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民办普通高校体育场馆现状调查与对策研究

体育科学研究 2010年第4期14卷 129-132页

作者：韩玉璋上海杉达学院体育教学部上海201209

通过文献资料法、调查法、统计法、对比分析法等,对上海市16所民办普通高校体育场馆设施现状进行调查研究,结果表明:要端正办学指导思想,加强科学管理,提高现有场馆、器材的使用效率,以内涵发展为主,外延发展为辅和制定民办高校体育工... 详细信息

通过文献资料法、调查法、统计法、对比分析法等,对上海市16所民办普通高校体育场馆设施现状进行调查研究,结果表明:要端正办学指导思想,加强科学管理,提高现有场馆、器材的使用效率,以内涵发展为主,外延发展为辅和制定民办高校体育工作评估体系等是促进民办高校体育教育健康有序发展的对策。

关键词：上海民办高校场馆设施发展建设

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo yu Zhenyu Sun Weichen Zheng Liangwei zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian zhang Zi-han Li Yi-Xin zhang Rong-Xuan Xu Wei Wu Zhi-han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-yu Xu Zhong-Shang Dai Guo-Zhong Gong Min zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(P<0.01).Notably,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei zhang Liang Li Hao-yu Qu Guang-yu Chen Meng-Zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

水泵水轮机水轮机工况全流道三维非定常数值模拟

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排灌机械工程学报 2017年第4期35卷 325-332页

作者：韩冬冬于凤荣张思青昆明理工大学冶金与能源工程学院云南昆明650093

为了研究水泵水轮机水轮机工况下的内部流场及压力脉动特性,对某蓄能电站的水泵水轮机几何建模,采用RNG k-ε模型和SIMPLE算法,对水泵水轮机水轮机工况时三维全流道的空载工况、25%负荷工况、50%负荷工况、75%负荷工况、额定工况及满负... 详细信息

为了研究水泵水轮机水轮机工况下的内部流场及压力脉动特性,对某蓄能电站的水泵水轮机几何建模,采用RNG k-ε模型和SIMPLE算法,对水泵水轮机水轮机工况时三维全流道的空载工况、25%负荷工况、50%负荷工况、75%负荷工况、额定工况及满负荷工况进行三维非定常模拟;同时,监测蜗壳入口、活动导叶之间、导叶与转轮之间无叶区,以及尾水管直锥段和弯肘段的压力脉动情况.结果表明:空载等低负荷工况下,活动导叶出口出现射流,使导叶与转轮间无叶区流场恶化及转轮叶片进水边附近产生涡结构,随负荷增加而缓解;50%负荷工况下,尾水涡带有多分支相互缠绕,导叶与转轮间无叶区受动静干涉高频脉动的影响,尾水管区域受尾水涡带低频脉动影响,且各自向上、下游传播;额定工况下,P1至P5测点压力脉动的压力呈现阶梯依次降低,转轮前、后部分转轮与导叶间无叶区测点P3、尾水管锥段测点P4的脉动压力值出现很大的落差;各工况下导叶与转轮间无叶区脉动频率不变,各频率幅值随负荷增加而增大.

关键词：水泵水轮机水轮机工况流场压力脉动频谱分析

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超重力场下钢液中夹杂物上浮行为的数值模拟

钢铁 2022年第7期57卷 54-62页

作者：杜依诺郭磊杨洋张帅于含樟郭占成北京科技大学钢铁冶金新技术国家重点实验室

超重力技术可以有效提高固液两相间的重力差，在冶金领域，超重力场的引入可以大幅度增加金属熔体中夹杂物的去除效率。基于超重力冶金装置模型，根据动网格与流-固耦合理论，建立了不同重力场下固态夹杂物在钢液中上浮的流体动力学模... 详细信息

