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Microsystems & Nanoengineering 2021年第3期7卷 63-72页

作者： han Wang Gloria M.Conover Song-i han James C.Sacchettini Arum han Department of Biomedical Engineering School of MedicineTsinghua University100084 BeijingChina Department of Biochemistry and Biophysics Texas A&M UniversityCollege StationTX 77843USA Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Medical Education Health Sciences CenterTexas A&M UniversityBryanTX 77807USA

Analysis of growth and death kinetics at single-cell resolution is a key step in understanding the complexity of the nonreplicating growth phenotype of the bacterial pathogen Mycobacterium ***,we developed a single-cell-resolution microfluidic mycobacterial culture device that allows time-lapse microscopy-based iong-term phenotypic visualization of the live replication dynamics of *** technology was successfully applied to monitor the real-time growth dynamics of the fast-growing model strain Mycobacterium smegmatis(***)while subjected to drug treatment regimens during continuous culture for 48 h inside the microfluidic device.A clear morphological change leading to significant swelling at the poles of the bacterial membrane was observed during drug *** addition,a small subpopulation of cells surviving treatment by frontline antibiotics was observed to recover and achieve robust replicative growth once regular culture media was provided,suggesting the possibility of identifying and isolating nonreplicative *** device is a simple,easy-to-use,and low-cost solution for studying the single-cell phenotype and growth dynamics of mycobacteria,especially during drug treatment.

关键词： fluid culture treatment Mycobacterium

Ai-infused Semantic Model to Enrich and Expand Programming Question Generation

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Journal of Artificial intelligence and Technology 2022年第2期2卷 47-54页

作者： i-han Hsiao Cheng-Yu Chung Santa Clara University Santa ClaraCAUSA Arizona State University TempeAZUSA

Creating practice questions for programming learning is not *** requires the instructor to diligently organize heterogeneous learning resources,that is,conceptual programming concepts and procedural programming ***’s programming question generation(PQG)is still largely relying on the demanding creation task performed by the instructors without advanced technological *** this work,we propose a semantic PQG model that aims to help the instructor generate new programming questions and expand the assessment *** PQG model is designed to transform conceptual and procedural programming knowledge from textbooks into a semantic network by the Local Knowledge Graph(LKG)and Abstract Syntax Tree(AST).For any given question,the model queries the established network to find related code examples and generates a set of questions by the associated LKG/AST semantic *** conduct analysis to compare instructor-made questions from 9 undergraduate introductory programming courses and textbook *** results show that the instructormade questions had much simpler complexity than the textbook *** disparity of topic distribution intrigued us to further research the breadth and depth of question quality and also to investigate the complexity of the questions in relation to the student ***,we report a user study results on the proposed Artificial intelligent-infused semantic PQG model in examining the machine-generated questions’quality.

关键词： Assessment Programming Semantic Modeling Automatic Question Generation

Development of anti-corrosive coating on AZ31 Mg alloy subjected to plasma electrolytic oxidation at sub-zero temperature

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Journal of Magnesium and Alloys 2022年第7期10卷 1915-1929页

作者： S.Fatimah M.P.Kamil D.i.han W.Al-Zoubi Y.G.Ko Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea

Plasma electrolytic oxidation(PEO)is a promising surface treatment to generate adherent and thick anti-corrosive coating on light-weight metals(Al,Mg,Ti,etc.)using an eco-friendly alkaline *** energy plasma,however,inevitably generates porous structures that limit their practical *** present study proposes a straight-forward simple method by utilizing sub-zero electrolyte(268 K)to alter the plasma characteristics during formation of the protective coating on AZ31 Mg alloy via PEO with a comparison to the electrolyte at room temperature(298 K).in refrigerated electrolyte,the formation of micro-defects is suppressed relatively at the expense of low coating growth,which is measured to be twice lower than that at 298 K due to the temperature-dependent soft plasma discharges contributing to the development of the present *** a consequence,corrosion resistance of the sample processed at 268 K is superior to that of 298K,implying that the effect of coating thickness is less dominant than that of *** phenomenon is interpreted in relation to the ionic movement and oxide solidification controlled by soft plasma discharges arising from the temperature gradient between electrolyte and surface of the substrate during PEO.

