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Improving the Construction Industry Quality Using the Seven Basic Quality Control Tools

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Primmorph extracts and mesohyls of marine sponges inhibit proliferation and migration of hepatocellular carcinoma cells in vitro

Journal of Minerals and Materials Characterization and Engineering（矿物质和材料特性和工程） 2019年第6期

作者： mohamed Abdel-Hamid hanaa mohamed abdelhaleem

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Journal of Pharmaceutical Analysis 2019年第4期9卷 284-291页

作者： hanaa Rady Sohair Salem mohamed Ez El-Arab Chemistry of Natural Compound Department National Research Centre Cairo Egypt Molecular Genetics and Enzymology Department National Research Centre Cairo Egypt National Institute of Oceanography and Fisheries (NIOF) Hurghada Egypt

Cancer recurrence and severe side effects of currently being used chemotherapeutic agents reduce their clinical efficacy. Thus, there is a constant need to develop alternative anticancer drugs. Sustainable supply is an important challenge facing marine-based drug discovery. Primmorph, a 3D cell culture system, could provide a sustainable source to produce metabolites for anticancer drugs from marine sponges. In the present work, the anticancer activity of primmorph extracts and mesohyls of Negombata magnifica, Hemimycle arabica, Crella spinulata, and Stylissa carteri sponges was evaluated. Antiproliferative activity was studied in terms of cytotoxicity, colony formation, cell cycle, and apoptosis. Migration was assessed by migration assay and matrix metalloproteinase activity. The expression of proliferation and migration-related genes was analyzed using real time PCR. Migration and proliferation activities of HepG2 cells were inhibited by treatment with primmorph extracts and mesohyls of N. magnifica, H. arabica, and C. spinulata. The mesohyl of S. carteri did not show any anticancer activity although the primmorph extract led to cell cycle arrest. Among the selected sponge species, the primmorph extract of C. spinulata was the most promising anticancer agent regarding antiproliferative and antimigratory activities. In addition, primmorph extracts have the advantage of working under welldefined and controlled conditions, which allows the easy application as a bioreactor.

关键词： Marine sponge Primmorph Mesohyl Proliferation Migration Hepatocellular carcinoma cell line

Variant Wasserstein Generative Adversarial Network Applied on Low Dose CT Image Denoising

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Computers, Materials & Continua 2023年第5期75卷 4535-4552页

作者： Anoud A.Mahmoud hanaa A.Sayed Sara S.mohamed Department of Mathematics and Computer Science Faculty of ScienceNew Valley UniversityNew Valley72511Egypt Department of Computer Science College of Computer Science and Engineering Taibah UniversityMedina42221KSA Department of Mathematics Faculty of ScienceAssiut UniversityAssiut71516Egypt

Computed Tomography(CT)images have been extensively employed in disease diagnosis and treatment,causing a huge concern over the dose of radiation to which patients are *** the radiation dose to get a better image may lead to the development of genetic disorders and cancer in the patients;on the other hand,decreasing it by using a Low-Dose CT(LDCT)image may cause more noise and increased artifacts,which can compromise the ***,image reconstruction from LDCT image data is necessary to improve radiologists’judgment and *** study proposed three novel models for denoising LDCT images based on Wasserstein Generative Adversarial Network(WGAN).They were incorporated with different loss functions,including Visual Geometry Group(VGG),Structural Similarity Loss(SSIM),and Structurally Sensitive Loss(SSL),to reduce noise and preserve important information on LDCT images and investigate the effect of different types of loss ***,experiments have been conducted on the Graphical Processing Unit(GPU)and Central Processing Unit(CPU)to compare the performance of the proposed *** results demonstrated that images from the proposed WGAN-SSIM,WGAN-VGG-SSIM,and WGAN-VGG-SSL were denoised better than those from state-of-the-art models(WGAN,WGAN-VGG,and SMGAN)and converged to a stable equilibrium compared with WGAN and *** proposed models are effective in reducing noise,suppressing artifacts,and maintaining informative structure and texture details,especially WGAN-VGG-SSL which achieved a high peak-signalto-noise ratio(PNSR)on both GPU(26.1336)and CPU(25.8270).The average accuracy of WGAN-VGG-SSL outperformed that of the state-ofthe-art methods by 1 *** prove that theWGAN-VGG-SSL is more stable than the other models on both GPU and CPU.

