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Fundamental Research 2024年第1期4卷 167-177页

作者： Xin Sun han hao Yong Geng Zongwei Liu Fuquan Zhao State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Belfer Center for Science and International Affairs Harvard UniversityCambridgeMA 02138United States Tsinghua-Rio Tinto Joint Research Center for Resources Energy and Sustainable Development Tsinghua UniversityBeijing 100084China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200240China

Lithium-ion battery(LIB)is the key technology for climate change *** sustainability of LIB supply chain has caused widespread concern since the material utilization efficiency of LIB supply chain has not been well *** study aims to fill this research gap by conducting a dynamic material flow analysis of lithium in China from 2015 to *** indicate that within the temporal boundary,lithium flow and in-use stock grew significantly in China due to the rapid development of the EV market,with lithium flow in domestic production of basic chemicals increasing by 614%to 100 kt,end-use consumption increasing by 160%to 35 kt,and in-use stock increasing by 62%to 195 *** has been a net importer of lithium,of which cumulative imports and exports were 343 kt and 169 kt,*** addition,103 kt of lithium was converted to inventories or was lost during the processing from 2015 to *** optimizing inventory and processing,developing substitutes for lithium for non-battery applications,and improving lithium recycling,China's net import dependency of lithium could be reduced from 27%-86%to 0%-16%.Our study demonstrates that it is urgent to improve material utilization efficiency so that the lithium resource supply can be secured.

关键词： Lithium Lithium-ion battery Critical material Supply chain Material flow analysis

Production of charmonium pentaquarks from b-baryon and B-meson decays:SU(3)analysis

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Chinese Physics C 2024年第5期48卷 107-116页

作者：韩伟毫邢晔徐吉 School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Physics China University of Mining and TechnologyXuzhou 221000China

Here,we study the production of charmonium pentaquarks cc¯qqq from bottom baryon and B-meson decays under the flavor SU(3)*** amplitudes for various processes are parameterized in terms of SU(3)irreducible nonperturbative *** relations between decay widths are ***,the strong decays of pentaquarks are *** results can be tested in future measurements at LHCb,Belle II,and *** decay branching fractions are measured,this study will be useful for the exploration of new decay channels and pentaquark states.

关键词： pentaquark SU(3)symmetry decay

ATP6AP2,a regulator of LRP6/β-catenin protein trafficking,promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner

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Bone Research 2024年第2期12卷 453-468页

作者： Lei Xiong hao-han Guo Jin-Xiu Pan Xiao Ren Daehoon Lee Li Chen Lin Mei Wen-Cheng Xiong Department of Neurosciences School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Louis Stoke VA Medical Center ClevelandOH 44106USA

Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types,including osteoblast(OB)differentiation and *** how Wnt/β-catenin signaling is regulated in OBs remain ***6AP2,an accessory subunit of V-ATPase,plays important roles in multiple cell types/organs and multiple signaling ***,little is known whether and how ATP6AP2 in OBs regulates Wnt/β-catenin signaling and bone *** we provide evidence for ATP6AP2 in the OB-lineage cells to promote OB-mediated bone formation and bone homeostasis selectively in the trabecular bone *** knocking out(CKO)ATP6AP2 in the OB-lineage cells(Atp6ap2^(Ocn-Cre))reduced trabecular,but not cortical,bone formation and bone *** and cellular biochemical studies revealed that LRP6 and N-cadherin were reduced in ATP6AP2-KO BMSCs and OBs,but not *** in vitro and in vivo studies revealed impairedβ-catenin signaling in ATP6AP2-KO BMSCs and OBs,but not osteocytes,under both basal and Wnt stimulated conditions,although LRP5 was decreased in ATP6AP2-KO osteocytes,but not *** cell biological studies uncovered that osteoblastic ATP6AP2 is not required for Wnt3a suppression ofβ-catenin phosphorylation,but necessary for LRP6/β-catenin and N-cadherin/β-catenin protein complex distribution at the cell membrane,thus preventing their *** of activeβ-catenin diminished the OB differentiation deficit in ATP6AP2-KO *** together,these results support the view for ATP6AP2 as a critical regulator of both LRP6 and N-cadherin protein trafficking and stability,and thus regulatingβ-catenin levels,demonstrating an un-recognized function of osteoblastic ATP6AP2 in promoting Wnt/LRP6/β-catenin signaling and trabecular bone formation.

