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Wireless sequential dual light delivery for programmed PDT in vivo

Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li han-joon kim Shu Uin Gan John S.Ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

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Pressures secondary to circumferential digital dressings in clay models

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Plastic and Aesthetic Research 2017年第3期4卷 41-48页

作者： han joon kim Kun Hwang Department of Plastic Surgery Inha University School of MedicineIncheon 22332South Korea

Aim: With little manipulation, compression bandages placed circumferentially around the digit can be rolled up the digit, creating a tourniquet effect. The aim of this study was to elucidate the pressures induced by self-adherent bandages applied circumferentially around the fingers. Methods: After fabricating various clay finger models using the live finger as a model, the pressure of each self-adherent bandage was measured at the level of the proximal phalanx. Two different self-adherent bandages were applied with variables of different levels of tightness, number of wraps, and whether each was rolled up or not. Pressure was measured using a digital measuring device at a standardized location. Results: The measured pressure of 3 wraps along the adult finger model was higher than 1 wrap or 2 wraps, and untightened bandages had lower pressures than those of tightened bandages. The pressures of the unrolled bandages were lower than those of rolled up bandages, and pressures along the live finger of the rolled up group were higher than those in the adult finger model. Additionally, measured pressures from the child finger model were higher than those from the adult model. Conclusion: Precautions should be taken to prevent rolling up dressing materials, especially in children.

关键词： Pressure fingers compression bandages occlusive dressings

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Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway

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Neural Regeneration Research 2013年第35期8卷 3269-3274页

作者： Ji-Young kim Beom Seok Jeon han-joon kim Tae-Beom Ahn Department of Neurology Inje University Seoul Paik Hospital Department of Neurology College of Medicine Seoul National University Hospital Department of Neurology Kyung Hee University Medical Center

Although alpha-synuclein is generally thought to have a pathological role in Parkinson＇s disease, accumulative evidence exists that alpha-synuclein has a neuroprotective effect. The aim of this study was to evaluate the effect of extracellular alpha-synuclein on dopaminergic cell survival. We assessed cell viability using the 3-（4,5-dimethyt-thiazol-2-yt）-2,5-diphenyltertazolium bromide （MTT） assay both in undifferentiated SH-SY5Y （SHSY） cells and neuronally-differentiated SH-SY5Y （ndSHSY） cells after 24 hour treatment with monomeric alpha-synuclein at various concentrations （0 [control], 50, 100 nmol/L, 1 IJmol/L）. To determine whether cell viability assessed by MTT assay was affected by cell proliferation, 5-bromo-2＇-deoxyuridine （BrdU） incorporation assay was per- formed. Level of both Akt and phosphorylated Akt was measured using western blot method in ndSHSY cells with or without 24 hour alpha-synuclein treatment. Cell viability was increased in ndSHSY cells at the nanomolar concentration of alpha-synuclein, but not in SHSY cells. Proportion of BrdU-positive ndSHSY cells was decreased in alpha-synuclein-treated group compared with control group. Level of phosphorylated Akt in alpha-synuclein-treated group was higher compared with the control group. Our study shows that extracellular alpha-synuclein at nanomolar concentra- tion benefits dopaminergic cell survival via Akt pathway.

关键词： neural regeneration alpha-synuclein neuronal survival nanomolar extracellular phosphorylatedAkt SH-SY5Y cell neuronal differentiation proliferation dopaminergic 5-bromo-2'-deoxyuridine grants-supported paper neuroregeneration

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Fe_(3)GeTe_(2):a site-differentiated Hund metal

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npj Computational Materials 2022年第1期8卷 2355-2360页

作者： Taek Jung kim Siheon Ryee Myung joon han Department of Physics KAISTDaejeon34141Republic of Korea I.Institute of Theoretical Physics University of HamburgNotkestrasse 9-11Hamburg22607Germany

