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Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function

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World Journal of Psychiatry 2024年第7期14卷 1095-1105页

作者： Sha Li Nan Zhang Wang Li han-lai Zhang Xiao-Xi Wang Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100000China Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100000China

BACKGROUND Autism spectrum disorder(ASD)is a developmental disorder characterized by social deficits and repetitive ***(GI)problems,such as constipation,diarrhea,and inflammatory bowel disease,commonly occur in patients with ***,GI problems of ASD patients were attributed to intestinal inflammation and vertical mother-to-infant microbiome *** To explore whether GI problems in ASD are related to maternal intestinal inflam-mation and gut microbiota *** An ASD rat model was developed using valproic acid(VPA).Enzyme-linked immunosorbent assay and fecal 16S rRNA sequencing were used to test GI *** VPA exposure during pregnancy led to pathological maternal intestinal changes,resulting in alterations in maternal gut ***,the levels of inflammatory factors also ***,prenatal exposure to VPA resulted in impaired duodenal motility in the offspring as well as increased levels of infla-mmatory *** GI problems in ASD may be associated with maternal intestinal inflammation and microbiota *** research is required to find more evidence on the etiology and treatment of GI problems in ASD.

关键词： Autism spectrum disorder Gastrointestinal problems Gut microbiota Intestinal inflammation Intestinal motility

A Telepresence-Guaranteed Control Scheme for Teleoperation Applications of Transferring Weight-Unknown Objects

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 1015-1025页

作者： Jinfei Hu Zheng Chen Xin Ma han lai Bin Yao State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China IEEE Ocean College Zhejiang UniversityZhoushan 316021 the State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027 Ocean Research Center of Zhoushan Zhejiang UniversityZhoushan 316021China School of Engineering Technology Purdue UniversityWest LafayetteIN 47907 USA Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China School of Mechanical Engineering Purdue UniversityWest LafayetteIN 47907 USA

Currently,most teleoperation work is focusing on scenarios where slave robots interact with unknown ***,in some fields such as medical robots or rescue robots,the other typical teleoperation application is precise object ***,the object’s weight is unknown yet essential for both accurate control of the slave robot and intuitive perception of the human ***,due to high cost and limited installation space,it is unreliable to employ a force sensor to directly measure the ***,in this paper,a control scheme free of force sensor is proposed for teleoperation robots to transfer a weight-unknown object *** this scheme,the workspace mapping between master and slave robot is firstly established,based on which,the operator can generate command trajectory on-line by operating the master ***,a slave controller is designed to follow the master command closely and estimate the object’s weight rapidly,accurately and robust to unmodeled ***,for the sake of telepresence,a master controller is designed to generate force feedback to reproduce the estimated weight of the *** the end,comparative experiments show that the proposed scheme can achieve better control accuracy and telepresence,with accurate force feedback generated in only 500 ms.

关键词： Adaptive robust control teleoperation telepresence transparency weight estimation

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一种宽频微带谐波滤波器设计

电光系统 2024年第2期 29-32,39页

作者：潘进鹿森韩来辉中国电子科技集团公司第二十七研究所郑州450047

针对某项目S频段宽带固态功率放大器寄生输出的谐波分量过大,对其他系统产生干扰的问题,提出了一种微带高低阻抗相间连接宽频带谐波滤波器的结构形式,并基于ADS(Advanced Design System)电路仿真和HFSS(HighFrequency Structure Simulat... 详细信息

针对某项目S频段宽带固态功率放大器寄生输出的谐波分量过大,对其他系统产生干扰的问题,提出了一种微带高低阻抗相间连接宽频带谐波滤波器的结构形式,并基于ADS(Advanced Design System)电路仿真和HFSS(HighFrequency Structure Simulator)电磁结构仿真对该滤波器进行了仿真计算,该滤波器仿真结果很好地满足设计要求,最终完成了一种宽频带微带滤波器的设计。该滤波器设计方法简单,具有插入损耗和回波损耗低、功率容量适中、结构尺寸紧凑等特点。基于电路和电磁结构仿真进行了印制板加工。实测结果表明,该滤波器通带内插入损耗小于0.2dB,阻带抑制大于23dB,整个滤波器的尺寸约为:57.38mm(L)×30mm(W)×20mm(H),该滤波器实测结果与仿真结果有很好的吻合度,满足工程应用的要求。

关键词：宽带微带滤波器 HFSS 电磁场

Microbiome technology empowers the development of traditional Chinese medicine

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Science China(Life Sciences) 2020年第11期63卷 1759-1761页

作者： Hongtao Liu Junping Zheng Hsin-Chih lai Baifei Hu Lin Zhu Elaine lai-han Leung Hong Wei College of Basic Medicine Hubei University of Chinese MedicineWuhan 430065China Department of Medical Biotechnology and Laboratory Science Chang Gung UniversityTao-Yuan 33302China State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao SARChina Central Laboratory Clinical Medicine Scientific and Technical Innovation ParkShanghai Tenth People’s HospitalTongji UniversityShanghai 200435China State Key Laboratory of Agricultural Microbiology College of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China

Application of microbiome technology to traditional Chinese medicine (TCM). Microbiome refers to the integration of composition, genetic information and bio-function of all microbial species under a specific environment.

