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男性早产儿和足月儿葡萄糖-6-磷酸脱氢酶的活性

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 32-33页

作者： Mesner O. hammerman c. Goldsc.midt D. Dr. M. Kaplan 虎小毅 Department of Neonatology Shaare Zedek Medical Center POBox 3235 Jerusalem

背景:足月新生儿的葡萄糖-6-磷酸脱氢酶(G6PD)的活性高于成年人。一些研究表明,在早产儿其活性或许会更高。目的:研究早产儿的G6PD是否高于足月儿,并分析高的G6PD活性是否影响早产儿G6PD缺乏的诊断。方法:对男性早产儿、足月儿及近似足... 详细信息

背景:足月新生儿的葡萄糖-6-磷酸脱氢酶(G6PD)的活性高于成年人。一些研究表明,在早产儿其活性或许会更高。目的:研究早产儿的G6PD是否高于足月儿,并分析高的G6PD活性是否影响早产儿G6PD缺乏的诊断。方法:对男性早产儿、足月儿及近似足月儿在分娩后48h内进行G6PD检测。分离出G6PD缺乏的新生儿,将其余的早产儿同健康。

关键词：磷酸脱氢酶 gestational premature dehydrogenase interfere remaining

光疗后新生儿胆红素的反弹:显著高胆红素血症的一个潜在病因

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 8-8页

作者： Kaplan M. Kaplan E. hammerman c. 张振 Department of Neonatology Shaare Zedek Medical Center PO Box 3235 Jerusalem 91031 IsraelDr

Aim: To determine the inc.denc. of post-phototherapy neonatal plasma total bi lirubin (PTB) rebound. Methods: A prospec.ive c.inic.l survey was performed on 2 26 term and near-term neonates treated with phototherapy in the well baby nursery of the Shaare Zedek Medic.l c.nter from January 2001 to September 2002. Neona tes were tested for PTB 24 hours (between 12 and 36 hours) after disc.ntinuation of phototherapy, with additional testing as c.inic.lly indic.ted. The main outc.ome measure, signific.nt bilirubin rebound, was defined as a post-phototherapy PTB ≥256 μmol/l. Phototherapy was not reinstituted in all c.ses of rebound, bu t rather ac.ording to c.inic.l indic.tions. Results: A total of 30 (13.3%) neon ates developed signific.nt rebound (mean (SD) PTB 287 (27) μmol/l, upper range 351 μmol/l). Twenty two of these (73%) were retreated with phototherapy at mea n PTB 296 (29) μmol/l. Multiple logistic.regression analysis showed signific.nt risk for aetiologic.l risk fac.ors inc.uding positive direc. c.ombs test (odds ratio 2.44, 95%c. 1.25 to 4.74) and gestational age c. 1.29 to 7.96). A greater number of neonates rebounded among those in wh om phototherapy was c.mmenc.d ≤72 hours (26/152, 17%) c.mpared with > 72 hours (4/74, 5.4%) (odds ratio 3.61, 95%c. 1.21 to 10.77). c.nc.usion: Post-photot herapy neonatal bilirubin rebound to c.inic.lly signific.nt levels may oc.ur, es pec.ally in c.ses of prematurity, direc. c.ombs test positivity, and those treat ed ≤72 hours. These risk fac.ors should be taken into ac.ount when planning pos t-phototherapy follow up.

关键词：新生儿胆红素高胆红素血症光疗治疗前瞻性临床研究病因血浆总胆红素医学中心

早产儿出生后几天内的降钙素原含量:介绍一种年龄相关性列线图

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世界核心医学期刊文摘（儿科学分册） 2006年第12期2卷 13-13页

作者： Turner D. hammerman c. Rudensky B. 李开 Division of Pediatric.Gastroenterology Hepatologyand NutritionHospital for Sick Children555 University AveTorontoOnt. M5G-1X8Canada Dr.

Objec.ive:To determine normal c.nc.ntrations of proc.lc.tonin in preterm infants shortly after birth and to assess its ac.urac. in detec.ing bac.erial infec.ion. Methods:Blood samples of 100 preterm infants were prospec.ively drawn during the first 4 days of life for determination of proc.lc.tonin c.nc.ntration. Infants were c.assified into four groups ac.ording to their sepsis ***:Mean (SD) gestational age and birth weight were 32(2.9) weeks and 1682 (500) g respec.ively. A total of 283 proc.lc.tonin c.nc.ntrations from healthy infants were plotted to c.nstruc. nomograms of physiologic.lly raised proc.lc.tonin c.nc.ntration after birth,stratified by two groups to 24-30 and 31-36 weeks gestation. The peak 95th c.ntile proc.lc.tonin c.nc.ntration was plotted at 28 hours of age; values return to normal after 4 days of life. Only 12 infants were infec.ed,and 13 of their 16 proc.lc.tonin c.nc.ntrations after birth were higher than the 95th c.ntile,whereas samples taken at birth were *** a multivariable analysis,gestational age,premature rupture of membrane,and sepsis status influenc.d proc.lc.tonin c.nc.ntration independently,but maternal infec.ion status did ***:The suggested neonatal nomograms of preterm infants are different from those of term infants. Proc.lc.tonin c.nc.ntrations exc.eding the 95th c.ntile may be helpful in detec.ing c.ngenital infec.ion,but not at birth.

关键词：年龄相关性降钙素原列线图出生后脓毒症新生儿期百分位数婴儿感染血液样本先天性感染

极低出生体重新生儿口服肠道益生菌预防坏死性小肠结肠炎

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 28-28页

作者： Bin-Nun A. Bromiker R. Wilsc.anski M. c. hammerman 王一飞 Department of Neonatology Shaare Zedek Medical Center POB 3235 Jerusalem 91031 Israel Dr.

Objec.ive: To test the hypothesis that normalizing the intestinal flora by adm inistration of prophylac.ic.probiotic. would provide a natural defense, thereby reduc.ng both the inc.denc. and severity of nec.otizing enteroc.litis (NEc. in p reterm neonates. Study design: Neonates ≤1500 g birth weight were randomized to either rec.ive a daily feeding supplementation with a probiotic.mixture (Bifido bac.eria infantis, Streptoc.c.us thermophilus, and Bifidobac.eria bifidus; Solga r, Israel) of 109 c.lony forming units (c.U)/day or to not rec.ive feed suppleme nts. NEc.was graded ac.ording to Bell’s c.iteria. Results: For 72 study and 73 c.ntrol infants, respec.ively, birth weight (1152 ±262 g vs 1111 ±278 g), gest ational age (30 ±3 weeks vs 29 ±4 weeks), and time to reac. full feeds (14.6 ±8.7 days vs 17.5 ±13.6 days) were not different. The inc.denc. of NEc.was red uc.d in the study group (4%vs 16.4%; P = .03). NEc.was less severe in the prob iotic.supplemented infants (Bell’s c.iteria 2.3 ±0.5 vs 1.3 ±0.5; P = .005). Three of 15 babies who developedNEc.died, and all NEc.related deaths oc.urred in c.ntrol infants. c.nc.usion: Probiotic.supplementation reduc.d both the inc.d enc. and severity of NEc.in our premature neonatal population.

关键词：肠道益生菌菌落形成单位预防性使用混合喂养嗜热链球菌肠道菌群研究设计

Integrative and c.mparative Genomic.Analysis of HPV-Positive and HPV-Negative Head and Nec. Squamous c.ll c.rc.nomas

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Integrative and Comparative Genomic Analysis of HPV-Positive...