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Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice

Chinese Journal of Integrative Medicine 2020年第9期26卷 683-687页

作者： Zahra Ehtemami hamed shafaroodi Jinous Asgarpanah Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical SciencesTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacology School of MedicineTehran University of Medical SciencesTehranIran

Objective:To evaluate the effects of Zhumeria majdae essential oil(ZMEO)on morphine dependence and tolerance in ***:ZMEO(10,20,and 40 mg/kg)and clonidine(0.1 mg/kg)as the positive control were injected intraperitoneally(i.p.).The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone(5 mg/kg)while the tolerance was evaluated by the tail-flick ***:ZMEO at the dose of 10 mg/kg during the development period led to a significant inhibition of morphine tolerance(P<0.01),while it led to reduced morphine dependence with the doses of 20 and 40 mg/*** at two dose levels of 20 and 40 mg/kg indicated significant antinociceptive activity(P<0.01),and significantly reduced the withdrawal signs(number of jumps)of mice(P<0.01).Conclusions:ZMEO had significant effects on morphine tolerance and *** linalool rich essential oil of Zmajdae plays a major role in the reduction of tolerance and dependence induced by morphine.

关键词： Zhumeria majdae morphine dependence tolerance

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Prognostic value of cortisol and thyroid function tests in poisoned patients admitted to toxicology ICU

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World Journal of Emergency Medicine 2018年第1期9卷 51-55页

作者： Shahin Shadnia Nasim Zamani Hossein Hassanian-Moghaddam hamed shafaroodi Mina Padandar Mohammad Hasan Rezaeizadeh Toxicological Research Center Department of Clinical ToxicologyLoghman Hakim HospitalShahid Beheshti University of Medical Sciences Excellence Center of Clinical Toxicology Iranian Ministry of Health Pharmaceutical Sciences Branch Islamic Azad University(IAUPS)

BACKGROUND: Prognostic value of cortisol and thyroid function tests(TFTs) has previously been evaluated in medical ICUs. We aimed to evaluate prognostic efficacy of cortisol and TFTs in critically ill poisoned patients admitted to toxicology intensive care unit(ICU).METHODS: In a prospective study of consecutively enrolled subjects admitted to the toxicology ICU, lab analyses included TFTs(total T3 and T4 as well as TSH) and cortisol levels drawn between 8 am–10 am during period of the first 24 hours post-ingestion/exposure. Simplified Acute Physiology Score Ⅱ(SAPS Ⅱ) and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ) were recorded. All scores were compared to detect the best prognostic factor. Type of poisoning was also ***: In 200 patients evaluated, 129 were male and mean age was 31 years. In general, SAPS Ⅱ, T4, and cortisol could prognosticate death. After regression analysis, only cortisol had such efficacy(P=0.04; OR=1.06; 95%CI=1.05–1.08; cut-off=42 μg/d L; sensitivity=70%; specificity=82%). Between aluminium phosphide(ALP)-and non ALP-poisoned patients, level of consciousness, mean arterial pressure, and cortisol level could prognosticate death in ALP poisoning(all Ps<0.001 in both uni and multivariate analyses). Median(interquartile range; IQR) GCS was 7(6, 10) and 15(8, 15) in non-ALP and ALP-poisoned patients(P<0.003). SAPS Ⅱ and APACHE Ⅱ could not prognosticate death at ***: Cortisol best prognosticated outcomes for subjects admitted to the toxicology ICU. Its level is higher in ALP-poisoned patients probably due to the higher stress while they remain conscious till the final stages of toxicity and are aware of deterioration of their clinical condition or may be due to their significantly lower blood pressures.

关键词： Prognosis Intensive care unit Cortisol Thyroid function tests Poisoning

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