关键词： environment. powers technology

Sb掺杂Li_(2)SnO_(3)增加氧化电势提升2,4-DCP光催化降解的研究

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化学研究与应用 2024年第4期36卷 816-823页

作者：洪传冰赖寒代朋姜文陈姚宇王熙李雷张涛重庆第二师范学院生物与化学工程学院重庆400067

本文通过固相法制备Sb掺杂Li_(2)SnO_(3)光催化剂并将其用于光催化降解2,4-DCP。通过粉末X射线多晶衍射技术(PXRD)、高分辨透射电镜(TEM)及扫描电镜(SEM)对合成的光催化剂分别进行了物相结构和表面形貌表征。光催化实验表明,Sb掺杂之后... 详细信息

本文通过固相法制备Sb掺杂Li_(2)SnO_(3)光催化剂并将其用于光催化降解2,4-DCP。通过粉末X射线多晶衍射技术(PXRD)、高分辨透射电镜(TEM)及扫描电镜(SEM)对合成的光催化剂分别进行了物相结构和表面形貌表征。光催化实验表明,Sb掺杂之后的样品具有较为优越的光催化性能,其在紫外光下12 min内,其降解率可达100%。然而母体Li_(2)SnO_(3)在同样的条件下,12 min内光催化降解率仅有58.20%。紫外漫反射吸收光谱表明,Sb掺杂之后,光学吸收带宽增加;时间分辨光谱测试表明,Sb掺杂后样品的光生载流子寿命下降。综合以上分析,光催化效率提升的原因,来自于其价带氧化电势的增强。自由基捕获实验表明,空穴(h+)和超氧阴离子自由基(O_(2)·-)是2,4-DCP降解过程中的主要活性自由基。本文的研究为半导体掺杂对光催化效率的提升提供重要的指导。

关键词：无机非金属材料半导体掺杂 Li_(2)SnO_(3) 光催化 2,4-DCP

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基于测井曲线包络面积预测油气藏产能

科学技术与工程 2024年第15期24卷 6254-6262页

作者：韩鸿来刘之的张志强王猛刘海波刘志杰西安石油大学地球科学与工程学院西安710065 陕西省油气成藏地质学重点实验室西安710065 中海油田服务股份有限公司油田技术事业部燕郊065201

为了准确预测油气藏产能,解决复杂孔隙结构致使测井响应特征弱化,常规测井手段预测产能精度低的问题,通过采用交会图手段研究了东海盆地西湖凹陷碎屑岩储层测井曲线包络面积与产能间的关系,并优选了产能敏感性包络面积作为产能预测指标... 详细信息

为了准确预测油气藏产能,解决复杂孔隙结构致使测井响应特征弱化,常规测井手段预测产能精度低的问题,通过采用交会图手段研究了东海盆地西湖凹陷碎屑岩储层测井曲线包络面积与产能间的关系,并优选了产能敏感性包络面积作为产能预测指标,借助波叠加性原理构建了包络面积产能预测指数,利用熵权法确定了各预测指标的权值,进而分储层类型建立了产能预测模型。结果表明:补偿中子-渗透率、电阻率-密度、电阻率-视波阻抗和视波阻抗-声波时差四组包络面积对产能的敏感性较强;本文所构建的产能预测模型精度较高,平均误差为19.4%。可见基于包络面积的产能预测模型可用于未开展动态测试的油气藏产能预测,为油气藏产能预测方法提供了新思路。

关键词：油气藏产能预测测井包络面积熵权法

ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria

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Nano-Micro Letters 2020年第6期12卷 138-151页

作者： Xing-xing Fan Meng-ze Xu Elaine lai-han Leung Cai Jun Zhen Yuan Liang Liu State Key Laboratory of Quality Research in Chinese Medicine Macao Institute For Applied Research in Medicine and HealthMacao University of Science and TechnologyAvenida Wai LongTaipaMacao SARChina Faculty of Health Sciences University of MacaoTaipaMacao SARChina

Rheumatoid arthritis(RA)is an autoimmune disease,which attacks human joint system and causes lifelong inflammatory *** date,no cure is available for RA and even the ratio of achieving remission is very ***,to enhance the efficacy of RA treatment,it is essential to develop novel approaches specifically targeting pathological *** this study,we discovered that RA synovial fibroblasts exhibited higher reactive oxygen species(ROS)and mitochondrial superoxide level,which were adopted to develop ROS-responsive nano-medicines in inflammatory microenvironment for enhanced RA treatment.A selenocystamine-based polymer was synthesized as a ROS-responsive carrier nanoplatform,and berberine serves as a tool *** assembling,ROS-responsive berberine polymeric micelles were fabricated,which remarkably increased the uptake of berberine in RA fibroblast and improved in vitro and in vivo efficacy ten times ***,the anti-RA effect of micelles was blocked by the co-treatment of AMPK inhibitor or palmitic acid,indicating that the mechanism of micelles was carried out through targeting mitochondrial,suppressing lipogenesis and finally inhibiting cellular *** together,our ROS-responsive nano-medicines represent an effective way of preferentially releasing prodrug at the inflammatory microenvironment and improving RA therapeutic efficacy.

