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LKB1 de.le.ion-me.iate. e.ithe.ial-me.e.chymal transition induce. fibroblast activation in lung fibrosis

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Ge.e. & Dise.se. 2024年第3期11卷 417-426页

作者： Zijian Xu e.izabe.h R.Davie. Liudi Yao Yilu Zhou Juanjuan Li Aiman Alze.ani Be. G.Marshall David hancock Tim Wallis Julian Downward Rob M.e.ing Donna e.Davie. Mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK Unive.sity Hospital Southampton Southampton SO166YDUK Oncoge.e.Biology The Francis Crick InstituteLondon NW11ATUK

The.factors that de.e.mine.fibrosis progre.sion or normal tissue.re.air are.large.y *** pre.iously de.onstrate. that autophagy inhibition-me.iate. e.ithe.ial-me.e.chymal transition(e.T)in human alve.lar e.ithe.ial type.Il(ATIl)ce.ls augme.ts local myofibroblast diffe.e.tiation in pulmonary fibrosis by paracrine.***,we.re.ort that live. kinase.B1(LKB1)inactivation in ATIl ce.ls inhibits autophagy and induce. e.T as a *** IPF lungs,this is cause. by the.down-re.ulation of CAB39L,a ke. subunit within the.LKB1 comple..3D co-culture. of ATIl ce.ls and MRC5 lung fibroblasts couple. with RNA se.ue.cing(RNA-se.)confirme. that paracrine.signaling be.we.n LKB1-de.le.e. ATIl ce.ls and fibroblasts augme.te. myofibroblast ***,the.e.data sugge.t that re.uce. autophagy cause. by LKB1 inhibition can induce.e.T in ATIl ce.ls and contribute.to fibrosis via abe.rant e.ithe.ial-fibroblast crosstalk.

关键词： CAB39L Crosstalk e.T LKB1 Pulmonary fibrosis

-lormone.le.e.s following surgical and me.ical castration： de.ining optimal androge. suppre.sion

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Asian Journal of Andrology 2018年第4期20卷 405-406页

作者： Michae. T Schwe.ze. Michae. L hancock Robe.t H Ge.ze.be.g e.an Y Yu Division of Oncology Department of Medicine University of Washington Seattle WA 98116 USA Clinical Re.e.rch Division Fred Hutchinson Cancer Research Center Seattle WA 98116 USA Ve.u He.lthcare Miami FL 33137 USA

De.r e.itor, In the.1940s, Charle. Huggins discove.e. that surgical castration produce. re.arkable.palliative.be.e.its for me. with advance. prostate.cance., an e.fe.t we.now unde.stand to be.me.iate. through de.rivi... 详细信息

关键词： FRe. Te.TOSTe.ONe De.RIVATION THe.APY PROSTATe.CANCe. ADRe.AL-GLANDS Me.

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图象角点检测的矢量场方法

中国图象图形学报（A辑） 1998年第10期3卷 832-835页

作者：罗斌 e.R.hancock 安微大学电子系英国约克大学计算机系

提出一种新的图象角点检测方法。该方法利用电磁场理论表达图象特征，进而从特征图象中提取出角点。Ｃａｎｎｙ边缘图象中的边缘被视为电流密度源而产生磁场。根据电磁场理论，可计算出相应的矢势。提出图象的角点位于该矢势图的鞍点和... 详细信息

提出一种新的图象角点检测方法。该方法利用电磁场理论表达图象特征，进而从特征图象中提取出角点。Ｃａｎｎｙ边缘图象中的边缘被视为电流密度源而产生磁场。根据电磁场理论，可计算出相应的矢势。提出图象的角点位于该矢势图的鞍点和基于模板匹配的鞍点检测算法，并给出实际的角点检测结果。

关键词：角点检测矢势微分算子计算机图象处理

Optimizing me.hyl-e.ge.ol aromathe.apy to maximize.posttre.tme.t e.fe.ts to e.hance.mating compe.itive.e.s of male.Bactroce.a carambolae.（Dipte.a： Te.hritidae.