关键词： AZ31 Mg alloy Plasma electrolytic oxidation Sub-zero electrolyte Anti-corrosive coating Corrosion

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Physicochemical principles of hydrogen metallurgy in blast furnace

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Journal of iron and Steel Research international 2024年第1期31卷 46-63页

作者： han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China

Based on the stoichiometric method and the free energy minimization method,an ideal model for the reduction of iron oxides by carbon and hydrogen under blast furnace conditions was established,and the reduction efficiency and theoretical energy consumption of the all-carbon blast furnace and the hydrogen-rich blast furnace were *** results show that after the reduction reaction is completed at the bottom of the blast furnace,the gas produced by reduction at 1600℃still has a certain excessive reduction capacity,which is due to the hydrogen brought in by the hydrogen-rich blast as well as the excess carbon monoxide generated by the reaction of the coke and the oxygen brought in by the *** the process of the gas with excessive reduction capacity rising from the bottom of the blast furnace and gas reduction process,the excessive reduction capacity of the gas gradually decreases with the increase in the dydrogen content in the *** the all-carbon blast furnace,the excess gas reduction capacity is the strongest,and the total energy consumption per ton of iron reduction is the *** shows that,for the current operation mode of the blast furnace,adding hydrogen in the blast furnace cannot reduce the consumption of carbon required for reduction per ton of iron,but rather increases the consumption of carbon.

关键词： Hydrogen metallurgy Excess gas reduction capacity Theoretical energy consumption Hydrogen-rich blast furnace Thermodynamic model Gibbs minimum free energy method

Engineered plant extracellular vesicles for autoimmune diseases therapy

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Nano Research 2024年第4期17卷 2857-2873页

作者： Ruina han Yan Wu Yafei han Xiangfei Liu han Liu Jiacan Su institute of Translational Medicine Shanghai UniversityShanghai 200444China Organoid Research Center Shanghai UniversityShanghai 200444China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China Department of Orthopedics Shanghai Zhongye HospitalShanghai 200941China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Autoimmune diseases(AiD)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body’s own healthy *** extracellular vesicles(PEVs)are nanoscale particles enclosed by phospholipid bilayers,secreted by plant cells,which facilitate intercellular communication by transporting various bioactive *** to their nanoscale structure,safety,abundant sources,low immunogenicity,high yield,biocompatibility,and effective targeting of the colon and liver,PEVs are regarded as a promising platform for the treatment of *** review provides a comprehensive summary of PEV biogenesis,physicochemical and biological properties,internalization mechanisms,isolation methods,and their applications in various diseases,with a specific focus on their potential roles in ***,we propose engineering approaches and administration methods for ***,we present an overview of the advantages and challenges associated with utilizing PEVs for the treatment of *** gaining a comprehensive understanding of PEVs,we anticipate the development of innovative therapeutic strategies for *** and engineered PEVs hold substantial promise as a valuable resource for innovative technologies in AiD treatment.

关键词： autoimmune diseases plant extracellular vesicles extracellular vesicles engineering modification

FAST unveils a new era in the discovery of long-period pulsars in globular clusters

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 185-186页

作者： Zhanwen han international Centre of Supernovae Yunnan Key LaboratoryYunnan ObservatoriesChinese Academy of SciencesKunming 650011China

Globular clusters(GC)are among the oldest celestial bodies in the Milky *** possessing millions of stars and have been going through abundant stellar interactions,GCs are futile ground for hunting for compact objects,particularly,neutron stars.A significant number of fast-spinning millisecond pulsars(MSPs)have been discovered,comprising the majority of known GC pulsars.