Magnetism in two-dimensional(2D)van der Waals(vdW)materials has lately attracted considerable attention from the point of view of both fundamental science and device ***,establishing a detailed and solid understanding of their magnetism is the key first step toward various *** Fe_(3)GeTe_(2)is a representative ferromagnetic(FM)metal in this family,many aspects of its magnetic and electronic behaviors still remain ***,we report our new finding that Fe_(3)GeTe_(2)is a special type of correlated metal known as“Hund metal”.Furthermore,we demonstrate that Hund metallicity in this material is quite unique by exhibiting remarkable site dependence of Hund correlation strength,hereby dubbed“site-differentiated Hund metal”.Within this new picture,many of the previous experiments can be clearly understood,including the ones that were seemingly contradictory to one another.

关键词： strength establishing metallic

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab

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Oncology research 2025年第1期33卷 57-65页

作者： Ryul kim Joo Kyung Park Minsuk Kwon Minae An Jung Yong Hong joon Oh Park Sung Hee Lim Seung Tae kim Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Department of Hematology-Oncology Ajou University School of Medicine Suwon-si Gyeonggi-do Korea. Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea.

Background:Immune checkpoint inhibitors (ICIs) are effective in a subset of patients with metastatic solid tumors. However, the patients who would benefit most from ICIs in biliary tract cancer (BTC) are still controversial.Materials and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line therapy.Results:All patients had microsatellite stable (MSS) type tumors. Three of the 32 patients achieved partial response (PR), with an objective response rate (ORR) of 9.4% (95% confidence interval [CI], 2.0-25.2) and nine showed stable disease (SD), exhibiting a disease control rate (DCR) of 37.5% (95% CI, 21.1-56.3). For the 31 patients who had access to PD-1 ligand 1 (PD-L1) combined positive score (CPS) testing (cut-off value ≥1%), the ORR was not different between those who had PD-L1-positive (PD-L1+; 1/11, 9.1%) and PDL1-(2/20, 10.0%) tumors ( = 1.000). The tumor mutational burden (TMB) of PD-L1+ BTC was comparable to that of PD-L1-BTC ( = 0.630). TMB and any exonic somatic mutations were also not predictive of pembrolizumab response. Molecular analysis of blood and tumor samples demonstrated a relatively high natural killer (NK) cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor response. Moreover, the tumors of these patients presented high enrichment scores for NK cells, antitumor cytokines, and Th1 signatures, and a low enrichment score for cancer-associated fibroblasts.Conclusions:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Biliary tract cancer Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing

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Fault area estimation using traveling wave for wide area protection

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Journal of Modern Power Systems and Clean Energy 2016年第3期4卷 478-486页

作者： Jae-Won LEE Won-Ki kim joon han Won-Hyeok JANG Chul-Hwan kim Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Daewoo Shipbuilding&Marine Engineering Co. Ltd.GeojeRepublic of Korea Electrical and Computer Engineering Department University of Illinois at Urbana-ChampaignChampaignILUSA

As the increasing number of Phasor Measurement Units(PMUs) are deployed, wide area protection in power systems has been gaining interest. In particular, fault detection, fault classification and fault area estimation are essential to reduce the damage of faults, and even prevent catastrophic cascades of failures. In this paper, we present a scheme for fault area estimation using PMUs and traveling wave theory. The purpose of this paper is to formulate a scheme for fault area estimation by calculating the approximate fault location based on traveling wave *** research has targeted at reliable operation of wide transmission system through the estimation of fault *** verify the suggested scheme, the various simulations are performed in practical Korean power transmission *** simulation results show that the proposed scheme has a good performance with high accuracy for estimating fault area.

