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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan ching-Ho Ko Cindy Yeuk-Lam Hong Samuel chi-hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam chi-Kwok Chan chi-Fai Ng Peter Ka-Fung chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： hang chi Suo-Qun Zhao Ru-Yi Chen Xing-Xing Suo Rong-Rong Zhang Wen-Hui Yang Dong-Sheng Zhou Min Fang Bo Ying Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat *** development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing ***-encoded antibodies have emerged as a powerful and universal platform for rapid antibody ***,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against *** vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing *** importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form *** summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

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数字化人机界面复杂度对人因失误的影响研究

价值工程 2024年第8期43卷 163-165页

作者：陈驰航杭州电子科技大学管理学院杭州310018

为了减少数字化制造企业由于人因失误而产生的各类事故,从人机交互的角度,构建影响机制模型。将人机界面复杂度分为界面显示复杂度以及界面控制复杂度,以认知负荷和生理负荷为中介变量,发放问卷获取一线操作员工数据,用SPSS和AMOS对数... 详细信息

为了减少数字化制造企业由于人因失误而产生的各类事故,从人机交互的角度,构建影响机制模型。将人机界面复杂度分为界面显示复杂度以及界面控制复杂度,以认知负荷和生理负荷为中介变量,发放问卷获取一线操作员工数据,用SPSS和AMOS对数据进行回归分析,探究人机界面复杂度对人因失误产生的影响。结果表明:界面显示复杂度和控制复杂度均会对人因失误产生正向影响;认知负荷以及生理负荷在人机界面复杂度与人因失误之间起中介作用。

关键词：数字化制造人机界面复杂度人因失误认知负荷生理负荷

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黄热病毒保护性抗体研究进展

军事医学 2024年第8期48卷 636-640页

作者：索星星迟航邓永强韩晓东内蒙古农业大学生命科学学院军事科学院军事医学研究院病原微生物生物安全全国重点实验室

黄热病毒（YFV）是世界上最重要的蚊媒黄病毒之一，每年造成约20万例感染和3万例死亡，严重威胁人民健康和经济发展。目前，临床上尚无批准的YFV特异性治疗药物。抗体药物安全性高、靶向性强、治疗显著，是病毒性传染病预防和治疗的有... 详细信息

黄热病毒（YFV）是世界上最重要的蚊媒黄病毒之一，每年造成约20万例感染和3万例死亡，严重威胁人民健康和经济发展。目前，临床上尚无批准的YFV特异性治疗药物。抗体药物安全性高、靶向性强、治疗显著，是病毒性传染病预防和治疗的有效手段之一。该文阐述了近年国内外研发的YFV保护性抗体及发展方向，以期为研制高效安全的YFV特异性治疗药物提供参考。

关键词：黄热病毒包膜蛋白中和抗体

Numerical test of scale relations for modelling coastal sandbar migration and inspiration to physical model design

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Journal of Hydrodynamics 2022年第4期34卷 700-711页

作者： Yuan Li chi Zhang Shan-hang chi Yun-han Yang Jian Shi Ti-ti Sui State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210024China College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210024China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China

Physical model experiments on sandbar migration are widely conducted in the wave flume to reveal its hydro-sediment dynamic *** an appropriate scale relation is an important part of designing a laboratory ***,evaluating the scale effect is complicated since it is impractical to design wave flume experiments based on strict geometry scales derived from the prototype beach or other laboratory ***,a process-based numerical model is used to test the Dean and Shields similitudes by comparing sandbar migration and sediment transport in different undistorted model scales using natural *** numerical model provides excellent predictions for both offshore sandbar migration on a real-world beach and onshore sandbar migration in the wave *** with previous studies,sandbar offshore migration and suspended sediment transport are similar when the Dean similitude is *** onshore migration and bedload transport can be well reproduced only if the Shields similitude is *** previous laboratory experiments of sandbar migration generally used the Dean similitude,it is found that the Shields similitude is effective and indispensable for modelling sandbar onshore migration,which will be underestimated if the Dean similitude is only *** scale relation cannot be used simultaneously for modelling both onshore and offshore sandbar migration in physical models.

