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Effects of intravenous administration of polysaccharide purified from fermented barley on tumor metastasis inhibition via immunostimulating activities

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Food Bioscience 2022年第5期49卷 130-138页

作者： Seung-U Son han wool kim Min Seung Park Kwang-Soon Shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceGraduate SchoolKorea UniversitySeoul02841Republic of Korea

The present study was aimed that determine the effects of polysaccharide isolated from fermented barley about tumor metastasis inhibition via immune related factors such as complementary system,macrophages,natural killer(NK)cells,and cytotoxic T lymphocyte(CTL).To characterize the tumor inhibition effects through immunostimulation of polysaccharides purified from fermented barley,the active crude polysaccharide(BF-CP)was isolated from fermented barley and further fractionated into three purified polysaccharides(BF-I,-II,and-III)with different molecular weights through gel permeation ***-I was mainly composed of four monosaccharides,including xylose(32.90%),arabinose(26.71%),and glucose(33.43%).BF-I augmented the secretion of cytokines,such as interleukin(IL)-6,IL-12,and tumor necrosis factor-α,through peritoneal macrophages and potently activated the complement *** the experiment for NK cells and CTL activities,intravenous(i.v.)administration of BF-I significantly augmented the cytotoxicity of NK cells and CTL-mediated cytotoxicity against tumor *** addition,*** of BF-I potently inhibited tumor metastasis in a mouse model of lung cancer and tumor metastasis in mice with suppressed NK cell function through anti-asialo ***,BF-I shows potent tumor inhibition effects,and these effects are related to various immune factors such as macrophages,the complement system,NK cells,and ***,BF-I,the polysaccharide purified from fermented barley possess the new possibility for developing functional foods and medical ingredients.

关键词： Fermented barley Polysaccharide Immune system Anti-cancer

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Structural identification of active moiety in anti-tumor metastatic polysaccharide purified from fermented barley by sequential enzymatic hydrolysis

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Food Bioscience 2022年第6期50卷 139-149页

作者： Seung-U Son han wool kim Kwang-Soon Shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea

The potent anti-cancer metastatic effects induced by the immunostimulatory activities of intravenously administered BF–I,an active polysaccharide purified from fermented barley,were previously *** study aimed to evaluate the anti-cancer metastatic effect of orally administered BF–I and elucidated the microstructure and active moiety of BF–I using sequential enzymatic *** experiments using Colon26-M3.1 carcinoma,prophylactic oral administration of BF–I potently suppressed lung cancer ***,gas chromatography-mass spectrometry analysis of partially methylated alditol acetate showed that BF–I comprised 15 different glycosyl linkages,including 4-linked Xylp(16.1%),terminal Araf(12.4%),4-linked Glcp(32.8%),3-linked Glcp(13.5%),3,6-linked Glcp(1.5%),and 3,6-linked Galp(5.3%).These glycosyl linkage combinations are typical for arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II *** clarify the microstructure,BF–I was sequentially degraded via linkage-specific enzymatic hydrolysis using five ***,the sugar composition,glycosyl linkage,and reactivity with theβ-glucosyl Yariv reagent were analyzed,along with sequencing based on tandem mass spectra of partially degraded fragment *** results confirmed that BF–I comprises a mixture of four different types of polysaccharides(arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II arabinogalactan)with similar molecular ***,different polysaccharides contribute significantly to cytokine(interleukin-6,-12,and tumor necrosis factor-α)secretion by peritoneal ***,the potent anti-cancer metastatic activity of BF–I is proposed to be related to the immunostimulatory activities of the four different types of polysaccharides.

关键词： Barley Polysaccharide structure Anti-cancer Enzymatic hydrolysis

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Commuting Toeplitz Operators on Fock-Sobolev Spaces of Negative Orders

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Acta Mathematica Sinica,English Series 2023年第10期39卷 1989-2005页

作者： Hong Rae CHO han-wool LEE Department of Mathematics Pusan National UniversityBusan 46241Korea

In the setting of Fock-Sobolev spaces of positive orders over the complex plane,Choe and Yang showed that if the one of the symbols of two commuting Toeplitz operators with bounded symbols is non-trivially radial,then the other must also be *** this paper,we extend this result to the Fock-Sobolev space of negative order using the Fock-type space with a confluent hyper geometric function.