关键词： Machine learning deep learning image denoising low dose CT loss function

SOX9 in biliary atresia: New insight for fibrosis progression

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 154-162页

作者： hanaa Ahmed El-Araby Magdy Anwar Saber Noha mohamed Radwan Doha Maher Taie Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterologyand NutritionNational Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt Department of Pathology National Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt

Background:Liver fibrosis is a hallmark determinant of morbidity in biliary atresia(BA)even in successfully operated *** factors for this rapid progression of fibrosis are not completely *** expression of the transcription factor SOX9 and hepatic progenitor cells(HPCs)proliferation have roles in fibrogenesis in cholestatic ***,they were not investigated sufficiently in *** aimed to delineate the relation of SOX9 and HPCs to fibrosis and its progression in ***:Forty-eight patients with BA who underwent an initial diagnostic liver biopsy(LB)and consequent intraoperative LB were recruited and compared to 28 cases with non-BA cholestasis that had an LB in their diagnostic *** fibrosis,tissue SOX9 and HPC expressions were studied in both BA and non-BA-cholestasis *** fibrosis,SOX9,and HPCs’dynamic changes in BA cases were *** of fibrosis and its progression to SOX9 and HPCs in BA was ***:SOX9 and HPCs in ductular reaction(DR)form were expressed in 100%of BA and their grades increased significantly in the second *** rapidly progressive fibrosis in BA,represented by fibrosis grade of the intraoperative LB,correlated significantly to SOX9-DR and HPC-DR at the diagnostic(r=0.420,P=0.003 and r=0.405,P=0.004,respectively)and the intraoperative(r=0.460,P=0.001 and r=0.467,P=0.001,respectively)*** the other hand,fibrosis,SOX9-DR,and HPC-DR were significantly lower in non-BA cases at a comparable age(P<0.001,P=0.006,and P=0.014,respectively).Conclusions:Fibrosis in BA is rapidly progressive within a short time and is significantly correlated to SOX9 and *** of targeting SOX9 and HPCs on fibrosis progression is warranted.

关键词： Biliary atresia Fibrosis Hepatic progenitor cells Immunohistochemistry Neonatal cholestasis SOX9

Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 214-221页

作者： Fateheya mohamed Metwally Hend mohamed Rashad hanaa Hamdy Ahmed Asmaa Ahmed Mahmoud Ehab Ragaa Abdol Raouf Aboelfetoh mohamed Abdalla Environmental and Occupational Medicine National Research CentreGizaEgypt Department of Hormones National Research CentreGizaEgypt Department of Zoology Faculty of ScienceAin Shams UniversityCairoEgypt Department of Research on Children with Special Needs National Research CentreGizaEgypt Department of Horticulture Crops Technology National Research CentreGizaEgypt

Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam.(M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic and vascular risks in the experimental model of visceral ***: M. oleifera ethanolic extract was orally administered at 600 mg/kg body weight in obese female rats daily for 12 weeks. At the end of treatment, body weight was determined, and the atherogenic index, coronary artery index, glucose level, insulin resistance status, liver and kidney functions were assessed. Also, the m RNA of leptin, adiponectin and resistin in visceral adipose tissue was determined by quantitative real ***: The results showed that M. oleifera extract down-regulated m RNA expression of leptin and resistin, while it up-regulated adiponectin gene expression in obese rats relative to untreated obese control counterparts. This amelioration of genes expression was paralleled by a reduction in body weight and improvement of the atherogenic index and coronary artery index, as well as glucose level and insulin resistance value without adverse effects on liver or kidney functions, versus the untreated obese control ***: It is reasonable to assume that the anti-obesity, anti-atherogenic and antidiabetic properties of M. oleifera are mechanistically achieved via working directly on the adipokines of the visceral adipose tissue. Therefore, M. oleifera may be a good therapeutic candidate for the symptoms of metabolic syndrome.

关键词： Moringa oleifera Lam Visceral adipose tissue Adipokines Gene expression Rats

Bayesian belief-based model for reliability improvement of the digital reactor protection system

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Nuclear Science and Techniques 2020年第10期31卷 55-73页

作者： hanaa Torkey Amany S.Saber mohamed K.Shaat Ayman El-Sayed Marwa A.Shouman Faculty of Electronic Engineering Menoufia UniversityCairoEgypt Nuclear Research Center Egyptian Atomic Energy AuthorityCairoEgypt

The digital reactor protection system(RPS)is one of the most important digital instrumentation and control(I&C)systems utilized in nuclear power plants(NPPs).It ensures a safe reactor trip when the safety-related parameters violate the operational limits and conditions of the *** high reliability and availability of digital RPS is essential to maintaining a high degree of reactor safety and cost *** main objective of this study is to develop a general methodology for improving the reliability of the RPS in NPP,based on a Bayesian Belief Network(BBN)*** structure of BBN models is based on the incorporation of failure probability and downtime of the RPS I&C *** architectures with dual-state nodes for the I&C components were developed for reliability-sensitive analysis and availability optimization of the RPS and to demonstrate the effect of I&C components on the failure of the entire system.A reliability framework clarified as a reliability block diagram transformed into a BBN representation was constructed for each architecture to identify which one will fit the required *** results showed that the highest availability obtained using the proposed method was *** are 120 experiments using two common component importance measures that are applied to define the impact of I&C modules,which revealed that some modules are more risky than others and have a larger effect on the failure of the digital RPS.

