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Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier

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药学学报:英文版 2023年第9期13卷 3834-3848页

作者： Thuy Giang Nguyen Cao Ji Hee kang Su Jin kang Quan Truong Hoang han chang kang Won Jong Rhee Yu Shrike Zhang Young Tag Ko Min Suk Shim Division of Bioengineering Incheon National UniversityIncheon 22012Republic of Korea College of Pharmacy Gachon UniversityIncheon 21936Republic of Korea Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciencesand BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future PharmacyCollege of Pharmacythe Catholic University of KoreaGyeonggi-do 14662Republic of Korea Research Center for Bio Materials&Process Development Incheon National UniversityIncheon 22012Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Glioblastoma(GBM)is the most aggressive malignant brain tumor and has a high mortality *** therapy(PDT)has emerged as a promising approach for the treatment of malignant brain ***,the use of PDT for the treatment of GBM has been limited by its low blood-brain barrier(BBB)permeability and lack of cancer-targeting ***,brain endothelial cell-derived extracellular vesicles(bEVs)were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the *** enhance PDT efficacy,the photosensitizer chlorin e6(Ce6)was linked to mitochondria-targeting triphenylphosphonium(TPP)and entrapped into *** Ce6(TPP-Ce6)selectively accumulated in the mitochondria,which rendered brain tumor cells more susceptible to reactive oxygen species-induced apoptosis under light ***,the encapsulation of TPP-Ce6 into b EVs markedly improved the aqueous stability and cellular internalization of TPP-Ce6,leading to significantly enhanced PDT efficacy in U87MG GBM *** in vivo biodistribution study using orthotopic GBM-xenografted mice showed that b EVs containing TPP-Ce6[b EV(TPP-Ce6)]substantially accumulated in brain tumors after BBB penetration via transferrin receptor-mediated *** such,b EV(TPP-Ce6)-mediated PDT considerably inhibited the growth of GBM without causing adverse systemic toxicity,suggesting that mitochondria are an effective target for photodynamic GBM therapy.

关键词： Extracellular vesicle Chlorin e6 Triphenylphosphonium Mitochondria-targeting photosensitizer Photodynamic therapy Blood-brain barrier Glioblastoma Transferrin receptor

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An Experimental Study on Response and Control of a Flapping-Wing Aerial Robot Under Wind Gusts

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Journal of Bionic Engineering 2024年第1期21卷 209-223页

作者： Kazuki Shimura Hikaru Aono chang-kwon kang Graduate School of Science and Technology Shinshu University3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical Engineering and Robotics 3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical and Aerospace Engineering University of Alabama in HuntsvilleTechnology Hall N266HuntsvilleAL35899USA

Bioinspired flapping-wing micro-air-vehicles(FWMAVs)have the potential to be useful aerial tools for gathering information in various *** recent advancements in manufacturing technologies and better understanding of aerodynamic mechanisms behind of the flapping flight,outdoor flights have become a ***,to fully realize the potential of FWMAVs,further improvements are necessary,particularly in terms of stability and robustness under gusty *** this study,the response and control of a tailless two-winged FWMAV under the wind gusts are *** experiments are conducted with a one-degree-of-freedom gimbal to focus on effects of wind gusts on the rotational motion of the ***-derivative and sliding-mode controls are adopted for the attitude *** present that the body angles changed in time and reached approximately 50°at the maximum due to the wing *** sliding-mode controller can more effectively control the rotational angle in the presence of disturbances and both the wing speed and changes in wind speed have an impact on the effectiveness of attitude *** results contribute to the development of of tailless two-winged,single-motor driven FWMAVs in terms of the design of attitude controller and testing apparatus.

关键词： Flapping-wing micro-air vehicles Sliding-mode control Pitch and roll angle-Wind gus

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Editor Profile: Guest Editors of the Special Issue“Functional Materials, Nanocarriers,and Formulations for Targeted Therapy”

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Acta Pharmaceutica Sinica B 2016年第4期6卷 259-260页

作者： Zhonggao Gao han-chang kang the Chinese Academy of Medical Sciences the Department of Pharmaceutics Institute of Materia Medica The Catholic University of Korea The University of Utah

Interest in functional materials,nanocarriers,and formulations for targeted therapy,which can selectively deliver therapeutic or diagnostic payloads to target sites such as organs,tissues,cells,and subcellular organel... 详细信息

关键词： targeted deliver facilitate organs targeting diagnostic Editor Profile continuously pharmaceutical sustained

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Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

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Science China Chemistry 2024年第3期67卷 755-758页

作者： Qinglin Zhang kang Liang chang Guo Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026China

Electrosynthesis has gained widespread recognition for its extraordinary ability to precisely control the redox *** outstanding capability enables the direct conversion of non-functionalized substrates into reactive intermediates by utilizing easily accessible starting materials, eliminating the need for preliminary functionalization procedures and allowing for unconventional bond activations.

