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Deciphering resistancemechanisms and novel strategies to overcome drug resistance in ovarian cancer:a comprehensive review

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Oncology Research 2024年第5期32卷 831-847页

作者： EFFAT ALEMZADEH LEILA ALLAHQOLI AFROOZ MAZIDIMORADI ESMAT ALEMZADEH FAHIMEH GHASEMI hamid salehiniya IBRAHIM ALKATOUT Infectious Diseases Research Center Birjand University of Medical SciencesBirjandIran Department of Midwifery Ministry of Health and Medical EducationTehranIran Student Research Committee Shiraz University of Medical SciencesShirazIran Department of Biotechnology Faculty of MedicineBirjand University of Medical SciencesBirjandIran Cellular and Molecular Research Center Birjand University of Medical SciencesBirjandIran Social Determinants of Health Research Center Birjand University of Medical SciencesBirjandIran Kiel School of Gynaecological Endoscopy Campus KielUniversity Hospitals Schleswig-HolsteinKielGermany

Ovarian cancer is among the most lethal gynecological cancers,primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to *** resistance(DR)poses the most significant challenge in treating patients with existing *** Food and Drug Administration(FDA)has recently approved three new therapeutic drugs,including two poly(ADP-ribose)polymerase(PARP)inhibitors(olaparib and niraparib)and one vascular endothelial growth factor(VEGF)inhibitor(bevacizumab)for maintenance ***,resistance to these new drugs has ***,understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective *** this review,we summarize the major molecular mechanisms of DR and discuss novel strategies to combat DR.

关键词： Chemotherapy Drug resistance mechanisms Ovarian cancer PARP inhibitors VEGF inhibitor

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Circulating tumor cells and circulating tumor DNA in breast cancer diagnosis and monitoring

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Oncology Research 2023年第5期31卷 667-675页

作者： EFFAT ALEMZADEH LEILA ALLAHQOLI hamidEH DEHGHAN AFROOZ MAZIDIMORADI ALIREZA GHASEMPOUR hamid salehiniya Infectious Diseases Research Center Birjand University of Medical SciencesBirjand***Iran Midwifery Department Ministry of Health and Medical EducationTehran***Iran Student Research Committee Birjand University of Medical SciencesBirjand***Iran Department of Health Assistant Shiraz University of Medical SciencesShiraz***Iran Social Determinants of Health Research Center Birjand University of Medical SciencesBirjand32048321Iran

Liquid biopsy,including both circulating tumor cells and circulating tumor DNA,is becoming more popular as a diagnostic tool in the clinical management of breast *** concentrations of these biomarkers during cancer treatment may be used as markers for cancer progression as well as to understand the mechanisms underlying metastasis and treatment ***,these circulating markers serve as tools for cancer assessing and monitoring through a simple,non-invasive blood ***,despite several study results currently noting a potential clinical impact of ctDNA mutation tracking,the method is not used clinically in cancer diagnosis among patients and more studies are required to confirm *** review focuses on understanding circulating tumor biomarkers,especially in breast cancer.

关键词： Breast cancer Liquid biopsy Circulating tumor cells Circulating tumor DNA

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Effect of magnesium on severity and mortality of COVID-19 patients: A systematic review

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Journal of Acute Disease 2022年第4期11卷 120-126页

作者： Razieh Avan Afrooz Mazidimoradi hamid salehiniya Department of Clinical Pharmacy School of PharmacyMedical Toxicology and Drug Abuse Research CenterBirjand University of Medical SciencesBirjandIran Shiraz University of Medical Sciences ShirazIran Social Determinants of Health Research Center Birjand University of Medical SciencesBirjandIran

Unbalanced magnesium levels in the body,like other minerals,are a factor that is important in the severity and mortality of *** study was designed to investigate the relationship between serum magnesium levels and clinical outcomes in COVID-19 *** this systematic review,a comprehensive search was performed in PubMed,Scopus,and Web of Science databases until September 2021 by using the keywords COVID-19,severe acute respiratory syndrome coronavirus 2,coronavirus disease,SARS-COV-infection 2,SARS-COV-2,COVID 19,and ***-Note X7 software was used to manage the *** that evaluated effect of magnesium on COVID-19 were included in the *** reviewing several articles,12 studies were finally included in the ultimate *** studies show that hypomagnesemia and hypermagnesemia are both factors that increase mortality in patients with COVID-19,even in one study,hypomagnesemia is the cause of doubling the deaths in COVID-19 *** studies have also found a negative correlation between magnesium deficiency and infection severity,while some others have reported no correlation between magnesium level and disease *** to the important role of magnesium in the body and its involvement in many physiological reactions,as well as differences in physical and physiological conditions of COVID-19 patients,in addition to the need for studies with larger sample sizes,monitoring and maintaining normal serum magnesium levels during the disease seems necessary as a therapeutic target,especially in patients admitted to the intensive care unit.

关键词： Magnesium Severity Mortality COVID-19 Systematic review

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