关键词： Fock–Sobolev spaces commutator of Toeplitz operators Mellin Transform Confluent Hypergeometric Function

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Factors associated with metastasis in superior mesenteric vein lymph node in subtotal gastrectomy for gastric cancer:Retrospective case control study

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Chinese Journal of Cancer Research 2020年第1期32卷 43-50页

作者： Won Ho han Jungnam Joo Bang wool Eom Keun Won Ryu Young-Woo kim Myeong-cherl Kook Hong Man Yoon Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea Division of Cancer Epidemiology and Prevention National Cancer CenterGoyang-si 410-769Republic of Korea

Objective: The revised Japanese treatment guideline for gastric cancer recommends dissection of the superior mesenteric vein lymph node(No. 14v LN) if there is metastasis in infrapyloric lymph node(No. 6 LN). However,it is still controversial whether LN dissection is necessary. The aim of this study was to investigate the factors associated with metastasis in No. 14v ***: Patients who underwent D2 lymphadenectomy between 2003 and 2010 were included. We excluded patients who underwent total gastrectomy, had multiple lesions, or had missing data about the status of metastasis in the LNs that were included in D2 lymphadenectomy. Clinicopathologic characteristics and the metastasis in regional LNs were compared between patients with No. 14v LN metastasis(14v+) and those without(14v-).Results: Five hundred sixty patients were included in this study. Univariate analysis showed that old age, larger tumor size, tumor location, differentiation, lymphatic invasion, venous invasion, perineural invasion, T classification, and N classification were related to metastasis in No. 14v LN. Multivariate analysis showed differentiation(P=0.027) and N classification(P<0.001) were independent related factors. Metastasis in infrapyloric lymph node(No. 6 LN) and proxiaml splenic lymph node(No. 11p LN) was independently associated with metastasis in No. 14v ***: Differentiation and N classification were independent factors associated with No. 14v LN metastasis, and No. 6 and No. 11p LN metastasis were independent risk factors for No. 14v LN metastasis.

关键词： Gastric cancer gastrectomy lymphadenectomy superior mesenteric vein risk factor

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A comparative study of totally laparoscopic distal gastrectomy versus laparoscopic-assisted distal gastrectomy in gastric cancer patients: Short-term operative outcomes at a high-volume center

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Chinese Journal of Cancer Research 2018年第5期30卷 537-545页

作者： Won Ho han Amir Ben Yehuda Deok-Hee kim Seung Geun Yang Bang wool Eom Hong Man Yoon Young-Woo kim Keun Won Ryu Center for Gastric Cancer National Cancer Center Department of Surgery Assaf Harofeh Medical Center

Objective： Laparoscopic gastrectomy has been established as a standard treatment for early gastric cancer, and its use is increasing recently. Compared with the conventional laparoscopy-assisted distal gastrectomy （LADG）, totally laparoscopic distal gastrectomy （TLDG） involves intracorporeal reconstruction, which can avoid the additional incision, resulting in pain reduction and early recovery. This study aimed to compare the short-term postoperative outcomes of TLDG vs. LADG in gastric cancer in a high-volume ***： A retrospective cohort study was conducted on 1,322 patients who underwent laparoscopic distal gastrectomy from June 2012 to June 2017 at the National Cancer Center, Korea. LAD G was performed in the early period before July 2015, and TLDG was applied in the later period. Postoperative short-term outcomes were compared in terms of complication and clinical course between the two groups. Pain score was measured by rating the pain intensity from 0 to 10 points on postoperative day （POD） 1 and 3. Results： A total of 667 patients underwent LADG and 655 patients underwent TLDG. Clinieopathologic characteristics were not different in both groups. Intraoperative estimated blood loss （EBL） was significantly lower in the TLDG group （P〈0.001）. Postoperative pain scores were significantly lower in the TLDG group than in the LADG group on POD 1 （5.1±1.5 vs. 4.8±1.4, P=0.015）. First flatus passage after operation was significantly earlier in the TLDG group （3.4±0.8 d vs. 3.2±0.6 d, P〈0.001）. There were no differences in postoperative complications and hospital stay between the two groups. Conclusions： Based on the reported short-term postoperative outcomes, TLDG is safe and feasible as well as LADG. Moreover, compared with LADG, TLDG can reduce intraoperative EBL and postoperative pain and enhance the bowel motility in gastric cancer surgery.