关键词： Coastal sandbar migration sediment transport scale relations numerical modelling

Performance of ground penetrating radar in root detection and its application in root diameter estimation under controlled conditions

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Science china Earth Sciences 2016年第1期59卷 145-155页

作者： YEUNG Shan Wing YAN Wai Man HAU chi hang Billy Department of Civil Engineering The University of Hong Kong Kadoorie Institute The University of Hong Kong

A plant is stabilized by its root system. In congested urban cities such as Hong Kong, ground trenching is frequently seen due to the installation of utility lines along the roadside. Soil nailing, which involves soil coring in slopes, is a common solution to improve the slope stability. However, both activities inevitably pose a risk to the integrity of any root sys- tems present, and thus reduce the root anchorage. To prevent or minimize such damage, a careful design of the excava- tion/drilling location is of prime importance. Ground penetrating radar （GPR） provides a non-destructive method for locating roots by examining the contrast between the dielectric properties of the roots and the surrounding soil. To examine the perfor- mance of GPR and promote its use in Hong Kong, a test bed was prepared using local materials to create a controlled envi- ronment in which to conduct a series of systematic tests evaluating the performance of a 900 MHz GPR. The reflected radar- grams were subject to the influence of the following factors： size and depth of roots, horizontal distance between roots, and contrast between the root and soil water content. Correlations between root size and a number of waveform parameters were also explored. Limiting values for root size, root embedded depth, horizontal separation distance between roots, and water content contrast between root and soil were obtained. A significant correlation was found between the root diameter and time travel parameter T2 （p〈0.001, t=0.795）. Because GPR root detection is highly site-specific, this study provides a local refer- ence for GPR performance in the Hong Kong environment. The findings demonstrate that the 900 MHz GPR is applicable in Hong Kong for the detection of main roots.

关键词： GPR Radar profile Root detection Root water content Root size

Field observation of wave overtopping at sea dike using shore-based video images

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Journal of Hydrodynamics 2021年第4期33卷 657-672页

作者： Shan-hang chi chi Zhang Ti-ti Sui Zhu-bin Cao Jin-hai Zheng Jiang-shan Fan State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing210098China Key Laboratory of Ministry of Education for Coastal Disaster and Protection Hohai UniversityNanjing210098China College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing210098China Rizhao Port Group Co. Ltd.Rizhao276826China

Wave overtopping at a sea dike was observed using video images during a storm in July 2018 at Rizhao Coast,china.A shore-based video monitoring system was mounted to collect coastal images with a sample frequency of 1 Hz in the beginning 10 min of each hour during daylight.A method to extract the frequency,location,width and duration of individual overtopping events based on the shore-based video monitoring system was developed.A total of 6252 individual overtopping events were detected over a 360m long sea dike during the storm of 10 h in a safe and labor-saving way,enabling a detailed analysis of the temporal and spatial variation of wave *** temporal variation of overtopping duration,frequency and volume is basically in sync with the change of tidal level(R=0.87,0.82 and 0.76,respectively).The increase of wave height increases the overtopping frequency *** found a high correlation between the hourly observed data and the predicted results of two commonly used *** the previous field measurements of overtopping that were limited in a single location,significant spatial variation of overtopping in the alongshore direction is *** overtopping volume varies with a factor of 6 within the range of several wave *** is further revealed that the spatial variation of overtopping is highly correlated with the alongshore variation of surf zone width with a correlation coefficient of *** present study suggests the feasibility of shore-based video monitoring technique to capture the main features of wave overtopping at coastal dikes,providing new possibilities to monitor wave overtopping in the field and to improve prediction tools.