关键词： Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

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Research on Optimal Preload Method of Controllable Rolling Bearing Based on Multisensor Fusion

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3329-3352页

作者： Kuosheng Jiang Chengrui han Yasheng chang School of Mechanical and Electrical Engineering Anhui University of Science and TechnologyHuainan232001China School of Optical and Electronic Information Suzhou City University&Suzhou Key Laboratory of BiophotonicsSuzhou215104China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an710054China

Angular contact ball bearings have been widely used in machine tool spindles,and the bearing preload plays an important role in the performance of the *** order to solve the problems of the traditional optimal preload prediction method limited by actual conditions and uncertainties,a roller bearing preload test method based on the improved D-S evidence theorymulti-sensor fusion method was ***,a novel controllable preload system is proposed and ***,multiple sensors are employed to collect data on the bearing parameters during preload ***,a multisensor fusion algorithm is used to make predictions,and a neural network is used to optimize the fitting of the preload *** limitations of conventional preload testing methods are identified,and the integration of complementary information frommultiple sensors is used to achieve accurate predictions,offering valuable insights into the optimal preload *** results demonstrate that the multi-sensor fusion approach outperforms traditional methods in accurately measuring the optimal preload for rolling bearings.

关键词： Multi-sensor information fusion neural network preload force

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CFD-DEM study on the synergistic effect of coke consumption and particle dynamics in the blast furnace raceway

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Particuology 2024年第6期89卷 270-278页

作者： Peng Xu Peng han Zhijun He Xizhong An kang Sun Lihua Gao Key Laboratory of Green Low-Carbon and Intelligent Metallurgy School of Materials and MetallurgyUniversity of Science and Technology LiaoningAnshan 114000China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education School of MetallurgyNortheastern UniversityShenyang110819China

In this study,the gas-solid flow process in the blast furnace raceway is numerically simulated using coupled computational fluid dynamics and the discrete element method(CFD-DEM).The coke reaction kinetics data are imported into the DEM model to reproduce the consumption process of each coke *** effects of inlet gas velocity and angle on the morphology of the raceway,coke consumption rate,coke bed temperature,and particle size distribution in the blast process are systematically investigated and *** results show that the consumption of coke particles promotes the formation of raceways during the blast *** the same time,a coke mixture layer is produced at the edge of the *** higher the inlet gas velocity,the thicker the coke mixture layer in the middle and upper parts of the raceway region,and the larger the proportion of small particles in the coke mixture *** effect of the inlet gas angle on the raceway region is less than the inlet gas ***,with the increase in the inlet gas angle,the high-temperature region of the coke bed extends downward gradually,which is conducive to activating the hearth.

关键词： Blast furnace Raceway Multiphase flow CFD-DEM Modeling

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Molecular Chaperone-Dependent Polymer Translocation through Nanopores: The Effects of Chaperone Concentration and Chaperone-Polymer Interaction

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Chinese Journal of Polymer Science 2024年第1期42卷 125-132,I0011页

作者： chang-Sheng Zuo kang Wang Li-Zhen Sun Ting-Ting Sun Department of Physics Zhejiang University of Science and TechnologyHangzhou 310023China Department of Applied Physics Zhejiang University of TechnologyHangzhou 310014China

The polymer translocation through a nanopore from a donor space(or named cis side) to a receiver space(trans side) in the chaperone-induced crowded environment has attracted increasing attention in recent years due to its significance in biological systems and technological applications. In this work, we mainly focus on the effects of chaperone concentration and chaperone-polymer interaction on the polymer translocation. By assuming the polymer translocation to be a quasi-equilibrium process, the free energy F of the polymer can be estimated by Rosenbluth-Rosenbluth method and then the translocation time τ can be calculated by Fokker-Plank equation based on the obtained free energy landscape. Our calculation results show that the translocation time can be controlled by independently tuning the chaperone concentration and chaperone-polymer interaction at the cis side or the trans side. There exists a critical chaperone-polymer attraction ε~*=-0.2 at which the volume exclusion and interaction effects of the chaperone can balance each other. Additionally, we also find that at large chaperone-polymer attraction, the translocation time is mainly governed by the diffusion coefficient of the polymer.

