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Decidual Natural Killer Cells Are Essential for a Successful Pregnancy (Review)

Advances in Reproductive Sciences 2022年第3期10卷 73-90页

作者： Ehab A. m. Elagab m.jed Alshahrani Am.n A. A. Elbadawi Abdullah I. Aedh Ahm.d m. osman hanadi m. osman Departm.nt of Hem.tology and Im.unohem.tology Faculty of Medical Laboratory Science University of Gezira Wadmedani Sudan Departm.nt of Pathology College of Medicine Najran University Najran Saudi Arabia Departm.nt of Obstetrics and Gynecology College of Medicine Najran University Najran Saudi Arabia Departm.nt of Biochem.stry College of Medicine Najran University Najran Saudi Arabia Departm.nt of Internal m.dicine College of Medicine Najran University Najran Saudi Arabia Departm.nt of Em.rgency Najran University Hospital Najran University Najran Saudi Arabia Departm.nt of Fam.ly m.dicine Najran Armed Forces Hospital Najran Saudi Arabia

Pregnancy is a com.lex physiological process involving several interconnected system.. m.ny researchers were concerned that the form.tion of a fetus with different genetic com.onents m.y contradict the norm.l state of im.unity, which attem.ts to reject and fight foreign bodies. This piqued the interest of biologists and im.unologists, who set out to discover the im.une system.s com.osition and m.de of response in the uterus. According to several studies, natural killer (NK) cells are present in a significant percentage that differs from.what is seen in peripheral blood. As a result, several scientific studies have been conducted on uterine NK cells, investigating their types, characteristics, receptors, secretions, and interactions with the surrounding environm.nt. Research has also indicated the capacity of uterine NK cells to strike a balance between eradicating uterine infections and effectively contributing to different phases of pregnancy. Various studies have shown that NK cell activity is intim.tely related to the success or failure of pregnancy. In this review, we describe the uterine NK cell subtypes;decidual (dNK) cells and endom.trial NK cells (eNK) cells and their im.ortant role during different phases of pregnancy.

关键词： Uterine NK Cells Decidual NK Cells Pregnancy

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Intelligent Energy Consum.tion For Sm.rt Hom.s Using Fused m.chine-Learning Technique

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Com.uters, m.terials & Continua 2023年第1期74卷 2261-2278页

作者： hanadi AlZaabi Khaled Shaalan Taher m.Ghazal m.ham.ad A.Khan Sagheer Abbas Beenu m.go m.hsen A.A.Tom. m.nir Ahm.d Faculty of Engineering and IT The British University in DubaiUnited Arab Emirates Center for Cyber Security Faculty of Information Science and TechnologyUniversity Kebangsaan Malaysia(UKM)Bangi43600SelangorMalaysia School of Inform.tion Technology Skyline University CollegeUniversity City SharjahSharjah1797United Arab Emirates Riphah School of Com.uting&Innovation Faculty of ComputingRiphah International University Lahore CampusLahore54000Pakistan Pattern Recognition and m.chine Learning Lab. Department of SoftwareGachon UniversitySeongnamGyeonggido13120Korea Faculty of Com.uter Science NCBA&ELahore54660Pakistan

Energy is essential to practically all exercises and is im.erative for the developm.nt of personal ***,valuable energy has been in great dem.nd for m.ny years,especially for using sm.rt hom.s and structures,as individuals quickly im.rove their way of life depending on current ***,there is a shortage of energy,as the energy required is higher than that *** new plans are being designed to m.et the consum.r’s energy *** m.ny regions,energy utilization in the housing area is 30%–40%.The growth of sm.rt hom.s has raised the requirem.nt for intelligence in applications such as asset m.nagem.nt,energy-efficient autom.tion,security,and healthcare m.nitoring to learn about residents’actions and forecast their future *** overcom. the challenges of energy consum.tion optim.zation,in this study,we apply an energy m.nagem.nt *** fusion has recently attracted m.ch energy efficiency in buildings,where num.rous types of inform.tion are *** proposed research developed a data fusion m.del to predict energy consum.tion for accuracy and m.ss *** results of the proposed approach are com.ared with those of the previously published techniques and found that the prediction accuracy of the proposed m.thod is 92%,which is higher than the previously published approaches.

关键词： Energy consum.tion intelligent m.chine learning technique sm.rt hom.s prediction

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m.xillary denture flange and occlusal discrepancies of Vertex Therm.Sens in com.arison with conventional heat-cured denture base m.terials

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The Journal of Biom.dical Research 2019年第2期33卷 139-144页

作者： hanadi A.Lam.on Ibrahim.m.Ham.uda m.xillofacial and Oral Rehabilitation Departm.nt Umm Al-Qura University Conservative Dentistry Faculty of Dentistry Umm Al-Qura University Dental Biom.terials Faculty of Dentistry Mansoura University

This study was conducted to investigate the m.xillary denture bases and occlusal discrepancies using the Vertex Therm.sens in com.arison with the conventional polym.thyl-m.thacrylate m.terials. Twenty m.xillary denture bases were prepared from.the Vertex Therm.Sens and a conventional heat-cured denture base m.terials. Acrylic m.xillary second m.lars were arranged in their respective positions on the ridge. After curing of both types of denture bases, they were deflasked with their respective m.ster casts. Reference points were prepared for m.asurem.nts of the antero-posterior and cross-arch dim.nsions at the denture borders using caliper device. Furtherm.re, the teeth discrepancies were m.asured between reference points in the ligual aspect of the second m.xillary m.lars. The recorded data was analyzed using SPSS statistical software version 20. The results showed initial shrinkage of both denture bases in the antero-posterior and cross-arch dim.nsions im.ediately after decasting. This contraction was com.ensated gradually during storage in water up to 2 weeks. Regarding the variable tim., there was a significant difference between the tested m.terials. m.reover, the results revealed occlusal discrepancies and shifting of teeth inward im.ediately after decasting, followed by outward m.vem.nt after storage in water for 2 weeks. Regarding the variables tim. and m.terials, there were significant differences. Both m.terials exhibited inward shrinkage in the antero-posterior and cross-arch dim.nsions im.ediately after decasting. Both denture bases showed inward shifting of teeth im.ediately after decasting, followed by outward m.vem.nt after storage in water up to 2 weeks.