关键词： Distal gastrectomy gastric cancer intracorporeal anastomosis laparoscopic surgery

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Microstructure and texture evolution of Ti-Nb-Si based alloys for biomedical applications

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Rare Metals 2006年第Z2期25卷 163-167页

作者： kim Won-Yong kim han-Sol Advanced Materials R&D Division Korea Institute of Industrial Technology Incheon 406-130 Korea

Microstructure and texture of Ti-Nb-Si based alloys, prepared by water quenching from β-phase field, cold rolling and recrystallization heat treatment followed by water quenching, were investigated in terms of optical microstructure and analysis of X-ray pole figure result. In as-quenched sample, relatively random distribution of pole figure was detected without showing a specific texture component. In as-cold rolled sample, however, it is found well-developed several texture components consisting of rotated cube, α-fiber and γ-fiber texture components which are frequently observed in bcc-structured metals and alloys were found. Therefore, texture components developed in the present alloys are closely related to the deformation of β-phase even though small amount of α″ phase co-exist in the microstructure. In recrystallized sample, α-fiber texture component is weakly detected while the other texture components, rotated cube and γ-fiber components, appears to be relatively unchanged. No additional texture components were detected besides those texture components observed in the cold rolled samples.

关键词： Ti-Nb-Si based alloys microstructure texture

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Laparoscopy-assisted pylorus-preserving gastrectomy for early gastric cancer: A retrospective study of long-term functional outcomes and quality of life

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World Journal of Gastroenterology 2019年第36期25卷 5494-5504页

作者： Bang wool Eom Boram Park Hong Man Yoon Keun Won Ryu Young-Woo kim Center for Gastric Cancer National Cancer Center Goyang 10408 South Korea Biostatistics Collaboration Team Research Core Research institute National Cancer Center Goyang 10408 South Korea

BACKGROUND Laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG) was known to have benefits of function-preserving surgery compared to laparoscopy-assisted distal gastrectomy (LADG). However, in clinical settings, delayed gastric emptying and esophageal reflux following LAPPG can be serious issues, making surgeons reluctant to perform LAPPG. It is unclear that LAPPG had better longterm functional outcomes and quality of life compared to LADG. AIM To evaluate the long-term functional outcomes and patient-reported quality of life of LAPPG compared to those of LADG. METHODS We reviewed the clinicopathological data of 195 patients who underwent LADG with Billroth II anastomosis and 101 patients who underwent LAPPG for cT1N0 gastric cancer in the middle third of the stomach between 2012 and 2015. Postoperative complications, nutritional parameters, and survey results of the European Organization for Research and Treatment of Cancer Questionnaire C30 and STO22 questionnaire were compared between the two groups. RESULTS The serum hemoglobin level was significantly higher in the LAPPG group than in the LADG group (P han in the LADG group (P < 0.001). Regarding the quality of life score, the LAPPG group had a better physical functioning score (86.7 vs 90.0, P = 0.032) but also greater pain and reflux when compared to the LADG group [8.3 vs 16.7 in pain, 11.1 (interquartile range, 0, 22.2) vs 11.1 (interquartile range, 11.1, 33.3) in reflux, P = 0.034 and 0.001, respectively]. CONCLUSION LAPPG is beneficial to recovery of anemia and to bile reflux, however, it might be unfavorable in terms of pain and reflux symptoms compared to LADG with Billroth II anastomosis.