关键词： Rheumatoid arthritis Reactive oxygen species Nanoparticles Berberine Oxygen consumption rate

细菌定量计数联合尿沉渣白细胞检验在尿路感染诊断中的应用价值分析

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中国现代药物应用 2024年第12期18卷 77-79页

作者：赖寒光林先娘吴海明三明市第二医院 366000

目的观察分析细菌定量计数联合尿沉渣白细胞检验在尿路感染诊断中的应用价值。方法200例疑似尿路感染患者,均接受细菌定量计数、尿沉渣白细胞检验及尿细菌培养。分析尿细菌培养结果,以尿细菌培养为金标准,比较细菌定量计数、尿沉渣白细... 详细信息

目的观察分析细菌定量计数联合尿沉渣白细胞检验在尿路感染诊断中的应用价值。方法200例疑似尿路感染患者,均接受细菌定量计数、尿沉渣白细胞检验及尿细菌培养。分析尿细菌培养结果,以尿细菌培养为金标准,比较细菌定量计数、尿沉渣白细胞单一检验及联合检验的诊断效能。结果200例疑似尿路感染患者经尿细菌培养诊断,阳性标本为104例,阳性率为52.00%。以尿细菌培养为金标准,联合检验对尿路感染的诊断敏感性、特异性、阳性预测值及阴性预测值分别为98.08%、96.88%、97.14%、97.89%,细菌定量计数检验对尿路感染的诊断敏感性、特异性、阳性预测值及阴性预测值分别为80.77%、69.79%、74.34%、77.01%,尿沉渣白细胞检验对尿路感染的诊断敏感性、特异性、阳性预测值及阴性预测值分别为91.35%、92.71%、93.14%、90.82%,联合检验对尿路感染的诊断敏感性、特异性、阳性预测值及阴性预测值均高于细菌定量计数检验,敏感性、阴性预测值高于尿沉渣白细胞检验(P<0.05)。结论在尿路感染诊断中,应用细菌定量计数联合尿沉渣白细胞检验的结果与尿细菌培养更相近,具有较高的诊断价值。

关键词：细菌定量计数尿沉渣白细胞联合检验尿路感染尿培养诊断价值

最好自我训练对集训期新兵心理健康影响的干预研究

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陆军军医大学学报 2024年第8期46卷 912-918,F0003页

作者：靳子豪赖寒陈功金郝文赵爱军闫炫匀刘博彭李李敏陆军军医大学(第三军医大学)医学心理系军事心理学教研室重庆400038 中国人民解放军75733部队广州510000 中国人民解放军95275部队广西柳州545000

目的探究最好自我(best possible self,BPS)训练对集训期新兵心理健康状况(乐观与悲观情绪、知觉压力和主观幸福感)的干预效果。方法采用非随机对照试验设计方案,以整群抽样法于2023年9月在某新兵训练基地抽取212名新兵,根据建制分为研... 详细信息

目的探究最好自我(best possible self,BPS)训练对集训期新兵心理健康状况(乐观与悲观情绪、知觉压力和主观幸福感)的干预效果。方法采用非随机对照试验设计方案,以整群抽样法于2023年9月在某新兵训练基地抽取212名新兵,根据建制分为研究组(100人,行BPS训练15 min/d)和对照组[112人,行日常生活(typical day,TD)表象训练,15 min/d],连续干预2周。于干预当天(T0),干预实施1周(T1)、2周(T2),干预结束后1周(T3)采用未来预期量表(Future Expectation Scale,FEX)、知觉压力量表(Chinese Perceived Stress Scale,CPSS)、正负性情绪量表(Positive and Negative Affect Scale,PANAS)和生活满意度量表(Satisfaction with Life Scale,SWLS)对2组被试进行测量,评估BPS训练对上述心理健康指标的训练效果。结果2组被试的人口统计学信息及各心理学基线指标均衡。随着训练的进行,2组在悲观情绪、知觉压力和主观幸福感(包含情感和认知幸福感)上的训练效果表现出明显的差异(P<0.05)。研究组T1~T3的悲观情绪相比基线(T0)明显降低(P<0.01),情感幸福感(P<0.01)和认知幸福感(P<0.01)明显升高,其知觉压力在T1(P<0.05)和T3(P<0.01)也明显降低;而对照组在训练前后却无上述明显变化。结论2周BPS训练可有效降低集训期新兵悲观情绪和知觉压力水平,提升其主观幸福感,促进新兵心理健康。

关键词：最好自我训练乐观情绪悲观情绪知觉压力主观幸福感新兵