关键词： denture distortion flange discrepancy acrylic resin occlusal discrepancies denture base

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Predicted Functional Shifts Due to Type of Soil m.crobiom. and Watering of Two Wild Plants in Western Region of Saudi Arabia

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Phyton-International Journal of Experim.ntal Botany 2022年第10期91卷 2249-2268页

作者： Lina Baz Aala A.Abulfaraj m.nal A.Tashkandi hanadi m.Baeissa m.ham.ed Y.Refai Am.nah A.Barqawi Ashwag Sham. Haneen W.Abuauf Ruba A.Ashy Rewaa S.Jalal Departm.nt of Biochem.stry Faculty of ScienceKing AbdulAziz UniversityJeddah21589Saudi Arabia Biological Sciences Departm.nt College of Science&ArtsKing Abdulaziz UniversityRabigh21911Saudi Arabia Departm.nt of Biochem.stry College of ScienceUniversity of JeddahJeddahSaudi Arabia Departm.nt of Chem.stry Al-Leith University College Umm Al Qura UniversityMakkahSaudi Arabia Departm.nt of Biology College of SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Departm.nt of Biology Faculty of Applied ScienceUmm Al-Qura UniversityMakkahSaudi Arabia Departm.nt of Biology College of ScienceUniversity of JeddahJeddahSaudi Arabia

The present study aim.d to predict differential enrichm.nt of pathways and com.ounds in the rhizosphere m.crobiom.s of the two wild plants(Abutilon fruticosum.and Nitrosalsola verm.culata)and to predict functional shifts in m.crobiom.s due to *** sequencing of 16S rRNA region V3–V4 was done and gene-based m.crobial com.ositions were enrolled in PICRUSt to predict enriched pathways and *** results indicated that“ABC transporters”and“Quorum.sensing”pathways are am.ng the highest enriched pathways in rhizosphere m.crobiom.s of the two wild plants com.ared with those of the bulk soil *** highest enriched com.ounds in soil m.crobiom.s of the two wild plants included five proteins and three enzym.s participating in one or m.re KEGG *** of these eight com.ounds showed higher predicted enrichm.nt in rhizosphere soil m.crobiom.s,while only one,nam.ly phosphate transport system.substrate-binding protein,showed higher enrichm.nt in the surrounding bulk soil *** term. of differentially enriched com.pounds due to watering,only the dual-specific aspartyl-tRNA(Asn)/glutam.l-tRNA(Gln)am.dotransferase subunit A showed higher enrichm.nt in rhizosphere soil of the two wild plants after 24 h of *** of the highly enriched com.ounds nam.ly branched-chain am.no acid transport system.ATP-binding protein and branched-chain am.no acid transport system.substrate-binding protein,are encoded by genes stim.lated by the plant’s GABA that participates in conferring biotic and abiotic stresses in plants and im.roves the plant’s growth *** 3-Oxoacyl-[ACP]reductase,a m.m.er of the short-chain alcohol dehydrogenase/reductase(SDR)superfam.ly,participates in fatty acids elongation cycles and contributes to plant-m.crobe sym.biotic relationships,while enoyl-CoA hydratase has a reverse action as it participates in“Fatty acid degradation”*** m.thyl-accepting chem.taxis protein is an environm.ntal signal that sense“Bacteri

关键词： Am.licon sequencing PICRUSt KEGG GABA sym.ionts wild plants

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Safety and im.unogenicity of a m.saic vaccine booster against Om.cron and other SARS-CoV-2 variants:a random.zed phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian Yang Salah Hussein m.ham.d Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao m.ng Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang m.ng Li hanadi m.kki m.kki Walid Zaher Sally m.hm.ud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang m.ngjie Yang Islam.Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing m. Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao Yan m.o Jin Zhang Liang Qu Yun Tao Zhang Xiao m.ng Yang Guizhen Wu Qi m.ng Li Sheikh Khalifa m.dical City SEHAAbu DhabiUAE College of m.dicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Com.any Lim.ted BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical m.dicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Com.any Lim.ted LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Com.any Lim.ted BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing random.zed,double-blind,controlled phase 2 trial was conducted to evaluate the safety and im.unogenicity of a m.saic-type recom.inant vaccine candidate,nam.d NVSI-06-09,as a booster dose in subjects aged 18 years and older from.the United Arab Em.rates(UAE),who had adm.nistered two or three doses of inactivated vaccine BBIBP-CorV at least 6 m.nths prior to *** participants were random.y assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** prim.ry outcom.s were im.unogenicity and safety against severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2)Om.cron variant,and the exploratory outcom. was cross-im.unogenicity against other circulating *** m.y 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a sim.lar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** im.unogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geom.tric m.an titers(Gm.s)from.baseline elicited by NVSI-06-09 were rem.rkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Om.cron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Sim.larly,the neutralizing Gm.s boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum.neutralizing responses against divergent SARS-CoV-2 variants,including Om.cron and its sub-lineages.

关键词： phase neutral spectrum

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