关键词： Fault area estimation Phasor measurement unit(PMU) Transmission line system Traveling wave Wide area protection

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Bilateral dislocation of the long head of biceps tendon with intact rotator cuff tendon:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6304-6310页

作者： Hyuk-joon Sohn Chul-Hyun Cho Du-han kim Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND Dislocation of the long head of biceps tendon(LHBT)usually involves rotator cuff injury,and isolated dislocation with an intact rotator cuff is *** cases of isolated dislocation have been ***,to the best of our knowledge,there has been no report of bilateral dislocation of the LHBT without rotator cuff *** SUMMARY A 23-year-old male presented to our outpatient clinic with left side dominant pain in both *** patient had no history of trauma or *** patient underwent intra-articular injection and physical therapy,but his symptoms *** on preoperative imaging,the diagnosis was bilateral dislocation of the *** of the bicipital groove was detected in both *** dislocation of the biceps tendon over an intact subscapularis tendon was identified by diagnostic *** biceps tenodesis was performed and continuous passive motion therapy was administered immediately after *** patient’s pain was resolved,and full functional recovery was achieved,and he was satisfied with the condition of his *** This study describes a rare case of bilateral dislocations of the LHBT without rotator cuff injury due to dysplasia of the bicipital groove.

关键词： Shoulder Biceps Dislocation Rotator cuff Tenodesis Case report

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A new species of Zanclognatha Lederer and three new records of the families Erebidae and Noctuidae(Lepidoptera,Noctuoidea)from Korea,with notes on larval feeding habits

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Journal of Forestry Research 2021年第3期32卷 1235-1240页

作者： Kang-Won Lee joon-Mo Koo Jae-Dong kim Hui-Lin han Kyu-Tek Park Holoce Ecosystem Conservation Research Institution HoengseongGangweon Province 225-841Republic of Korea Department of Plant Medicine Chungbuk National UniversityCheongju28644Republic of Korea Department of Applied Biology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea School of Forestry Northeast Forestry UniversityHarbin 150040China Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education Northeast Forestry UniversityHarbin 150040People’s Republic of China Bioresource and Environmental Center Incheon National UniversityIncheon 22012Republic of Korea

A new species of Zanclognatha Lederer,1857 of the family Erebidae,*** sp.n.,one species of Family Erebidea,Asota egens(Walker,1854)and two species of Family Noctuidae:Meganephria retinea Gyulai and Ronkay,1999 and Amphipyra subrigua Bremer and Grey,1853,are reported for the first time from *** addition,larval feeding habits with their host plants for three species are newly recognized from *** of adults,larvae for Zanclognatha querciella and Meganephria retinea,and the genitalia of male or female for all species are provided.

关键词： Host plants New species New records Korean peninsula Taxonomy

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Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： joon-Hyung kim Uk-Hee Jung Sung kim joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

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Feasibility of wear reduction for soft nanostructured thin film through enhanced elastic recoverability and contact stress relief

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Friction 2023年第7期11卷 1292-1306页

作者： Kuk-Jin SEO Hyun-joon kim Dae-Eun kim Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Precision Mechanical Engineering Kyungpook National UniversitySangju 37224Republic of Korea Department of Advanced Science and Technology Convergence Kyungpook National UniversitySangju 37224Republic of Korea

This work shows that a soft,thin film comprising randomly aligned carbon nanotubes(CNTs)can reduce surface wear more effectively than a homogeneous thin film because of enhanced elastic recoverability and contact stress relief originating from its mesh *** investigate the wear characteristics of the mesh structure compared to those of the homogeneous thin film,multi-walled CNTs(MWCNTs)and diamond-like carbon(DLC)thin films were prepared to conduct nanoscale tribological experiments using the atomic force microscopy(AFM).The MWCNT thin film showed unmeasurably low wear compared with the DLC thin film under a certain range of normal *** demonstrate the wear reduction mechanism of the MWCNT thin film,its indentation and frictional behaviors were *** indentation behavior of the MWCNT thin film revealed repetitive elastic deformation with a wide strain range and a significantly lower elastic modulus than that of the DLC thin *** permanent deformation of the MWCNT thin film was observed through frictional experiments under relatively high normal load *** results are expected to provide insights into the design of highly wear-resistant surfaces using nanostructures.

关键词： carbon nanotube(CNT) thin film wear friction elastic recovery

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