超重力技术可以有效提高固液两相间的重力差，在冶金领域，超重力场的引入可以大幅度增加金属熔体中夹杂物的去除效率。基于超重力冶金装置模型，根据动网格与流-固耦合理论，建立了不同重力场下固态夹杂物在钢液中上浮的流体动力学模型。该模型模拟了夹杂物在不同系数的重力场中上浮的运动状态，研究了超重力场中的重力系数与夹杂物尺寸等因素对颗粒上浮和流场分布的影响。模拟结果表明，在重力场系数恒定时，夹杂颗粒经短暂的加速上浮过程后，后续的上浮运动将趋于匀速，夹杂物的上浮速度会随着施加重力场的增大而增长，夹杂物附近的钢液也会被更快地“推开”,从而出现改变流动状态的趋势。尺寸d为1、10μm的夹杂物颗粒由于其尺寸较小，在施加一定的超重力场后仍满足Stokes上浮模型；尺寸d为100μm的大尺寸夹杂物则仅在约10倍重力场作用下符合Stokes上浮模型，当施加更大的重力场时，夹杂物附近的流场会由层流流动转变为湍流流动，不再满足Stokes定律。在研究不同系数重力场中夹杂物上浮的模型时发现，当重力场的系数大小随时间变化时，尺寸为1μm量级的小尺寸夹杂上浮速度的变化幅度与重力场的变化幅度呈正比；而尺寸为10、100μm的夹杂物在脱离层流流场后，上浮速度与重力场不再呈线性关系。

关键词：超重力技术非金属夹杂物数值模拟流固耦合洁净钢

超声造影对直径≤3cm肝脏局灶性病变的诊断价值

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中国医学科学院学报 2016年第3期38卷 335-340页

作者：何蒙娜吕珂姜玉新夏宇韩洁张雪鹤中国医学科学院北京协和医学院北京协和医院超声诊断科北京100730 北京市平谷区医院超声科北京101200

目的探讨超声造影对直径≤3 cm肝脏局灶性病变的诊断价值。方法回顾性分析69例直径≤3 cm肝局灶性占位病变的临床资料、超声造影表现及病理检查资料,按照患者病灶大小进行分组,探讨不同组超声造影的增强模式是否存在差异。结果超声造影... 详细信息

目的探讨超声造影对直径≤3 cm肝脏局灶性病变的诊断价值。方法回顾性分析69例直径≤3 cm肝局灶性占位病变的临床资料、超声造影表现及病理检查资料,按照患者病灶大小进行分组,探讨不同组超声造影的增强模式是否存在差异。结果超声造影对69例肝脏局灶性病灶的诊断准确率、敏感性、特异性、阳性预测值和阴性预测值分别为94.2%、95.2%、93.8%、87.0%和97.8%。恶性病灶中,直径≤2 cm组超声造影门脉期快速廓清者明显少于>2 cm组(P<0.05)。结论超声造影对直径≤3 cm的肝脏局灶性病灶具有较高的诊断价值。直径≤2 cm肝恶性病灶的超声造影门脉期表现常不典型,需要结合其病史等临床特征进行综合诊断。

关键词：超声造影肝脏局灶性病变诊断价值

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土壤有机氮组分研究进展

土壤通报 2018年第5期49卷 1240-1246页

作者：吴汉卿张玉龙张玉玲邹洪涛虞娜沈阳农业大学土地与环境学院农业部东北耕地保育重点实验室辽宁沈阳110866

有机氮组分作为土壤氮素的重要组成,是土壤中有效态氮的源和库,在氮素矿化、固定、迁移以及为植物生长供氮过程中起到至关重要的作用。总结近年来国内外土壤有机氮组分的研究进展,详述了土壤有机氮组分的组成、功能及其影响因素。结果表... 详细信息

有机氮组分作为土壤氮素的重要组成,是土壤中有效态氮的源和库,在氮素矿化、固定、迁移以及为植物生长供氮过程中起到至关重要的作用。总结近年来国内外土壤有机氮组分的研究进展,详述了土壤有机氮组分的组成、功能及其影响因素。结果表明,土壤有机氮组分与土壤供氮能力紧密相关,其中酸解铵态氮和酸解氨基酸氮为土壤有机氮组分的主要组成,一定程度上可作为土壤供氮潜力的表征。最后,对未来的研究重点—同位素标记技术和分子生物学技术等在土壤有机氮组分研究的应用进行展望,以期为深入开展土壤氮素循环和供氮能力的研究提供一定的理论参考。

关键词：土壤有机氮组分组成功能影响因素供氮能力