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Inse.t Scie.ce 2015年第5期22卷 661-669页

作者： Ihsan ul Haq Marc J.B. Vre.se. Carlos Cace.e. Todd e. She.ly Jorge.He.drichs Inse.t Pe.t Control Laboratory Joint FAOIIAEA Division of Nuclear Techniques in Food and Agriculture Seibersdorf Austria National Agricultural Re.e.rch Ce.tre Park Road Islamabad Pakistan USDAIAPHIS 41-650 Ahiki Street Waimanalo HI 96795 USA and Inse.t Pe.t Control Se.tion Joint FAOIIAEA Division of Nuclear Techniques in Food and Agriculture Vienna Austria

Me.hyl-e.ge.ol （Me. （1,2-dime.hoxy-4-（2-prope.yl）be.ze.e., a natural phy- toche.ical, did e.hance.male.Bactroce.a carambolae.Dre. ＆ hancock （Dipte.a： Te.hri- tidae. mating compe.itive.e.s 3 d afte. inge.tion. e.hance. male.mating compe.itive.e.s can significantly incre.se.the.e.fe.tive.e.s of the.ste.ile.inse.t te.hnique.（SIT）. Me.appli- cation to mass re.re. ste.ile.flie. by fe.ding is infe.sible. Me.application by aromathe.apy howe.e., would be.a ve.y practical way of Me.application in fly e.e.ge.ce.and re.e.se.facilitie.. This approach was shown to e.hance.mating compe.itive.e.s ofB. carambolae.3 d posttre.tme.t （DPT）. De.pite.this adde. be.e.it, e.e.y additional day of de.aying re. le.se.will re.uce.ste.ile.fly quality and will add cost to SIT application. The.pre.e.t study was planne. to asse.s the.e.fe.ts of Me.aromathe.apy on male.B. carambolae.mating compe.itive.e.s 1DPT and 2DPT. Me.aromathe.apy 1DPT or 2DPT did e.hance.mating compe.itive.e.s of B. carambolae.male. whe.e.s Me.fe.ding 1DPT and 2DPT did not. Male.mating compe.itive.e.s was e.hance. by the.Me.aromathe.apy irre.pe.tive.if the. re.e.ve. 1DPT, 2DPT or 3DPT. Me.aromathe.apy, be.ng a viable.approach for its applica- tion, did e.hance.mating compe.itive.e.s of male.B. carambolae.1 d posttre.trne.t as Me.fe.ding did 3 d afte. inge.tion.

关键词： Bactroce.a carambolae mating compe.itive.e.s Me.aromathe.apy me.hyl-e.ge.ol Me.fe.ding posttre.tme.t e.fe.t SIT

Biode.radable.ste.t or balloon dilatation for be.ign oe.ophage.l stricture. Pilot randomise. controlle. trial

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World Journal of Gastroe.te.ology 2014年第48期20卷 18199-18206页

作者： Anjan Dhar He.e. Close.Yirupaiahgari K Viswanath Colin J Re.s He.e. C hancock A De.pak Dwarakanath Re.e.ca H Maie. Douglas Wilson Jame. M Mason De.artme.t of Gastroe.te.ology County Durhamand Darlington NHS Foundation Trust Co. Durham DL14 6ADUnited Kingdom Durham Clinical Trials Unit School of Medicine Pharmacy and Health Durham University Queen’s Campus Wolfson Research Institute University Boulevard Stockton-on-Tees TS17 6BH United Kingdom De.artme.t of Surge.y James Cook University Hospital Marton Road Middlesbrough TS4 3BW United Kingdom De.artme.t of Gastroe.te.ology South Tyneside Hospitals NHS Foundation Trust Harton Lane South Shields NE34 0PL United Kingdom De.artme.t of Gastroe.te.ology University Hospitals of North Tees Hardwick Stockton on Tees TS19 8PE United Kingdom

AIM: To unde.take.a randomise. pilot study comparing biode.radable.ste.ts and e.doscopic dilatation in patie.ts with stricture..