关键词： stars pulsars abundant

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On equivalence of state-based potential games

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Science China(information Sciences) 2024年第6期67卷 313-327页

作者： han WU Jinhuan WANG institute of Mathematics School of ScienceHebei University of Technology

in this paper, we explore state-based potential games using the semi-tensor product of ***, applying the potential equation, we derive both a necessary and sufficient condition as well as a sufficient condition to verify whether a state-based game qualifies as a potential game. Next, we present two static equivalence conditions of state-based potential games. We then delve into dynamic equivalence. We propose a criterion that allows us to identify state-based games that are dynamically equivalent to state-based potential games and share similar dynamic properties. Ultimately, we introduce the concept of state-based networked evolutionary games. We provide a necessary and sufficient condition to ensure that a state-based networked evolutionary game can be classified as a state-based potential game.

关键词： semi-tensor product of matrices state-based potential game verification equivalence state-based networked evolutionary game

Track-before-detect for bistatic radar based on pseudo-spectrum

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Chinese Journal of Aeronautics 2024年第1期37卷 236-246页

作者： Tao han Gongjian ZHOU School of Electronics and information Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Marine Environmental Monitoring and information Processing Ministry of Industry and Information TechnologyHarbin 150001China

Track-Before-Detect(TBD) is an efficient method to detect dim targets for radars. Conventional TBD usually follows an approximate motion model of the target, which may cause an inaccurate integration of the target energy. A TBD technique on basis of pseudo-spectrum in mixed coordinates adopting an accurate motion model for bistatic radar system is developed in this *** predicted position in bistatic polar plane is derived according to a nonlinear function that exactly describes the constant Cartesian velocity motion. Then around the predicted position, a pseudo-spectrum is formulated and its samples are accumulated to the integration frame for energy integration. The evolution of the state and the procedure of accumulation of the target energy are derived elaborately. The superior performance of the proposed method is demonstrated by some simulations.

关键词： Weak target detection Bistatic radar Track-before-detect Pseudo-spectrum Multiframe integration

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Fatigue and Corrosion Fatigue Properties of Mg-Zn-Zr-Nd Alloys in Glucose-Containing Simulated Body Fluids

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1533-1550页

作者： Xue han Dan Zhang Song Zhang Mohammed R.i.Abueida Lili Tan Xiaopeng Lu Qiang Wang Huanye Liu School of Materials Science and Engineering Shenyang University of TechnologyShenyang110870China School and Hospital of Stomatology China Medical UniversityShenyang110001China Shi-Changxu innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang110819China

Medical bone implant magnesium(Mg)alloys are subjected to both corrosive environments and complex loads in the human *** increasing number of hyperglycemic and diabetic patients in recent years has brought new challenges to the fatigue performance of Mg ***,it is significant to study the corrosion fatigue(CF)behavior of medical Mg alloys in glucose-containing simulated body fluids for their clinical ***,the corrosion and fatigue properties of extruded Mg-Zn-Zr-Nd alloy in hank’s balanced salt solution(HBSS)containing different concentrations(1 g/L and 3 g/L)of glucose were *** average grain size of the alloy is about 5μm,which provides excellent overall mechanical *** conditional fatigue strength of the alloy was 127 MPa in air and 88 MPa and 70 MPa in HBSS containing 1 g/L glucose and 3 g/L glucose,*** crack initiation points for alloys in air are oxide inclusions and in solution are corrosion *** corrosion rate of the alloy is high at the beginning,and decreases as the surface corrosion product layer thickens with the increase of immersion *** corrosion products of the alloy are mainly Mg(OH)_(2),MgO and a small amount of Ca-P *** electrochemical results indicated that the corrosion rate of the alloys gradually decreased with increasing immersion time,but the corrosion tendency of the alloy was greater in HBSS containing 3 g/L *** the one hand,glucose accelerates the corrosion process by adsorbing large amounts of aggressive Cl^(-)*** the other hand,glucose will be oxidized to form gluconic acid,and then reacts with Mg(OH)_(2) and MgO to form Mg gluconate,which destroys the corrosion product film and leads to the aggravation of corrosion and the accumulation of fatigue damage.

关键词： Mg alloys Corrosion fatigue Glucose Gluconic acid Corrosion product

Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

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Journal of iron and Steel Research international 2024年第1期31卷 108-120页

作者： Zi-han Wang Jing Guo han-jie Guo Bin Li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics Zinc removal iron reduction High-temperature reduction roasting integrated utilization