关键词： LRP6 impaired organs

Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function

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Food Science and Human Wellness 2024年

作者： hao han Lei Tian Yajing Dong Yanyang han Xiaoman Wang Qian Cheng Haibo Zhang Yan Zhang Department of Nutrition and Food Hygiene School of Public Health Shanxi Medical University Hubei Provincial Key Laboratory of Yeast Function Research Center of Nutrition and Health Food Yichang School of Health Science and Engineering Shanghai Engineering Research Center of Food Microbiology University of Shanghai for Science and Technology

Alcoholic liver disease (ALD) is one of the major global public health problems. Yeast extract (YE)， a product prepared from yeast， has been proven to have antioxidant and anti-inflammatory properties. However， the potential role of YE in the prevention of ALD remains unclear. The present study aimed to investigate the protective effects of YE on ALD and explore the underlying mechanism based on gut microbiota. The result showed that YE supplementation significantly ameliorated chronic alcohol exposure-induced liver injury in mice. In addition， YE counteracted alcohol-induced gut dysbiosis， intestinal barrier dysfunction， lipopolysaccharide (LPS) leakage-induced inflammatory response in the liver. Moreover， microbiota depletion by a broad-spectrum antibiotic was sufficient to block the protective effect of YE on ALD， indicating the contribution of gut dysbiosis modulation to the hepatoprotective role of YE. Furthermore， we demonstrated the causal relationship between gut microbiota and hepatoprotective effects of YE with the fecal microbiota transplantation (FMT) experiment. Compared with the ALD-FMT mice， gut dysbiosis， intestinal barrier dysfunction， LPS/TLR4 signaling pathway activation， and liver inflammatory response were significantly improved in the YE-FMT mice. Together， our findings highlight that dietary YE protects against ALD through gut dysbiosis correction.

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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-Pe Xuning Zhang Sako Mirzaie hao han R.Chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-Shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRASD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

20世纪中国聚碳酸酯的发展(1949—2000)

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化学教育（中英文） 2024年第6期45卷 119-129页

作者：韩昊中国科学院自然科学史研究所北京100190 中国科学院大学北京100049

聚碳酸酯是一种工程塑料,具有优良的综合性能。新中国成立以来,聚碳酸酯被广泛用于电气、机械、航空、汽车、仪表等领域,对国防、经济建设以及尖端技术产生重大影响。考察了20世纪我国聚碳酸酯的发展历程并将其分为3阶段:第一阶段是1949... 详细信息

聚碳酸酯是一种工程塑料,具有优良的综合性能。新中国成立以来,聚碳酸酯被广泛用于电气、机械、航空、汽车、仪表等领域,对国防、经济建设以及尖端技术产生重大影响。考察了20世纪我国聚碳酸酯的发展历程并将其分为3阶段:第一阶段是1949—1970年,参考国外成果进行试制,自主建立起百吨至千吨级生产装置,解决聚碳酸酯从无到有的问题;第二阶段是1970—1978年,自主开展聚碳酸酯质量与技术攻关会战,解决产品质量不佳与技术改造升级的问题;第三阶段是1978—2000年,自主开展新技术开发并扩大产能,加快核心生产技术突破与产业规模化的问题。根据考察结果从工业化和技术、技术创新以及化学史和化学教育角度做了讨论。

关键词：高分子化学聚碳酸酯合成工艺技术攻关发展史

Geological conditions and reservoir characteristics of various shales in major shalehosted regions of China

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China Geology 2024年第1期7卷 138-149页

作者： Shu-jing Bao Tian-xu Guo Jin-tao Yin Wei-bin Liu Sheng-jian Wang hao-han Li Zhi Zhou Shi-zhen Li Xiang-lin Chen The Key Laboratory of Unconventional Petroleum Geology China Geological SurveyMinistry of Natural Resources100083 BeijingChina Oil and Gas Survey China Geological Survey100083 BeijingChina Research Institute of Yanchang Petroleum(Group)CO.LTD 710076 Xi’anChina

China is home to shales of three facies:Marine shale,continental shale,and marine-continental transitional *** types of shale gas are associated with significantly different formation conditions and major controlling *** study compared the geological characteristics of various shales and analyzed the influences of different parameters on the formation and accumulation of shale *** general,shales in China’s several regions exhibit high total organic carbon(TOC)contents,which lays a sound material basis for shale gas *** strata generally show high degrees of thermal *** contrast,continental shales manifest low degrees of thermal evolution,necessitating focusing on areas with relatively high degrees of thermal evolution in the process of shale gas surveys for these *** shales of the Wufeng and Silurian formations constitute the most favorable shale gas reservoirs since they exhibit the highest porosity among the three types of *** shales are followed by those in the Niutitang and Longtan *** contrast,the shales of the Doushantuo,Yanchang,and Qingshankou formations manifest low ***,the shales of the Wufeng and Longmaxi formations exhibit high brittle mineral *** a low siliceous mineral content,the shales of the Doushantuo Formation feature a high carbonate mineral content,which can increase the shales’brittleness to some *** marine-continental transitional shales,where thin interbeds of tight sandstone with unequal thicknesses are generally found,it is recommended that fracturing combined with drainage of multiple sets of lithologic strata should be employed to enhance their shale gas production.

