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Antioxidant therapy in the management of acute,chronic and post-ERCP pancreatitis:A systematic review

World Journal of Gastroenterology 2009年第36期15卷 4481-4490页

作者： Seyed Sajad Mohseni Salehi Monfared hamed vahidi Amir Hossein Abdolghaffari Shekoufeh Nikfar Mohammad Abdollahi Endocrinology and Metabolism Research Centre Tehran University of Medical Sciences Student Scientific Research Center Tehran University of Medical Science Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Food&Drug Affairs and Food&Drug Laboratory Research Center Ministry of Health&Medical Education Faculty of Pharmacy and Pharmaceutical Sciences Research Center and Endocrinology&Metabolism Research CentreTehran University of Medical Sciences

We systematically reviewed the clinical trials which recruited antioxidants in the therapy of pancreatitis and evaluated whether antioxidants improve the outcome of patients with pancreatitis. Electronic bibliographic databases were searched for any studies which investigated the use of antioxidants in the management of acute pancreatitis （AP） or chronic pancreatitis （CP） and in the prevention of post-endoscopic retrograde cholangio-pancreatography （post-ERCP） pancreatitis （PEP） up to February 2009. Twenty-two randomized, placebo-controlled, clinical trials met our criteria and were included in the review. Except for a cocktail of antioxidants which showed improvement in outcomes in three different clinical trials, the results of the administration of other antioxidants in both AP and CP clinical trials were incongruent and ***, antioxidant therapy including allopurinol and N-acetylcysteine failed to prevent the onset of PEP in almost all trials. In conclusion, the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP, CP or PER Further double blind, randomized, placebo-controlled clinical trials with large sample size need to be conducted.

关键词： Antioxidant Post-endoscopic retrogradecholangio-pancreatography pancreatitis Oxidative stress,Therapy Acute pancreatitis Chronic pancreatitis

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