为50%,两组间病变性质的良性和恶性诊断率相比较,差异均具有统计学意义(P<0.05)。与对照组相比,实验组不良反应发生率2.86%低于对照组不良反应发生率18.57%,差异具有统计学意义(P<0.05)。结论:虚拟导航支气管镜联合EBUS-GS技术是一种可行且有效的方法,可用于直径≤2 cm的肺外周结节的诊断。该技术既可提高诊断准确性,又可减少不必要的切除手术,对患者具有重要的临床意义。

关键词：虚拟导航支气管镜气道内超声-引导鞘管(EBUS-GS) 肺外周结节诊断

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超表达HnCYP82M3和DsTRI基因对颠茄托品烷生物碱合成的影响

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药学学报 2024年第3期59卷 775-783页

作者：穆德会刘艳红陈漂漂谭艾娟马炳南潘航张明生强玮贵州大学生命科学学院/农业生物工程研究院山地植物资源保护与种质创新教育部重点实验室贵州贵阳550025

托品烷生物碱(TAs)是一类临床上广泛应用的抗胆碱药物,颠茄是提取TAs的主要药源植物,利用代谢工程技术大量获取TAs具有重要的产业价值。本研究基于开源引流代谢工程策略,在颠茄发根中超表达TAs合成途径分支处的细胞色素氧化酶(cytochrom... 详细信息

托品烷生物碱(TAs)是一类临床上广泛应用的抗胆碱药物,颠茄是提取TAs的主要药源植物,利用代谢工程技术大量获取TAs具有重要的产业价值。本研究基于开源引流代谢工程策略,在颠茄发根中超表达TAs合成途径分支处的细胞色素氧化酶(cytochrome oxidase,CYP82M3)HnCYP82M3(来源于天仙子)和托品酮还原酶I(tropinone reductase I,TRI)DsTRI(来源于曼陀罗)两个酶基因,以期通过CYP82M3催化合成托品酮(开源),TRI进而将托品酮引入TAs合成的代谢方向(引流),大量促进3种TAs的积累。从天仙子根中克隆了HnCYP82M3基因,其编码氨基酸与颠茄AbCYP82M3序列一致性高达91.7%。单独超表达HnCYP82M3不影响颠茄发根TAs的含量,说明CYP82M3不是TAs合成的关键酶。同时超表达HnCYP82M3和DsTRI极大促进了3种TAs的积累,莨菪碱、山莨菪和东莨菪碱含量分别是对照的4.97倍、2.83倍和2.19倍,并且提高幅度大于DsTRI单表达。本研究证明分支点处酶基因共表达的开源引流策略是有效提高颠茄TAs合成的代谢工程新方法,为工业化大量获取TAs奠定了理论和技术基础。

关键词： CYP82M3 TRI 托品烷生物碱颠茄代谢工程

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