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Evaluation of Targeted Therapy for Locally Advanced or Metastatic Renal Cell Carcinoma in Tunisia

Open Journal of Gastroenterology 2016年第7期6卷 197-204页

作者： Khaled Ben Ahmed Amira Daldoul Ghassen Tlili Laila Ben Fatma Olfa Gharbi Mahdi Afrit Jihene Fkih hammouda boussen Mounir Frikha Faouzi Mosbah Slim Ben Ahmed Department of Urology Sahloul University Hospital Sousse Tunisia Department of Medical Oncology Farhat Hached University Hospital Sousse Tunisia Department of Medical Oncology Abderrahman Mami University Hospital Ariana Tunisia Department of Medical Oncology Habib Bourguiba University Hospital Sfax Tunisia

Introduction: Renal cell carcinoma (RCC) is known to be chemo resistant but with the introduction of targeted therapies;there has been a “revolution” in its treatment strategies. The only targeted therapy available in Tunisia for the treatment of metastatic and/or locally advanced RCC is sunitinib. Objective of the Study: To evaluate therapeutic results and tolerance of sunitinib in metastatic and/or locally advanced RCC. Subjects and Methods: This was a retrospective study covering a period of six years (from January 2008 to January 2014) conducted in 5 medical oncology departments in Tunisia. The population of the study consisted of 29 patients treated with sunitinib for metastatic and/or locally advanced RCC. Results: The mean age of patients was 51 years. Three patients had tumor recurrence and 26 patients had a metastatic RCC. The prognosis was good for 5 patients, intermediate for 19 patients and poor for 5 patients. The median duration of treatment was 5 months. Because of side effects, treatment was discontinued in 12.5% of cases and the dose was reduced in 10.3% of cases. Side effects consisted of asthenia (95.8%), stomatitis (70.8%), anemia (50%), hand-foot syndrome (55.8%) in addition to nausea and vomiting (54.2%). Objective response was observed in 37.5% of patients after 3 months of treatment and in 50% after 6 months. The median progression-free survival was 14 months (95% CI, 7.9 to 20.6). The median overall survival was 22 months (95% CI, 15.6 to 28.7). Conclusion: The prognosis of RCC in Tunisian patients has clearly improved with the introduction of sunitinib, but other therapies with a proven efficacy as a first and second line therapy should be considered.

关键词： Renal Cell Carcinoma Metastasis Molecular Targeted Therapy Sunitinib Drug Tolerance

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