关键词： Shale gas Marine shale Continental shale Marine-continental transitional shale Neoproterozoic-Cretaceous strata Geological conditions Reservoir characteristics Petroleum geological survey engineering

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多策略改进的闪电连接过程算法及其应用

控制与决策 2024年第8期39卷 2560-2568页

作者：付华刘尚霖韩冰管智峰韩昊通李琨刘昊辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125100 国网辽宁省电力有限公司盘锦供电公司辽宁盘锦124010 内蒙古电力(集团)有限责任公司乌兰察布供电分公司内蒙古乌兰察布012000

针对闪电连接过程算法鲁棒性欠佳、个体多样性有限等不足的问题,提出一种多策略改进的闪电连接过程算法.首先,采用透射学习策略和准对立学习策略有效提升初始化实验点个体质量,避免自有随机因子过度影响算法收敛性能;然后,设计实验点自... 详细信息

针对闪电连接过程算法鲁棒性欠佳、个体多样性有限等不足的问题,提出一种多策略改进的闪电连接过程算法.首先,采用透射学习策略和准对立学习策略有效提升初始化实验点个体质量,避免自有随机因子过度影响算法收敛性能;然后,设计实验点自适应动态跟随机制,在提升算法寻优性能的同时兼顾探索开发能力的协调;接着,采用镜像均值替代策略替换当前最优解和种群均值,防止算法因个体同化程度升高造成局部停滞;最后,选取基准测试函数进行智能算法对比寻优实验、改进算法对比寻优实验以及Wilcoxon符号秩检验实验,实验结果表明了所提出改进算法寻优性能的优越性以及改进策略的有效性.通过多策略改进的闪电连接过程算法优化长短时门循环控制单元参数进行变压器故障诊断工程应用实验,进一步验证所提出改进算法的工程实用性.

关键词：智能优化算法闪电连接过程算法门控循环单元变压器故障诊断油中溶解气体分析

数智技术赋能公共卫生治理:理论阐释与优化路径

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社会科学战线 2024年第2期344卷 201-211页

作者：陈书全郝翰中国海洋大学法学院山东青岛266100

数智技术以数据互通为基础,通过全方位的数据整合,力图形成公共部门、技术企业和社会公众的多元共治格局,实现公共治理水平的全面提升。公共卫生治理的集中式组织结构、多样化治理手段和分流式程序理路,为数智技术赋能公共卫生治理提供... 详细信息

数智技术以数据互通为基础,通过全方位的数据整合,力图形成公共部门、技术企业和社会公众的多元共治格局,实现公共治理水平的全面提升。公共卫生治理的集中式组织结构、多样化治理手段和分流式程序理路,为数智技术赋能公共卫生治理提供了基础空间。基于数智理念、数智结构、数智技术的分析框架,公共卫生治理得以接受数智技术的全方位赋能。在数智理念层面,应当树立包容共治理念、普惠共享价值和群体安全追求,为结构重塑和技术铺陈提供宏观基础;在数智结构层面,应当完善公共卫生治理主体、行为和程序制度结构,构建内外共治、包容审慎、守正创新的制度体系;在数智技术层面,应当通过厘清概念、设定阈值、评估效能的方法,为技术赋能提供手段支撑。

关键词：数智技术公共卫生治理治理效能多元参与外部监督

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基于能量场的城市道路车辆交互强度研究

公路交通科技 2024年第2期41卷 203-211页

作者：周贝妮韩皓李易上海海事大学物流研究中心上海201306 上海海事大学物流工程学院上海201306

由于交通环境的复杂性、车辆之间的交互多变性,无人驾驶的行为决策研究一直存在应用灵活性较差、精度不高的瓶颈。因此,以探究车辆之间的交互机理为目标,深入研究车流运行的微观规律,为无人驾驶的行为决策研究提供理论依据。首先,基于... 详细信息

由于交通环境的复杂性、车辆之间的交互多变性,无人驾驶的行为决策研究一直存在应用灵活性较差、精度不高的瓶颈。因此,以探究车辆之间的交互机理为目标,深入研究车流运行的微观规律,为无人驾驶的行为决策研究提供理论依据。首先,基于能量场的物理性质,将车辆类比于引力场中的场源,建立车辆的行车交互场模型,并依据能量场中的质量和车辆物理特性定义了交互虚拟质量,例如速度、加速度、车型。采用行车交互力模型量化车辆之间的交互程度,依据临界车头间距与多普勒效应分别重新定义交通环境中的距离和速度。其次,利用实车在上海浦东新区同顺大道采集速度、相对距离等相关数据,通过视频处理软件Kinovea提取行车记录仪中的数据,采用高斯混合模型验证行车交互力与实际驾驶行为之间的关系。最后,通过K-means算法对行车交互力聚类分析,量化车辆行驶风险等级。结果表明:通过高斯混合模型计算出的跟驰、换道分类结果与实际分类结果的误差分别为1.12%和9.1%,说明行车交互力对车辆交互的量化描述能力较好;同时,在行车交互力模型的基础上将行车风险分为4级,有效评估了行车风险。本研究提出的行车交互力模型不仅可以拓展以往行车安全场的应用范围,也为驾驶行为决策研究提供一定的理论支撑。

关键词：智能交通行车交互能量场行车风险临界车头间距高斯混合模型