关键词： Polymer translocation Rosenbluth-Rosenbluth method Fokker-Plank equation Free energy landscapes

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A semantic segmentation-based underwater acoustic image transmission framework for cooperative SLAM

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Defence Technology（防务技术） 2024年第3期33卷 339-351页

作者： Jiaxu Li Guangyao han Shuai chang Xiaomei Fu School of Marine Science and Technology Tianjin UniversityTianjin 300072China

With the development of underwater sonar detection technology,simultaneous localization and mapping(SLAM)approach has attracted much attention in underwater navigation field in recent *** the weak detection ability of a single vehicle limits the SLAM performance in wide ***,cooperative SLAM using multiple vehicles has become an important research *** key factor of cooperative SLAM is timely and efficient sonar image transmission among underwater ***,the limited bandwidth of underwater acoustic channels contradicts a large amount of sonar image *** is essential to compress the images before ***,deep neural networks have great value in image compression by virtue of the powerful learning ability of neural networks,but the existing sonar image compression methods based on neural network usually focus on the pixel-level information without the semantic-level *** this paper,we propose a novel underwater acoustic transmission scheme called UAT-SSIC that includes semantic segmentation-based sonar image compression(SSIC)framework and the joint source-channel codec,to improve the accuracy of the semantic information of the reconstructed sonar image at the *** SSIC framework consists of Auto-Encoder structure-based sonar image compression network,which is measured by a semantic segmentation network's *** that sonar images have the characteristics of blurred target edges,the semantic segmentation network used a special dilated convolution neural network(DiCNN)to enhance segmentation accuracy by expanding the range of receptive *** joint source-channel codec with unequal error protection is proposed that adjusts the power level of the transmitted data,which deal with sonar image transmission error caused by the serious underwater acoustic *** results demonstrate that our method preserves more semantic information,with advantages over existing methods at the sa

关键词： Semantic segmentation Sonar image transmission Learning-based compression

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Toward a Direct Measurement of the Cosmic Acceleration: The Pilot Observation of HI 21 cm Absorption Line at FAST

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Research in Astronomy and Astrophysics 2024年第7期24卷 50-58页

作者： Jiangang kang chang-Zhi Lu Tong-Jie Zhang Ming Zhu Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences

This study presents results on detecting neutral atomic hydrogen（H I） 21 cm absorption in the spectrum of PKS PKS1413+13 at redshift z = 0.24670041. The observation was conducted by FAST, with a spectral resolution of10 Hz, using 10 minutes of observing time. The global spectral profile is examined by modeling the absorption line using a single Gaussian function with a resolution of 10 kHz within a 2 MHz bandwidth. The goal is to determine the rate of the latest cosmic acceleration by directly measuring the redshift evolution of the H I 21 cm absorption line with Hubble flow toward a common background quasar over a decade or longer time span. This will serve as a detectable signal generated by the accelerated expansion of the Universe at redshift z < 1, referred to as redshift drift z（5） or the SL effect. The measured H I gas column density in this DLA system is approximately equivalent to the initial observation value, considering uncertainties of the spin temperature of a spiral host galaxy. The high signal-to-noise ratio of 57,obtained at a 10 kHz resolution, strongly supports the feasibility of using the H I 21 cm absorption line in DLA systems to accurately measure the redshift drift rate at a precision level of around 10-10per decade.

关键词： (cosmology:) cosmological parameters (cosmology:) dark energy cosmology: observations cosmology: theory ISM: clouds radio lines: galaxies radio lines: ISM

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Nonlinear Registration of Brain Magnetic Resonance Images with Cross Constraints of Intensity and Structure

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Computers, Materials & Continua 2024年第5期79卷 2295-2313页

作者： han Zhou HongtaoXu Xinyue chang Wei Zhang Heng Dong Digital Fujian Research Institute of Big Data forAgriculture and Forestry Fujian Agriculture and Forestry UniversityFuzhou350002China College of Computer and Information Science Fujian Agriculture and Forestry UniversityFuzhou350002China

Many deep learning-based registration methods rely on a single-stream encoder-decoder network for computing deformation fields between 3D ***,these methods often lack constraint information and overlook semantic consistency,limiting their *** address these issues,we present a novel approach for medical image registration called theDual-VoxelMorph,featuring a dual-channel cross-constraint *** innovative network utilizes both intensity and segmentation images,which share identical semantic information and feature *** encoder-decoder structures calculate deformation fields for intensity and segmentation images,as generated by the dual-channel cross-constraint *** design facilitates bidirectional communication between grayscale and segmentation information,enabling the model to better learn the corresponding grayscale and segmentation details of the same anatomical *** ensure semantic and directional consistency,we introduce constraints and apply the cosine similarity function to enhance semantic *** on four public datasets demonstrates superior performance compared to the baselinemethod,achieving Dice scores of 79.9%,64.5%,69.9%,and 63.5%for OASIS-1,OASIS-3,LPBA40,and ADNI,respectively.

关键词： Medical image registration cross constraint semantic consistency directional consistency dual-channel

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