关键词： Be.ign oe.ophage.l stricture Biode.radable.ste.t e.doscopic balloon dilatation Pilot study Randomise. controlle. trial Dysphagia

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丙烯及其工业衍生物

丙烯及其工业衍生物

作者： e.G.·汉考克(e.G. hancock)

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苯及其工业衍生物

苯及其工业衍生物

Clarifying sub-ge.omic positions of QTLs for flowe.ing habit and fruit quality in U.S. strawbe.ry (Fragaria×ananassa) bre.ding populations using pe.igre.-base. QTL analysis

作者： e.G.·汉考克(e.G. hancock)

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Horticulture.Re.e.rch 2017年第1期4卷 85-93页

作者： Suje.t Ve.ma Jason D Zurn Natalia Salinas Me.an M Mathe. Be.trice.De.oye. Jame. F hancock Chad e.Finn Nahla V Bassil Vance.M Whitake. IFAS/De.artme.t of Horticulture University of FloridaGulf Coast Research and Education Center14625 CR 672Wimauma33598FLUSA USDA-ARS National Clonal Ge.mplasm Re.ository 33447 Peoria RoadCorvallis97333ORUSA De.artme.t of Horticulture Oregon State University4017 Agriculture and Life Sciences BuildingCorvallis97331ORUSA De.artme.t of Horticulture UMR 1332 Biologie du Fruit et PathologieINRAUniv.BordeauxVillenave d’OrnonF-33140France Michigan State.Unive.sity East Lansing48824MIUSA USDA-ARS HCRU3420 NW Orchard AvenueCorvallis97330ORUSA

The.cultivate. strawbe.ry(Fragaria×ananassa)is consume. worldwide.for its flavor and nutritional *** analysis of comme.cially important traits in strawbe.ry are.important for the.de.e.opme.t of bre.ding me.hods and tools for this *** se.e.al quantitative.trait loci(QTL)have.be.n pre.iously de.e.te. for fruit quality and flowe.ing traits using low-de.sity ge.e.ic maps,clarity on the.sub-ge.omic locations of the.e.QTLs was *** discove.ie. in allo-octoploid strawbe.ry ge.omics le. to the.de.e.opme.t of the.IStraw90 single.nucle.tide.polymorphism(SNP)array,e.abling high-de.sity ge.e.ic maps and fine. re.olution QTL *** this study,bre.de.-spe.ifie. traits we.e.e.aluate. in the.e.ste.n(Michigan)and We.te.n(Ore.on)Unite. State. for a common se. of bre.ding populations during 2 *** QTLs we.e.validate. for soluble.solids conte.t(SSC),fruit we.ght(FWT),pH and titratable.acidity(TA)using a pe.igre.-base. QTL analysis *** fruit quality,a QTL for SSC on linkage.group(LG)6A,a QTL for FWT on LG 2BII,a QTL for pH on LG 4CII and two QTLs for TA on LGs 2A and 5B we.e.*** addition,a large.e.fe.t QTL for flowe.ing was de.e.te. at the.distal e.d of LG 4A,coinciding with the.FaPFRU *** haplotype.analysis in the.FaPFRU re.ion indicate. that the.homozygous re.e.sive.ge.otype.was highly pre.ictive.of se.sonal *** probe. in the.FaPFRU re.ion may he.p facilitate.marke.-assiste. se.e.tion for this trait.

关键词： bre.ding straw Fragaria

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饲养管理对家禽生产性能的影响

中国家禽 2011年第6期33卷 40-41页

作者： e.A.Cruz-He.nande. G.CascoMonte.e.ro O.Ce.giz J.B.He.s S.F.Bilgili N.Graham C.hancock C.M.Rude 德克萨斯A&M大学土耳其阿德南曼德列斯大学美国奥本大学美国堪萨斯州立大学

1料槽与水槽间的距离影响青年肉鸡体重和骨骼强度增加机体运动有助于改善动物骨骼强度和行走能力。本研究的目的是考察料槽与水槽间的距离对肉鸡体重、胫骨强度以及胫骨灰分含量(占干物质的百分比)的影响。将90只1日龄雏鸡分别带翅号,... 详细信息

1料槽与水槽间的距离影响青年肉鸡体重和骨骼强度增加机体运动有助于改善动物骨骼强度和行走能力。本研究的目的是考察料槽与水槽间的距离对肉鸡体重、胫骨强度以及胫骨灰分含量(占干物质的百分比)的影响。将90只1日龄雏鸡分别带翅号,地面平养,自由采食和饮水.

关键词：胫骨灰分采食饮水足垫皮炎动物行为试验鸡垫料松木屑