关键词： Wave overtopping coastal video monitoring field measurement temporal and spatial variations storm events

TWO-LAYER MODEL DESCRIPTION OF POLYMER THIN FILM DYNAMICS

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chinese Journal of Polymer Science 2013年第1期31卷 12-20页

作者： Dong-dong Peng Ran-xing Nancy Li chi-hang Lam Ophelia K.C.Tsui Department of Physics Boston University Department of Applied Physics Hong Kong Polytechnic University

Experiments in the past two decades have shown that the glass transition temperature of polymer films can become noticeably different from that of the bulk when the film thickness is decreased below ca. 100 nm. It is broadly believed that these observations are caused by a nanometer interfacial layer with dynamics faster or slower than that of the bulk. In this paper, we examine how this idea may be realized by using a two-layer model assuming a hydrodynamic coupling between the interfacial layer and the remaining, bulk-like layer in the film. Illustrative examples will be given showing how the two-layer model is applied to the viscosity measurements of polystyrene and polymethylmethacrylate films supported by silicon oxide, where divergent thickness dependences are observed.

关键词： Polymer films Glass transition Viscosity.

Ras相关区域家族10蛋白在非小细胞肺癌中的表达及预后价值

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天津医科大学学报 2024年第5期30卷 385-390页

作者：张静怡迟航杨鑫汪玉龙赵伟鹏天津医科大学肿瘤医院国家恶性肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津300060 天津市中西医结合医院肿瘤内科天津300102 天津市中西医结合医院呼吸内科天津300102

目的:探讨ras-相关结构域家族(ras-association domain family,RASSF)10在非小细胞肺癌中的表达,分析其与非小细胞肺癌临床病理特征和预后的关系。方法:采用qRT-PCR和Western印迹检测RASSF10 mRNA和蛋白的表达;甲基化特异性聚合酶链式反... 详细信息

目的:探讨ras-相关结构域家族(ras-association domain family,RASSF)10在非小细胞肺癌中的表达,分析其与非小细胞肺癌临床病理特征和预后的关系。方法:采用qRT-PCR和Western印迹检测RASSF10 mRNA和蛋白的表达;甲基化特异性聚合酶链式反应(MSP)检测RASSF10启动子甲基化状态,采用免疫组化和酶联免疫吸附测定法(ELISA)检测石蜡组织和血液中RASSF10蛋白表达,Cox回归模型进行生存分析。结果:在非小细胞肺癌细胞株SPCA-1中RASSF10 mRNA及蛋白(z=21.38、33.14,均P<0.05)、在NCI-H157中RASSF10 mRNA及蛋白(z=56.73、56.34,均P<0.05)均低于非肿瘤细胞株。MSP发现RASSF10在SPCA-1和NCI-H157细胞株启动子区甲基化,用5-氮杂-2′-脱氧胞苷处理后,RASSF10在SPCA-1和NCI-H157细胞株中mRNA和蛋白(t=18.14、56.13,均P<0.05)的表达增加。RASSF10启动子甲基化状态与组织中和血清中RASSF10的低表达密切相关(χ^(2)=19.271、4.831,均P<0.05)。预后多因素分析石蜡组织中RASSF10表达(HR=0.508,P<0.05)和N分期(HR=1.839,P<0.001)为非小细胞肺癌患者预后独立因素,RASSF10表达与肿瘤直径(χ^(2)=4.787,P<0.05)、气道内播散(χ^(2)=15.618,P<0.001)和N分期(χ^(2)=11.588,P<0.01)密切相关。结论:RASSF10在非小细胞肺癌中表达降低,与非小细胞肺癌肿瘤进展密切相关,是非小细胞肺癌早期诊断及预后有价值的肿瘤标志物。

关键词：非小细胞肺癌 RASSF10 甲基化预后

Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-Chun Teoh chi-Kwok Chan Maggie Haitian Wang chi-Ho Leung Eddie Shu-Yin Chan Peter Ka-Fung chiu chi-hang Yee Hon-Ming Wong Simon See-Ming Hou chi-Fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,china).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate