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恩格列净对射血分数保留型心力衰竭患者运动耐量的改善效果研究

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罕少疾病杂志 2024年第5期31卷 58-59,64页

作者：杨菊月宋建强韩克丽南阳师范学院校医院内科河南南阳473000 南阳市第一人民医院心血管内科河南南阳473000

目的观察恩格列净治疗射血分数保留型心力衰竭(HEpEF)的效果及对运动耐量改善的影响。方法前瞻性地选取2020年6月至2023年6月我院收治的73例HEpEF患者作为研究对象。根据数字随机表法随机分成给予沙库巴曲缬沙坦(36例,对照组)和恩格列净... 详细信息

目的观察恩格列净治疗射血分数保留型心力衰竭(HEpEF)的效果及对运动耐量改善的影响。方法前瞻性地选取2020年6月至2023年6月我院收治的73例HEpEF患者作为研究对象。根据数字随机表法随机分成给予沙库巴曲缬沙坦(36例,对照组)和恩格列净+沙库巴曲缬沙坦(37例,观察组)。对比疗效、运动耐量[代谢当量、峰值摄氧量(PeakVO_(2))、通气二氧化碳当量斜率(VE/VCO_(2)slope)]、生活质量[明尼苏达心力衰竭生活质量问卷(MLHFQ)]和安全性。结果观察组显效率56.76%(21/37),高于对照组的33.33%(12/36)(P0.05)。结论恩格列净治疗HEpEF可提高运动耐量改善效果,并提升预后效果,且安全性可靠。

关键词：心力衰竭恩格列净运动耐量心肺功能

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Insertion of O—H Bond of Rh(Ⅱ)-methylene Carbene into Alcohols: A Stepwise Mechanism More Plausible than a Concerted Mechanism

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Chemical Research in Chinese Universities 2007年第2期23卷 221-225页

作者： liU Zhen-feng WANG Yong YUE Xian-fang han ke-li State key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Dcdian 116023 P. R. China

The mechanisms of insertion of O-H bond of Rh（ Ⅱ ）-methylene carbene into methanol and ethanol were studied by using B3LYP functional both in gas phase and in CH2 C12. The formation of free alcoholic oxonium ylides is found to be impossible. Alcoholic oxonium ylide are formed as the intermediates before beth the stepwise and the concerted transition states of insertion of O-H bend of Rh（ Ⅱ ）-methylene carbene into methanol and ethanol. With re- gard to the mechanisms of insertion of O-H of Rh（ Ⅱ ） -methylene carbene into alcohols, analysis of the energy bartiers of the two mechanisms indicate that the stepwise mechanism is more plausible than the concerted mechanism.

关键词： Oxonium ylide 1,2-Hydrogen shift Density functional calculation Dirhodium( Ⅱ ) methylene carbene

Quantum Wave Packet Studies on F+HBr Reaction

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Chemical Research in Chinese Universities 2007年第1期23卷 96-100页

作者： QUAN Wei-long TANG Ping-ying TANG Bi-yu han ke-li Department of Physics Institute of Modern Physics Xiangtan University Xiangtan 411105 P. R. China School of Mathematics and Physics Lanzhou Jiaotong University Lanzhou 730070 P. R. China Center for Computational Chemistry and State key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China

Time-dependent quantum wave packet calculations were carried out for the F ＋ HBr reaction on the latest London-Erying-Polanyi-Sato potential energy surface constructed by Persky et al. The calculated reaction probabilities dramatically increase near the zero collision energy and then slightly decrease with increasing collision energy, which corresponds well to the behavior of a barrierless reaction. The effects of reagent HBr excitation were examined, it is shown that both the vibrational and the rotational excitations of reagent HBr have a negative effect on the reactivity of F ＋ HBr. The integral cross-section for the ground state of the reagent HBr decreases at a low collision energy and then becomes plat with increasing collision energy, which is reasonable for the feasibility of such an exothermal reaction. The rate constant that was obtained is slightly higher than that obtained in the quasi-classical trajectory calculation.

关键词： Barrierless reaction Reaction cross-section Rate constant Ro-vibrational excitation

Nectin-like Molecule 1 Inhibits the Migration and Invasion of U251 Glioma Cells by Regulating the Expression of An Extracellular Matrix Protein Osteopontin

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Chinese Medical Sciences Journal 2010年第2期25卷 100-104页

作者： Bin Yin ke-han li Tai An Tao Chen Xiao-zhong Peng National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100005 China

Objective To investigate the molecular mechanism of nectin-like molecule 1(NECL1) inhibiting the migration and invasion of U251 glioma *** We infected U251 glioma cells with adeno-nectin-like molecule 1(Ad-NECL1) or empty adenovirus(Ad).Transwell and wound healing assays were performed to observe the migration of U251 cells incubated with the cell supernatant from Ad-NECL1 or Ad infected U251 *** microarray was applied to screen the gene expression profile after the restoration of NECL1 in U251 glioma cell *** differential expression of osteopontin(OPN),a gene related to migration and invasion,was further analyzed with semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR),Western blot,and *** The restoration of NECL1 inhibited migration of U251 cells significantly(Pkedly reduced extracellular matrix protein,were found decreased in U251 cells after restoration of *** assay also detected an increase of OPN in glioma tissues,related with the progressing of malignant *** A link might exist between NECL1 and the extracellular matrix protein OPN in inhibiting the migration and invasion of U251 glioma cells.

关键词： nectin-like molecule 1 glioma cell line extracellular matrix protein osteopontin

Fewer is more:efficient object detection in large aerial images

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Science China(Information Sciences) 2024年第1期67卷 105-123页

作者： Xingxing XIE Gong CHENG Qingyang li Shicheng MIAO ke li Junwei han School of Automation Northwestern Polytechnical University Zhengzhou Institute of Surveying and Mapping

Current mainstream object detection methods for large aerial images usually divide large images into patches and then exhaustively detect the objects of interest on all patches,no matter whether there exist objects or *** paradigm,although effective,is inefficient because the detectors have to go through all patches,severely hindering the inference *** paper presents an objectness activation network(OAN) to help detectors focus on fewer patches but achieve more efficient inference and more accurate results,enabling a simple and effective solution to object detection in large *** brief,OAN is a light fully-convolutional network for judging whether each patch contains objects or not,which can be easily integrated into many object detectors and jointly trained with them *** extensively evaluate our OAN with five advanced *** OAN,all five detectors acquire more than 30.0% speed-up on three large-scale aerial image datasets,meanwhile with consistent accuracy *** extremely large Gaofen-2 images(29200 × 27620 pixels),our OAN improves the detection speed by 70.5%.Moreover,we extend our OAN to driving-scene object detection and 4K video object detection,boosting the detection speed by 112.1% and 75.0%,respectively,without sacrificing the accuracy.

关键词： efficient object detection large aerial images objectness activation network

Observation of ballistic-diffusive thermal transport in GaN transistors using thermoreflectance thermal imaging

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Rare Metals 2024年第1期43卷 389-394页

作者： Zhi-ke liu Yang Shen han-ling li Bing-Yang Cao key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

To develop effective thermal management strategies for gallium-nitride (GaN) transistors, it is essential to accurately predict the device junction temperature. Since the width of the heat generation in the devices is comparable to phonon mean free paths (MFPs) of GaN, phonon ballistic transport exists and can significantly affect the heat transport process.

关键词： temperature. transistors GaN

Broadening environmental research in the era of accurate protein structure determination and predictions

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 169-178页

作者： Mingda Zhou Tong Wang ke Xu han Wang Zibin li Wei-xian Zhang Yayi Wang State key Laboratory of Pollution Control and Resources Reuse Shanghai Institute of Pollution Control and Ecological SecurityCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Fourth People's HospitalSchool of MedicineTongji UniversityShanghai 200434China

The deep-learning protein structure prediction method AlphaFold2 has garnered enormous attention beyond the realm of structural biology,for its groundbreaking contribution to solving the"protein foiding problem"In this perspective,we explore the connection between protein structure studies and environmental research,delving into the potential for addressing specific environmental *** are promising for environmental applications because of the functional diversity endowed by their structural ***,structural studies on proteins with environmental significance remain ***,we present the opportunity to study proteins by advancing experimental determination and deep-learning prediction ***,the latest progress in environmental research via cryogenic electron microscopy is *** allows us to determine the structure of protein complexes in their native state within cells at molecular resolution,revealing environmentally-associated structural *** the remarkable advancements in computational power and experimental resolution,the study of protein structure and dynamics has reached unprecedented depth and *** advancements will undoubtedly accelerate the establishment of comprehensive environmental protein structural and functional *** opportunities for protein engineering exist to enable innovative solutions for environmental applications,such as the degradation of persistent contaminants,and the recovery of valuable metals as well as rare earth elements.

关键词： Environmental proteins Protein structure Cryogenic electron microscopy Protein structure prediction Protein engineering Artificial Intelligence

Photoinduced superlubricity on TiO_(2) surfaces

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Friction 2024年第3期12卷 428-438页

作者： ke han liran MA Yu TIAN Jianbin LUO State key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Received:16 September 2022/Revised:28 October 2022/Accepted:27 December 2022The author(s)2022.

Superlubricity control is of great interest in both industry and scientific research,and several methods have been proposed to achieve this *** this work,ultraviolet(UV)light was introduced into titanium dioxide(TiO_(2))and silicon nitride(Si_(3)N_(4))tribosystems to accomplish photoinduced *** friction coefficients(COFs)between Si_(3)N_(4) balls and TiO_(2) plates in the mixtures of sulfuric acid(H^(2)SO_(4))solution and glycerol solution were obviously reduced,and the system entered the superlubricity region(COFhan that with UV *** formation of silica(SiO_(2))layers on the surfaces of Si_(3)N_(4) balls and the elastohydrodynamic effects were determined to be fundamental to the low friction in this experiment,and the enhancement of the combination between the TiO_(2) surface and the hydroxy group of glycerol by UV illumination was the key to the photoinduced superlubricity in this *** findings showed one method for achieving superlubricity by introducing a light field that could be further applied to special working conditions.

关键词： light control friction superlubricity glycerol titanium dioxide(TiO_(2))

Phomaketals A and B,pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.

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Chinese Chemical Letters 2024年第7期35卷 350-354页

作者： Chuan li Yangyang han Yanan Zhai ke li Xingzhong liu Zhuan Zhang Cai Jia Yongsheng Che NHC key Laboratory of Biotechnology of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State key Laboratory of Toxicology&Medical Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850China Department of Microbiology College of Life SciencesNankai UniversityTianjin 300071China

Phomaketals A(1)and B(2),two tropolonic meroterpenoids with the unprecedented pentacyclic skeletons,were isolated from the solid-substrate fermentation cultures of a eupC overexpressed mutant strain of the fungus Phoma sp.,together with a biogenetically related secondary metabolite pughiinin B(3),and the known one noreupenifeldin B(4).The structures of 1–3 were elucidated primarily by nuclear magnetic resonance(NMR)*** absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations and the calculated NMR with DP4+analysis,while that of 3 was established by single-crystal X-ray diffraction analysis using Cu Kα***,phomaketals A(1)and B(2)could be derived from the hypothetical tropolonic sesquiterpene intermediates neosetophomone B(6)and 9-R-neosetophomone B(6),respectively,via different reactions *** 1 showed antiproliferative effect only against the SUPB15 cells,with an 50%inhibitory concentration(IC50)value of 4.85μmol/L,while the co-isolated known meroterpenoid 4 displayed potent effects against three tumor cell lines,SUPB15,EL4,and H9,showing IC50values of 0.36–27.08μmol/L.

关键词： Phoma sp. Tropolonic sesquiterpenes Biosynthetic pathways Hetero-Diels–Alder Cytotoxicity