关键词： Gastric cancer Pylorus-preserving gastrectomy Function Quality of life

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Recent updates and current issues of sentinel node navigation surgery for early gastric cancer

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Chinese Journal of Cancer Research 2021年第2期33卷 142-149页

作者： Sung Gon kim Bang wool Eom Hong Man Yoon Chan Gyoo kim Myeong-Cherl Kook Young-Woo kim Keun Won Ryu Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea

With the increase in the incidence of early gastric cancer(EGC),several endoscopic and laparoscopic approaches,such as endoscopic submucosal dissection and function-preserving gastrectomy,have been accepted as standard *** node navigation surgery(SNNS)is an ideal surgical option for preservation of most parts of the stomach and consequent maintenance of normal gastric function to improve quality of life in patients with *** many previous studies and clinical trials have demonstrated the safety and feasibility of the sentinel node concept in gastric cancer,the clinical application of SNNS is *** issues regarding technical standardization and oncological safety need to be *** several studies to resolve these problems are being actively performed,and SNNS might be an important surgical option in the treatment of gastric cancer in the future.

关键词： Sentinel node navigation surgery function-preserving surgery early gastric cancer SENORITA

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Synthesis of high-performance nickel hydroxide nanosheets/gadolinium doped-α-MnO_(2) composite nanorods as cathode and Fe_(3)O_(4)/GO nanospheres as anode for an all-solid-state asymmetric supercapacitor

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Journal of Energy Chemistry 2022年第1期31卷 475-484,I0013页

作者： Milan Babu Poudel han Joo kim Department of Convergence Engineering Technology Jeonbuk National UniversityJeonju Jeollabuk-do 54896Republic of Korea

The wide use of manganese dioxide(MnO_(2))as an electrode in all-solid-state asymmetric supercapacitors(ASCs)remains challenging because of its low electrical *** complication can be circumvented by introducing trivalent gadolinium(Gd)ions into the MnO_(2).Herein,we describe the successful hydrothermal synthesis of crystalline Gd-doped MnO_(2) nanorods with Ni(OH)_(2) nanosheets as cathode,which we combined with Fe_(3)O_(4)/GO nanospheres as anode for all-solid-state *** tests dem on strate that Gd dopi ng sign ifica ntly affected the electrochemical activities of the MnO_(2),which was further enhanced by introducing Ni(OH)_(2).The GdMnO_(2)/Ni(OH)_(2) electrode offers sufficient surface electrochemical activity and exhibits excellent specific capacity of 121.8 mA h g^(-1),at 1A g^(-1),appealing rate performance,and ultralong lifetime stability(99.3%retention after 10,000 discharge tests).Furthermore,the GdMnO_(2)/Ni(OH)_(2)//PVA/KOH//Fe_(3)O_(4)/GO solid-state ASC device offers an impressive specific energy density(60.25 W h kg^(-1))at a high power density(2332 W kg^(-1)).This investigation thus shows its large potential in developing novel approaches to energy storage devices.

关键词： Solid-state supercapacitor Manganese dioxide Gadolinium doping Nickel hydroxide nanosheets

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Gastric cancer surgery in South Korea: Past, present, and future

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Chinese Journal of Cancer Research 2023年第6期35卷 627-635页

作者： Sung Gon kim Sang Eok Lee Bang wool Eom Hong Man Yoon Young-Woo kim Keun Won Ryu Department of Surgery Konyang University HospitalDaejeon 35365Republic of Korea Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea

Gastric cancer remains a significant global health concern and its surgical management approaches have undergone significant changes in South Korea and worldwide. Subtotal or total gastrectomy with D2 lymph node dissection is well established as a standard surgical procedure for gastric cancer. With the active implementation of cancer screening in South Korea, the proportion of early gastric cancer cases has significantly increased over the past few decades, leading to a steady increase in the survival rate among patients. Furthermore, recent advances in surgical instruments and techniques have made minimally invasive surgery increasingly prevalent, not only for early but also for advanced gastric cancer. We aim to provide a comprehensive overview of the evolution and current status of gastric cancer surgery in South Korea.

关键词： Function-preserving surgery gastric cancer minimally invasive surgery surgery

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