关键词： Nuclear power plants Reactor protection system Bayesian belief network

Serum ferritin in neonatal cholestasis: A specific and active molecule or a non-specific bystander marker?

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 173-180页

作者： Behairy El-Sayed Behairy Hatem Abd-Alsattar Konswa hanaa Talaat Ahmed Dina Shehata El-Azab Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterology and Nutrition National Liver Institute Menofiya University Department of Pathology National Liver Institute Menofiya University

Background: Serum ferritin(SF) and consequently hepatic iron have long been considered important in liver fibrosis progression. They have been studied in different liver diseases with no previous reports in neonatal cholestasis(NC). This study aimed to measure SF in different etiologies of NC and investigate its relation to hepatic iron and fibrosis. Methods: SF was measured in 75 infants, including 50 with NC and 25 with sepsis. SF was compared between these two groups. Biochemical parameters, hepatic iron grades, and liver fibrosis and other histopathological characteristics and correlated with SF were assessed in NC group. Finally, a comparison between intrahepatic cholestasis and obstructive etiology was performed. Results: SF was elevated in NC(1598 ± 2405 ng/mL) with no significant difference from those with sepsis( P = 0.445). NC and sepsis constituted augmenting factors leading to more elevation of SF(2589 ± 3511 ng/mL). SF was significantly correlated with hepatic iron grades( r = 0.536, P < 0.0 0 01) and a cut-off value of 803.5 ng/mL can predict higher grades( ≥ grade 3) of iron deposition with sensitivity of 100%, specificity of 70% and accuracy of 85%. Moreover, SF was significantly higher( P < 0.0 0 01) in those with intrahepatic cholestasis(2602 ± 3154 ng/mL) and their prevalent pathological findings of giant cell transformation( P = 0.009) and hepatocyte swelling( P = 0.023) than those with obstructive etiology(672 ± 566 ng/mL) and their prevalent pathological findings of ductular proliferation( P = 0.003) and bile plugs( P = 0.002). SF was unrelated to the grade of liver fibrosis( P = 0.058). Conclusions: SF is non-specifically elevated in NC, with positive correlation to hepatic iron grades. SF ≥ 803.5 ng/mL can predict higher grades( ≥ grade 3) of hepatic iron. However, an active role of increased SF and hepatic iron in disease progression remains questionable.

关键词： Biliary atresia Liver fibrosis Hepatic iron grade Intrahepatic cholestasis Iron

Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 389-396页

作者： Aisha Hussein Abou Zeid mohamed Ali Farag Manal Abdel Aziz Hamed Zeinab Abdel Aziz Kandil Radwa Hassan El-Akad hanaa mohamed El-Rafie Pharmacognosy Department National Research Centre Pharmacognosy Department College of PharmacyCairo University Therapeutic Chemistry Department National Research Centre

Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided ***:In vitro antioxidant activity was evaluated for *** different extracts using DPPH assay and vitamin C as *** activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference *** glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic *** and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral ***:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,*** of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and ***:This study highlights the potential use of *** leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

关键词： STZ-induced diabetes Diaion fractionation Flavonoid glucuronides Brachychiton acerifolius

Applicability and efficacy of a model for prevention of perinatal transmission of hepatitis B virus infection:Single center study in Egypt

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World Journal of Gastroenterology 2014年第45期20卷 17075-17083页

作者： hanaa M El-Karaksy Lamiaa M Mohsen Doa'a A Saleh Mona S Hamdy Noha A Yassin mohamed Farouk mohamed E Salit Mortada H El-Shabrawi Department of Pediatrics Kasr Al-Ainy School of Medicine Cairo University Department of Community Medicine Kasr AlAiny School of Medicine Cairo University Department of Clinical and Chemical Pathology Kasr Al-Ainy School of Medicine Cairo University Department of Obstetrics and Gynecology Kasr Al-Ainy School of Medicine Cairo University

AIM: To identify possible maternal risk factors for hepatitis B virus (HBV) acquisition and assess the efficacy of immunoprophylaxis given to infants born to hepatitis B virus surface antigen (HBsAg) positive mothers.

关键词： Egypt Hepatitis B virus Hepatitis B virus surface antigen positive mothers Immunoprophylaxis Perinatal transmission